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Aircraft Mechanic 1-C-12 US Airforce - San Angelo ,TX.
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Principal Engineer, Clinical Data and AI Platforms
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Natera

Senior Software Engineer

Remote, United States

$125,600 - $157,000 USD

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Job details

Pay: $125,600 - $157,000 USD
Experience: 7+ years of professional software engineering experience, including meaningful time building complex data or process-management applications
Posting language: English
Posted: Nov 4, 2026

Original job description

POSITION SUMMARY

Natera is seeking a Senior Software Engineer to join a small, high-leverage team inside the Case Management Platform (CMP) organization. This is a new and intentionally unique role: you will sit organizationally within CMP - the engine that drives Natera's cases from order through result - and work shoulder-to-shoulder on priorities set by the commerce side of the business. Your job is to help bridge the gap between how Natera sells, orders, and interacts with customers and how Natera fulfills every one of those commitments in the lab.

You will be a force multiplier - fluent in modern AI tools, an orchestrator of agents, and comfortable owning problems end-to-end from a napkin sketch through production.

If you light up at the intersection of commerce workflows and operational systems, build with AI as a native part of your toolkit, and want to work on software whose outcomes are measured in patient impact - this is a role worth your attention.

PRIMARY RESPONSIBILITIES

Own meaningful initiatives end-to-end - from problem framing through design, implementation, release, and operation - in service of commerce-driven priorities that land in CMP
Design and build cloud-native services on AWS, with a strong bias toward stateless, event-driven architectures (AWS Lambda and similar serverless patterns, SQS/SNS/EventBridge, API Gateway, DynamoDB/RDS)
Use AI agents and AI-assisted workflows as a core part of how you work: compose, direct, and evaluate agent systems to accelerate development, reduce manual toil, and solve problems that would otherwise require a much larger team
Translate business needs - spanning commerce systems and fulfillment operations - into clear technical specifications, APIs, and operations-friendly services
Write your own stories; break down epics, identify dependencies, estimate complexity, and drive delivery without waiting for tickets to be handed to you
Contribute to the technical bar through strong code, thoughtful participation in design reviews, and support for your teammates
Partner directly with commerce product managers, business stakeholders, and CMP peers; translate between those worlds and shield each from the other's complexity
Participate in on-call rotations and production support; own the fix when something you built breaks, regardless of who wrote the original code
Challenge the status quo thoughtfully; propose better patterns, tools, and ways of working
Deliver quality software in a regulated environment: automation-first testing, shift-left mindset, "works on my machine" is never the answer

Compliance and training

This role works with Protected Health Information (PHI) on a regular basis in both paper and electronic form
Employee must complete HIPAA/PHI privacy, General Policies and Procedure Compliance, and security training within the first 30 days of hire, and maintain current status on all Natera training requirements
Employee must pass a post-offer criminal background check

QUALIFICATIONS

BS in Computer Science, a comparable program, or equivalent experience; MS preferred
7+ years of professional software engineering experience, including meaningful time building complex data or process-management applications
Strong fluency in Java or another modern object-oriented language (Kotlin, C#, Python with OO design, etc.); willingness to work across languages when the job calls for it
Hands-on experience with AWS, including serverless and stateless patterns (Lambda, Step Functions, API Gateway, event-driven messaging) and relational and/or non-relational data stores
Demonstrated adoption of AI-assisted development - a genuine, current practice of using and orchestrating AI tools and agents to deliver real work, not just surface familiarity
Experience designing and operating distributed systems, including basics of observability, resilience, security, and performance in production
Strong SQL and data modeling skills
Experience partnering with product managers and non-engineering stakeholders to shape requirements and trade-offs
Experience in biotech, healthcare, commerce, order management, or another regulated or operations-critical domain is a plus

KNOWLEDGE, SKILLS, AND ABILITIES

Solid understanding of software engineering fundamentals: OO, SOLID, design patterns, API design, and clean architecture
AI-native engineer - treats AI tools and agents as standard parts of the workflow and actively invests in getting more leverage from them
Fluent in cloud infrastructure and in choosing the right tool for the shape of the problem - not everything is a Lambda, and not everything is a container
Full-stack comfort when needed, with a backend/platform center of gravity
Excellent written and verbal communication; able to make the complex understandable to commerce stakeholders and the ambiguous actionable for engineers
Extreme ownership - keeps promises, surfaces blockers early, closes loops without being asked
"Yes if" attitude; focused on paths forward, explicit about trade-offs
Humility and curiosity; reads code written by others, asks "why" until it reaches the real constraint, and welcomes being wrong when it leads to a better answer
Commitment to diversity in engineering and to building a team where the best idea wins

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. Remote USA

$125,600 - $157,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:

BBB announcement on job scams
FBI Cyber Crime resource page

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