Archived listing. The details below describe a past opening.
Required Skills & Experience
-B.S. with 3+ years, a M.S. with 2+ years, or a PhD in biomedical sciences with 1+ year of flow cytometry laboratory experience -Extensive hands-on experience in developing, validating, implementing and testing high-dimensional flow cytometry assays -Proficient with analysis of such multi-dimensional flow cytometry experiments with the appropriate instruments (BD/Waters & Cytek preferred) and software (particularly FlowJo, OMIQ) and ability to learn new analytical software packages -Proficiency in PBMC/BMMC isolation and cryopreservation -Experience with primary cell culture techniques
Nice to Have Skills & Experience
-Experience with FACS cell sorting -Expertise in immune cell isolation from whole blood, tissues or tumor dissociation -Background in Oncology and/or Immunology -Ability to understand and willingness to integrate current scientific literature into research practice -Experience with managing research projects at clinical flow cytometry specialty labs/CROs including assay development, analytical validation, and assay implementation
Job Description
Our large pharmaceutical client in Spring House, PA is seeking a passionate and talented scientist to join the Clinical Cytometry group within Biomarker Development & Operations. This role will support Oncology clinical programs by delivering fit-for-purpose flow cytometry biomarker assays and high-quality clinical data in a highly collaborative clinical research environment.
The successful candidate will be lab-based and should have experience with flow cytometry, primary cell handling, and cell-based assays. The role will focus on designing and executing robust ex vivo flow cytometric assays with immunophenotyping and functional readouts. Hands-on experience with clinical flow cytometry assay development, optimization, analytical validation and clinical sample analysis is highly valued.
Primary responsibilities:
- Execute multi-parameter clinical flow cytometry biomarker assays end-to-end including assay development, optimization, fit-for-purpose validation, on-time assay deployment for clinical sample testing, and downstream analysis
- Design, develop, and perform robust ex vivo and in vitro cell-based assays that incorporate functional readouts, including activation, proliferation, cytokine production, and cytotoxicity
- Handle and isolate primary human cells from blood and cryopreserved specimens for characterization and functional assessment
- Record experimental data and results accurately and well-organized following SOPs and internal document requirements including writing validation reports
- Demonstrate the ability to analyze, interpret, and present data in professional 'publication ready' format
- Demonstrate clear and professional verbal and written communication and effectively present scientific data and concepts
- Support clinical flow cytometry research projects implemented externally at external service providers/CROs.
- Monitor data quality resulting from outsourced clinical flow cytometry assays. Perform assay troubleshoot to correct errors, identify root-cause of errors and prevent re-occurrence.
- Work independently and manage multiple projects simultaneously
- Demonstrate the ability to contribute to various projects outside of his/her own, and collaborate with stakeholders from all relevant functions