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Sr. Commercial Collector
Houston Methodist
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Proficient computer skills and ability to learn and navigate multiple software programs
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Strategic Human Resources Business Partner
Houston Methodist
Katy, TX
Eight years as an HR professional in a progressive business environment to include at least seven years designing and implementing HR programs
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Manager Revenue Cycle
Houston Methodist
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Fleet Maintenance Manager
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…features and functions and / or supporting aspects of a larger program…
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Senior Manager, US Domestic Tax Planning & Technical
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Dialysis Clinical Manager Registered Nurse - RN
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Fleet Maintenance Manager
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Houston, TX
POSITION SUMMARY: The Fleet Maintenance Manager is responsible for the management of fleet equipment at one or more locations and managing a team(s) of technicians who are responsible for…
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Chief Medical Officer
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OneStream Lead Analytics and Insights Engineer II Manager
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Houston, TX · Fort Worth, TX · Westlake, TX · Dallas, TX
…budgeting and forecasting across finance and other functions. Using advanced, scalable data and tech platforms, we also generate actionable insights and analytics, streamline decision…
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Senior Technical Program Manager, CDN and Edge Security
Google
Addison, TX · Austin, TX
Share Senior Technical Program Manager, CDN and Edge Security
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Head of Program Management Office, Google Enterprise Network
Google
Austin, TX
…everyone, whether down the street or across the globe. As a Program Manager at Google, you’ll lead complex, multi-disciplinary projects from start to finish - working with stakeholders to…
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Program Manager, Enterprise AI Literacy & Enablement - (E4)
Applied Materials
Austin, TX
5+ years of program or change management experience inside a large, complex enterprise; experience in a technology, semiconductor, or advanced manufacturing environment is a plus.
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Engagement Manager II/Data
TEKsystems
Austin, TX
- $105,000 to $150,000 USD / year
The Engagement Manager II (EM II) is a delivery leadership role within the organization. The individual manages one or more projects/project teams/programs at a time. The Engagement Manager…
Added 1 min ago
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Program Manager, RES (Risk Engineering Solutions)
CBRE
Austin, TX
- $105,000 to $125,000 USD / year
CBRE is seeking a detail-oriented Program Manager to supportproject planning, management, and execution activities for Amazon's GlobalBuilding Design Risk & Recovery (GBDR) organization,…
Added 1 min ago
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Program Manager, RES (Risk Engineering Solutions)
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Austin, TX
- $105,000 to $125,000 USD / year
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Added 1 min ago
Manager, Enterprise Communications & Channels
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Austin, TX
The Manager, Enterprise Communications & Channels is responsible for developing and delivering employee communication programs that inform, engage, and connect employees to Amentum's…
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Quality Programs Data Specialist
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Vancouver, WA
Perform a variety of duties, including administrative support for the Quality Programs Manager.
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Program Manager, Space and Mission Systems
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Carlsbad, CA
- $224,500 to $336,500 USD / year
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Engineering Project Manager
City of Coeur d'Alene
Coeur d'Alene, ID
- $77,688 to $109,366 USD / year
The Engineering Project Manager performs a variety of advanced professional and technical administrative duties related to planning, coordination, design, development, review, management,…
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Customer Project Manager
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Birmingham, AL
The Customer Projects Manager reports to the Director, Field Service Operations. The role carries two areas of ownership. First, it leads the planning and execution of special…
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Sr. Program Manager I - FinOps
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At Uber Freight, we simplify the movement of goods to help communities thrive. We are seeking an experienced Senior Program Manager I to join our dynamic Financial Operations (FinOps) team.…
Added 1 hour ago
Physician Assistant/Advanced Practice Registered Nurse 1 (PCN 062293)
State of Alaska
Anchorage, AK
…professional certification in MANDT and CPR, opportunities for advanced training from specialists in advanced psychiatric and health care topics, comprehensive orientation, and annual…
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Assistant Manager(02660) - 7411 N Keystone AVE. Suite A-1
Domino's
Indianapolis, IN
The Assistant Manager is one of the most important positions in our stores. They are responsible for running great shifts, taking great care of customers, working towards store’s goals,…
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Assistant Manager(01098) - 101 N Clinton Ave
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Professional Development & Advancement – Continuous learning and development are at our core. With training programs across multiple platforms and locations, you’ll gain skills that will…

Vertex Pharmaceuticals Inc (US)

Senior Director, Portfolio & Program Management

Boston, MA, United States

$242,200 - $363,200

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Job details

Pay: $242,200 - $363,200
Experience: Typically requires 12 years of experience and 5 years of management experience, or the equivalent combination of education and experience
Posting language: English
Posted: Nov 4, 2026

Original job description

Job Description

General Summary:

The Senior Director, Portfolio & Program Management is a global role within the Program and Portfolio Management (PPM) organization. The incumbent is responsible for championing cross-functional project management excellence to programs across the drug development lifecycle (Research, Pre-clinical and Clinical Development, Registration and Commercialization). The incumbent is expected to lead the application of project management to identify opportunities, shape objectives and drive execution of global strategy for cross-functional drug development teams and portfolio operations initiatives. This role is a key leadership position within PPM, with accountability for the performance and end results of a department/area.

Key Duties and Responsibilities:

Provide strategic and operational project leadership to one or more cross-functional teams, directing activities at all stages of the project lifecycle (initiation through closeout)
Drive communication cross-functionally and with senior leaders on integrated program planning topics including timelines, status, risks and issues
Proactively identify roadblocks and/or constraints impacting strategic imperatives or project execution and lead the team through scenario planning activities
Partner with governance forums, senior leaders and/or team lead(s) to align strategy, goals and milestones with corporate objectives
Propose innovative approaches, define process improvements and advise leaders on opportunities to optimize project results
Determine approach and stakeholders for cross-functional decision-making and issue resolution
Oversee completion of project team deliverables and contribute to content development, when appropriate
Establish project team operating norms and measure performance
Apply subject matter expertise to mentor subordinate managers and high level professionals
As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned high level professionals and subordinate managers

Knowledge and Skills:

Broad and comprehensive understanding of project and portfolio management principles, options analysis, strategic planning, business case generation, finance and resource management
Leadership experience managing cross-functional teams with an ability to influence teams to prioritize activities and allocate resources to contribute to the development of operational strategy
Excellent written and oral communication skills, including well-developed presentation skills
Pharmaceutical drug discovery and development expertise across multiple disciplines
Organizational skills, an ability to manage multiple priorities
Strong collaboration skills to effectively interact with internal or external stakeholders at all levels in the organization
Advanced business management knowledge to assess the impact of project decisions on financial and corporate objectives

Education and Experience:

Typically requires a Bachelor’s degree in Life Sciences or a relevant field
Typically requires 12 years of experience and 5 years of management experience, or the equivalent combination of education and experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$242,200 - $363,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

Hybrid: work remotely up to two days per week; or select
On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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