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Lead Data Engineer
Docusign
San Francisco, CA · Seattle, WA
…business and simplify people’s lives. With intelligent agreement management, Docusign unleashes business-critical data that is trapped inside of documents. Until now, these were…
Added 1 min ago
Sr CRM Account Executive - Federal
ServiceNow
Remote, United States
It all started when engineer Fred Luddy wrote code that automated a tedious task for his coworker, Phyllis. She cried tears of joy. That moment inspired Fred to build a company that could…
Added 1 min ago
Sr CRM Account Executive - Federal
ServiceNow
Remote, United States
It all started when engineer Fred Luddy wrote code that automated a tedious task for his coworker, Phyllis. She cried tears of joy. That moment inspired Fred to build a company that could…
Added 1 min ago
Sr CRM Account Executive - Federal
ServiceNow
Remote, United States
It all started when engineer Fred Luddy wrote code that automated a tedious task for his coworker, Phyllis. She cried tears of joy. That moment inspired Fred to build a company that could…
Added 4 mins ago
Senior DevSecOps Engineer (Contingent)
Mile Two, LLC
Dayton, OH
…always got your back. Humble Expertise: We respect everyone's knowledge and skills, creating an environment where we can all learn and get better together. Success is a Team Effort: We…
Added 4 mins ago
Engineer
Scotiabank
Dallas, TX
We are seeking a Senior AI Engineer to design, build, and operate AI and agentic solutions supporting Canadian Banking, International Banking, Global Banking and Markets (GBM), Global…
Added 5 mins ago
Product Development Engineer – Wiper/Washer (Subject Matter Expert)
Ford
Dearborn, MI · Dearborn
Demonstrated expert level knowledge in body exterior wiper and washer attributes, including material properties, design attributes for durability / NVH, corrosion mitigation, control plan…
Added 6 mins ago
Manager, Engineering
Priority Technology Holdings, LLC
Remote, United States
Craft - Hiring, feedback, and performance management operate as a system, not events: the bar is consistent, the assessments are honest, and underperformance is addressed early and…
Added 11 mins ago
Sr., IT Systems Engineer- Azure Virtual Desktop, AI & Automation SME
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- Must have knowledge of products such as word processing, spreadsheets and management of database tables in a PC environment.
Added 11 mins ago
QA Automation Engineer
DRB
Akron, OH
The Quality Assurance Automation Engineer I is a key contributor to ensuring overall hardware and software quality through proven test automation practices. The role includes working…
Added 12 mins ago
Lead Data Engineer
projects/helpful-passage-853/companies/9810ab3a-d8cd-4ba4-9ee5-ca421241fe3c
San Francisco, CA · Seattle, WA
…business and simplify people’s lives. With intelligent agreement management, Docusign unleashes business-critical data that is trapped inside of documents. Until now, these were…
Added 15 mins ago
Supplier Process Senior Engineer
Honda Dev. and Mfg. of Am.,LLC
Lincoln, AL
The Supplier Process Sr. Engineer position supports supplier delivery and characteristic improvement activity with automotive part suppliers in North America. Responsible for evaluating…
Added 16 mins ago
Senior Entra ID / Active Directory Migration Engineer
Two95 International Inc.
Newtown Square, PA
We are seeking an experienced Entra ID / Active Directory Engineer to support an enterprise SSO migration project, transitioning 100+ applications from PingFederate to Microsoft Entra ID.…
Added 17 mins ago
Thermal Fluids Mechanical Engineer - LiquidStack Cooling Solutions
LQS Liquid Stack LLC
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Within Sustaining Engineering, the Thermal Fluids Mechanical Engineer - LiquidStack Cooling Solutions applies heat transfer, thermodynamics, and fluid mechanics to support the performance,…
Added 18 mins ago
Senior Software Engineer (ICAM / Zero Trust)
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Hanover, MD · MD · Elkridge
Job Title: Senior Software Engineer (ICAM / Zero Trust)
Added 20 mins ago
Senior Manager, Facilities Services Operations
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1530 FM 973 Taylor, TX
Samsung Austin Semiconductor is seeking a Facilities Senior Manager to join the Infra Technology Team. The Senior Manager of Facilities Services is a critical leadership role focused on the…
Added 20 mins ago
Facilities Operations Manager
Samsung Austin Semiconductor, LLC.
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Collaborate with the Senior Manager to scale operational capabilities for multi-fab support.
Added 21 mins ago
Senior Electrical Engineer - Industrial Market
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In-depth knowledge of design and application of power distribution equipment, protection, and control systems required for large industrial projects.
Added 23 mins ago
Senior IT Security Specialist
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Cloud security knowledge in AWS, Azure or Google Cloud: identity and access management, network security groups, logging and cloud security posture management (CSPM).
Added 23 mins ago
Senior Project Manager, Owners Engineering
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Houston, TX · Austin, TX · Medford, MA · Oakland, CA · San Diego, CA · Portland, OR · Seattle, WA
DNV’s Owner’s Engineering (OE) team is seeking a Senior Project Manager-Owner’s Engineering to perform a variety of engagements related to storage, solar, wind and other emerging…
Added 24 mins ago
Senior Decision Intelligence Engineer
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The Senior Machine Learning Engineer, Decision Intelligence is a hands-on individual contributor responsible for building, deploying, and operating ML and decisioning pipelines for the NBA…
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Senior Transportation Engineering Project Manager
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French & Parrello Associates (FPA) is seeking an experienced and motivated Senior Transportation Engineering Project Manager to join our growing Highway & Bridge Departments at our…
Added 25 mins ago
Bridge Manager
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The successful candidate will provide leadership for FPA’s Bridge Department while serving as a Senior Project Manager on major transportation and bridge assignments throughout New Jersey…
Added 27 mins ago
Senior NPI Program Manager – FACTS FSC & SC
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Knowledge of and experience using IEEE, IEC, ANSI, NEC, and NESC standards and codes, and ability to engineer design packages

Hologic

Principal Software Algorithm Engineer - Digital Cytology AI

Marlborough, MA, United States

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Job details

Posting language: English
Posted: Nov 6, 2026

Original job description

At Hologic, we are driven by a singular purpose: to enable healthier lives everywhere, every day. As a global leader in women’s health, we design innovative diagnostic and imaging solutions that help detect disease earlier and improve outcomes for patients worldwide. Join a team where your work in AI and digital diagnostics directly supports clinicians in delivering better care for women.

Job Summary Hologic is seeking a Principal Software Algorithm Engineer to design, train and validate deep learning models for cytology on the Genius™ Digital Diagnostics System. This role owns the cell-level CNN classifier, nuclear-to-cytoplasmic (NC) ratio segmentation pipeline, and the technical evidence needed to support FDA and other regulatory submissions. The engineer serves as the technical lead for model design and verification under design controls, working closely with cytopathologists, imaging scientists, regulatory and quality teams.

Key Responsibilities

Design, train and tune multi-class CNNs to classify cells and aggregate predictions into specimen-level diagnostic categories.
Develop multi-task models with shared encoders and feature heads for diagnostic class, cytomorphologic features and NC ratio category.
Build nucleus and cytoplasm segmentation networks to measure NC ratio and nuclear area, including overlapping cells in clusters.
Own the data pipeline, including patient-grouped splits, color profile application, class balance and imaging metadata.
Run disciplined experiments, benchmark lightweight backbones against larger reference models and define evaluation metrics and reports.
Collaborate with pathologists on labeling protocols, inter-observer agreement and adjudication processes.
Prepare design documentation, verification/validation protocols and technical content for regulatory submissions.
Mentor engineers and establish coding, reproducibility and MLOps standards.
Ensure model performance and interpretability, including Grad-CAM checks and feature outputs that align with pathologist expectations.
Support regulatory strategy for AI-enabled medical devices under design controls and PCCP guidance.

Qualifications

Education

MS or PhD in computer science, biomedical engineering, electrical engineering or a related field, or BS with equivalent experience.

Experience

10+ years of software development, including 5+ years building and deploying deep learning models for computer vision.

•

Demonstrated leadership experience, with the ability to set strategic direction, influence senior stakeholders, lead cross-functional initiatives, and drive accountability and execution in a complex, matrixed organization.

Skills

Expert Python and PyTorch (or TensorFlow), including CNN fine-tuning, transfer learning and segmentation (e.g., U-Net, segmentation_models_pytorch).
Experience with imbalanced, multi-class and multi-task problems, and metrics such as per-class sensitivity, F1, kappa and AUROC.
Experience with medical or microscopy imaging, including color handling, stain variation and high-resolution tiling.
Strong discipline in data splitting, leakage prevention, experiment tracking and reproducible training.
Clear written communication for technical reports and design documentation.
Preferred: digital pathology or cytology AI experience (ideally urine cytology); experience with FDA 510(k), De Novo, PMA or EU IVDR; familiarity with IEC 62304, ISO 13485, ISO 14971, 21 CFR Part 820 and FDA PCCP guidance.
Preferred: ICC color management, stain deconvolution and scanner color calibration; cell instance segmentation tools (StarDist, Cellpose) and annotation tools (QuPath, CVAT, napari).
Preferred: model optimization for edge or embedded inference (quantization, ONNX, TensorRT) and experience leading or technically guiding a small team.

Why join Hologic?

We are committed to making Hologic the destination for top talent. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career.

The annualized base salary range for this role is $157,000 - $220,000 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, education, business needs and market demand.

Agency and Third-Party Recruiter Notice

Agencies that submit a resume to Hologic must have a current executed Hologic Agency Agreement executed by a member of the Human Resource Department. In addition, Agencies may only submit candidates to positions for which they have been invited to do so by a Hologic Recruiter. All resumes must be sent to the Hologic Recruiter under these terms or they will not be considered.

Hologic is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.

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More about this job

Skills

Deep learning
Documentation
Medical devices
Computer science
Biomedical engineering
Electrical engineering
Software development
Leadership
Python
PyTorch
TensorFlow
Communication skills

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