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Added 4 mins ago
Staff Engineer (Multiple Openings)
Samsung Austin Semiconductor, LLC.
San Jose, CA
…create a better world for all. At Samsung Austin Research and Development Center (SARC) and Advanced Computing Lab (ACL), we are building a center of excellence for Intellectual Property…
Added 4 mins ago
Senior Staff Engineer (Multiple Openings)
Samsung Austin Semiconductor, LLC.
San Jose, CA
…create a better world for all. At Samsung Austin Research and Development Center (SARC) and Advanced Computing Lab (ACL), we are building a center of excellence for Intellectual Property…
Added 4 mins ago
Senior Engineer (Multiple Openings)
Samsung Austin Semiconductor, LLC.
San Diego, CA
…create a better world for all. At Samsung Austin Research and Development Center (SARC) and Advanced Computing Lab (ACL), we are building a center of excellence for Intellectual Property…
Added 4 mins ago
Engineer
Samsung Austin Semiconductor, LLC.
San Jose, CA
…create a better world for all. At Samsung Austin Research and Development Center (SARC) and Advanced Computing Lab (ACL), we are building a center of excellence for Intellectual Property…
Added 6 mins ago
Software Engineering Manager, AI/ML, Google Labs
Google
Mountain View, CA
8 years of experience in software development.
Added 6 mins ago
Senior Research Engineer, GenMedia Safety, DeepMind
DeepMind
Mountain View, CA · New York, NY · San Francisco, CA
…generation capability), and successor GenMedia models. We drive the development of the foundational technology adopted by numerous product areas including Gemini App, Cloud API, Search, and…
Added 11 mins ago
Senior Engineer - Database Infrastructure
Hard Rock Digital
Remote, United States
Operate PostgreSQL and MySQL on Amazon RDS across production, staging, and development: replication, failover, backup and recovery, upgrades, and each engine's own failure modes, from…
Added 17 mins ago
Senior Cloud Software Engineer
Modern Technology Solutions Inc
Dayton, OH · Dayton
Lead design and development of cloud‑native services, including microservices architectures, API interfaces, and distributed data flows.
Added 17 mins ago
Junior Cloud/Software Engineer
Modern Technology Solutions Inc
Dayton, OH · Dayton
Support the development and enhancement of Catalog Collection services such as the Catalog Service, Object Store, Metadata/Tagging services, Source Citation Manager, and Enterprise Search.
Added 17 mins ago
Cloud Software Engineer
Modern Technology Solutions Inc
Dayton, OH · Dayton
Lead design and development of cloud‑native services, including microservices architectures, API interfaces, and distributed data flows.
Added 23 mins ago
Lead Network Engineer
Fortitude Mining, LLC
Aurora, NE · Grand Island, NE · Prosser, NE
The Lead Network Engineer is a key member of the IT & Cybersecurity team, responsible for implementing, maintaining, and securing network infrastructure supporting mission-critical mining…
Added 31 mins ago
O
Principal Platform Software Engineer
Oracle
Nashville, TN
- $104,500 to $234,600 USD / year
…problems. This role is ideal for engineers with strong software development fundamentals, experience building distributed systems, and a solid understanding of Kubernetes and cloud-native…
Added 32 mins ago
Manufacturing Line Manager - 2nd Shift
Siemens
Roebuck, SC
…the opportunity to lead high-impact initiatives in a custom, engineer-to-order electrical-products manufacturing…
Added 32 mins ago
Lead .NET Developer
EPAM Systems
Fort Mill, SC
Identify, prioritize, and execute tasks in the software development life cycle (SDLC)
Added 32 mins ago
Industrial Engineer, Distribution Center
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Fort Mill, SC
The Productivity Engineer I is responsible for the development, implementation, documentation, and support of the engineered production standards as well as the development and…
Added 32 mins ago
AU
Electrical Engineer I
Adecco US, Inc.
Florence, SC
- $19 to $30 USD / hour
The Electrical Engineer will provide support for a variety of electrical systems and electronic components. This role will be responsible for troubleshooting, testing, design improvements,…
Added 32 mins ago
Solutions Engineer
CGI Technologies and Solutions, Inc.
Charleston, SC
CGI Federal is looking for a Solutions Engineer to deliver client facing applications, integrations, and automation that streamline operations and improve business processes. This role is…
Added 32 mins ago
Software Engineer IV
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Charleston, SC
Added 32 mins ago
R&D Engineer
GE Vernova
Greenville, SC
The R&D Engineer works with a broad network of engineers within GE Vernova, including technical experts, Platform, Configuration and Product Management teams, and also with critical…
Added 32 mins ago
ENGINEER QUALITY 3
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Goose Creek, SC
…evaluation and reliability, inventory control and/or research and development as they apply to product or process quality. May be certified in lean and six-sigma quality engineering…
Added 38 mins ago
Product Engineer
Tenneco
Bhiwadi, IN
Creates product designs and specifications in conjunction with Research and Development. Ensures new products are designed to meet customer expectations.
Added 38 mins ago
IC
Building Engineer
ISS Conversational ATS
WESTFORD, MA
- $35 to $45 USD / hour
The Building Engineer ensures all facilities related equipment is maintained to the highest standards in the Hard Services line. Additionally, the Building Engineer will partner with the…
Added 39 mins ago
Systems Yield Engineer, Quantum AI
Google
Goleta, CA
As a part of the Quantum Systems Yield Engineer, you will drive development and execution of comprehensive testing to characterize the yield and reliability of critical components and…
Added 39 mins ago
Engineering Leader, Google COE
Fractal Analytics Inc
CA
Familiarity with Google internal AI development tooling and developer productivity systems.
Added 41 mins ago
Senior RF Systems & Business Development Engineer
Matrix Research, Inc.
Beavercreek, OH
Matrix Research is currently seeking an experienced Senior RF Systems and Business Development Engineer to lead technical hardware design and drive strategic growth for our growing business…

insitro

Lead/ Senior Machine Learning Scientist, Integrative Phenotyping

South San Francisco, CA, United States

Our target starting salary for successful US-based applicants for this role is $183,000 - $224,000.

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Job details

Pay: Our target starting salary for successful US-based applicants for this role is $183,000 - $224,000.
Experience: Proven Tenure: PhD in computer science, machine learning, or a related field, or 5+ years of equivalent applied ML research experience.
Posting language: English
Posted: Nov 2, 2026

Original job description

THE OPPORTUNITY

insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics - whether small molecules, biologics, or oligos. With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.

As a Lead/ Senior Machine Learning Scientist on the Integrative Phenotyping team, you will develop, productionize, and deploy cutting-edge ML approaches to build precise phenotypes from large-scale multimodal datasets - clinical imaging, electronic health records, longitudinal outcomes, biomarkers, and multi-omic readouts - and use them to understand patient state, predict clinical endpoints, and identify therapeutic targets.

You’ll work alongside machine learning scientists, statistical geneticists, life scientists, software engineers, and clinicians, and your expertise will shape how the company builds rigorous ML on complex human data.

Based in South San Francisco, this position reports directly to the Head of Integrative Phenotyping and offers an in-person hybrid schedule of three days per week.

RESPONSIBILITIES

ML Methods & Platform

Build Precise Phenotypes: Develop and deploy ML methods that extract biological insight from complex, high-dimensional human cohort data such as MRI and functional genomics.
Model Patient State: Develop models that characterize patient state and predict outcomes and clinical endpoints from multimodal data including clinical imaging, EHRs, longitudinal outcomes, biomarkers, and multi-omic readouts.
Set the Bar: Ensure modeling strategies are rigorous, effective, and aligned with best practices in the field.
Engineer Reusable Components: Build robust, reusable platform components in partnership with the software engineering team.

Target Discovery & Translation

Integrate Causal Evidence: Combine causal, multimodal analyses across diverse phenotypic readouts to select better therapeutic targets.
Biomarkers & Endpoints: Partner with Therapeutic Area and Clinical Development colleagues to develop new biomarkers for patient selection and clinical endpoints.
Connect Genetics to Phenotypes: Work with the Statistical Genetics team to associate human genetics with ML-derived phenotypes.

ABOUT YOU

Experience & Qualifications

Proven Tenure: PhD in computer science, machine learning, or a related field, or 5+ years of equivalent applied ML research experience.
Modern ML Expertise: Hands-on experience developing and deploying state-of-the-art ML methods, including multimodal techniques, to extract clinically relevant signals from complex data.
Clinical Data Depth: Experience with several of: clinical imaging (e.g., MRI, DEXA, CT, echocardiography), clinical records (e.g., EHRs, medications, outcomes), physiological recordings (e.g., EEG, ECG), or biobank-scale human genetic data.
Multimodal Experience: Experience with high-content modalities such as single-cell or bulk omics, genetic perturbation screening, spatial proteomics, or pooled optical screening.
Publication Record: Meaningful, high-quality contributions in ML, ML for health, computational biology, or biomedical venues.
Engineering Fluency: Strong Python in a cloud environment and modern deep learning frameworks, with a track record of reusable, tested, version-controlled ML code.

Core Competencies

End-to-End Delivery: You work with other ML scientists and engineers to take a real-world problem from sourcing and qualifying training data through model design, testing, and benchmarking.
Cross-Functional Translator: You collaborate well with statistical geneticists, life scientists, software engineers, and clinicians, and can make ML results legible to each.
Biology-Curious: You want to understand the physiology behind the data, and prior exposure to cardiovascular disease, neuroscience, or metabolism is a plus.

COMPENSATION & BENEFITS AT INSITRO

Our target starting salary for successful US-based applicants for this role is $183,000 - $224,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

401(k) plan with employer matching for contributions
Excellent medical, dental, and vision coverage as well as mental health and well-being support
Open, flexible vacation policy
Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
Quarterly budget for books and online courses for self-development
New hire stipend for home office setup
Monthly cell phone & internet stipend
Access to free onsite baristas and daily lunch for employees who are either onsite or hybrid
Access to a free commuter bus network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.

Please be aware of recruitment scams: we never request payments, all recruitment communications are from @insitro.com http://insitro.com, and if in doubt, contact us at info@insitro.com.

About insitro

insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro’s approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit www.insitro.com http://www.insitro.com.

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