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Keros Therapeutics

Director, Program Management

Lexington, MA, United States

$201,000 - $239,000 USD

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Job details

Pay: $201,000 - $239,000 USD
Experience: At least 10 years of biotechnology or pharmaceutical drug-development experience, including substantial experience in clinical-stage development
Posting language: English
Posted: Nov 6, 2026

Original job description

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

Job Summary

The Director, Program Management, will provide strategic and operational leadership for the rinvatercept (KER-065) development program. This individual will lead cross-functional program planning and execution as rinvatercept advances through clinical development. The ideal candidate will combine strong drug-development program leadership with meaningful experience running clinical trials across Phase 1, Phase 2 and Phase 3.

The successful candidate will move effectively between strategic planning and hands-on execution, anticipate and mitigate risks, drive timely decisions and maintain alignment across Clinical Development, Clinical Operations, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Biometrics and other functions.

Primary Responsibilities

Program Strategy and Leadership

Serve as the program management lead for rinvatercept, partnering with functional leaders to define and execute the optimal global development strategy
Lead the cross-functional program team, including representatives from Clinical Development, Clinical Operations, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Biometrics, Medical Affairs, Commercial and Corporate Strategy
Guide the program through proof of concept, registration-enabling studies, regulatory submissions and potential marketing authorization
Translate development strategy into clear program objectives, operational priorities and measurable deliverables
Mobilize and align the organization around the program strategy and drive timely decision-making through appropriate governance forums
Balance day-to-day program execution with long-range strategic planning

Integrated Development Planning

Create and maintain an integrated strategic development plan covering program goals, value-creation milestones, critical-path activities, cross-functional dependencies, timelines, decision points, assumptions, risks, alternative scenarios, budget and resource requirements
Ensure functional plans are aligned with the overall development strategy and that interdependencies are clearly understood and actively managed
Identify potential gaps, conflicts and constraints before they affect clinical, regulatory or operational milestones
Lead scenario planning to evaluate alternative development approaches and their implications for timeline, resources, risk and program value

Clinical Development and Trial Execution

Partner with Clinical Development and Clinical Operations to plan and execute rinvatercept clinical trials across Phase 1, Phase 2 and Phase 3
Integrate clinical activities with regulatory, CMC, nonclinical, biometrics and other program workstreams
Identify and manage dependencies affecting protocol development, regulatory submissions, site activation, patient enrollment, study conduct, data delivery and clinical readouts
Support transitions between stages of development, including progression from early clinical studies into proof-of-concept and registration-enabling trials
Apply an understanding of neuromuscular and rare-disease trial challenges, including specialized investigator sites, patient recruitment, natural-history considerations, endpoints and global execution
Ensure clinical-trial plans are supported by realistic timelines, budgets, resources and risk-mitigation plans

Cross-Functional Team Effectiveness

Establish and lead an effective operating cadence for program team meetings, working sessions and governance reviews
Prepare agendas, facilitate discussions and ensure decisions, action items, owners and deadlines are clearly documented and communicated
Foster strong relationships with program team members and functional line leaders, and serve as a central point of contact for program communications and issue resolution
Create clarity around roles, responsibilities and decision rights to enable efficient execution and accountability
Promote a program culture characterized by urgency, transparency, scientific rigor, collaboration and respect

Governance and Decision-Making

Represent the rinvatercept program team at internal governance meetings, in collaboration with relevant team members
Develop high-quality program updates, recommendations and decision materials for senior management and governance committees
Present program strategy, operating plans, progress, risks and alternative scenarios clearly and persuasively
Ensure governance decisions are documented and translated into executable cross-functional plans
Proactively escalate issues requiring senior-management attention and provide clear options and recommendations
Maintain a decision log capturing major decisions, assumptions, rationale and implications

Risk, Issue and Dependency Management

Establish and maintain an integrated risk register covering clinical, regulatory, CMC, nonclinical, operational, financial and strategic risks
Work with functional leaders to define mitigation plans, contingency actions, owners and escalation thresholds
Proactively identify emerging issues that could affect program timelines, clinical execution, regulatory strategy or key value-creation milestones
Facilitate timely resolution of cross-functional issues and ensure agreed mitigation actions are completed

Executive and External Communication

Communicate program strategy, operating plans, progress and risks effectively to senior management
Represent the program team in scientific and business discussions, conveying complex information concisely and in a decision-oriented manner
As appropriate, represent rinvatercept and Keros in interactions with investigators, scientific experts, development partners, patient-advocacy organizations and other external stakeholders
Partner with Clinical Development, Medical Affairs and other functions to incorporate relevant external perspectives into program planning

Program Operations, Budget and Resources

Coordinate program budgets, forecasts and resource assumptions with Finance and functional leaders
Monitor execution against approved timelines, budgets and resource plans
Identify resource constraints and capacity risks early and work with functional leadership to develop practical solutions
Support vendor and external-partner planning where activities span multiple program functions
Establish and continuously improve fit-for-purpose program-management processes, tools, reporting practices and documentation

Core Competencies (Required Skills)

At least 10 years of biotechnology or pharmaceutical drug-development experience, including substantial experience in clinical-stage development
At least 5 years in program management, program leadership, clinical operations or a closely related cross-functional development role
Demonstrated experience supporting or leading clinical programs across Phase 1, Phase 2 and Phase 3
Strong understanding of end-to-end drug development and the interdependencies among clinical, regulatory, CMC, biometrics, nonclinical and commercial activities
Demonstrated ability to lead complex cross-functional teams and influence at all levels of an organization
Experience applying program-management principles and practices to integrated development plans, timelines, dependencies, risks, decisions, budgets and resources
Must be located in the Boston area or willing to relocate and able to work from the office four days per week
Ability to travel up to 10%, including domestic and international travel

Preferred Skills

Strong analytical and problem-solving skills, combining attention to detail with a broad strategic perspective
Ability to thrive in a fast-paced biotechnology environment that requires both strategic leadership and hands-on execution
Excellent written and oral communication, presentation and facilitation skills, with the ability to be persuasive in scientific and business forums

Education Requirements

Bachelor's degree in a scientific, medical, engineering or related discipline; advanced degree preferred

This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, and other relevant factors.

Potential base pay range

$201,000 - $239,000 USD

Our Diversity, Equity & Inclusion Mission Statement: Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.

Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Recruitment & Staffing Agencies:

Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly. Any unsolicited submission by an agency to Keros is prohibited. Any resume submitted by an agency without a signed contract or expressed consent by a member of the Keros Therapeutics Human Resources Department, will be considered property of Keros Therapeutics, and no fee shall be owed with respect thereto.

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More about this job

Skills

Program management
Leadership
Clinical trials
Strategic planning
Regulatory affairs
Decision making
Recruitment
Natural history
Collaboration
Communication skills
Reporting
Documentation
Biotechnology
Pharmaceutical drug development
Problem solving
Attention to detail
Coaching

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