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Vaxcyte

Process Engineer I, Data and Knowledge Management

San Carlos, CA, United States

Salary Range: $121,000 - $142,000

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Job details

Pay: Salary Range: $121,000 - $142,000
Posting language: English
Posted: Oct 30, 2026

Original job description

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

As we grow, we are seeking a strategic and collaborative Process Engineer I, Data and Knowledge Management to ensure the integrity, accessibility, and effective use of data and knowledge assets across the organization. This role will execute component-level analysis, utilizing data and knowledge resources critical to our process development, regulatory, and operational activities. The Process Engineer I, Data and Knowledge Management is instrumental in ensuring scientific data integrity, regulatory readiness, and the preservation of institutional knowledge in a dynamic, fast-paced clinical environment.

Essential Functions:

Engineering Analytics & Process Insights:

Assess process trends and discrepancies using engineering knowledge, and evaluate the technical rationale and potential impact of proposed process improvements
Apply chemical and biochemical engineering principles to evaluate relationships between process parameters, unit operation performance, and product quality attributes
Partner with data science team to drive data visualization, reporting, and insights.
Support the use of AI/ML and automation for improved data analysis and knowledge extraction.

Manufacturing Process Data Management & Governance:

Acquire, integrate, and technically evaluate manufacturing process data from internal teams and contract manufacturing sites to support process monitoring, continuous improvement, and CMC regulatory submissions.
Develop data management and verification workflows that preserve the accuracy, integrity, and traceability of manufacturing process data.
Lead and own data verification for all commercial regulatory submissions.

Process Knowledge Management:

Develop structured systems and workflows to capture and retain organizational knowledge, including protocols, study results, lessons learned, and decision rationales.
Develop tools and processes that enable technical teams to access, share, and apply process knowledge to support manufacturing and process improvement.
Champion a knowledge-sharing culture across technical, scientific and operational functions.

Collaboration & Technical Leadership:

Partner with regulatory, quality, R&D, IT and contract manufacturing teams to understand technical needs and develop appropriate solutions.

Compliance & Risk Management:

Ensure compliance with data protection and clinical trial regulations, including GDPR, HIPAA, and 21 CFR Part 11.
Identify and mitigate risks related to data security, access, and retention.

Requirements:

Bachelor’s degree in Chemical Engineering, Bioprocess Engineering, or a related engineering discipline is required. 8+ years of relevant experience in biopharmaceutical process engineering, Manufacturing Science and Technology (MSAT), process development, manufacturing technical support, or related engineering work, including at least 3 years in the life sciences or biotechnology industry. Other combinations of education and/or experience may be considered.

Experience interpreting manufacturing process data and applying engineering and statistical methods to evaluate process performance.
Proven experience leading enterprise data governance and knowledge sharing initiatives in a highly regulated environment.
Strong technical communication, project management, and cross-functional collaboration skills, with the ability to work effectively with engineering, scientific, and manufacturing teams.
Experience with tools like SharePoint, Veeva Vault, Confluence, Tableau, and SQL is highly desirable.

Preferred:

Experience supporting clinical trials and regulatory submissions (e.g., IND, BLA).
Background in immunology, vaccines, or infectious disease R&D.
Experience in scaling systems and processes in a high-growth, early- to mid-stage.

Reports to: Senior Director, Process Validation, Global MSAT

Location: United States

Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy):

Remote

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $121,000 - $142,000

Relocation:

This role is not eligible for relocation assistance. Equal Opportunity

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

Recruitment Fraud Notice

Please be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers.

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More about this job

Skills

Decision making
Engineering principles
Data visualization
Reporting
ML
Data analysis
Manufacturing processes
Process improvement
Data management
Regulatory compliance
Data protection
Apply information security policies
Chemical engineering
Process engineering
Technical support
Biotechnology
Communication skills
Project management
Collaboration
Microsoft SharePoint
Atlassian Confluence
Tableau
SQL
Clinical trials

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