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Lead Artificial Intelligence (AI) Engineer
Robert Half
Avon, MN
Description We are looking for an experienced Lead Artificial Intelligence (AI) Engineer to guide the design and delivery of advanced AI solutions for a growing construction-focused…
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Sr. Application Infrastructure Engineer
Medtronic
Mounds View, MN
…unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and…
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Software Test Engineer I
Medtronic
Mounds View, MN
…unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and…
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Principal Supplier Quality Engineer
Medtronic
Mounds View, MN
…unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and…
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Senior Supplier Quality Engineer
Medtronic
Mounds View, MN
…unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and…
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Software Quality Engineer I
Medtronic
Mounds View, MN
…unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and…
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Principal Application Infrastructure Engineer
Medtronic
Mounds View, MN
…unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and…
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AI-Native Software Engineer Advisor Senior
Elevance Health
Mendota Heights, MN
The AI-Native Software Engineer Advisor Senior will be responsible for shipping, evaluating, securing, and supporting real systems. The ideal candidate is a strong engineer who has real…
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Senior Software Engineer (Multiple openings)
U.S. Bank National Association
Hopkins, MN
…(IaC) methodologies to automate provisioning and deployment. 6) Building and maintaining data persistence layers using relational databases (PostgreSQL, MS SQL Server) and NoSQL databases -…
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Digital Application Engineer (SSA)
Smiths Group
Remote, United States
The Digital Applications Engineer enables the digital (pre) sales team by providing application expertise and technical customer support throughout complex sales opportunities. Acting as a…
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Senior Financial Analyst
Medtronic
Fridley, MN
…unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and…
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Operational Technology Engineer
Syensqo
Winona, MN
- $99,000 to $123,000 USD / year
The Operational Technology (OT) Engineer reports to the Maintenance and Engineering Manager, and is responsible for maintaining, troubleshooting, and upgrading the plant’s operational…
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Environmental Program Leader – Hazardous Waste and Dangerous Goods Compliance
GE Aerospace
Minnetonka, MN
Bachelor's degree in environmental or engineering, an advanced technical degree, and/or Professional Engineer (PE) license
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Principal Engineer - AI Platform (Forward Deployed Engineering and AI Builder Experience)(Remote Or Hybrid)
Target
Brooklyn Park, MN
JOIN TARGET AS A PRINCIPAL ENGINEER –AI PLATFORMS, FORWARD DEPLOYED ENGINEERING and AI BUILDER EXPERIENCE
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Electrical Controls Engineer, Automation Development
Tesla, Inc.
Brooklyn Park, MN
- $82,440 to $147,960 USD / year
…Development Team in Brooklyn Park, Minnesota in designing and building the automation and robotic equipment that builds world-class Tesla products. Electrical engineers are responsible for…
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ENGINEERING MANAGER
Wells Concrete Products, Inc.
Maple Grove, MN
- $130,000 to $170,000 USD / year
At Wells, you're part of a team that takes pride in building something that lasts. Whether you're in operations, a manufacturing facility, or out in the field, your work plays a direct role…
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Electrical Engineer - Power System Protection (Transmission) Job Details | Black & Veatch Family of Companies
Black & Veatch
Bloomington, MN
Electrical Engineer - Power System Protection (Transmission)
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Senior Geothermal Consultant Job Details | Black & Veatch Family of Companies
Black & Veatch
Bloomington, MN
…engineering, procurement, consulting and construction, together we are building a world of…
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Electrical Systems Diagnostics Engineer
ALTEN Technology USA
Foster City, CA · Irvine, CA
…advancing space exploration and life-saving medical devices to building autonomous electric vehicles. With 3,000+ experts across North America, we partner with leading companies in…
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Senior Security GRC Engineer, AI & Automation
American Express Global Business Travel
Saint Paul, MN
AmexGBT’s Security GRC team is looking for a talented Senior Security GRC Engineer to design, build, and scale automation and AI-driven solutions that modernize our governance, risk, and…
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Software Engineer 2 - Mobile Developer (iOS & Android)
U.S. Bank
Saint Paul, MN · Hopkins, MN
As a wholly owned subsidiary of U.S. Bank, Elavon is committed to building the platforms and ecosystems that help over 1.5 million customers around the world to achieve their financial…
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Senior Software Engineer (Institutional, Financing)
Coinbase
Saint Paul, MN
As a Senior Software Engineer on the Financing Engineering team within the Institutional group, you'll design, build, and scale the systems that safely manage billions of dollars in loans…
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Head of Forward Deployed Engineering
Bausch + Lomb
Saint Paul, MN
Bausch + Lomb is seeking a Head of Forward Deployed Engineer (FDE) to turn AI from pilots into production capability across B+L. This is a hands-on builder role embedded in manufacturing,…
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Lead Software Engineer
Highmark Health
Saint Paul, MN
The job is an integral member of an agile software engineer team responsible for building scalable software applications across all digital channels to serve our customers. The position…
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Associate Software Engineer
Highmark Health
Saint Paul, MN
This job is an integral member of an agile software engineer team responsible for building scalable software applications across all digital channels to serve our customers. Responsible for…

Hologic

Principal Software Algorithm Engineer - Digital Cytology AI

Marlborough, MA, United States

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Job details

Posting language: English
Posted: Nov 6, 2026

Original job description

At Hologic, we are driven by a singular purpose: to enable healthier lives everywhere, every day. As a global leader in women’s health, we design innovative diagnostic and imaging solutions that help detect disease earlier and improve outcomes for patients worldwide. Join a team where your work in AI and digital diagnostics directly supports clinicians in delivering better care for women.

Job Summary Hologic is seeking a Principal Software Algorithm Engineer to design, train and validate deep learning models for cytology on the Genius™ Digital Diagnostics System. This role owns the cell-level CNN classifier, nuclear-to-cytoplasmic (NC) ratio segmentation pipeline, and the technical evidence needed to support FDA and other regulatory submissions. The engineer serves as the technical lead for model design and verification under design controls, working closely with cytopathologists, imaging scientists, regulatory and quality teams.

Key Responsibilities

Design, train and tune multi-class CNNs to classify cells and aggregate predictions into specimen-level diagnostic categories.
Develop multi-task models with shared encoders and feature heads for diagnostic class, cytomorphologic features and NC ratio category.
Build nucleus and cytoplasm segmentation networks to measure NC ratio and nuclear area, including overlapping cells in clusters.
Own the data pipeline, including patient-grouped splits, color profile application, class balance and imaging metadata.
Run disciplined experiments, benchmark lightweight backbones against larger reference models and define evaluation metrics and reports.
Collaborate with pathologists on labeling protocols, inter-observer agreement and adjudication processes.
Prepare design documentation, verification/validation protocols and technical content for regulatory submissions.
Mentor engineers and establish coding, reproducibility and MLOps standards.
Ensure model performance and interpretability, including Grad-CAM checks and feature outputs that align with pathologist expectations.
Support regulatory strategy for AI-enabled medical devices under design controls and PCCP guidance.

Qualifications

Education

MS or PhD in computer science, biomedical engineering, electrical engineering or a related field, or BS with equivalent experience.

Experience

10+ years of software development, including 5+ years building and deploying deep learning models for computer vision.

•

Demonstrated leadership experience, with the ability to set strategic direction, influence senior stakeholders, lead cross-functional initiatives, and drive accountability and execution in a complex, matrixed organization.

Skills

Expert Python and PyTorch (or TensorFlow), including CNN fine-tuning, transfer learning and segmentation (e.g., U-Net, segmentation_models_pytorch).
Experience with imbalanced, multi-class and multi-task problems, and metrics such as per-class sensitivity, F1, kappa and AUROC.
Experience with medical or microscopy imaging, including color handling, stain variation and high-resolution tiling.
Strong discipline in data splitting, leakage prevention, experiment tracking and reproducible training.
Clear written communication for technical reports and design documentation.
Preferred: digital pathology or cytology AI experience (ideally urine cytology); experience with FDA 510(k), De Novo, PMA or EU IVDR; familiarity with IEC 62304, ISO 13485, ISO 14971, 21 CFR Part 820 and FDA PCCP guidance.
Preferred: ICC color management, stain deconvolution and scanner color calibration; cell instance segmentation tools (StarDist, Cellpose) and annotation tools (QuPath, CVAT, napari).
Preferred: model optimization for edge or embedded inference (quantization, ONNX, TensorRT) and experience leading or technically guiding a small team.

Why join Hologic?

We are committed to making Hologic the destination for top talent. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career.

The annualized base salary range for this role is $157,000 - $220,000 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, education, business needs and market demand.

Agency and Third-Party Recruiter Notice

Agencies that submit a resume to Hologic must have a current executed Hologic Agency Agreement executed by a member of the Human Resource Department. In addition, Agencies may only submit candidates to positions for which they have been invited to do so by a Hologic Recruiter. All resumes must be sent to the Hologic Recruiter under these terms or they will not be considered.

Hologic is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.

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More about this job

Skills

Deep learning
Documentation
Medical devices
Computer science
Biomedical engineering
Electrical engineering
Software development
Leadership
Python
PyTorch
TensorFlow
Communication skills

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