Jobs in the United States

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Added 3 mins ago
SO
Management Analyst 4 – Nonpermanent (MA4/AHSO)
State of Washington
Remote, United States
- $71,136 to $95,628 USD / year
Participates with senior level management staff in developing strategies for the available use of resources, defining departmental needs and priorities, long range planning, and setting…
Added 3 mins ago
SO
IT Application Development - Senior/Specialist
State of Washington
Olympia, WA
- $99,300 to $133,608 USD / year
…Child Nutrition Services administer the USDA Food Distribution Program by allocating entitlement dollars to participating programs, offering food for ordering and subsequent delivery to…
Added 19 mins ago
G
Mechanical Project Manager
GPAC
Winder, GA
- $110,000 to $150,000 USD / year
5+ years of commercial mechanical project management experience
Added 22 mins ago
Commissioning Senior Manager (data centers)
Equinix LLC
United States
As Senior Manager, Commissioning, you will lead the planning and execution of commissioning across large-scale greenfield data center developments and complex retrofit projects within live,…
Added 29 mins ago
UA
Chief, Engineering and Construction Division
U.S. Army Corps of Engineers
Buffalo, NY
- $154,707 to $197,200 USD / year
…Engineers (USACE), ensuring clear communication, comprehensive risk management, and strategic decision-making. | Program and Project Management: Provide effective management and supervisory…
Added 30 mins ago
SC
Sr. Consultant, Professional Services (Microsoft Security)
Softchoice Corporati
Denver, CO
- $116,800 to $146,000 USD / year
As a Senior Microsoft Security Consultant within the Professional Services organization, you will have the opportunity to consult with and advise our valued enterprise and public sector…
Added 30 mins ago
IL
Senior Manager, Development
Invenergy LLC
Denver, CO
- $165,000 to $200,000 USD / year
The Senior Manager of Renewable Development will manage the development of utility-scale solar and wind energy projects throughout the upper Midwest.
Added 30 mins ago
Technical Program Manager, Pacing
Anthropic
San Francisco, CA · New York City, NY
We're hiring a Technical Program Manager to run Pacing. It spans many projects led by people across Safety, Research, Policy, Legal, Communications, and Engineering, most of whom have other…
Added 42 mins ago
SS
Provider Relations Lead - Village Health
SHPCA SCAN Health Plan
Long Beach, CA
- $71,700 to $123,490 USD / year
Founded in 1977 as the Senior Care Action Network, SCAN began with a simple but radical idea: that older adults deserve to stay healthy and independent. That belief was championed by a…
Added 47 mins ago
FA
Management and Program Analyst
Federal Aviation Administration
Honolulu, HI · San Diego, CA · Longmont, CO · El Segundo, CA · Grand Junction, CO · Fairbanks, AK · Anchorage, AK · Auburn, WA · Rancho Cordova, CA · Fremont, CA · Salt Lake City, UT · Des Moines, WA · Las Vegas, NV
- $77,351 to $119,883 USD / year
Your application/resume must have your official title, grade and series in your work history
Added 49 mins ago
DI
PROGRAM ANALYST (INTERNATIONAL CASE COORDINATOR)
Defense Information Systems Agency
Fort Meade, MD
- $143,913 to $187,093 USD / year
…near-term and long-range plans and schedules to manage major program changes; OR, experience using qualitative and quantitative methods and techniques to assess program/project…
Added 49 mins ago
UA
Engineering Technician (Civil)
U.S. Army Corps of Engineers
New Orleans, LA
- $40,736 to $80,243 USD / year
…and impacts to contract administration, modifications, and project…
Added 52 mins ago
Electrical Project Manager
Stryker Electrical Contracting
Palm City, FL
In this role, you’ll partner directly with senior leadership, field teams, and our Estimating Department to drive successful project outcomes. If you are a hands-on project leader with…
Added 1 hour ago
J
Sr. Customer Sales Manager- Military
Jobgether
Remote, United States
- $120,800 to $151,000 USD / year
As a Senior Customer Sales Manager, you will lead strategic sales development and business growth across a major military customer portfolio representing approximately $70 million in annual…
Added 1 hour ago
J
Senior Associate Technical Consultant - CTEM / Vulnerability Management Engineer
Jobgether
Remote, United States
- $100,000 to $120,000 USD / year
…all applications and next steps. Our partner is looking for a Senior Associate Technical Consultant – CTEM / Vulnerability Management Engineer based in the United…
Added 1 hour ago
Property Manager
Team Architects
Manchester, NH
Realty Management Partners (RMP) is a growing third-party real estate management company with approximately 50 employees across five business divisions: Commercial Property Management,…
Added 1 hour ago
Senior Creative Producer, Podcasts & Branded Content
Full Picture
West Hollywood, CA
We are in office 3 days per week and remote for 2 days per week
Added 1 hour ago
Senior Creative Producer, Podcasts & Branded Content
Full Picture
NY · New York, NY
We are in office 3 days per week and remote for 2 days per week
Added 1 hour ago
Director of Information Technology
KRUSH Tech Inc
Austin, TX
Core IT processes (onboarding and offboarding, access management, change management, asset management, and incident response) documented, owned, and running consistently.
Added 1 hour ago
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Controller
STIIIZY
Vernon, CA
- $160,000 to $210,000 USD / year
Communicate and present clearly to all levels of the organization, including senior management
Added 1 hour ago
SC
TopStitch - Early Career Development Program
Stitch Consulting Services, Inc.
Indianapolis, IN
- $70,000 USD / year
TopStitch is our early-career developmental program at Stitch, built to develop a new generation of AI-enabled young professionals. You'll join a select group of just 2-3 high-caliber peers…
Added 1 hour ago
BH
Director of Data Center Development
Black Hills Energy
Golden, CO
- $170,000 to $280,550 USD / year
…in fields related to business development, finance, account management, project management, strategic planning, or commercial growth is…
Added 1 hour ago
Sr. Director, Program Performance - NPC
Vizient, Inc.
Centennial, CO
…inclusive environment both now and in the future. Summary: The Senior Director, Program Performance, Northeast Purchasing Coalition (NPC) will be accountable for the performance, execution,…
Added 1 hour ago
Engineering Manager III
General Atomics
Centennial, CO
Generate electrical and avionics architecture solutions for new project needs; perform electrical engineering analyses for systems and circuits; document findings; communicate results to…
Added 1 hour ago
Director of Operations and Special Projects, Product Technologies - 1111
Quantinuum
Broomfield, CO

Vertex Pharmaceuticals Inc (US)

Portfolio & Program Management Director

Boston, MA, United States

$162,200 - $243,200

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Job details

Pay: $162,200 - $243,200
Experience: Typically requires 10 years of experience, or the equivalent combination of education and experience.
Posting language: English
Posted: Nov 2, 2026

Original job description

Job Description

Position Summary:

The Director of Portfolio and Program Management (PPM) sits within the COO organization and provides strategic and operational leadership across a portfolio of cross-functional Research programs and projects, spanning early research through candidate preclinical development. The role is accountable for both portfolio-level oversight and direct program management, ensuring alignment with research priorities and delivery against organizational objectives. Working in close partnership with the Cell and Gene Therapies (CGT) Site Head, Chief of Staff, Program Leaders, and cross-functional stakeholders, the Director provides integrated portfolio insights, enables prioritization, drives strategic decision-making, and ensures execution of critical site and program objectives. As a key leader within Research PPM, the Director promotes high-performing, data-driven ways of working, strengthens portfolio governance and visibility, and serves as a trusted thought partner to research leadership. The role also includes line management responsibilities and contributes to the development of PPM capabilities, talent, and organizational effectiveness.

Key Duties and Responsibilities:

Partner with Program Leaders to lead portfolio planning, drive strategic decision-making, and ensure effective execution across research and early development programs.
Lead and oversee a portfolio of Research programs and projects from early research through candidate preclinical development, ensuring alignment to organizational and corporate priorities.
Directly lead priority cross-functional projects and programs, driving planning, execution, decision-making, and delivery against key milestones and goals.
Partner closely with the CGT Site Head and Chief of Staff to provide clear, accurate, and timely portfolio and program updates, including status, risks, milestones, resource needs, and decision points, while helping ensure delivery of site objectives.
Guide cross-functional R&D teams to establish high-performing, data-driven ways of working that deliver on corporate objectives and priorities.
Lead the approach for cross-functional decision-making and issue resolution, identifying key stakeholders and driving alignment on priorities, governance, and actions.
Develop and maintain integrated portfolio and project timelines and reporting, defining critical path activities, interdependencies, and potential bottlenecks.
Proactively identify, assess, mitigate, and escalate risks, gaps, challenges, and roadblocks that could impact program or site delivery.
Lead the generation of program assumptions for annual resource allocation and budgeting across Research and Development functions.
Identify, communicate, and manage resource constraints, synergies, and redundancies across the portfolio.
Effectively manage key meetings, stakeholder communications, action items, decisions, and follow-through to support execution and accountability.
Communicate complex topics to stakeholders through effective storytelling and content creation.
Establish team operating norms and identify opportunities to improve team and portfolio performance.
Work with Portfolio and Program leadership to build, manage, coach, and retain PM staff.
Serve as a key PPM leader, translating site goals into actionable portfolio and project plans.

Knowledge and Skills:

Demonstrated ability to lead a portfolio of complex projects in a fast-paced Research environment.
Strong ability to partner with senior site leadership to translate strategic priorities into executable plans.
Proven ability to drive accountability and delivery across matrixed cross-functional teams.
Comprehensive knowledge of project and portfolio management principles, best practices, tools, technology and methods.
Leadership experience managing cross-functional teams.
Excellent written and oral communication skills, including well-developed presentation skills.
Comprehensive pharmaceutical drug discovery and development knowledge across multiple disciplines.
Exceptional organizational skills and an ability to manage multiple priorities.
Strong collaboration skills to effectively interact with internal or external stakeholders at all levels of the organization.
Ability to work in a fast-paced and collaborative environment and manage multiple concurrent projects with a high degree of independence.
Experience in carrying out Risk Analysis, Decision Analysis and Contingency Planning.
A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society.
Ability to embody the Vertex Core Values of Uncompromising Commitment to Patients, Fearless Pursuit of Excellence, Innovation is Our Lifeblood, and “We” Wins.

Education and Experience:

Typically requires an advanced degree in Life Sciences or a relevant field, (PhD degree preferred or strong demonstration of equivalent combination of relevant educational and professional training).
Typically requires 10 years of experience, or the equivalent combination of education and experience.
Typically requires significant experience in portfolio and program management within drug discovery and/or early development, including leadership of cross-functional teams and complex project portfolios.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$162,200 - $243,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

Hybrid: work remotely up to two days per week; or select
On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Apply on vrtx.wd501.myworkdayjobs.com About employer

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Jobs in the United States