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Senior Consulting Manager, AI-Led Mainframe Modernization
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Added 1 min ago
Mechanical Engineer
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Technical Program Manager, Flight Software
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Mechanical Design Eng I
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Added 36 mins ago
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Mechanical Engineering Manager
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As the Manager of the Mechanical Design Engineering team, you will lead a group of talented space vehicle Mechanical Engineers responsible for the design of space vehicle systems,…
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Senior Technical Program Manager
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Added 49 mins ago
Sr. Systems Engineering Tools and Process Assurance Manager
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…Power Systems (E&PS) business has a need for a Sr. Engineering Manager to lead development and process assurance of systems engineering tools and processes. As the product development…
Added 55 mins ago
Mechanical Engineer
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Software Quality Assurance Engineer and Tester (FM Test/App Training Specialist & CM Test/App Training Specialist)
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Author comprehensive System Design Documentation (SDD) and collaborate with test leads under the Test Evaluation Program Plan (TEPP - CDRL 0013) to achieve zero defect leakage for…
Added 58 mins ago
Commissioning Program Manager, Data Centers
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…team as we help shape a brighter way forward. Commissioning Program Manager, Data Centers Preferred Location: Atlanta, Chicago, Dallas, Denver, New York, Phoenix or Remote Position…
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Mechanical Design Manager
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Help select commissioning agents and review and approve their plans, reports, sequences of operations and test scripts.
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Cyber System Security Engineer (CSSE)
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Added 1 hour ago
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Controls Engineer
Actalent
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- $38 to $40 USD / hour
Configure and test switchgear-related equipment, including USB trip units, PDCs, DLBs, SERs, ATSs, and Power Quality Meters (PQMs).
Added 1 hour ago
Electrical Engineer
U.S. Coast Guard
Birmingham, AL
Summary This vacancy is for a GS - 0850 - 12, Electrical Engineer located in the Department of Homeland Security, U.S. Coast Guard, TRACEN BIRMINGHAM SOUTHERN TECHNICAL BRANCH in…
Added 1 hour ago
Electrical Engineer
U.S. Coast Guard
Birmingham, AL
Summary This vacancy is for a GS - 0850 - 12, Electrical Engineer located in the Department of Homeland Security, U.S. Coast Guard, TRACEN BIRMINGHAM SOUTHERN TECHNICAL BRANCH in…
Added 1 hour ago
AI & Software Engineering Manager
Westinghouse Electric Company, LLC
Cranberry Township, NC
As a Manager, AI & Software Engineering you will lead the AI & Software Engineering team within Data & AI, made up of AI/software engineers and UI/UX designers. The team designs…
Added 1 hour ago
Wireless Module Engineer
Apple
Austin, TX · San Diego, CA · Sunnyvale, CA
The Wireless Module Engineer (WME) is a highly motivated, self-driven technical lead responsible for driving the development of wireless modules from early architecture definition through…
Added 1 hour ago
Commissioning Specialist/Engineer
Primoris Renewable Energy
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The Commissioning Specialist/Engineer provides hands-on support to commissioning activities across multiple projects, contributing to planning, documentation, and test execution readiness.…
Added 1 hour ago
EU
Technical Project Manager - Mobile Engineering
Experis USA
Phoenix, AZ
- $55 to $60 USD / hour
Experience across the full life cycle of product development (from concept to delivery), including Test Driven Development; plus experience in program delivery or project management and…
Added 2 hours ago
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Senior Database Developer
Publicis Groupe Holdings B.V
Irving, TX
- $88,540 to $127,155 USD / year
Epsilon is seeking a Senior Databricks Developer to join our development team. You will design, build, test, deploy, and support scalable data engineering solutions on the Databricks…
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TECHNICAL PROJECT MANAGER
Naval Sea Systems Command
Naval Surface Warfare Center, MD
Added 2 hours ago
IASE / ISSE
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Practice Manager
TEKsystems
Hanover, MD
- $125,000 to $180,000 USD / year
Added 2 hours ago
Facilities Construction Project Manager - Interdisciplinary
National Institute of Standards and Technology
Gaithersburg, MD
Summary NIST seeks a Facilities Construction Project Manager to drive multi-discipline construction management, modernizing research and administrative facilities. Working independently…

Freenome

Senior Systems Integration Engineer

Brisbane, CA, United States

The US target range of our base salary for new hires is $156,750 - $200,025.

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Job details

Pay: The US target range of our base salary for new hires is $156,750 - $200,025.
Posting language: English
Posted: Oct 29, 2026

Original job description

About this opportunity:

Freenome is hiring a Senior Systems Integration Engineer to provide technical leadership and drive hands on contribution to the development of next generation NGS assays/products for early cancer detection. You will work in a Product Development team of world-class Scientists and Engineers focused on delivering Freenome’s IVD assay portfolio. If you are passionate about deploying the power of NGS-based diagnostics in clinical care, have a high sense of ownership, and take pride in providing technical leadership to a growing team of Systems Integration Engineers, while continuing to make an individual impact, we would love to speak with you!

As part of a dynamic, flexible company you will be adapting to rapid technological progress and change, and help the team building the platform do the same.The role reports to the Senior Manager, Systems Integration. This role will be an onsite role based in our Brisbane, California headquarters.

What you’ll do:

Lead Functional Integration strategy and execute end to end assay workflows, system verification and validation activities while maintaining a strong hands on role in automation platform operation and system level testing.
Independently define study scope, validation strategies, success criteria, and execution plans. Develop and execute system level protocols, analyze results against User Needs, Design Input Requirements and Product Requirements, and communicate conclusions to inform AV/CV and development exit readiness.
Partner with Development, SW Test Engineering, Automation, and SLIMS to align test coverage, entry and exit criteria, and deployment derisking strategies. Incorporate qualified software releases into Functional Integration and coordinate or execute lab deployment and fleet wide configuration verification.
Drive the System Reliability program and lead its cross functional core team. Establish reliability metrics, trend recurring failure modes, prioritize and triage risks, and coordinate mitigation follow through with accountable subsystem owners. Lead prioritized technical investigations and communicate improvement opportunities, mitigation status, and resource needs.
Evaluate system performance, proactively identify roadblocks, characterize root causes, and apply analytical problem solving skills to develop and execute scalable solutions for prioritized reagent, workflow, automation, hardware, software, and system integration issues.
Author and review system level requirements, test strategies, validation protocols, traceability documentation, technical reports, and other design control documentation within the Design Control framework and Design History Files.
Provide subject matter expertise to system level dFMEA, pFMEA, risk management, hazard assessment, and design review activities; identify hardware, firmware, software, workflow, and process mitigations with accountable subsystem owners to support adequate risk control measures.
Build cross functional buy in by clearly communicating opportunities, risks, needs, problems, proposed solutions, and results in the appropriate forums. Facilitate project debriefs to improve future integration and validation activities.
Provide technical guidance and mentorship to SI engineers in study design, hands on execution, troubleshooting, and documentation while maintaining individual ownership of assigned deliverables.

Must haves:

Bachelor’s degree with 8+ years of relevant work experience, Master’s degree with 6+ years of relevant work experience, or Doctoral degree with 3+ years of relevant work experience; or equivalent experience.
Education or equivalent experience in a relevant field such as Biology, Biochemistry, Bioengineering, Biomedical Engineering, Systems Engineering, Mechanical Engineering, Electrical Engineering, or a related discipline.
Direct experience developing, integrating, or evaluating NGS assays and/or NGS based diagnostics, including hands on experience with automated NGS workflows.
Experience driving hands on system integration activities, including assay workflow execution, automation platform operation, system evaluation, troubleshooting, performance characterization, and validation or verification testing.
Experience developing and executing system level test plans and protocols, including data analysis, interpretation of test results, assessment of requirements conformance, failure investigation, and root cause analysis.
Data analysis expertise and experience with various data analysis software packages, including well developed statistical analysis skills and design of experiments (DOE), using JMP, R, or equivalent tools. Knowledge of SQL, Python, R, or other programming languages is highly desired.
Experience analyzing reliability data, identifying recurring failure modes, and coordinating cross functional investigations and mitigation follow through.
Direct experience working in an FDA regulated, IVD, medical device, diagnostics, or other regulated product development environment.
Strong working knowledge of requirements management, design controls, risk management, traceability, technical report authoring, Design History Files, and applicable quality system requirements.
Demonstrated ability to operate independently on complex technical assignments, lead key projects, prioritize work based on company objectives and available resources, provide technical guidance to others, and build cross functional buy in.

Benefits and additional information:

The US target range of our base salary for new hires is $156,750 - $200,025. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.

Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Applicants have rights under Federal Employment Laws.

Family & Medical Leave Act (FMLA)
Equal Employment Opportunity (EEO)
Employee Polygraph Protection Act (EPPA)

California applicants please review the CCPA Notice at Collection here:

California Consumer Privacy Act (CCPA)

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More about this job

Skills

Leadership
Team building
Product comprehension
Problem solving
Workflow
ICT system integration
Documentation
Risk management
Hazard assessment
Firmware
Troubleshooting
Biomedical engineering
Mechanical engineering
Electrical engineering
Data analysis
Root cause analysis
Statistics
R
SQL
Python
Programming languages

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