Jobs in the United States

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Added 1 min ago
Full Stack Developer
Jobgether
Remote, United States
We are seeking an experienced Full Stack Developer to lead the design, development, and deployment of secure, scalable, and client-focused software solutions. This role combines full-stack…
Added 23 mins ago
Senior Principal Engineer- Autonomous Driving (ADAS) Data Loop & Flywheel
Bosch Group
Sunnyvale, CA
…E2E Autonomous Driving Data Engine, including fleet data loop automation, active learning pipelines, auto-labeling, simulation, and MLOps…
Added 28 mins ago
Software Engineering Lead and Application Architect - TS/SCI with Polygraph
GD Information Technology, Inc.
United States
Deep production experience in at least two enterprise language stacks, such as Python, Java, C#/.NET, TypeScript/JavaScript/Node, Go, or C++.
Added 28 mins ago
Senior Cloud Platform and DevSecOps Engineer - TS/SCI with Polygraph
GD Information Technology, Inc.
United States
Strong Linux and Windows administration fundamentals plus proficiency in Python, PowerShell, Bash, or another automation language.
Added 32 mins ago
EG
Staff AI & Data Engineer – Databricks
Eliassen Group
Phoenix, AZ
- $80 to $90 USD / hour
Added 35 mins ago
J
Sr Cyber Engineer
Jobgether
Remote, United States
- $120,500 USD / year
Security Automation: Automate Palo Alto Networks operations through PAN-OS and Strata Cloud Manager APIs, Terraform, Ansible, and Python.
Added 55 mins ago
AI Architect
Quest Global
Houston, TX
…involving AI agents, multi-agent systems, RAG, copilots, workflow automation, and intelligent decision-making…
Added 55 mins ago
Senior AI Solution Architect
Quest Global
Houston, TX
…involving AI agents, multi-agent systems, RAG, copilots, workflow automation, and intelligent decision-making…
Added 1 hour ago
O
Lead Principal Platform Software Engineer
Oracle
Nashville, TN
- $113,600 to $306,400 USD / year
…together scientific workflows, AI, robotics, and laboratory automation in support of the Ellison Institute of Technology…
Added 1 hour ago
Senior Security Engineer
PathAI
Boston, MA
You have demonstrated experience building tools and automation that improve developer workflows, ideally in Python.
Added 1 hour ago
Senior Site Reliability Engineer
Jobgether
Remote, United States
The ideal candidate is an experienced reliability engineering professional with strong cloud infrastructure, software development, and automation expertise. You should bring:
Added 1 hour ago
J
SENIOR NETWORK SECURITY ENGINEER
Jobgether
Remote, United States
- $120,000 to $140,000 USD / year
Scripting and automation experience using PowerShell, Python, or Terraform, including Zscaler Terraform providers.
Added 1 hour ago
TL
Vice President, Data Systems
The Los Angeles Lakers, Inc
El Segundo, CA
- $275,000 to $300,000 USD / year
Familiarity with programming languages and frameworks such as Python, SQL, JavaScript/TypeScript, and related development technologies.
Added 1 hour ago
Fusion/All Source CUAS Analyst
CACI International
Aberdeen Proving Ground, MD
Proficient in utilizing standard MS Office computer applications and intelligence related automation to support analytical efforts and product development.
Added 1 hour ago
Fusion/All Source CUAS Analyst
CACI International
Aberdeen Proving Ground, MD
Proficient in utilizing standard MS Office computer applications and intelligence related automation to support analytical efforts and product development.
Added 1 hour ago
Fusion/All Source CUAS Analyst
CACI International
Aberdeen Proving Ground, MD
Proficient in utilizing standard MS Office computer applications and intelligence related automation to support analytical efforts and product development.
Added 1 hour ago
Fusion/All Source CUAS Analyst
CACI International
Aberdeen Proving Ground, MD
Proficient in utilizing standard MS Office computer applications and intelligence related automation to support analytical efforts and product development.
Added 1 hour ago
DevOps Engineer (Hybrid) - 31013
Huntington Ingalls Industries
Fort Meade, MD
…and Container Orchestration, Configuration Management, CI/CD, Automation, Linux systems administration, Scripting in Bash and Programming in Python, AWS and a background in Big Data…
Added 1 hour ago
DevOps Engineer - $20K Sign On Bonus - 31011
Huntington Ingalls Industries
Fort Meade, MD
…and Container Orchestration, Configuration Management, CI/CD, Automation, Linux systems administration, Scripting in Bash and Programming in Python, AWS and a background in Big Data…
Added 1 hour ago
DevOps Engineer - $20K Sign On Bonus - 31012
Huntington Ingalls Industries
Fort Meade, MD
…and Container Orchestration, Configuration Management, CI/CD, Automation, Linux systems administration, Scripting in Bash and Programming in Python, AWS and a background in Big Data…
Added 1 hour ago
DevOps Engineer (Hybrid) - 31007
Huntington Ingalls Industries
Columbia, MD
…and Container Orchestration, Configuration Management, CI/CD, Automation, Linux systems administration, Scripting in Bash and Programming in Python, AWS and a background in Big Data…
Added 1 hour ago
Avionics Test Engineer I- Onsite
RTX Corporation
annapolis, MD
Support continuous improvement efforts related to test methods, automation, and processes.
Added 1 hour ago
Security Engineer
BOOZ, ALLEN & HAMILTON, INC.
Annapolis Junction, MD
Experience building SOAR- related automation around Elastic, including webhook actions, connector integrations, or n8n or XSOAR orchestration
Added 2 hours ago
J
Advanced Analytics, AI & Automation Lead
Jobgether
Remote, United States
- $165,000 to $195,000 USD / year
…steps. Our partner is looking for an Advanced Analytics, AI & Automation Lead based in the United…
Added 2 hours ago
EG
Staff AI & Data Engineer – Databricks
Eliassen Group
Helena, MT
- $80 to $90 USD / hour

Scribe Therapeutics

Senior Scientist, Computational Biology

Alameda, CA, United States

$150,000 to $180,000 USD / year

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Job details

Pay: $150,000 to $180,000 USD / year
Posting language: English

Original job description

About Scribe:

Scribe Therapeutics is a clinical-stage biotechnology company engineering CRISPR-based technologies into purpose-built in vivo genetic medicines designed to become standard of care treatments for patients suffering from highly prevalent diseases, starting with cardiometabolic disease. Leveraging its CRISPR by Design™ approach and nature’s blueprint for improved cardiovascular health, Scribe’s initial programs focus on addressing the key drivers of ASCVD such as elevated LDL-C, lipoprotein(a), and triglycerides. The company’s lead candidate, STX-1150, is a novel liver-targeted therapy designed to epigenetically silence the PCSK9 gene and reduce LDL-C levels without inducing permanent DNA changes. To broaden and accelerate the impact of its engineered CRISPR technologies for patients, Scribe has formed strategic collaborations with world-leading pharmaceutical companies including Sanofi and Eli Lilly. Co-founded by Nobel Prize winner Jennifer Doudna and backed by leading life sciences investors, Scribe is advancing scalable, transformative, and preventative genetic medicines with the goal of improving outcomes and democratizing access to the protective effects of beneficial human genetics.

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Position Summary:

We are looking for a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. We are seeking a Senior Scientist in Computational Biology to lead multi-omics data analyses supporting our therapeutic programs and platform development. This is a hands-on scientific role responsible for experiment design, computational analysis, statistical modeling, and biological interpretation. The successful candidate will work closely with colleagues in Discovery, Pharmacology, NGS, and Data Science to characterize therapeutic activity, mechanism of action, and specificity and deliver clear, reproducible analyses that guide program decisions and support regulatory data packages.

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Competencies:

Computational Biology
Bioinformatics
Experiment Design
Statistical Modeling
Project Leadership
Multi-Omics Analysis
Cross-Functional Collaboration

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Key Duties / Responsibilities / “What you’ll do”:

Lead bioinformatics analyses of multi-omics datasets, including whole genome sequencing, transcriptomics, epigenomic sequencing, targeted amplicon sequencing, and off-target discovery NGS sequencing to guide gene-editing experiments.
Develop and maintain version-controlled, reproducible computational pipelines with quality checks and standardized reporting; collaborate with engineering colleagues to support automation and LIMS integration.
Apply machine learning methods to support target identification and molecular engineering.
Support NGS assay development and qualification by evaluating analytical performance, sources of variation, and the reliability of biological conclusions.
Collaborate with cross-functional teams on experiment design, results interpretation, and troubleshooting.
Demonstrate strong statistical judgment in assessing reproducibility, experimental controls, batch effects, and measurement uncertainty across complex biological datasets.
Contribute to the planning and delivery of scientific projects, regulatory submissions, and project presentations.

Requirements

Knowledge Requirements (Background/Skills/Experience):

PhD in Bioinformatics, Computational Biology, Genomics, Biostatistics, or a related field with 3+ years of relevant postdoctoral or industry experience; or a master’s degree with 6+ years of relevant experience.
Strong hands-on experience analyzing RNA-seq and DNA methylation data, with a track record of translating results into biological insights and experimental decisions.
Experience analyzing genomic sequencing data, including variant interpretation and assessment of copy number or structural variation.
Strong grounding in experimental design and statistics, including generalized linear models, mixed-effects models, multiple-testing correction, and interpretation of effect sizes and uncertainty.
Proficiency in R and Python, Linux command-line tools, and Git, with experience building reproducible workflows using Nextflow, Snakemake, or similar tools.
Experience with AWS or other cloud computing environments, containers, and Benchling or another LIMS.
Ability to evaluate sequencing quality, recognize technical artifacts and confounding factors, and explain the limitations of analytical results.
Demonstrated ability to lead analysis projects independently, manage competing priorities, and collaborate effectively with other scientists.
Clear written and verbal communication, including the ability to explain complex analyses to colleagues with different scientific backgrounds.

Preferred Qualifications

Experience in biotechnology or pharmaceutical R&D, particularly CRISPR genome editing, epigenetic regulation, or genetic medicines.
Experience assessing genome editing outcomes, off-target activity, or genomic integrity using short-read or long-read sequencing.
Experience with assay qualification, traceable analysis documentation, and data packages supporting regulatory submissions.

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Physical Requirements:

Prolonged periods of sitting at a desk and working on a computer.
Must be able to lift up to 15 pounds at times.

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More about this job

Skills

Pharmacology
Leadership
Collaboration
Editing
Statistical quality control
Reporting
LIMS
Machine learning
Troubleshooting
Presentation skills
Statistics
R
Python
Linux
Git
Snakemake
AWS
Cloud computing
Communication skills
Biotechnology
Documentation
Heavy lifting

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