Scientist, Cell Therapy Downstream Product Development

Job Description

Our large pharmaceutical client in Spring House, PA is seeking an Associate Scientist to join their growing Cell Therapy Development organization and support ongoing CAR-T programs. Primary responsibilities include:

Downstream -Support CAR-T formulation and cryopreservation activities in BSL2+ labs -Formulation execution across various studies -Participate in data analysis of process characterization studies

In Vivo -Develop in vitro model systems to support in vivo CAR T screening efforts -Conduct and analyze in vitro studies to assess product potency, efficacy and safety -Perform hands on laboratory work including process design, optimization and characterization

General -Collect, verify and analyze data and results -Review, understand, and follow protocols and SOPs -Document/review experimental work and results to ensure data integrity -Implement and maintain high quality standards for all aspects of work conducted including adherence to regulatory GLP/GMP, departmental, and safety & compliance guidelines -Track and coordinate inventory and manage sample coordination, hand-off, and storage across other internal teams

Skills and Requirements

-1+ year of experience with cell culture and aseptic techniques -Cell cryopreservation experience including formulation, freezing, and transfer to storage -Bachelor's or MS Degree in Biology, Biochemistry, Bioengineering or related discipline -CAR T Cell Therapy experience (autologous ex vivo or in vivo CAR T) -Experience with primary immune cell culture -Experience with Liquid Nitrogen Freezer (LN2) -Cell washing equipment such as Lovo and Cue -Flow cytometry -Ability to work effectively in a cross functional matrixed environment -Prior industry experience is preferred -Cell selection equipment such as Xuri and Sefia -Experience using Prodigy -Experience in a GMP lab setting -Experience with data presentation software (i.e. GraphPad Prism)

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to HR@insightglobal.com.