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Stoke Therapeutics

Associate Director, Clinical Science

Bedford, MA, United States

The anticipated salary range for this role is $200,000 - $245,000.

Apply on stoketherapeutics.com About employer

Applications open in a new tab.

Job details

Pay: The anticipated salary range for this role is $200,000 - $245,000.
Education: Doctoral degree
Experience: 5+ years of clinical drug development experience
Posting language: English
Posted: Nov 13, 2026

Original job description

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/

Position Purpose:

The Associate Director, Clinical Science will play a pivotal role in advancing Stoke's ongoing clinical programs. The Clinical Scientist will work with the cross-functional team to define medical data review requirements that ensure data quality and interpret data to support strategy. They will contribute/author regulatory documents, publications, and presentations that accurately communicate study results. The Clinical Scientist will support or lead design of clinical protocols, serve as the subject matter expert in clinical outcome assessments and endpoint measures and will provide training for investigators and study teams as needed.

The Clinical Scientist will provide scientific leadership across cross-functional teams. They will partner with the cross-functional team including medical directors, data management, clinical operations, regulatory, medical affairs and external stakeholders to align program and study documents, support endpoint strategy, and provide scientific input across program and study level activities. This position will report into the Senior Director, Clinical Science.

Key Responsibilities:

Lead cross-functional efforts to identify clinical data analysis needs across studies and programs
Define and drive the clinical data analysis strategy to support clinical decision-making, safety/efficacy evaluation, publications and communications, and regulatory filings
Lead the completion of exploratory and ad hoc analyses to support the clinical data analysis strategy
Ensure analytical outputs align with scientific objectives and regulatory expectations, maintaining data integrity and consistency across documents
Present complex data findings clearly to cross-functional teams and externally as needed
Develop, co-author and review key strategic documents including but not limited to Clinical Development Plans, Protocol Concepts and Full Protocols, Investigator Brochures, Briefing Documents, Safety Updates, IND/NDA submission documents, Responses to Health Authorities Inquires and Clinical Study Reports in conjunction with other members of the clinical study/program teams as needed
Serve as an interface for clinical studies between clinical development and multiple internal functions including clinical development operations, data management, biostatistics, regulatory, program management and DMPK/biomarkers and external teams as needed for clinical-development initiated projects
Develop expertise in core clinical assessments incorporated in clinical studies and provide education and training to key stakeholders, including at investigator meetings, as needed, in order to ensure quality completion
Support medical monitoring activities, including review of eligibility, safety data review and trend identification
Collaborate with functions including data management to continuously enhance processes for the timely and efficient internal review of clinical data
Develop effective working relationships with key stakeholders including investigators to optimize scientific quality and innovation in clinical study design, execution, reporting and publication
Represent clinical development at advisory boards, investigator meetings, site initiations, and other external engagements
Attend scientific meetings to interact with investigators and advisors and to present clinical data, as needed

Required Skills & Experience:

Advanced degree required (e.g., M.S., PharmD, Psy.D. or Ph.D. ) in a life science, clinical research or another similar field
5+ years of clinical drug development experience
Experience in neurology indications or experience with interpretation of clinical outcome assessments of neurodevelopment, cognition, adaptive functioning and behavior (eg, BSID-IV, WPPSI-IV, Vineland-3) is preferred
Proficient knowledge and skills to support clinical trial data review, trend identification, data interpretation
Experience having close collaboration with data management, biostatistics/programming teams
Exceptional written and oral communication skills tailored to varied audiences
Proven ability to work independently and collaboratively, as required, in a dynamic, fast-paced environment consisting of internal and external team members
Strong interpersonal skills commensurate with the need to work closely with a broad range of stakeholders, from investigators to internal teams
Attention to detail and a commitment to delivering high-quality work
Strong planning, organization and time management skills including the ability to prioritize multiple complex initiatives
A sense of passion and urgency to achieve goals and improve the lives of patients

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Location(s):

This position has a flexible work arrangement, with regular presence at our Waltham office, which we will be moving to in January 2026. At Stoke, we value in-person time together for the work that benefits most from it. Expect to be in the office a couple of days most weeks.

Travel:

This position will require approximately 5% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $200,000 - $245,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.

Apply on stoketherapeutics.com About employer

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Jobs in the United States