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Added 2 mins ago
Cyber Security Engineering Senior Associate
DTCC Candidate Experience
Tampa, FL · Coppell, TX · Dallas, TX
…capabilities that strengthen DTCC's cyber defense program. As a Senior Associate, you will play a key role in enhancing security operations through orchestration, threat response…
Added 4 mins ago
Senior Cloud Security Engineer
Cherokee Federal
Remote, United States
Cherokee Federal is seeking a Senior Cloud Security Engineer to support cloud security operations for the U.S. National Science Foundation. This role identifies and mitigates…
Added 5 mins ago
Systems Engineer
Grantek Systems Integration
Remote, United States
…off their careers at Grantek and have grown into successful senior team members who are integral to our client's manufacturing…
Added 5 mins ago
Systems Engineer
Grantek Systems Integration
Indianapolis, IN
…mentoring program, where they will work directly beside our Senior Engineer…
Added 5 mins ago
Systems Designer
Grantek Systems Integration
Cleveland, OH
…mentoring program, where they will work directly beside our Senior Engineer…
Added 5 mins ago
Systems Engineer
Grantek Systems Integration
Remote, United States
…off their careers at Grantek and have grown into successful senior team members who are integral to our client's manufacturing…
Added 5 mins ago
GS
Systems Engineer
Grantek Systems Integration
San Jose, CA
- $95,000 to $120,000 USD / year
…mentoring program, where they will work directly beside our Senior Engineer…
Added 5 mins ago
Senior Customer Success Engineer
Copeland Cold Chain LP
Remote, United States
We are looking for an experienced Senior Customer Success Engineer to support our B2B clients, including partners and end customers. Your responsibilities include:
Added 5 mins ago
CI
Senior Mechanical Engineer, Pyrolysis
Charm Industrial
Fort Lupton, CO
- $94,822 to $142,234 USD / year
As a Senior Mechanical Engineer based out of our Fort Lupton facility, you’ll be responsible for designing the next generation of pyrolysis technology, implementing and troubleshooting…
Added 11 mins ago
Process Engineer II (Food & Beverage Industry)
Dennis Group
Salt Lake City, UT
Dennis Group’s process engineers are key in our projects of designing and building food and beverage processing facilities. Process Engineers work in every aspect of a project - controls,…
Added 13 mins ago
Senior Lead Software Engineer
JPMorgan Chase
Jersey City, NJ
As a Senior Lead Software Engineer at JPMorganChase within the Commercial and Investment Bank Payments Technology team, you are an integral part of an agile team that works to enhance,…
Added 14 mins ago
EG
Senior Data Engineer
Eliassen Group
Trenton, NJ
- $101,000 to $161,800 USD / year
Our client seeks a Senior Data Engineer to own the governed transformation layer end-to-end. The role will design and build Snowflake transformation layers, migrate legacy SQL views and…
Added 16 mins ago
Senior Staff Engineer, Program / Project Management - MTL
Celestica International LP
Austin, TX
…phases, and the enforceability of documentation and change controls across the product development…
Added 27 mins ago
Quality Assurance Automation Engineer (5637)
SMX
Washington, DC
…testing, defect resolution times, and adherence to security…
Added 27 mins ago
Deputy Director Nuclear Technology Division
National Nuclear Security Administration
Washington, DC
…Division; (2) negotiating and establishing bilateral agreements and controls for radiation protection and radiological emergency preparedness for U.S. nuclear-powered warships serving as…
Added 28 mins ago
CC
Electrical Engineer
Custom Control Mfr
Overland Park, KS
- $70,000 to $90,000 USD / year
We are seeking a motivated, detail-oriented Electrical Engineer to join our growing team. This position requires a relevant bachelor's degree but no prior professional work experience. You…
Added 28 mins ago
EG
Senior Data Engineer
Eliassen Group
Washington, DC
- $101,000 to $161,800 USD / year
Our client seeks a Senior Data Engineer to own the governed transformation layer end-to-end. The role will design and build Snowflake transformation layers, migrate legacy SQL views and…
Added 28 mins ago
UG
Senior Software Engineer - Cloud Platform - Remote
UnitedHealth Group
Eden Prairie, MN
- $91,700 to $163,700 USD / year
…infrastructure across Microsoft Azure and Amazon Web Services. This senior software engineering role combines advanced Infrastructure as Code development, domain-level cloud architecture,…
Added 30 mins ago
Senior Systems Engineer
Salesforce, Inc.
TX · IN
If you need a reasonable accommodation during the application or the recruiting process, please submit a request via this Accommodations Request Form.
Added 30 mins ago
Senior Security Engineer, Proactive Security - Platform
DoorDash USA
Remote, United States
Our Proactive Security Engineering team is looking for a Senior Security Engineer, Proactive Security - Platform to help build the paved paths that engineers across DoorDash, Wolt and…
Added 33 mins ago
Senior SIEM Engineer
DTCC Candidate Experience
Tampa, FL
Being a member of CISO team, this position will be reporting to the Associate Director, Cyber Threat Defense and Controls within Cybersecurity Engineering & Operations team. The Senior SIEM…
Added 34 mins ago
Electrical Commissioning Engineer I
Bureau Veritas
McLean
…position is also responsible for participating in the MEP design process, witnessing and/or performing the static and dynamic testing of mechanical, electrical, and controls systems, and…
Added 37 mins ago
S
Senior Validation Engineer
Syner-G
San Diego, CA
- $115,000 to $145,000 USD / year
…the most critical phases of the drug discovery and approval process through to commercialization. It is meaningful, varied and thought-provoking work with a strategic emphasis, a…
Added 37 mins ago
Project Engineer
Syner-G
Worcester, MA
Syner-G is seeking a Project Engineer to support the technical planning, coordination, and execution of capital projects across facility, infrastructure, and construction initiatives. This…
Added 37 mins ago
Project Engineer
Syner-G
Providence, RI
Syner-G is seeking a Project Engineer to support the technical planning, coordination, and execution of capital projects across facility, infrastructure, and construction initiatives. This…

Freenome

Senior Systems Integration Engineer

Brisbane, CA, United States

The US target range of our base salary for new hires is $156,750 - $200,025.

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Job details

Pay: The US target range of our base salary for new hires is $156,750 - $200,025.
Posting language: English
Posted: Oct 29, 2026

Original job description

About this opportunity:

Freenome is hiring a Senior Systems Integration Engineer to provide technical leadership and drive hands on contribution to the development of next generation NGS assays/products for early cancer detection. You will work in a Product Development team of world-class Scientists and Engineers focused on delivering Freenome’s IVD assay portfolio. If you are passionate about deploying the power of NGS-based diagnostics in clinical care, have a high sense of ownership, and take pride in providing technical leadership to a growing team of Systems Integration Engineers, while continuing to make an individual impact, we would love to speak with you!

As part of a dynamic, flexible company you will be adapting to rapid technological progress and change, and help the team building the platform do the same.The role reports to the Senior Manager, Systems Integration. This role will be an onsite role based in our Brisbane, California headquarters.

What you’ll do:

Lead Functional Integration strategy and execute end to end assay workflows, system verification and validation activities while maintaining a strong hands on role in automation platform operation and system level testing.
Independently define study scope, validation strategies, success criteria, and execution plans. Develop and execute system level protocols, analyze results against User Needs, Design Input Requirements and Product Requirements, and communicate conclusions to inform AV/CV and development exit readiness.
Partner with Development, SW Test Engineering, Automation, and SLIMS to align test coverage, entry and exit criteria, and deployment derisking strategies. Incorporate qualified software releases into Functional Integration and coordinate or execute lab deployment and fleet wide configuration verification.
Drive the System Reliability program and lead its cross functional core team. Establish reliability metrics, trend recurring failure modes, prioritize and triage risks, and coordinate mitigation follow through with accountable subsystem owners. Lead prioritized technical investigations and communicate improvement opportunities, mitigation status, and resource needs.
Evaluate system performance, proactively identify roadblocks, characterize root causes, and apply analytical problem solving skills to develop and execute scalable solutions for prioritized reagent, workflow, automation, hardware, software, and system integration issues.
Author and review system level requirements, test strategies, validation protocols, traceability documentation, technical reports, and other design control documentation within the Design Control framework and Design History Files.
Provide subject matter expertise to system level dFMEA, pFMEA, risk management, hazard assessment, and design review activities; identify hardware, firmware, software, workflow, and process mitigations with accountable subsystem owners to support adequate risk control measures.
Build cross functional buy in by clearly communicating opportunities, risks, needs, problems, proposed solutions, and results in the appropriate forums. Facilitate project debriefs to improve future integration and validation activities.
Provide technical guidance and mentorship to SI engineers in study design, hands on execution, troubleshooting, and documentation while maintaining individual ownership of assigned deliverables.

Must haves:

Bachelor’s degree with 8+ years of relevant work experience, Master’s degree with 6+ years of relevant work experience, or Doctoral degree with 3+ years of relevant work experience; or equivalent experience.
Education or equivalent experience in a relevant field such as Biology, Biochemistry, Bioengineering, Biomedical Engineering, Systems Engineering, Mechanical Engineering, Electrical Engineering, or a related discipline.
Direct experience developing, integrating, or evaluating NGS assays and/or NGS based diagnostics, including hands on experience with automated NGS workflows.
Experience driving hands on system integration activities, including assay workflow execution, automation platform operation, system evaluation, troubleshooting, performance characterization, and validation or verification testing.
Experience developing and executing system level test plans and protocols, including data analysis, interpretation of test results, assessment of requirements conformance, failure investigation, and root cause analysis.
Data analysis expertise and experience with various data analysis software packages, including well developed statistical analysis skills and design of experiments (DOE), using JMP, R, or equivalent tools. Knowledge of SQL, Python, R, or other programming languages is highly desired.
Experience analyzing reliability data, identifying recurring failure modes, and coordinating cross functional investigations and mitigation follow through.
Direct experience working in an FDA regulated, IVD, medical device, diagnostics, or other regulated product development environment.
Strong working knowledge of requirements management, design controls, risk management, traceability, technical report authoring, Design History Files, and applicable quality system requirements.
Demonstrated ability to operate independently on complex technical assignments, lead key projects, prioritize work based on company objectives and available resources, provide technical guidance to others, and build cross functional buy in.

Benefits and additional information:

The US target range of our base salary for new hires is $156,750 - $200,025. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.

Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Applicants have rights under Federal Employment Laws.

Family & Medical Leave Act (FMLA)
Equal Employment Opportunity (EEO)
Employee Polygraph Protection Act (EPPA)

California applicants please review the CCPA Notice at Collection here:

California Consumer Privacy Act (CCPA)

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More about this job

Skills

Leadership
Team building
Product comprehension
Problem solving
Workflow
ICT system integration
Documentation
Risk management
Hazard assessment
Firmware
Troubleshooting
Biomedical engineering
Mechanical engineering
Electrical engineering
Data analysis
Root cause analysis
Statistics
R
SQL
Python
Programming languages

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