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Principal Platform Software Engineer - Oracle Health
Oracle
United States
- $105,900 to $234,600 USD / year
Lead the design, development, and maintenance of full-stack applications for the CDA platform, including modern React-based user interfaces and cloud-native backend services.
Added 3 mins ago
Lead Strategic Finance & Analytics Engineer
Klaviyo
Boston, MA
We're looking for a Lead Strategic Finance & Analytics Engineer to build and maintain the models that forecast Klaviyo's recognized revenue and cost of goods sold (COGS). This role blends…
Added 4 mins ago
Mechanical Engineer
Actalent
Coral Springs, FL
We are seeking a Mechanical Engineer to join our growing Product Development team in Coral Springs, FL. This is an exciting opportunity to work on innovative products from concept through…
Added 4 mins ago
Project Engineer
Actalent
Annapolis Junction, MD
Job Title: Project EngineerJob DescriptionWe are seeking a customer-focused Project Engineer to manage mechanical design projects from initial technical requirements through customer…
Added 4 mins ago
A
Principal Engineer
Actalent
Hanover, MD
- $155,000 to $185,000 USD / year
Lead process engineering efforts for sophisticated chamber-based or batch processes, including scale-up from development to manufacturing environments.
Added 4 mins ago
Project Engineer
Actalent
Versailles, KY
Project Engineer - Natural Gas Pipelines & Metering Stations
Added 4 mins ago
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Senior Manufacturing Engineer
Actalent
Delano, MN
- $80,000 to $120,000 USD / year
Job Title: Manufacturing EngineerJob DescriptionThe higher level Manufacturing Engineer plays a key role in developing, optimizing, and supporting manufacturing processes for medical device…
Added 4 mins ago
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Manufacturing Engineer
Actalent
Rochester, MN
- $38 to $55 USD / hour
Job Title: Manufacturing Engineer (Level II)Job DescriptionThis role leads the manufacturing lifecycle of products from prototype through pilot and full production, ensuring robust…
Added 4 mins ago
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Substation Engineer
Actalent
Austin, TX
- $55 to $70 USD / hour
Job Title: Substation EngineerJob DescriptionThis role is for an experienced Substation / Protection & Control (P&C) Engineer based in Houston, Texas. The engineer will lead and execute…
Added 4 mins ago
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Systems Engineer
Actalent
Cedar Rapids, IA
- $60 to $65 USD / hour
Job Title: Systems EngineerJob DescriptionThis Systems Engineer role offers the opportunity to serve as a technical leader for complex, safety-critical systems, with a focus on avionics and…
Added 4 mins ago
Lead Artificial Intelligence (AI) Engineer
Robert Half
Avon, MN
Description We are looking for an experienced Lead Artificial Intelligence (AI) Engineer to guide the design and delivery of advanced AI solutions for a growing construction-focused…
Added 4 mins ago
Sr. Application Infrastructure Engineer
Medtronic
Mounds View, MN
…technology. Medtronic is looking for an experienced infrastructure engineer to help build and run the cloud infrastructure behind the Affera Digital Platform, which is transforming cardiac…
Added 4 mins ago
Software Test Engineer I
Medtronic
Mounds View, MN
Medtronic is seeking a motivated and detail-oriented Software Test Engineer to join our Affera Mapping and Ablation System team. This role is essential in supporting the testing and quality…
Added 4 mins ago
Principal Supplier Quality Engineer
Medtronic
Mounds View, MN
The Principal Supplier Quality Engineer will lead quality activities for supplier transfers, providing Quality Assurance Engineering expertise across design transfer, manufacturing…
Added 4 mins ago
Senior Supplier Quality Engineer
Medtronic
Mounds View, MN
The Senior Supplier Quality Engineer will lead quality activities supporting supplier transfers and product lifecycle changes. This role partners with suppliers and cross-functional teams…
Added 4 mins ago
Software Quality Engineer I
Medtronic
Mounds View, MN
…growth and cross-functional collaboration as we work together to engineer the…
Added 4 mins ago
Principal Application Infrastructure Engineer
Medtronic
Mounds View, MN
…technology. Medtronic is looking for an experienced infrastructure engineer to help build and run the cloud infrastructure behind the Affera Digital Platform, which is transforming cardiac…
Added 4 mins ago
AI-Native Software Engineer Advisor Senior
Elevance Health
Mendota Heights, MN
The AI-Native Software Engineer Advisor Senior will be responsible for shipping, evaluating, securing, and supporting real systems. The ideal candidate is a strong engineer who has real…
Added 5 mins ago
Senior Financial Analyst
Medtronic
Fridley, MN
…growth and cross-functional collaboration as we work together to engineer the…
Added 5 mins ago
Senior Software Engineer (Institutional, Financing)
Coinbase
Saint Paul, MN
As a Senior Software Engineer on the Financing Engineering team within the Institutional group, you'll design, build, and scale the systems that safely manage billions of dollars in loans…
Added 5 mins ago
Head of Forward Deployed Engineering
Bausch + Lomb
Saint Paul, MN
Bausch + Lomb is seeking a Head of Forward Deployed Engineer (FDE) to turn AI from pilots into production capability across B+L. This is a hands-on builder role embedded in manufacturing,…
Added 5 mins ago
Mechanical Engineer, Data Center Operations Engineering
Meta
Saint Paul, MN
Meta is seeking a Mechanical Engineer to join our Data Center Operations Engineering team. Our data centers are the foundation upon which our rapidly growing infrastructure efficiently…
Added 5 mins ago
Director - Customer Response Engineering
Trellix
Saint Paul, MN
Lead the global CRE team. Hire, develop, and retain senior engineers, and set the technical bar.
Added 5 mins ago
Enterprise Account Project Coordinator III (Remote, USA)
Medtronic
Minneapolis, MN
Added 5 mins ago
Senior Lead Engineer
PwC
Minneapolis, MN
As a Senior Lead Engineer you will lead custom application development and testing efforts that help clients turn business needs into scalable software solutions across cloud-native and…

Hologic

Principal Software Algorithm Engineer - Digital Cytology AI

Marlborough, MA, United States

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Job details

Posting language: English
Posted: Nov 6, 2026

Original job description

At Hologic, we are driven by a singular purpose: to enable healthier lives everywhere, every day. As a global leader in women’s health, we design innovative diagnostic and imaging solutions that help detect disease earlier and improve outcomes for patients worldwide. Join a team where your work in AI and digital diagnostics directly supports clinicians in delivering better care for women.

Job Summary Hologic is seeking a Principal Software Algorithm Engineer to design, train and validate deep learning models for cytology on the Genius™ Digital Diagnostics System. This role owns the cell-level CNN classifier, nuclear-to-cytoplasmic (NC) ratio segmentation pipeline, and the technical evidence needed to support FDA and other regulatory submissions. The engineer serves as the technical lead for model design and verification under design controls, working closely with cytopathologists, imaging scientists, regulatory and quality teams.

Key Responsibilities

Design, train and tune multi-class CNNs to classify cells and aggregate predictions into specimen-level diagnostic categories.
Develop multi-task models with shared encoders and feature heads for diagnostic class, cytomorphologic features and NC ratio category.
Build nucleus and cytoplasm segmentation networks to measure NC ratio and nuclear area, including overlapping cells in clusters.
Own the data pipeline, including patient-grouped splits, color profile application, class balance and imaging metadata.
Run disciplined experiments, benchmark lightweight backbones against larger reference models and define evaluation metrics and reports.
Collaborate with pathologists on labeling protocols, inter-observer agreement and adjudication processes.
Prepare design documentation, verification/validation protocols and technical content for regulatory submissions.
Mentor engineers and establish coding, reproducibility and MLOps standards.
Ensure model performance and interpretability, including Grad-CAM checks and feature outputs that align with pathologist expectations.
Support regulatory strategy for AI-enabled medical devices under design controls and PCCP guidance.

Qualifications

Education

MS or PhD in computer science, biomedical engineering, electrical engineering or a related field, or BS with equivalent experience.

Experience

10+ years of software development, including 5+ years building and deploying deep learning models for computer vision.

•

Demonstrated leadership experience, with the ability to set strategic direction, influence senior stakeholders, lead cross-functional initiatives, and drive accountability and execution in a complex, matrixed organization.

Skills

Expert Python and PyTorch (or TensorFlow), including CNN fine-tuning, transfer learning and segmentation (e.g., U-Net, segmentation_models_pytorch).
Experience with imbalanced, multi-class and multi-task problems, and metrics such as per-class sensitivity, F1, kappa and AUROC.
Experience with medical or microscopy imaging, including color handling, stain variation and high-resolution tiling.
Strong discipline in data splitting, leakage prevention, experiment tracking and reproducible training.
Clear written communication for technical reports and design documentation.
Preferred: digital pathology or cytology AI experience (ideally urine cytology); experience with FDA 510(k), De Novo, PMA or EU IVDR; familiarity with IEC 62304, ISO 13485, ISO 14971, 21 CFR Part 820 and FDA PCCP guidance.
Preferred: ICC color management, stain deconvolution and scanner color calibration; cell instance segmentation tools (StarDist, Cellpose) and annotation tools (QuPath, CVAT, napari).
Preferred: model optimization for edge or embedded inference (quantization, ONNX, TensorRT) and experience leading or technically guiding a small team.

Why join Hologic?

We are committed to making Hologic the destination for top talent. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career.

The annualized base salary range for this role is $157,000 - $220,000 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, education, business needs and market demand.

Agency and Third-Party Recruiter Notice

Agencies that submit a resume to Hologic must have a current executed Hologic Agency Agreement executed by a member of the Human Resource Department. In addition, Agencies may only submit candidates to positions for which they have been invited to do so by a Hologic Recruiter. All resumes must be sent to the Hologic Recruiter under these terms or they will not be considered.

Hologic is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.

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More about this job

Skills

Deep learning
Documentation
Medical devices
Computer science
Biomedical engineering
Electrical engineering
Software development
Leadership
Python
PyTorch
TensorFlow
Communication skills

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