Scientist, Protein Sciences

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a Scientist to join our Antigen Science team, where you will own the production and characterization of membrane protein antigens that support therapeutic discovery programs. You will design and run the experiments, make sound technical decisions, and deliver well-characterized reagents on program timelines. The team works on challenging membrane targets, including GPCRs and other multi-pass proteins, and you will bring independent scientific judgment to difficult expression, purification, and reconstitution problems.

Responsibilities

• Independently design, execute, and troubleshoot expression and purification workflows for membrane protein constructs.
• Engineer and optimize membrane protein antigen constructs to improve expression, and stability, selecting formats appropriate to the downstream application.
• Develop and refine detergent, lipid, and buffer conditions to maintain membrane protein integrity through purification and storage.
• Prepare and characterize alternative antigen formats, including nanodiscs, liposomes, and other detergent-free systems.
• Establish and execute quality control for each antigen batch, including purity, identity, homogeneity, and conformational integrity.
• Partner with antibody discovery, engineering, and assay development colleagues to understand their reagent needs and deliver accordingly.
• Present results to the team and cross-functional partners, and contribute to technical reports, publications, and patent applications.

Qualifications

• PhD in Biology, Biochemistry, Biophysics, Molecular Biology, or a related field, with 0-3 years of industry or postdoctoral experience.
• Demonstrated ability to work independently, from experimental design through analysis and reporting.
• Experience with mammalian or insect cell expression systems.
• Hands-on experience in membrane protein purification (e.g. GPCRs, ion channels, transporters).
• Familiarity with reconstitution approaches such as nanodiscs, liposomes, or detergent-free systems.
• Clear written and verbal communication skills and a collaborative approach to cross-functional work.

Preferred Qualifications

• Experience with mass photometry, SEC-MALS, BLI, SPR, or circular dichroism.
• Experience with antibody discovery or immunization workflows.
• Publications in peer-reviewed journals.

Compensation and Benefits:

The expected base salary range for this position is $90,000 - $115,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills. While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.