Jobs in the United States

25+ jobs

Save this search

Added 5 mins ago
Midwest Division Development Writer
The Nature Conversancy
Remote_IL, IL
Proficient in interpreting guidelines to achieve desired results and strategic program goals.
Added 5 mins ago
Midwest Division Development Writer
The Nature Conversancy
Remote_WI, WI
Proficient in interpreting guidelines to achieve desired results and strategic program goals.
Added 6 mins ago
Senior Manager - Cybersecurity Compliance
CVS Health
Hartford, CT
The Senior Manager of Cybersecurity Compliance will lead and execute strategic initiatives related to Regulatory Compliance for CVS Health’s Enterprise Information Security team, guiding…
Added 6 mins ago
Project Manager - Medicaid
Highmark Health
Hartford, CT
The Project Manager is responsible for driving organization-wide project execution, audit readiness, and strategic compliance initiatives for complex health plan accreditation and…
Added 6 mins ago
EG
Functional Solution Leader for Individual Productivity and Team Efficiency
Eliassen Group
Hartford, CT
- $120 to $135 USD / hour
…alignment for priority job roles, partners with the Product Manager to assess effort and value, and shapes a pragmatic execution plan that links learning outcomes to measurable business…
Added 27 mins ago
Project Manager-Project Manager Senior
Ohio Power Company
Gahanna, OH · Kenton, OH · Athens, OH · Newark, OH · Canton, OH
Manage one or more intermediate and/or complex projects, up to the highest-level project complexity or a program area of projects, within a matrix team environment. Provide leadership,…
Added 34 mins ago
M
Principal Technical Program Manager
Microsoft
WA · Redmond, WA · Redmond
- $142,800 to $304,200 USD / year
…without relying on direct authority. The Principal Technical Program Manager will work closely with engineering, product management, and partner teams to ensure that strategic programs…
Added 35 mins ago
M
Global Stock Compliance Manager
Microsoft
WA · Redmond, WA · Redmond
- $86,100 to $187,400 USD / year
Microsoft’s Total Rewards organization is looking for a strategic and analytical global equity compliance professional to join our team as a Global Compliance Manager. This is an…
Added 41 mins ago
Manager, Vulnerability Management
Jobgether
Remote, United States
…shape and lead a comprehensive Product Vulnerability Management program across multiple products and services. You will establish the strategy, operating model, and capabilities needed to…
Added 56 mins ago
Data Center Strategy & Planning Manager
Meta
Menlo Park, CA
We are looking for a Data Center Strategy & Planning Manager with experience in developing infrastructure strategies. In this role, you'll be part of the team that builds Meta’s end to end…
Added 56 mins ago
Strategic Sourcing Manager Intern - Reality Labs Hardware (2027)
Meta
Menlo Park, CA
…mechanical components for Smartglasses/MR/AR programs.Work with Strategic Sourcing Managers and teams in Engineering, Quality, Operations, and Program Management. Your work will connect…
Added 56 mins ago
Manager Supply Chain Programs 2 - Category Management
Northrop Grumman
Palmdale, CA · El Segundo, CA
Northrop Grumman Aeronautics Systems has an opening for a Manager Supply Chain Programs 2 - Category Management to join our team of qualified, diverse individuals.
Added 56 mins ago
Technical Program Manager, Ring & Blink Accessories, Ring/Blink Device
Amazon
Hawthorne, CA
Are you a passionate Technical Program Manager ready to facilitate breakthrough product development that directly reduces crime and enhances community safety? RBKS seeks a customer-obsessed…
Added 57 mins ago
CC
Program Manager II
Centene Corporation
Sacramento, CA
- $70,100 to $126,200 USD / year
Position Purpose: The Program Manager II provides strategic program management for Population Health Analytics initiatives that support provider engagement, quality, and operational…
Added 57 mins ago
Assistant Manager, Behavioral Health- Child Team
Kaiser Permanente
Sacramento, CA
…provide resources. Monitors others assessment of urgent, high-risk clinical situations. Leads team to advocate for members/patients, address care issues, implement feedback, and/or…
Added 57 mins ago
Vice President, Civil Engineering Transportation Project Manager
WSP USA
San Francisco, CA · Roseville, CA · Sacramento, CA · San Jose, CA · Oakland, CA
The Project Manager will lead and manage transportation projects from initiation through closeout, ensuring successful delivery in alignment with WSP’s core values, quality standards, and…
Added 58 mins ago
Financial Advisory Senior Area Manager
Wells Fargo
SAN DIEGO, CA
…develop a team of Financial Advisors with moderate complexity and risk to achieve improved sales results through consultative sales process leveraging financial planning and driving a full…
Added 58 mins ago
Associate Director, IT Regulatory, Clinical, and Enterprise Systems
Bristol Myers Squibb
San Diego, CA
The role also involves providing strategic feedback to vendors, synthesizing multiple analyses to solve broader business issues, and representing the discipline or function on…
Added 58 mins ago
Executive Protection Specialist
Navy Federal Credit Union
Vienna, VA
Serve as liaison with the Executive Protection Program Manager and internal stakeholders to ensure seamless coordination for scheduling and travel
Added 58 mins ago
EG
Functional Solution Leader for Individual Productivity and Team Efficiency
Eliassen Group
Sacramento, CA
- $120 to $135 USD / hour
…alignment for priority job roles, partners with the Product Manager to assess effort and value, and shapes a pragmatic execution plan that links learning outcomes to measurable business…
Added 1 hour ago
GL
Director of US Oncology Portfolio Delivery
GlaxoSmithKline LLC
PA
- $169,500 to $282,500 USD / year
…local US delivery of studies in support of global oncology R&D programs. The LDL-Director is accountable for a portfolio of assets, and manages the activities of US Program Leads (PLs) and…
Added 1 hour ago
FT
Director-Performance Attribution
Franklin Templeton
IL-Remote City, IL
- $180,000 to $235,000 USD / year
…clients, and business partners understand portfolio results and risk. Working globally across Investment Management, Risk, Technology, Client Service, and Client Reporting, the team…
Added 1 hour ago
FT
Investment Associate (Quantitative Research – FT Investment Solutions)
Franklin Templeton
Boston, MA
- $80,000 to $120,000 USD / year
…including developing alpha signals, enhancing our investment risk models, and supporting our ability advise clients on strategic asset allocation. The Associate will contribute meaningful…
Added 1 hour ago
J
Interim Executive Director
Jobgether
Remote, United States
- $12,500 USD / month
…organizational change. As Interim Executive Director, you will provide strategic, values-driven leadership in close partnership with the Board, staff, and member organizations. You will…
Added 1 hour ago
NA
GENERAL ENGINEER
Naval Air Systems Command
Patuxent River, MD
- $143,913 to $197,200 USD / year
You will serve as the E-130J TACAMO Recapitalization Air Vehicle Lead Assistant Program Manager for Systems Engineering (APMSE) with PMA-271, the Airborne Strategic Command, Control and…

Vertex Pharmaceuticals Inc (US)

Portfolio & Program Management Director

Boston, MA, United States

$162,200 - $243,200

Apply About employer

Applications open in a new tab.

Job details

Pay: $162,200 - $243,200
Experience: Typically requires 10 years of experience, or the equivalent combination of education and experience.
Posting language: English
Posted: Nov 2, 2026

Original job description

Job Description

Position Summary:

The Director of Portfolio and Program Management (PPM) sits within the COO organization and provides strategic and operational leadership across a portfolio of cross-functional Research programs and projects, spanning early research through candidate preclinical development. The role is accountable for both portfolio-level oversight and direct program management, ensuring alignment with research priorities and delivery against organizational objectives. Working in close partnership with the Cell and Gene Therapies (CGT) Site Head, Chief of Staff, Program Leaders, and cross-functional stakeholders, the Director provides integrated portfolio insights, enables prioritization, drives strategic decision-making, and ensures execution of critical site and program objectives. As a key leader within Research PPM, the Director promotes high-performing, data-driven ways of working, strengthens portfolio governance and visibility, and serves as a trusted thought partner to research leadership. The role also includes line management responsibilities and contributes to the development of PPM capabilities, talent, and organizational effectiveness.

Key Duties and Responsibilities:

Partner with Program Leaders to lead portfolio planning, drive strategic decision-making, and ensure effective execution across research and early development programs.
Lead and oversee a portfolio of Research programs and projects from early research through candidate preclinical development, ensuring alignment to organizational and corporate priorities.
Directly lead priority cross-functional projects and programs, driving planning, execution, decision-making, and delivery against key milestones and goals.
Partner closely with the CGT Site Head and Chief of Staff to provide clear, accurate, and timely portfolio and program updates, including status, risks, milestones, resource needs, and decision points, while helping ensure delivery of site objectives.
Guide cross-functional R&D teams to establish high-performing, data-driven ways of working that deliver on corporate objectives and priorities.
Lead the approach for cross-functional decision-making and issue resolution, identifying key stakeholders and driving alignment on priorities, governance, and actions.
Develop and maintain integrated portfolio and project timelines and reporting, defining critical path activities, interdependencies, and potential bottlenecks.
Proactively identify, assess, mitigate, and escalate risks, gaps, challenges, and roadblocks that could impact program or site delivery.
Lead the generation of program assumptions for annual resource allocation and budgeting across Research and Development functions.
Identify, communicate, and manage resource constraints, synergies, and redundancies across the portfolio.
Effectively manage key meetings, stakeholder communications, action items, decisions, and follow-through to support execution and accountability.
Communicate complex topics to stakeholders through effective storytelling and content creation.
Establish team operating norms and identify opportunities to improve team and portfolio performance.
Work with Portfolio and Program leadership to build, manage, coach, and retain PM staff.
Serve as a key PPM leader, translating site goals into actionable portfolio and project plans.

Knowledge and Skills:

Demonstrated ability to lead a portfolio of complex projects in a fast-paced Research environment.
Strong ability to partner with senior site leadership to translate strategic priorities into executable plans.
Proven ability to drive accountability and delivery across matrixed cross-functional teams.
Comprehensive knowledge of project and portfolio management principles, best practices, tools, technology and methods.
Leadership experience managing cross-functional teams.
Excellent written and oral communication skills, including well-developed presentation skills.
Comprehensive pharmaceutical drug discovery and development knowledge across multiple disciplines.
Exceptional organizational skills and an ability to manage multiple priorities.
Strong collaboration skills to effectively interact with internal or external stakeholders at all levels of the organization.
Ability to work in a fast-paced and collaborative environment and manage multiple concurrent projects with a high degree of independence.
Experience in carrying out Risk Analysis, Decision Analysis and Contingency Planning.
A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society.
Ability to embody the Vertex Core Values of Uncompromising Commitment to Patients, Fearless Pursuit of Excellence, Innovation is Our Lifeblood, and “We” Wins.

Education and Experience:

Typically requires an advanced degree in Life Sciences or a relevant field, (PhD degree preferred or strong demonstration of equivalent combination of relevant educational and professional training).
Typically requires 10 years of experience, or the equivalent combination of education and experience.
Typically requires significant experience in portfolio and program management within drug discovery and/or early development, including leadership of cross-functional teams and complex project portfolios.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$162,200 - $243,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

Hybrid: work remotely up to two days per week; or select
On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Apply About employer

Report this job