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Added 7 hours ago
Dist. Scientist, Research Science
Merck
Rahway, NJ
The Distinguished Scientist will provide scientific, technical, and strategic leadership for Brick 1 within CMC Lighthouse Pillar 2, Digitally Enabled Technology Transfer. This individual…
Added 7 hours ago
Principal Scientist, Combination Product Physics Based Modeling and Simulation Combination Products
Merck
Rahway, NJ
We are seeking a Principal Scientist to lead physics-based modeling and simulation within the Device Product Assessment and Innovation team in Device Development and Technology. The role…
Added 19 hours ago
Sr. Scientist, Analytical Development (Contract to Hire 6-9 Months)
Careers - MannKind Corporation
Danbury, CT
The Senior Scientist – Validation is a technical leader responsible for establishing, executing, and maintaining robust analytical method validation strategies across the product lifecycle,…
Added 2 days ago
CI
Manager/Principal Scientist Research & Development - Polymer Formulation
Cresilon, Inc.
Brooklyn, NY
- $130,000 to $180,000 USD / year
This is a senior technical role overseeing a small team within a dynamic, growing organization. . The R&D Manager/Principal Scientist is both a strategic leader and a hands-on contributor.…
Added 4 days ago
M
Senior Applied Scientist - AI for Safe Changes Health Gating
Microsoft
WA · Redmond, WA · Redmond
- $119,800 to $261,000 USD / year
We are seeking an Applied Scientist to develop machine-learning and AI solutions that improve the safety, reliability, and operational efficiency of Microsoft 365 services, including…
Added 4 days ago
Senior Scientist I
Phosphorex LLC
Hopkinton, MA
This position will be filled at either the Scientist I or Senior Scientist I level, depending on the candidate’s education and experience. The role specializes in the formulation and…
Added 4 days ago
Associate Scientist, Drug Formulation
Insmed Incorporated
Research Development Lab, NJ
We’re looking for an Associate Scientist, Drug Formulation on the Research team to help us expand what’s possible for patients with serious diseases. Reporting to the Senior Scientist,…
Added 4 days ago
Research Scientist/Engineer Senior
University of Washington
Seattle, WA
The Department of Biochemistry Institute for Protein Design's (IPD) has an outstanding opportunity for a Research Scientist/Engineer Senior to join their team.
Added 5 days ago
Senior Scientist - Minerology, Glass, & Petrography
Original Composites and Fibers
Granville, OH
…partnership.Purpose of the RoleAs a member of the Technology & Capital Delivery organization, the Sr. Engineer, R&D - Americas Minerals & Petrography serves as the regional technical expert…
Added 6 days ago
Senior Scientist
US Tech Solutions
Wilmington, DE
The Senior Scientist role is responsible for aiding in the supply of strategic drug product technical expertise and support to a portfolio of established products. The products are…
Added 6 days ago
E T Consultant - Data Scientist
World Bank Group
Washington, DC
…continuously, and expects high standards from concept through delivery. It values intellectual curiosity, rigorous analysis, direct communication, ownership, thoughtful risk-taking, and the…
Added 6 days ago
Senior Scientist, Sterile Product Development (Onsite)
Merck
Rahway, NJ
The Senior Scientist is a hands-on individual contributor supporting the scientific development of long-acting injectables, peptide drug conjugates, and other parenteral formulations. The…
Added 7 days ago
Senior Advisor, Separation Science - Analytical Development
Lilly
Boston, MA
We are seeking an accomplished Senior Advisor, Separation Sciences to provide scientific leadership for analytical development (AD) supporting next-generation mRNA-LNP-based in vivo CAR-T…
Added 7 days ago
Senior Scientist – LNP Formulation
ThermoFisher Scientific
Boston, MA
Troubleshoot low-yield processes and compositions to achieve formulation targets (i.e., composition design to enable specific delivery outcomes).
Added 8 days ago
Senior Scientist – LNP Formulation
PPD Development, LP
Boston, MA
Troubleshoot low-yield processes and compositions to achieve formulation targets (i.e., composition design to enable specific delivery outcomes).
Added 8 days ago
LI
R&D Senior Scientist (Product Development)
Liquid I.V.
El Segundo, CA
- $103,100 to $128,900 USD / year
…out-of-the-box thinker to join our R&D Product Development team as the Senior Scientist. Reporting to the R&D Director, Product Development, this role will execute core expansion and…
Added 8 days ago
Senior Research Associate, Formulation and Analytical Characterization
Pivotal
San Diego, CA
Job Summary: We are seeking a motivated Senior Research Associate with strong analytical characterization expertise to join our team. This hands-on, lab-based role centers on the…
Added 12 days ago
NP
Sr. Scientist - Formulation Development
Nivagen Pharmaceuticals
Sacramento, CA · Pittsburg, CA
- $115,000 to $140,000 USD / year
Must live in or be willing to move to the Sacramento Metropolitan Region (approximately 40 miles in radius)
Added 13 days ago
Senior Principal Scientist, Data Science - R&D DDSAI - Therapeutics Development & Supply (TDS)
J&J Family of Companies
Spring House, PA
The R&D Data, Data Science & AI (DDSAI) organization is seeking a Senior Principal Scientist, Data Science to lead the development and adoption of Operations Research and Decision…
Added 13 days ago
P
Senior Associate Scientist
Pfizer
Chesterfield, MO
- $68,600 to $114,300 USD / year
At Pfizer, our purpose is to deliver breakthroughs that change patients' lives. As a Senior Associate Scientist, you will be at the forefront of this mission, working within our Research &…
Added 13 days ago
Senior Principal Scientist, Data Science - R&D DDSAI - Therapeutics Development & Supply (TDS)
Janssen Research & Development, LLC Legal Entity
Spring House, PA · Malvern, PA
The R&D Data, Data Science & AI (DDSAI) organization is seeking a Senior Principal Scientist, Data Science to lead the development and adoption of Operations Research and Decision…
Added 13 days ago
Associate Principal Scientist, Biopharmaceutics
Merck Sharp & Dohme LLC
NJ
We are seeking an experienced Associate Principal Scientist to join our team and lead biopharmaceutics strategy for subcutaneously (SC) administered biologics across the pipeline - from…
Added 14 days ago
Scientist, Bioassay Development - Analytical Development
Lilly
Boston, MA
We are seeking a scientist to join the AD team within the Advanced Delivery Systems (ADS) organization in Boston, MA. Reporting to the Senior Advisor, Bioassay Development, this individual…
Added 14 days ago
Senior Advisor, Bioassay Development - Analytical Development
Lilly
Boston, MA
We are seeking an accomplished Senior Advisor for bioassay development within the Analytical Development (AD) team, supporting next-generation RNA-LNP-based therapies within the Advanced…
Added 15 days ago
P
Scientist, Preclinical Ophthalmology
Pharmaron
San Diego, CA
- $100,000 to $115,000 USD / year
Pharmaron is seeking a highly motivated Study Director/Senior Scientist/Scientist to join our Preclinical Ophthalmology team. The successful candidate will serve as a Study Director for GLP…

Lilly

Senior Advisor, Bioassay Development - Analytical Development

Boston, MA, United States

$141,000 - $231,000

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Job details

Pay: $141,000 - $231,000
Posting language: English
Posted: Oct 27, 2026

Original job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work - but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Summary

We are seeking an accomplished Senior Advisor for bioassay development within the Analytical Development (AD) team, supporting next-generation RNA-LNP-based therapies within the Advanced Delivery Systems (ADS) organization. This individual will lead bioassay scientists and serve as the technical SME for cell-based potency assays and other bioassays (e.g., flow cytometry, qPCR, ELISA) to characterize RNA-LNP drug product and other drug delivery systems.

The successful candidate will combine deep, hands-on bioassay expertise with strategic leadership, partnering closely with Lilly Genetic Medicines, Process and Formulation, Cell and Gene Therapy, and Quality teams to drive phase-appropriate analytical strategies and assay execution. The successful candidate will be self-motivated, independent, have hands-on bench skills, and able to lead and develop other scientist.

Key Responsibilities

Serve as the technical lead and group leader for the bioassay function within Analytical Development, defining and executing bioassay strategy and roadmap for RNA-LNP-based programs.
Lead end-to-end development, optimization, pre-qualification, and technical transfer of cell-based potency assays (e.g., transduction/transfection, cell-based potency assays, functional reporter) as the primary measure of product potency.
Design, develop, and execute cellular and molecular assays - including flow cytometry, qPCR/ddPCR, and ELISA-based methods - to characterize RNA-LNP drug product and process- and product-related impurities.
Represent the bioassay function on cross-functional project teams and in technical review settings, and act as the primary analytical SME for potency and bioassay topics.
Establish assay comparability and bridging strategies across process/formulation changes, scale-up, and method transfers; apply sound statistical design (e.g., DOE) to reduce variability and improve assay robustness.
Partner closely with Research, Process and Formulation, Bioproduct Research and Development, Quality, and Regulatory teams to ensure integrated, phase-appropriate analytical strategies, define CQAs, and assess assay suitability and readiness for research-to-development-to-manufacturing transitions.
Oversee technology transfer of bioassays to internal analytical teams, CDMOs, and external testing laboratories, providing technical oversight for specification development.
Evaluate and implement innovative bioassay platforms (e.g., next-generation potency and multiplex flow and d-PCR methods) to address emerging scientific and regulatory challenges.
Ensure bioassay data, methods, and practices comply with ICH/FDA guidelines and industry best practices for cell and gene therapies.
Identify and manage external collaborations (CROs/CDMOs) to enhance internal capabilities and drive bioassay innovation.
Author and review assay protocols, technical reports, and relevant sections of regulatory submissions.

Basic Qualifications

PhD in molecular biology, biochemistry, or a related discipline with 4+ years of industry experience in bioassay/potency assay development; or MS with 10 years of relevant experiences.
Extensive, hands-on experience developing, optimizing, and qualifying cell-based potency assays (cell transfection, antigen detection, cell killing).
Demonstrated hands-on experience with other bioassay techniques such as flow cytometry, qPCR/ddPCR and ELISA.
Knowledge of ICH/FDA guidelines and industry best practices related to bioassays and analytical methods for cell and gene therapies.
Proven experience defining and executing phase-appropriate assay strategies, including method transfer to internal and/or external (CDMO) labs.

Additional Skills and Preferences

Prior experience characterizing RNA-LNP based genetic medicines, process- and product-related impurities.
Experience with PBMC or engineered immune cell lines to measure T-cell activation and functional potency.
Experience authoring regulatory submission sections and supporting health authority interactions.
Strong critical thinking, communication, and problem-solving skills, with an ability to influence scientific direction and deliver in a matrixed, fast-paced environment.
Ability to manage external collaborations and deliver quality results within a stringent timeline.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$141,000 - $231,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

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Skills

Leadership
Research
Molecular biology
Critical thinking
Communication skills
Problem solving

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Jobs in the United States