Jobs in the United States

25+ jobs

Save this search

Added 7 hours ago
Principal Mechanical Engineer/Sr. Principal Mechanical Engineer
Northrop Grumman
Oklahoma City, OK
Advanced Test and Support Systems (ATSS) is seeking a Principle Mechanical Engineer / Senior Principle Mechanical Engineer (Level 3/4) to join our team of qualified and diverse individuals…
Added 7 hours ago
Sentinel Principal / Sr Principal Engineer Industrial 17263 Secret Clearance
Northrop Grumman
Roy, UT
Northrop Grumman is seeking a Principal / Sr Principal Engineer Industrial
Added 8 hours ago
Sr. Principal Systems Engineer - Configuration Manager
Northrop Grumman
Redondo Beach, CA · El Segundo, CA
Northrop Grumman’s Aeronautics Systems – Research & Advanced Design (R&AD) transforms breakthrough ideas into mission-ready capabilities through intelligent anticipation. We’re the…
Added 11 hours ago
Sr Principal Mechanical Engineer (Secret Clearance)
Northrop Grumman
Huntsville, AL
Provide technical contributions for conceptual and preliminary design and technology maturation of new advanced concepts for future deterrence needs in the areas of cruise missiles and…
Added 20 hours ago
Modeling Simulation & Analysis Engineer 3 or 4 (Principal or Sr. Principal Level)
Northrop Grumman
El Segundo
Northrop Grumman Aeronautics Systems has an opening for a Modeling Simulation and Analysis Engineer (Principal or Sr. Principal Level) to join our team of qualified, diverse individuals…
Added 21 hours ago
Sr Data Integration Engineer
Compeer Financial
Mankato, MN · Lakeville, MN · Bloomington, IL · Sun Prairie, WI · Prairie du Sac, WI
Casual/seasonal & intern team members are not eligible for benefits except for state-mandated programs.
Added 1 day ago
Principal/Sr. Principal Digital-RF Hardware Subsystem I&T Engineer
Northrop Grumman
Baltimore, MD
The BaPs E&S organization at Northrop Grumman Missions Systems in Baltimore, Maryland is seeking experienced Principal/Sr. Principal Digital-RF Hardware Subsystem Integration and Test…
Added 1 day ago
Sr. Principal Eng Support Services - RDC Warfighter Support Team
RTX
United States
The Systems Engineering and Test Capabilities (SE&TC) Surface Radars & Sensors Center is seeking a Senior Principal Systems Engineer to support the Sensors Warfighter Support Team onsite at…
Added 1 day ago
Sr. Principal Manufacturing Engineer (onsite)
RTX
United States
As a Sr. Principal Manufacturing Engineer, you will play a critical role in leading and driving manufacturing engineering efforts for energetic materials, components, and associated…
Added 1 day ago
Sr. Principal Electrical Engineer/Principal Electrical Engineer
Northrop Grumman
Oklahoma City, OK
Our Advanced Test and Support Systems (ATSS) is seeking a Principal Electrical Engineer OR Senior Principal Electronics Engineer (Level 3 or 4) to join our team of qualified and diverse…
Added 1 day ago
Sr. Geotechnical Engineer
Bechtel Corporation
Ogden, UT
…development and execution, design of complex ground improvement systems, deep foundation design and installation, advanced finite element modelling for geotechnical analysis, and other…
Added 1 day ago
Sr. Principal Tooling Design Engineer
Northrop Grumman
Sunnyvale, CA
Northrop Grumman Mission Systems is looking for you to join our team as a Sr. Principal Tooling Design Engineer based out of Sunnyvale, CA .
Added 1 day ago
Sr Principal Engineer - MES
Lilly
Indianapolis, IN
The MES Sr Principal Engineer will play a crucial role in delivering the Manufacturing Execution Systems through common modules that enable manufacturing sites to deliver world class…
Added 1 day ago
Modeling Simulation & Analysis Engineer 3 or 4 (Principal or Sr. Principal Level)
CORP-Corporate Office
United States
Northrop Grumman Aeronautics Systems has an opening for a Modeling Simulation and Analysis Engineer (Principal or Sr. Principal Level) to join our team of qualified, diverse individuals…
Added 1 day ago
Principal/Sr. Principal Systems Engineer
Northrop Grumman
Rolling Meadows
Northrop Grumman Mission Systems (NGMS) seeks to fill a Principal/Sr. Principal Systems Engineer position in the Mission Modeling Department at our Rolling Meadows, Illinois location. This…
Added 1 day ago
Sr Principal Mechanical Engineer (Secret Clearance) -18304
Northrop Grumman
Huntsville
Provide technical contributions for conceptual and preliminary design and technology maturation of new advanced concepts for future deterrence needs in the areas of cruise missiles and…
Added 2 days ago
Principal/Sr. Principal Systems Engineer
CORP-Corporate Office
United States
Northrop Grumman Mission Systems (NGMS) seeks to fill a Principal/Sr. Principal Systems Engineer position in the Mission Modeling Department at our Rolling Meadows, Illinois location. This…
Added 2 days ago
MACH-TB Junior Mission Systems Engineer
SAIC
Crane, IN
231622 - Hypersonics Advanced Concepts and Strategic Missions Research Development Test and Evaluation RDTE for the Navys Strategic Systems Programs SSP and the Naval Surface Warfare Center…
Added 2 days ago
Sr. Full Stack Engineer, Unified Ads Platform
Unity Technologies ApS
NY
À titre de développeur(euse) full-stack principal(e) au sein de l’équipe Unified Ads Platform, vous serez responsable de la couche de services où résident les entités des annonceur(euse)s…
Added 2 days ago
Sr Principal Mechanical Engineer (Secret Clearance) -18304
CORP-Corporate Office
United States
Provide technical contributions for conceptual and preliminary design and technology maturation of new advanced concepts for future deterrence needs in the areas of cruise missiles and…
Added 2 days ago
Sr Principal Engineer - MES
Eli Lilly and Company
United States
The MES Sr Principal Engineer will play a crucial role in delivering the Manufacturing Execution Systems through common modules that enable manufacturing sites to deliver world class…
Added 2 days ago
Principal Engineer - Software
Arena Technical Resources, LLC
Oshkosh, WI
The Principal Engineer – Software develops embedded software for various
Added 2 days ago
Thermal Engineer Level 3 /4 (AHT)
Northrop Grumman
Los Angeles, CA
Northrop Grumman is seeking a Thermal Structural Engineer level 3 or 4 located in Woodland Hills , Ca, which is part of our Advanced Weapon Systems business unit in Northridge. We are a…
Added 2 days ago
Sr Principal Engineer - Data
Lilly
Indianapolis, IN
We are seeking an experienced Senior Principal Data, Analytics & AI Engineer to join the Global DIA team within MQ Tech at Lilly. This role sits at the intersection of data engineering,…
Added 2 days ago
Sr. Principal EO Signal Image Processing Engineer - 4
Northrop Grumman
Chandler, AZ
Northrop Grumman Space Systems is looking for a Sr. Principal EO Signal Image Processing Engineer to support the Launch Vehicles business unit in Chandler, Arizona.

Lilly

Sr Principal Engineer - MES

Indianapolis, IN, United States

$129,000 - $189,200

Apply About employer

Applications open in a new tab.

Job details

Pay: $129,000 - $189,200
Experience: Experience: 8+ years of experience in MES
Posting language: English
Posted: Oct 30, 2026

Original job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work - but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

This is an opportunity you don’t want to miss!

Lilly is entering an exciting period of growth, and we are committed to delivering innovative medicines to patients around the world. Lilly is investing to create several new state-of-the-art manufacturing sites. These brand-new facilities will utilize the latest technology for API Manufacturing and will include several platforms including Vaccines, Radio Therapy and Gene Therapy Drug Substance Manufacturing. This is an exciting once-in-a-lifetime opportunity to help build and operate a new site. These new API sites will be built using the latest high-tech equipment, advanced highly integrated and automated manufacturing systems, and have a focus on minimizing the impact to our environment.

What You’ll Be Doing :

You will be part of Tech at Lilly MQ (Manufacturing and Quality), an organization that drives manufacturing operational excellence and productivity efforts through utilization of technology. Tech at Lilly MQ strives to enable the making of medicine “with safety first and quality always”.

The MES Sr Principal Engineer will play a crucial role in delivering the Manufacturing Execution Systems through common modules that enable manufacturing sites to deliver world class performance.

The role encompasses responsibility for both the architectural and technical components of the Manufacturing Execution Systems (MES) solution. This involves providing expert guidance and oversight in the design, implementation, and optimisation of MES architecture to ensure it aligns with the organisation’s strategic objectives and operational requirements.

A key part of the role is to establish and maintain the direction for Solution Architecture in collaboration with the global Group. This includes implementing defining standards, best practices, and technical frameworks that steer the development and evolution of the MES modules, ensuring consistency, scalability, and reliability across all manufacturing sites.

How You’ll Succeed:

Utilizes solid understanding of Manufacturing and Quality business processes to anticipate MES short term and future needs from an IT Architecture standpoint.
Works with global Architects, Enterprise Architects, local IT teams and other global teams to identify solutions to complex problems related to MES.
Sets direction through the formation of a strategic roadmap and evolution of the site design for API MES solution and systems interfaced to MES.
Collaborates, influences and/or leads the definition of global IT support and/or delivery processes.
Provides deep technical knowledge, monitors solution delivery projects for compliance with the defined reference architecture and proposes and facilitates proof-of-concepts to enable clarity around future state direction.
Collaborates with Enterprise Architects to research, identify, test, certify, select and introduce innovative technology products required for solution development and delivery.
Collaborates with the Data Management teams to ensure understanding of, and alignment with Data Architecture Standards
Actively collaborates with Cybersecurity and Protect Lilly teams to introduce operating principles for MQ IDS MES systems, interfaces and architecture (e.g. proper patching process, LCM, software version control).
Ensure IT vendors understand the Cyber Security and Protect Lilly requirements and are able to translate these into implementation specifications.
Acts as interface between IT and Business Partners on (or across) large projects and programs from a technical perspective (e.g. reporting, archival, performance, MES scope expansions).
Keeps outward focus to identify new trends and opportunities.
Keeps relationships with other large Pharma companies to ensure Lilly roadmap and decisions are in line and competitive with industry trends.
Acts as coach/mentor of global and local MES team members and others regarding technologies, architecture and technical design as appropriate.
Leads and/or supports development of business cases related to MES.
Proactively influence the business to drive value and implement the appropriate technical solutions
Find innovative ways to leverage MES to drive business value

Basic Requirements:

Education: Bachelor’s degree in Computer Science, Engineering or related field
Experience: 8+ years of experience in MES
Knowledge: Strong knowledge with distributed S95 Level 3 solutions, commercial configurable software (COTS) suppliers, and business intelligence. Strong technical Skills: including infrastructure, interfaces and configuration capabilities
Experience in Pharma and GMP Manufacturing

Additional Preferences

Experience: Experience managing programs/projects in the pharmaceutical business. Previous experience in the startup of a new facility or clinical development manufacturing site.
Skills: Strong analytical and problem-solving skills, with the ability to assess risks, manage trade-offs, and make sound decisions. Excellent communication and leadership skills to interact with stakeholders at all levels of the organization
Leadership Skills: Proven leadership experience in managing cross-functional teams.
Industry Engagement : Active participation in industry forums and standards organizations.
undefined

Other Information:

Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate other inputs (production schedules, shutdowns, etc.). Occasional extended hour and / or off-hour work may be required.
Roles will be based in Indianapolis IN,

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$129,000 - $189,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

Apply About employer

Report this job