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Added 6 hours ago
Principal Space Avionics Hardware Development Engineer
Varda Space Industries
El Segundo, CA
As a Principal Space Avionics Hardware Engineer at Varda, you will be the architect and designer of flight critical electrical hardware for our satellite bus, reentry vehicle, and customer…
Added 7 hours ago
Principal Security Engineer
Jobgether
Remote, United States
As a Principal Security Engineer, you will provide advanced security engineering expertise to support the assessment, authorization, and continuous monitoring of cloud-based systems within…
Added 10 hours ago
Principal Engineer - PVTP Architecture
General Motors LLC
Seattle, WA
As Principal Engineer, PVTP Architecture, you will be the senior technical authority and system architect for this ecosystem. You will set the long-term architecture and drive…
Added 11 hours ago
Principal Tech Ops Engineer, AWS Rack Manufacturing
Amazon Data Services, Inc.
Salt Lake City, UT
We are seeking a Principal Tech Operations Engineer to lead and scale regional manufacturing operations across a complex, multi vendor hardware production ecosystem. This role owns the end…
Added 13 hours ago
Principal Silicon Product Engineer
Google
Sunnyvale, CA
As the Principal Silicon Product Engineer, you will serve as the chief technical authority for the Silicon Sourcing organization bridging hardware engineering design, global manufacturing…
Added 13 hours ago
Principal Systems Engineer
Dynetics, Inc
Huntsville, AL · King Of Prussia, PA · San Diego, CA · Arlington, VA · Beavercreek, OH
Leidos Defense is seeking a highly skilled, visionary Principal Systems Engineer to join our multi-disciplinary engineering organization. In this role, you will drive the architectural…
Added 14 hours ago
SO
Principal Developer - OIT Internal Recruitment (Remote From Anywhere In CO)
State of Colorado
CO
- $122,000 to $137,000 USD / year
We’re looking for a strategic and collaborative Principal Developer to be a top team member in the operations of an applications delivery work unit to drive the modernization and…
Added 14 hours ago
Industrial Controls Engineer/Principal Industrial Controls Engineer
Northrop Grumman
Baltimore, MD
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Added 15 hours ago
Principal Analog Mixed-Signal Design Engineer
SiTime Corporation
CA
Collaborate with Digital Design Engineers, CAD, Systems Engineering, Test Engineering and Applications teams to ensure DFT, DFM features and achieve rapid silicon bring-up and time to…
Added 15 hours ago
Principal Software Engineer, Spacecraft Simulation
True Anomaly
Denver, CO · Long Beach, CA
…and the human and autonomous control of spacecraft and ground systems. True Anomaly is seeking a Principal Software Engineer, Spacecraft Simulation to define the long-term technical vision…
Added 16 hours ago
O
Principal Core Infrastructure Engineer, AI Infrastructure
Oracle
Nashville, TN
- $114,600 to $234,600 USD / year
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Added 16 hours ago
Principal Mechanical Architect – LiquidStack Cooling Solutions
Trane Technologies
Haslet, TX
As a Principal Mechanical Architect – LiquidStack Cooling Solutions at Trane Technologies, you will work as the lead electrical engineer dedicated exclusively to our LiquidStack product…
Added 17 hours ago
WD
Chief Memory Chip Design Engineer & Architect
Western Digital
San Jose, CA
- $242,900 to $323,800 USD / year
15+ years in memory or mixed-signal IC development; 5+ as architect or chief engineer
Added 17 hours ago
Principal Software Engineer - Mobile Applications
Boston Scientific
San Jose
3+ years of technical leadership experience as a Principal Engineer, Technical Lead, Software Architect, or equivalent, driving architecture, engineering standards, and software delivery.
Added 17 hours ago
Principal Software Engineer - Mobile Applications
Boston Scientific
San Jose, CA
3+ years of technical leadership experience as a Principal Engineer, Technical Lead, Software Architect, or equivalent, driving architecture, engineering standards, and software delivery.
Added 18 hours ago
Principal Engineer II - Data Engineering
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Plano, TX
Toyota's Digital Innovations group within TMNA's Supply Chain organization is seeking a highly experienced Principal Engineer II, Data Engineering to lead the technical strategy and…
Added 19 hours ago
Principal Enterprise Software Engineer
Wolters Kluwer United States Inc.
Kennesaw, GA · Houston, TX · Minneapolis, MN
Wolters Kluwer is seeking a hands-on Principal AI Solutions Engineer in our Architecture & Engineering Services (AES) Team to architect, build, and deploy enterprise-scale AI solutions on…
Added 21 hours ago
Principal Engineer, Agentic AI
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Remote, United States
…into the next generation of software - and we're looking for a Principal Engineer, Agentic AI to join our Core Platform…
Added 21 hours ago
Cybersecurity Architect, Sr. Principal
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United States
The Lead Cybersecurity Engineering, Sr. Principal owns the large DoW Defensive Cyber security posture end to end, from Zero Trust architecture to RMF/ATO lifecycle management.
Added 1 day ago
Principal Software Engineer
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As our Principal Software Engineer, you will be driving and supporting robotic water-jet cutting equipment and various JBT Marel systems using computer vision for the food processing…
Added 1 day ago
Principal Software Engineer - Virtualization
General Motors
Boston, MA
General Motors is seeking a Principal Software Engineer to shape and scale the engineering platforms that build, test, integrate, validate, and deliver embedded software for…
Added 1 day ago
Principal Mechanical Architect – LiquidStack Cooling Solutions
CFO Trane U.S. Inc.-CFO
United States
As a Principal Mechanical Architect – LiquidStack Cooling Solutions at Trane Technologies, you will work as the lead electrical engineer dedicated exclusively to our LiquidStack product…
Added 1 day ago
Principal Antenna & RF Sensor Test Range Architect & Integrator
RTX
United States
The Effector RF Design Team at Raytheon is seeking a talented Principal Engineer to join our team in Tucson, AZ.
Added 1 day ago
Principal Software Engineer - AI Platform
Western Governors University
Salt Lake City, UT
As Principal Software Engineer, AI Platform, you will architect and build this platform from the ground up. You will shape retrieval, inference, orchestration, guardrails, evaluation,…
Added 1 day ago
SB
PRINCIPAL SOFTWARE ENGINEER II
Sanford Burnham Prebys Medical Discovery Institute
San Diego, CA
- $228,000 USD / year
…deploying design, analysis and programming skills to create systems that improve code-quality and boost productivity of large development teams of mixed skillsets. In particular, they will…

Lilly

Sr Principal Engineer - Data

Indianapolis, IN, United States

$129,000 - $211,200

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Job details

Pay: $129,000 - $211,200
Posting language: English
Posted: Sep 29, 2026

Original job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work - but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

We are seeking an experienced Senior Principal Data, Analytics & AI Engineer to join the Global DIA team within MQ Tech at Lilly. This role sits at the intersection of data engineering, supply chain domain expertise, and applied AI. You will architect the near-real-time data foundations that AI agents reason over and lead the design of the agents themselves - multi-agent workflows that read across manufacturing and supply chain systems, correlate signals that today sit in disconnected platforms, and put clear, actionable insight in front of the people running the line and the network.

This is a senior principal, hands-on delivery role with technical leadership expectations. You will own solutions end to end, set technical direction for correlating supply chain and manufacturing data through data modernization and agentic AI, and mentor engineers on the team. The solutions you build reach production and are used every shift, bringing transparency and decision support to Lilly's Supply Chain and Manufacturing operations.

Job Responsibilities

Technical leadership and architecture

Own the technical design and architecture for agentic AI and data modernization solutions across the Global Supply Chain and MQ landscape, from problem framing through production support.
Set standards and reusable patterns for cloud based data modeling, pipeline design, agent orchestration, and evaluation that other engineers build on.
Mentor and provide technical guidance to junior and mid-level engineers; lead code and design reviews.
Partner with senior business stakeholders and IT leadership to shape roadmaps, sequence delivery, and make build/buy trade-offs; direct and hold accountable external vendor and partner teams.

Supply chain data domain and analytics

Develop and apply deep working knowledge of Global Supply Chain data domains - material master, BOM and recipe, procurement, inventory and stock movements, production orders and batch execution, planning and scheduling, warehouse management, transportation management, distribution and logistics, quality and deviations.
Work fluently across SAP (S/4HANA, ECC, BW/4HANA - master data, MM, PP, QM, SD, and IBP) and SHARP , translating source-system semantics into trusted, business-ready data models.
Bring an informed point of view on end-to-end supply chain processes - S&OP, MRP, plan-to-produce, source-to-pay, order-to-cash, capacity and inventory management - and the analytics that support them, including service level, inventory turns, cycle time, schedule adherence, and supply risk.
Correlate supply chain and manufacturing data - linking ERP, planning, MES, historian, and quality data across systems and time - to produce integrated business solutions that answer questions no single system can, using data modernization and agentic AI.

Agentic AI and machine learning

Closely collaborate with the business & other global teams on agentic solution design, requirement gathering, solution development and delivery to drive meaningful business value
Design, build, and deploy AI agents and multi-agent workflows that automate analysis and decision support across manufacturing and supply chain use cases - including prompt engineering, tool and function calling, agent orchestration, and retrieval-augmented generation (RAG) over technical documents and operational data.
Define how agent performance is measured and improved: test scenarios, evaluation criteria, accuracy and hallucination monitoring, user feedback loops, agent observability, and guardrails that keep agent behavior safe, grounded, and within scope.
Implement, test, and deploy machine learning and predictive models into production, ensuring performance, scalability, and interpretability.

Data engineering and delivery

Design, build, and maintain scalable, reliable data pipelines using modern ETL/ELT tooling to ingest, process, and transform large datasets from diverse operational and enterprise sources in support of advanced analytics, reporting, and agentic AI.
Lead data modernization efforts - migrating and re-platforming legacy supply chain reporting and data assets onto modern lakehouse and cloud architectures.
Monitor and troubleshoot data quality and agent behavior issues, ensuring data integrity and reliability across all platforms.
Develop and maintain documentation for data architecture, data flows, agent designs, prompts, model choices, and deployments to support maintainability, validation, and GxP/CSV requirements.
Ensure compliance with all relevant data privacy, security, and responsible AI requirements.
Stay abreast of the fast-moving agentic AI and data engineering landscape and bring practical, proven advances into the team's work.

Basic Qualifications

Bachelor’s in Computer Science, Engineering, Data Science, Statistics, Supply Chain, or related field with 8+ years in data engineering, analytics, or AI/ML, with hands-on production Gen-AI/agentic app delivery.
Experience in supply chain/manufacturing data, hands-on SAP (S/4HANA/ECC, BW/4HANA) , SHARP, MES and related data and analytics experience.
Hands-on advanced statistical, machine learning, LLM/agentic app development: prompt engineering, tool/function calling, RAG, vector search/embeddings, multi-step workflows.
Deep knowledge of agent frameworks (LangChain, LangGraph, or equivalent) and production LLM APIs (OpenAI, Azure OpenAI, Anthropic, Bedrock); Azure/AWS/Databricks.
Advanced Python (preferred); SQL,Java/Scala/R a plus, PowerBi/Tablue, Web Apps etc
Experience in end-to-end developing production grade analytics systems.

Preferred Qualifications

Masters in Computer Science, Engineering, Data Science, Statistics, Supply Chain, or related field with 5+ years in data engineering, analytics, or AI/ML, with hands-on production Gen-AI/agentic app delivery.
Experience in pharmaceutical, life sciences, or other regulated manufacturing supply chains.
Track record of taking multiple AI or agentic solutions through to production, including evaluation, monitoring, and iteration after go-live.
Strong command of manufacturing processes and metrics (OEE, downtime, yield, batch performance, right-first-time) alongside supply chain metrics.
Experience with supply chain planning software (SAP IBP, Kinaxis, o9) and IoT/streaming operational data.
Exposure to manufacturing data sources such as historians (OSI PI), MES/TrakSYS, PMX, or LIMS.
Experience working in a GxP-regulated environment, including CSV and validation practices.
Experience with data visualization tools (Power BI preferred).
Applied knowledge of responsible AI practices: model risk, bias, explainability, and data privacy.
Experience leading globally distributed teams or vendor partners.
Databricks, AWS or Azure certifications.

Additional Information:

· Position is located in Indianapolis, Indiana

· Full time position 5 days per week onsite

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$129,000 - $211,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

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