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Senior Java Full Stack Engineer – Spring Boot & AWS
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Nautilus Biotechnology

NPI Staff Scientist

835 Industrial Road, San Carlos, CA, United States

$145,000 to $196,000 USD / year

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Job details

Pay: $145,000 to $196,000 USD / year
Experience: PhD in chemistry, biochemistry, molecular biology or a related field with 10+ years of relevant industry experience, or a MS with 15+ years of relevant industry experience.
Posting language: English
Posted: Nov 9, 2026

Original job description

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

About the Role

We are seeking an experienced Staff Scientist to lead New Product Introduction (NPI) projects that bridge our R&D and manufacturing teams. In this role you will set the technical direction and own the execution of projects that take new reagents, proteins, antibodies, and assays from late-stage development into robust, scalable, commercial production.

As the scientific and project lead for NPI programs, you will define project scope, plans, and timelines; coordinate cross-functional teams across R&D, Reagent Manufacturing, Quality, and Supply Chain; and make data-driven decisions on scale-up, process validation, and technology transfer strategy. You will design the experimental strategy behind each transfer, establish specifications and release criteria, and mentor scientists and associates on the team. Our ideal candidate combines deep expertise in antibody structure and function, antibody conjugation, and protein expression and purification with a proven record of leading complex product transfers to completion.

This is an individual contributor position at the Staff Scientist level. The position is located in San Carlos, CA and requires full-time onsite presence.

Responsibilities

Lead NPI projects end to end – define scope, deliverables, milestones, and resource needs, and drive cross-functional teams to on-time, on-budget transfer of new reagents, proteins, antibodies, and assays from R&D to commercial production.
Serve as the technical lead and primary point of contact for assigned products across R&D, Reagent Manufacturing, Quality, Supply Chain, and Program Management; track progress, and communicate status, risks, and mitigation plans to stakeholders and leadership.
Set the technical strategy for scale-up, process characterization, and process validation; design and oversee studies that improve yield, stability, and robustness of complex formulations and processes.
Make and defend data-driven decisions at key project gates (e.g., design transfer, pilot readiness, validation, launch), escalating trade-offs between schedule, cost, and quality when needed.
Partner with R&D to establish QC release criteria, product specifications, guard-band and robustness studies for manufactured reagents; lead specification-setting discussions across teams.
Lead root-cause investigations of complex production and transfer issues during pilot and production phases; drive corrective and preventive actions (CAPA) to closure.
Own technical documentation for transferred products, including SOPs, batch records, BOMs, technical reports, and transfer packages, ensuring compliance with quality standards; review documents authored by others.
Develop and improve NPI processes, templates, and best practices (e.g., stage-gate checklists, transfer plans, risk assessments) that raise the standard for future product transfers.
Mentor and provide technical guidance to scientists and research/manufacturing associates; delegate and review work on project teams and contribute to hiring and onboarding.
Remain hands-on in the lab and production environment as needed, including reagent formulation, conjugation, and analytical sample preparation, particularly for new or high-risk processes.
Support supplier and contract manufacturer selection and technology transfer, including vendor qualification, costing analysis, and supply chain set-up for new products.

Requirements

PhD in chemistry, biochemistry, molecular biology or a related field with 10+ years of relevant industry experience, or a MS with 15+ years of relevant industry experience.
Proven track record leading cross-functional projects through new product introduction, scale-up, process validation, and technology transfer into manufacturing, ideally for life science reagents, antibodies, or diagnostic consumables.
Deep knowledge of protein biochemistry, protein purification, reagent formulation, or analytical chemistry (HPLC, MS, FPLC); expertise in antibody conjugation and protein expression and purification.
Demonstrated project leadership: building project plans, managing timelines, risks, and resources, and holding cross-functional team members accountable without direct authority.
Experience mentoring and guiding scientists and associates, and delegating and reviewing their work.
Experience in BOM setup using Arena/Agile software, costing analysis, supply chain set-up, and vendor management.
Hands-on experience working in controlled development or manufacturing environments (ISO 9001 & ISO 13485), including design control, process validation, and CAPA.
Excellent communication and influencing skills, with the ability to present complex technical data and recommendations to cross-functional teams and leadership.
Proficiency in Excel and statistical tools (e.g., JMP, Minitab, or R); experience with project tracking tools (Smartsheet, Microsoft Project, or similar).
Willingness to work hands-on in the lab and production environment.

Nautilus Team Culture

We are curious go-getters: this is a team of life-long learners who aren't afraid to tackle the big challenges and we embrace the journey.
We are detail-oriented: we do great science by working smart & with diligence where we learn from our trials and mistakes.
We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness.

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