Jobs in the United States

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US Scientific Communications Senior Director
AstraZeneca Pharmaceuticals LP Company
Wilmington, DE
- $197,390.4 to $296,085.6 USD / year
…Services (GBS), enterprise digital teams, and external agencies or platform…
Added 8 mins ago
O
Software Development Manager
Oracle
Juneau, AK
- $112,800 to $264,100 USD / year
Oracle Health Applications & Infrastructure is building a modern cloud platform for healthcare applications and services. The Identity and Access Management organization provides the…
Added 8 mins ago
Lead Director - Network and Data Center Engineering
CVS Health
Juneau, AK
This leader is accountable for building and guiding a high-performing team of network and data center engineers, while aligning infrastructure capabilities to evolving business and security…
Added 8 mins ago
O
Senior Platform Software Engineer - OCI
Oracle
Juneau, AK
- $92,500 to $209,500 USD / year
Oracle Cloud Infrastructure (OCI) is looking for a Senior Platform Software Engineer to join the PKI team responsible for building and operating cloud-scale Public Key Infrastructure…
Added 8 mins ago
Infrastructure Tool Kit (JTK) Developer
GovCIO
Juneau, AK
GovCIO is currently hiring for a Developer with Infrastructure Tool Kit (JTK) experience to develop and maintain systems code for the United States Postal Service (USPS). This position will…
Added 8 mins ago
SLED Account Executive (North Central)
Rubrik
Juneau, AK
Rubrik (NYSE: RBRK) is the Security and AI Operations Company, delivering one platform built at the intersection of data, identity, and AI. The platform enables agentic cyber resilience and…
Added 8 mins ago
Data, Communications, and Policy Analyst (Remote)
GovCIO
Juneau, AK
GovCIO is currently hiring for a Data, Communications, and Policy Analyst to support program management, tasking execution, strategic planning, policy review, metrics generation and…
Added 8 mins ago
Staff Full-stack Engineer - Shopping (Remote-eligible)
Capital One
Juneau, AK
Collaborate with senior engineering and architecture leaders to define long-term platform strategy and API standards
Added 8 mins ago
Patient Generated Health Data Project Manager (Remote)
GovCIO
Juneau, AK
GovCIO is currently hiring for a Project Manager to join the Patient Generated Health Data (PGHD) team. This position will be located remotely and will be fully remote within the United…
Added 8 mins ago
LH
Full Time - Scheduling Staffing Admin - Day
Lowe's Home Centers, LLC
Westminster, MD
- Full-time
2 years of administrative experience such as processing data, scheduling, monitoring and tracking information, and using office software.
Added 8 mins ago
MidMarket Account Executive - Common Room
Zoom
Juneau, AK
…expands Zoom's customer base by connecting growing businesses to platform capabilities that transform the way their go-to-market teams operate. Each day brings a blend of outbound…
Added 8 mins ago
Senior Product Manager, Eligibility & Learning Enablement
Humana
Juneau, AK
…integrated healthcare services, innovative technology, and data-driven…
Added 8 mins ago
Lead Project Manager, Delivery
Humana
Juneau, AK
…capability. As NBA expands across new use cases, channels, data sources, and platform capabilities, this role will provide project management support across multiple business and technology…
Added 8 mins ago
Data Scientist 1
Baylor Scott & White Health
Juneau, AK
Care Coverage Analytics supports the data science and advanced analytics needs of Baylor Scott & White
Added 8 mins ago
Senior Manager, Security Operations Center
Rubrik
Juneau, AK
…enable teams at Rubrik to develop secure software and protect data and systems with appropriate security controls. Information Security also develops systems to monitor and respond to…
Added 8 mins ago
AT
Senior Business Systems Analyst
Akamai Technologies, Inc.
Juneau, AK
- $88,900 to $160,100 USD / year
Join our dynamic Data Intelligent Services team!
Added 8 mins ago
Presales Solutions Architect - ICX Channel
Siemens
Juneau, AK
For the customers we serve, that shift shows up in very concrete ways: engineers and data leaders who can finally find and trust the data buried across decades of enterprise systems; teams…
Added 8 mins ago
AT
Senior Business Systems Analyst
Akamai Technologies, Inc.
Juneau, AK
- $88,900 to $160,100 USD / year
Enhancing system integration processes/data management across enterprise applications. Apply structured problem-solving frameworks to decompose ambiguous business challenges into…
Added 8 mins ago
Integrations Program Manager
Meta
Juneau, AK
…reliable, scalable, and positioned to support Meta's long-term platform…
Added 8 mins ago
O
Senior Applied Scientist
Oracle
Juneau, AK
- $113,000 to $234,600 USD / year
…product strategy for Oracle Health, while building out a complete platform supporting modernized, automated healthcare. This is a net new line of business, constructed with an…
Added 8 mins ago
Product Marketing Manager
Meta
Juneau, AK
…across our advertiser interfaces for all advertisers using our platform. This includes assessing market needs, conducting research to influence new product development, evaluating…
Added 8 mins ago
Buyer I or II
Intermountain Health
Juneau, AK
Added 8 mins ago
Clinical Pharmacist Investigational Drug Services
Intermountain Health
Juneau, AK
Added 8 mins ago
Director Supply Chain Business Operations
Intermountain Health
Juneau, AK
…enterprise-wide integrations, reporting and analytical strategies, data integrity, customizations, and automated controls and…
Added 8 mins ago
Product Manager - Technical
Intermountain Health
Juneau, AK
…cross-functional teams, including software developers, engineers, data analysts, and healthcare professionals, to define product roadmap, product requirements, prioritize features, and…

GlaxoSmithKline LLC

Principal Scientist, Predictive Sciences

King of Prussia, PA, United States

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Job details

Posting language: English
Posted: Oct 21, 2026

Original job description

We are building the next generation of biologics CMC with a rapid, efficient, and predict-first mindset. As a Principal Scientist in the Predictive Sciences group within our new CMC Digital and Knowledge Management department, you will sit at the intersection of late-phase CMC process development and design of cutting-edge digital tools, predictive solutions, and artificial intelligence that accelerate how we bring medicines from bench to patient. Biologics CMC is undergoing a fundamental shift, moving away from empirical and experiment-heavy development towards a predict-first, digitally augmented, and model-informed development. You will help define what that shift looks like, building tools and ways of working that will have an impact on the entirety of portfolio and shape how we develop medicines. You will be an AI-native builder who takes mechanistic, hybrid and data-driven models from prototype to production. This role will deploy models through machine learning workflows and agentic AI systems that actively drive development decisions across upstream and downstream unit operations for biologics process development across our fed-batch, intensified fed-batch and continuous perfusion platforms. Strong modelling expertise is required and expected; equal weight is placed on the ability to ship those models into a form scientists can run independently, through deployment, product build and model lifecycle management. This role will also impact tech transfer, scale-up and commercialization of processes, and requires a proven ability to drive digital transformation principles across the business, with the agility to lead change. This role sits within Predictive Sciences, in the CMC Digital & Knowledge Management department, reporting to the Team Lead for LM Drug Substance Development modelling. You will work in close partnership with process development, analytical development, and manufacturing science teams, and collaborate with the broader GSK digital science and data communities to share platforms, capabilities, and best practices. As a Principal Scientist you are an individual contributor with high scientific autonomy. You are expected to influence the direction of digital CMC through the quality of your technical contributions and the trust you build with scientific partners. This role will provide you the opportunity to lead key activities to progress your career, these responsibilities include some of the following: Modeling & Simulation 1. Build and deploy advanced process models: mechanistic, hybrid, and data-driven across upstream cell culture, chromatography, filtration, and formulation, including digital twins and PAT chemometric models for current and evolving continuous perfusion and capture platforms. Leverage engineering, biological, chemical, or materials science knowledge to postulate mechanisms for bioprocess behavior and develop or modify existing mathematical models to describe those mechanisms 2. Drive model-informed process development and characterization as an embedded matrix team member, using MBDoE and model-based risk assessments to define critical process parameters, design space, in-silico experimentation, reduce wet-lab cycle, accelerate process understanding, platform fit, and model-based monitoring and process control strategies. 3. Translate science into software by converting mathematical models into working computational tools via platforms (gPROMS, SIMCA, JMP) or custom code (Python, MATLAB), and ensure models are validated to meet GSK internal compliance and regulatory requirements. 4. Champion adoption of digitally redesigned CMC workflows across the Drug Development and Supply organization, supporting the CMC portfolio through GSK enterprise-wide digital transformation principles, enhancing digital fluency, and embedding modelling as a central pillar of process development and tech transfers. Given our high ambition for predict-first, very model is expected by default to transfer into use by the functions - in this case Large Molecule Drug Substance development - with a clear, credible path to routine use by function scientists - including documentation and reference to operating procedures - so that running the model does not depend on us. 5. Build and sustain the modeling ecosystem - not just individual models, but the shared infrastructure, tools and ways of working that keep them versioned, monitored and reliable over time. Align your work with this ecosystem so that what you build fits into it and strengthens it for others. Embed data integrity principles through model, data, and results, along with the requirements of quality, safety, and policies and procedures, and ensure that GSK intellectual property is protected. 6. Stay at the forefront of the field through publications, conferences, and academic collaborations, bringing new techniques into the organization to continuously raise the bar on what's possible. Leverage pre-competitive alliances and external expertise to advance capabilities. 7. Communicate and collaborate broadly - present results to CMC teams and senior leadership, and foster strong working relationships across R&D, pilot plants, and the commercial supply chain. Agentic AI based CMC Workflows 1. Design and build agentic AI systems that autonomously parse historical CMC data, propose experimental designs and strategies, call specific models, and surface actionable recommendations to lab scientists and decision makers. 2. Integrate large language models and AI agents into CMC workflows - from literature mining and predictive intelligence to process insights, accelerated progress, and single cycle development. 3. Develop AI-driven risk assessment and criticality ranking tools to support process characterization and control strategy definition. Data & Platform 1. Work closely with laboratory informatics, data engineering, and tech platform teams to ensure data-linked digital solutions from electronic lab notebooks, process historians, and analytical instruments. 2. Champion FAIR data principles and structured data capture practices across CMC development teams. 3. Contribute to shared modelling infrastructure, reusable components, and validated computational workflows. Scientific Partnership 1. Embed as a trusted scientific partner within CMC teams - translating biological and process complexity into computable problems and translating model outputs back into practical development decisions. 2. Present modelling results and AI-derived insights to senior stakeholders, regulatory teams, and cross-functional partners. 3. Author or co-author technical reports, model qualification packages, and regulatory submission sections as needed. Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD (or Master's with 2 years of industry experience) in data science, computational science, AI/ML, chemical engineering, biochemical engineering, computational biology, or a closely related field. Experience building predictive mo

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