Jobs in the United States

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Added 2 mins ago
Principal Automation Engineer Optical Inspection SME
Janssen Biotech, Inc. Legal Entity
Wilson, NC
Senior Automation Engineer will lead internal team members, suppliers, OEMs, system integrators, Digital/IT partners, automation-system owners, and cross-functional stakeholders to deliver…
Added 2 mins ago
Water Engineer II
SSR
Nashville, TN
As an Engineer II, you’ll independently apply standard design engineering techniques on small projects or selected segments of larger work - owning coordination, analyses, and documentation…
Added 3 mins ago
Systems Engineer 4
Ultra Electronics Advanced Tactical Systems, Inc.
United States
Ultra I&C is hiring a Model Based Systems Engineer to join us in our Huntsville, AL or Austin, TX locations. This position will lead a variety of system design and development efforts…
Added 4 mins ago
GE
Sr Staff Applications Operations Engineer – Engineering Tools Automation & AI Ops
General Electric Company
United States
- $131,000 to $174,000 USD / year
Serve as the senior technical operations authority across engineering application pods (software, hardware and electronic design, and project and portfolio management tools) for US and UK…
Added 5 mins ago
RU
Sr Application Security Manager
Randstad USA
Remote, United States
- $160,000 to $180,000 USD / year
Our West Michigan Client has a great opportunity for a Sr Application Security Engineer to join their team. This can be a remote role in or near Michigan. Ideal candidates will have a…
Added 5 mins ago
D
Senior Software Engineer - Platform Services
DRW
Chicago, IL
- $175,000 to $275,000 USD / year
As a Senior Software Engineer, you will define, develop, and own services that form the foundation of DRW's Unified Platform.
Added 5 mins ago
Member of Technical Staff – Tech Lead
ResolveAI
San Francisco, CA
- Software maintenance and production troubleshooting have become a massive tax of engineering velocity. Resolve AI is solving this by building a transformative, truly autonomous AI…
Added 7 mins ago
Pr. Quality Assurance Engineer
Nextern
Maple Grove, MN
Lead by example in Good Manufacturing Practices (GMP) and Good Documentation Practices (GMP)
Added 7 mins ago
Global Sr. Quality Assurance Engineer
Nextern
Maple Grove, MN
Lead by example in Good Manufacturing Practices (GMP) and Good Documentation Practices (GMP)
Added 7 mins ago
Senior Software Engineer
Eagan, MN · Frisco, TX · Ann Arbor, MI
We're looking for a Senior Front-End Software Engineer AI to join the CoCounsel team. We are building the next generation of AI agentic products for legal professionals. The team takes…
Added 7 mins ago
Principal Solutions Engineer, Strategic (East & Central)
Atlassian
Remote, United States
Atlassian is looking for a Principal Solutions Engineer, Strategic for our strategic business that’s passionate about being a product expert in the sales cycle, solving our customer’s…
Added 7 mins ago
Senior Software Engineer
Atlassian
Remote, United States
We’re looking for a Senior Software Engineer to own critical platform capabilities, lead complex initiatives, and raise the engineering bar across the team.
Added 9 mins ago
G
Transportation Engineer
GPAC
Washington DC
- $85,000 to $130,000 USD / year
We are seeking a Transportation Engineer to join a dynamic, multi-disciplinary engineering consulting firm. This individual will contribute to the planning, design, and delivery of…
Added 10 mins ago
Teacher, CTE HS Health Science / EOY (26-27)
Charlotte-Mecklenburg Schools
Charlotte, NC
…for all students in the area of Health Sciences and Project Lead the Way (PLTW) Biomedical. The teacher supervises, monitors, and evaluates students while developing lesson plans to ensure…
Added 10 mins ago
Thermal Fluids Mechanical Engineer - LiquidStack Cooling Solutions
LQS Liquid Stack LLC
Carrollton, TX
Within Sustaining Engineering, the Thermal Fluids Mechanical Engineer - LiquidStack Cooling Solutions applies heat transfer, thermodynamics, and fluid mechanics to support the performance,…
Added 10 mins ago
N
AI Product Operator Intern
Niural
New York City, NY
- $20 to $25 USD / hour
- Build lead enrichment, CRM hygiene, and outbound personalization workflows
Added 11 mins ago
Project Engineer
Malibu Electronics, LLC
Lenoir City, TN
The Project Engineer is responsible for creating, maintaining, revising, and managing production and prototype harness CAD drawings and associated engineering documentation to support…
Added 11 mins ago
C
Operations Engineer
Coast
NY
- $150,000 to $180,000 USD / year
…as one of two AI Operations Engineers, reporting to our AI…
Added 11 mins ago
Platform Engineer
Advocate Technologies Inc.
Long Island City, NY
We’re hiring a NYC based Platform Engineer to own the foundation that Advocate’s product and people build on.
Added 12 mins ago
Lead Project Engineer
Wabtec
West Melbourne, FL
As a Lead Project Engineer, you will serve as the technical execution leader for customer-facing Train Handling software projects. Working across Engineering, Program Management, Product…
Added 13 mins ago
Senior Robotics Software Engineer – AI-Enabled Manipulation & Industrial Automation
General Motors LLC
Mountain View, CA
The Senior Robotics Software Engineer – AI-Enabled Manipulation & Industrial Automation designs, develops, integrates, validates, and deploys AI-enabled robotic applications for industrial…
Added 13 mins ago
G
Water-Wastewater Engineer
GPAC
Washington DC
- $85,000 to $130,000 USD / year
We are seeking a Water/Wastewater Engineer to join a growing, multi-disciplinary engineering consulting firm. This individual will contribute to the planning, design, and delivery of…
Added 13 mins ago
Facilities Operations Manager
Samsung Austin Semiconductor, LLC.
1530 FM 973 Taylor, TX
Lead the change point process for transitioning new systems into the operational maintenance portfolio.
Added 13 mins ago
Mechanical Engineer-Tool Hookup
Samsung Austin Semiconductor, LLC.
Austin, TX
The Mechanical Engineer – Tool Hookup Scope is responsible for the design, integration, installation, and commissioning of mechanical utility connections to advanced semiconductor…
Added 13 mins ago
L
Network Engineer
lhh
Woodland, CA
- $100,000 to $125,000 USD / year
Our client is seeking an experienced Network Engineer to manage, support, and optimize enterprise network infrastructure across a global organization. This position is ideal for a hands-on…

Hologic

Principal Software Algorithm Engineer - Digital Cytology AI

Marlborough, MA, United States

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Job details

Posting language: English
Posted: Nov 6, 2026

Original job description

At Hologic, we are driven by a singular purpose: to enable healthier lives everywhere, every day. As a global leader in women’s health, we design innovative diagnostic and imaging solutions that help detect disease earlier and improve outcomes for patients worldwide. Join a team where your work in AI and digital diagnostics directly supports clinicians in delivering better care for women.

Job Summary Hologic is seeking a Principal Software Algorithm Engineer to design, train and validate deep learning models for cytology on the Genius™ Digital Diagnostics System. This role owns the cell-level CNN classifier, nuclear-to-cytoplasmic (NC) ratio segmentation pipeline, and the technical evidence needed to support FDA and other regulatory submissions. The engineer serves as the technical lead for model design and verification under design controls, working closely with cytopathologists, imaging scientists, regulatory and quality teams.

Key Responsibilities

Design, train and tune multi-class CNNs to classify cells and aggregate predictions into specimen-level diagnostic categories.
Develop multi-task models with shared encoders and feature heads for diagnostic class, cytomorphologic features and NC ratio category.
Build nucleus and cytoplasm segmentation networks to measure NC ratio and nuclear area, including overlapping cells in clusters.
Own the data pipeline, including patient-grouped splits, color profile application, class balance and imaging metadata.
Run disciplined experiments, benchmark lightweight backbones against larger reference models and define evaluation metrics and reports.
Collaborate with pathologists on labeling protocols, inter-observer agreement and adjudication processes.
Prepare design documentation, verification/validation protocols and technical content for regulatory submissions.
Mentor engineers and establish coding, reproducibility and MLOps standards.
Ensure model performance and interpretability, including Grad-CAM checks and feature outputs that align with pathologist expectations.
Support regulatory strategy for AI-enabled medical devices under design controls and PCCP guidance.

Qualifications

Education

MS or PhD in computer science, biomedical engineering, electrical engineering or a related field, or BS with equivalent experience.

Experience

10+ years of software development, including 5+ years building and deploying deep learning models for computer vision.

•

Demonstrated leadership experience, with the ability to set strategic direction, influence senior stakeholders, lead cross-functional initiatives, and drive accountability and execution in a complex, matrixed organization.

Skills

Expert Python and PyTorch (or TensorFlow), including CNN fine-tuning, transfer learning and segmentation (e.g., U-Net, segmentation_models_pytorch).
Experience with imbalanced, multi-class and multi-task problems, and metrics such as per-class sensitivity, F1, kappa and AUROC.
Experience with medical or microscopy imaging, including color handling, stain variation and high-resolution tiling.
Strong discipline in data splitting, leakage prevention, experiment tracking and reproducible training.
Clear written communication for technical reports and design documentation.
Preferred: digital pathology or cytology AI experience (ideally urine cytology); experience with FDA 510(k), De Novo, PMA or EU IVDR; familiarity with IEC 62304, ISO 13485, ISO 14971, 21 CFR Part 820 and FDA PCCP guidance.
Preferred: ICC color management, stain deconvolution and scanner color calibration; cell instance segmentation tools (StarDist, Cellpose) and annotation tools (QuPath, CVAT, napari).
Preferred: model optimization for edge or embedded inference (quantization, ONNX, TensorRT) and experience leading or technically guiding a small team.

Why join Hologic?

We are committed to making Hologic the destination for top talent. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career.

The annualized base salary range for this role is $157,000 - $220,000 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, education, business needs and market demand.

Agency and Third-Party Recruiter Notice

Agencies that submit a resume to Hologic must have a current executed Hologic Agency Agreement executed by a member of the Human Resource Department. In addition, Agencies may only submit candidates to positions for which they have been invited to do so by a Hologic Recruiter. All resumes must be sent to the Hologic Recruiter under these terms or they will not be considered.

Hologic is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.

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More about this job

Skills

Deep learning
Documentation
Medical devices
Computer science
Biomedical engineering
Electrical engineering
Software development
Leadership
Python
PyTorch
TensorFlow
Communication skills

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