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Added 11 hours ago
Principal / Sr. Principal Scientist - Molecular Biology & Protein Expression
Lilly
San Diego, CA
The Principal Scientist / Senior Principal Scientist in Molecular Biology & Protein Expression will join a centralized molecular biology and protein expression platform team within Lilly…
Added 1 day ago
Principal / Sr. Principal Scientist - Molecular Biology & Protein Expression
Eli Lilly and Company
United States
The Principal Scientist / Senior Principal Scientist in Molecular Biology & Protein Expression will join a centralized molecular biology and protein expression platform team within Lilly…
Added 3 days ago
Associate Principal Scientist, Upstream Process Development
Merck
Rahway, NJ
We are seeking a highly motivated and energetic individual to join our team as an Associate Principal Scientist. In this role, a successful candidate will work closely with a highly…
Added 3 days ago
Principal Ontologist - R&D DDSAI - Preclinical Sciences & Translational Safety
J&J Family of Companies
Spring House, PA
We are seeking a Principal Scientist/Ontologist to join our R&D DDSAI team, dedicated to developing and supporting ontologies, controlled vocabularies, and semantic data standards for PSTS.
Added 4 days ago
Principal Ontologist - R&D DDSAI - Preclinical Sciences & Translational Safety
Janssen Research & Development, LLC Legal Entity
Spring House, PA
We are seeking a Principal Scientist/Ontologist to join our R&D DDSAI team, dedicated to developing and supporting ontologies, controlled vocabularies, and semantic data standards for PSTS.
Added 4 days ago
Senior Scientist/Principal Scientist, RNA-LNP Formulation and Process Development
Lilly
Boston, MA
This position is responsible for designing and executing formulation and process development studies for RNA-lipid nanoparticle (RNA-LNP) drug products, and for supporting technology…
Added 4 days ago
Associate Principal Scientist, Biopharmaceutics
Merck Sharp & Dohme LLC
NJ
Biopharmaceuticals, Cell Line Development, Clinical Pharmacology, Downstream Process Development, Drug Delivery Technology, Drug Development, Expression Vectors, Immunogenicity, Molecular…
Added 4 days ago
Principal Laboratory Automation Scientist
J&J Family of Companies
Spring House, PA
We are searching for the best talent for a Principal Laboratory Automation Scientist to be located in Spring House, PA.
Added 4 days ago
AD/ Principal Scientist CMC AAV Gene Therapy
OCUGEN OPCO INC
Malvern, PA
…serves as the strategic technical interface between laboratory development, GMP manufacturing, regulatory affairs, and program leadership to ensure seamless transition from clinical…
Added 5 days ago
Senior Scientist/Principal Scientist, RNA-LNP Formulation and Process Development
Eli Lilly and Company
United States
This position is responsible for designing and executing formulation and process development studies for RNA-lipid nanoparticle (RNA-LNP) drug products, and for supporting technology…
Added 5 days ago
Sr. Principal Data Scientist – Market Access
Lilly USA, LLC
United States
The Lilly USA Technology at Lilly Market Access team is seeking a Senior Principal Data Scientist to design and build the next generation of agentic AI and machine learning solutions across…
Added 5 days ago
Principal Laboratory Automation Scientist
Janssen Research & Development, LLC Legal Entity
Spring House, PA
We are searching for the best talent for a Principal Laboratory Automation Scientist to be located in Spring House, PA.
Added 6 days ago
Process modeling (Protein/Antigen) Principal Data Scientist
(2605) Sanofi Vaccines US Inc.
Waltham, MA
As Principal Data Scientist within our Process Modeling – Vaccines R&D Data & Computational Science team, you'll lead the development of AI, machine learning, and hybrid modeling solutions…
Added 7 days ago
Domain Principal Architect (Remote)
CareFirst
Washington, DC
…traceability to business needs via business architecture and downstream alignment / traceability with solution building blocks. Leads the extension / enhancement of domain architecture…
Added 9 days ago
Associate Principal Scientist, Upstream Process Development
Merck Sharp & Dohme LLC
NJ
We are seeking a highly motivated and energetic individual to join our team as an Associate Principal Scientist. In this role, a successful candidate will work closely with a highly…
Added 9 days ago
PI
Senior Principal Scientist, Bioprocess Development
Pfizer, Inc.
NY
- $124,400 to $207,400 USD / year
We are seeking a highly motivated Senior Principal Scientist to lead the Polysaccharide Fermentation and Purification Development group within Vaccines, Early BioProcess Development. The…
Added 10 days ago
Principal Data Scientist, Capabilities & Acceleration
Intuit
Mountain View, CA · San Diego, CA
…them with rigor, and drives adoption across domain teams. As a Principal Data Scientist on this team, you will operate as a senior individual contributor at the intersection of data…
Added 11 days ago
NB
Principal Scientist, Pharmaceutical Development
Neurocrine Biosciences Inc.
United States
- $156,900 to $214,000 USD / year
The Principal Scientist will apply broad pharmaceutical industry experience to develop fit-for purpose analytical methods, guide preformulation strategies, assess developability risks,…
Added 11 days ago
Principal Detection Research Scientist, Cybersecurity
Quantum Sky
Reston, VA
Quantum Sky is searching for a mission-oriented Principal Detection Research Scientist, Cybersecurity to join our CTO shop and anchor the data science behind our preemptive-cyber detection…
Added 11 days ago
Sr. Software Development Manager, Outbound Agentic Marketing Demand
Amazon.com Services LLC
Seattle, WA · New York, NY
…project rather than an Amazon-only one: public roadmap, RFC process for spec changes, contribution and code-review standards, conformance tests, release management, security response, and…
Added 12 days ago
Strategic Clinical Research Program Manager/Clinical Scientist - PH - Rice Creek, MN (Onsite)
Medtronic
Minneapolis, MN
The Strategic Clinical Program Manager/Clinical Scientist develops and executes integrated clinical evidence strategies that support therapy development, commercialization, and market…
Added 15 days ago
Principal Scientist, Protein Purification, Team Lead
J&J Family of Companies
Spring House, PA
We are searching for the best talent for Principal Scientist, Protein Purification, Team Lead in Spring House, PA.
Added 15 days ago
Dir/Sr. Dir - Lab Automation Engineer, Discovery Oncology
Lilly
New York, NY
We're looking for a Director (Principal) Lab Automation Engineer to lead the design, architecture, and software/usability layer of the automated systems that power our NY lab's discovery…
Added 15 days ago
Advisor - Mixed Modality (Oligonucleotide) Scientist - Process Translation and Execution
Lilly
Indianapolis, IN · Lebanon, IN
The Mixed Modality (Oligonucleotide) Advisor sets technical strategy and direction for oligonucleotide manufacturing process transfers from development laboratories to pilot plant…
Added 15 days ago
Mixed Modality (Oligonucleotide) Scientist
Lilly
Lebanon, IN · Indianapolis, IN
In this role, the Mixed Modality (Oligonucleotide) Principal Scientist will be responsible with evaluating and facilitating the transfer of oligonucleotide manufacturing processes, under…

Lilly

Mixed Modality (Oligonucleotide) Scientist

Lebanon, IN, United States
Indianapolis, IN, United States

$67,500 - $173,800

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Job details

Pay: $67,500 - $173,800
Experience: B.S. with 10+ years or M.S. with 7+ years of experience in Oligonucleotide Product/Process Development, Manufacturing Technical Services, or related functional roles.
Posting language: English
Posted: Sep 20, 2026

Original job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work - but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Overview:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader, headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization and Position Overview

Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development, Lebanon, Indiana. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.

The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness, oversees technology transfer, implements phase-appropriate control strategies, and ensures right-first-time clinical manufacturing for a variety of modalities, including synthetic molecules, biologics, peptides, oligonucleotide, and bioconjugates (ADC, ARC, etc.) Through cross-functional collaboration, PTE influences process design, revolutionizes clinical manufacturing, builds capabilities in emerging technologies and aligns with corporate and Lilly Research Labs (LRL) goals, drives scientific excellence and innovation to accelerate manufacturing advancements and propels the site toward long-term business success.

In the Foundry Construction and Project Delivery/Startup Phase (2025 to 2028), roles will be ﬂuid and dynamic as we build a new organization, design and implement the necessary systems and business processes required to enable operational readiness, support the project delivery, and build the site culture. Success will require significant collaboration, creativity, and resilience as the Lilly Medicine Foundry transitions from design to startup and ultimately to steady-state operations and continuous improvement. This period presents a unique opportunity for learning, growth, and making a lasting impact.

We are seeking passionate and agile scientist to join the PTE team and help bring the Lilly Medicine Foundry’s vision to life.

Responsibilities

In this role, the Mixed Modality (Oligonucleotide) Principal Scientist will be responsible with evaluating and facilitating the transfer of oligonucleotide manufacturing processes, under appropriate supervisory guidance, from development laboratories to pilot plant operations (including kilo-scale and isolator production environments). This enables the successful transition to early-phase cGMP manufacturing of grams to kilogram quantities of API required for clinical trial supply.

Oversee the successful transfer of new oligonucleotide processes from development to manufacturing; ensure scalability and process fit to plant; apply scientific knowledge to troubleshoot production issues and implement new technologies or procedures.
Assess and scale-up synthesis and purification methods from early phase process research and development labs
Familiarity with performing oligonucleotide procedures, such as solid phase synthesis, preparative chromatography, TFF, & lyophilization.
Evaluate the safety of the incoming procedures in collaboration with the safety group and process engineering.
Analyze analytical data to make fact-based decisions.
Efficient with summarizing and presenting chemistry and challenges.
Lead familiarization executions to ensure plant readiness of process steps including synthesis, cleavage, purification, TFF, & lyophilization at the Lilly Medicine Foundry.
Perform use-tests of key in-process materials and document Definitive Lab Trials of processes to confirm plant readiness.
Documentation: Author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports.
Process improvement: Apply scientific knowledge to identify areas for improvement and implement new technologies or procedures.
Lead process-related investigations, assess deviations, and support CAPAs; collaborate closely with CMC, Product R&D, Manufacturing, and Quality teams; provide on-floor support for critical operations and train/mentor junior scientists and technicians in PTE activities.

Basic Requirements:

B.S. or M.S. in Chemistry, Biochemistry, Chemical/Biochemical Engineering, or a related discipline.
B.S. with 10+ years or M.S. with 7+ years of experience in Oligonucleotide Product/Process Development, Manufacturing Technical Services, or related functional roles.
Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Additional Preferences:

Strong knowledge of oligonucleotide process (upstream or downstream), including synthesis, cleavage & deprotection, chromatography, conjugation, and aseptic processing.
Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges; solid understanding of biopharmaceutical manufacturing principles and cGMP requirements.
Demonstrated success in cross-functional, dynamic, and matrixed environments; excellent written and verbal communication skills for technical report writing, presentations, and team collaboration.
Previous experience leading small projects, coordinating activities, and managing timelines; supervisory experience of junior scientists or technicians highly preferred.
Proactive engagement with external innovation and industry trends; proven ability to champion accelerated adoption of transformative technologies in manufacturing environments.
Experience with oligo synthesis and purification techniques used for developing and scaling-up process reactions. Experience using process chemistry concepts is a plus.
Comfortable working with larger sized reactors and preparative columns, TFF, and related-equipment.
Highly motivated, able to learn rapidly, and demonstrates strong attention to detail.
Has experience creating batch records and conducting scale-up experiments according to those records.
Ability to prioritize multiple activities and manage ambiguity.
Experience with a variety of analytical techniques: HPLC/UPLC, LC-MS, GC, etc.
Process quantification and acquiring mass balance for products and by-products.
Communication skills: Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams
Problem-solving skills: Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges.

Other Information:

Initial location at Lilly Technology Center, Indianapolis and/or Parkwood West
Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana.
Limited domestic and international travel (< 5%) may be required for this role
Role requires ability to work in manufacturing and laboratory environments

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

#WeAreLilly

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$67,500 - $173,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

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More about this job

Skills

Apply advanced manufacturing
Research
Manufacturing processes
Translation
Collaboration
Design process
Business processes
Process improvement
Troubleshoot
Process engineering
Documentation
CPT
J
Root cause analysis
Communication skills
Write technical reports
Presentation skills
Attention to detail
Problem solving
Leadership

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