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Vaxcyte

Senior Engineer, Conjugation Development

San Carlos, CA, United States

Salary Range: $170,000 - $198,000 (SF Bay Area).

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Job details

Pay: Salary Range: $170,000 - $198,000 (SF Bay Area).
Posting language: English
Posted: Nov 11, 2026

Original job description

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

The Development organization is comprised of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product. These Process Development teams are supported by Analytical Development and Formulation Development teams. Vaxcyte is looking for a Sr. Engineer with experience in campaign support, tech transfer, and GMP/regulatory authoring to join the Conjugation engineering team. The candidate will manage the TFF and dead end filtration operations of our CMO partners, transfer new conjugation processes from the San Carlos labs to a CDMO, and generate documentation supporting our regulatory filings.

Essential Functions:

Lead all pre-commercial CDMO TFF and filtration operations across our conjugation network, and provide technical support to our commercial operation partners
Contribute to CMO manufacturing preparation and oversight via document authoring, document review, person in plant responsibilities, and troubleshooting when necessary
Develop data analytics platforms to trend and summarize GMP and Commercial process performance, enabling both process optimization as well as Continued Process Verification
Support scale-up activities and tech transfer of early phase clinical candidates to an external CMO
Facilitate cross-functional process risk analysis using appropriate tools such as FMEA
Present/communicate data to the Conjugation Development team as well as broader CMC team
Collate data and author supplementary documents for BLA, CPV, and other regulatory interactions
Serve as a guide and mentor to junior team members

Requirements:

PhD in Chemical/Biochemical Engineering or similar, with 2+ years of industry experience; MS with 5+ years of industry experience; or BS with 10+ years of industry experience
Both practical experience with and theoretical knowledge of engineering principles involved in scaling processes from development lab to pilot / manufacturing plant
Working knowledge of the requirements of GMP manufacturing, preferably with hands on GMP experience through either a Manufacturing or MSAT role
Experience working with CMOs highly desired; ability to effectively transfer processes to CMO, and to oversee development and manufacturing activities performed at CMO; ability to travel to CMO (some international travel required) to perform person-in-plant oversight activities
Solid understanding of the principals of DoE (Design of Experiments)
Experience with late-stage process development activities such as risk assessments (e.g., FMEA) and identification of CPPs and CQAs is a plus
Experience writing IND, BLA, or CPV sections is a plus
General regulatory experience is a plus
Expertise in tangential flow filtration (TFF) and dead end filtrations
Bioconjugate or protein purification knowledge and experience, process scaling and optimization, and reactor scale up is a plus
Demonstrated success working in a cross-functional team environment on multiple projects; ability to work both on a team (as member and/or leader) and independently to deliver results
Strong interpersonal skills, with excellent written and verbal communication skills

Reports to: Associate Director, Conjugation Development

Location: San Carlos, CA

Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): Onsite (minimum of 4 days per week onsite)

Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $170,000 - $198,000 (SF Bay Area). Salary ranges for non-California locations may vary. Equal Opportunity

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

Recruitment Fraud Notice

Please be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers.

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More about this job

Skills

Decision making
Technical support
Troubleshooting
Data analysis
Good manufacturing practices
Engineering principles
Interpersonal skills
Communication skills

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Work requirements

Jobs in the United States