Jobs in the United States

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Added 3 mins ago
Director, Digital Twin & Intelligent Manufacturing Capabilities
AstraZeneca
Gaithersburg, MD · Gaithersburg
…Digital Twins, Process Twins, Process Intelligence, Modeling, Simulation, Automation-enabled Manufacturing, and AI-driven manufacturing capabilities across Global Technical Operations…
Added 3 mins ago
Reliability Modeling Engineer, In-Service Engineering
BETA Technologies
South Burlington, VT
Experience with Weibull analysis, reliability block diagrams, fault-tree analysis, Monte Carlo simulation, Bayesian methods, or related reliability-modeling techniques
Added 5 mins ago
PI
Senior Data Scientist
PayPal, Inc.
San Jose, CA
- $144,991 to $243,500 USD / year
Experience with probabilities modeling using Monte Carlo simulation and related stochastic techniques (1 years).
Added 5 mins ago
Senior Specialist, RF/Wireless Engineer
L3Harris Technologies
Carlsbad, CA
…lifecycle of designs from proposals, requirement definition, simulation, synthesis, place and route, and verification testing. We are looking for an engineer who enjoys challenging work…
Added 5 mins ago
School of Pharmacy - Associate Dean for Academic Affairs and Assessment
SOUTH COLLEGE
KNOXVILLE, TN
…combines distance-based didactic learning with on-site laboratory, simulation, and experiential components. The compressed three-year calendar leaves little room for remediation, sequencing…
Added 8 mins ago
K
Program Tooling & Analytics Developer
Kforce
Foster City, CA
- $25 to $30 USD / hour
Kforce has a client in Foster City, CA that is seeking a Program Tooling & Analytics Developer.
Added 11 mins ago
Director, Digital Twin & Intelligent Manufacturing Capabilities
AstraZeneca Pharmaceuticals LP Company
Gaithersburg, MD
…Digital Twins, Process Twins, Process Intelligence, Modeling, Simulation, Automation-enabled Manufacturing, and AI-driven manufacturing capabilities across Global Technical Operations…
Added 11 mins ago
SD
New Product Introduction Engineer
SST Direct
Windsor, CT
- $100,000 to $110,000 USD / year
Proficiency with CAD/CAM platforms such as SolidWorks, Esprit, and Siemens NX, along with CNC simulation and verification software such as Vericut.
Added 13 mins ago
Cloud Solutions Architect
Torch Technologies, Inc.
VA
Torch Technologies is seeking a seasoned Cloud Solutions Architect to support the Joint Staff J7 Joint Technology & Simulation Division (JTSD). This position may be based out of Suffolk, VA…
Added 13 mins ago
Cloud Simulation Integration Engineer
Torch Technologies, Inc.
VA
Torch Technologies is seeking a Cloud Simulation Integration Engineer based in Suffolk, VA to bridge the gap between legacy joint training architectures and modern cloud environments. You…
Added 15 mins ago
LCS Modernization Project Manager
Precise Systems
Bethesda, MD
…Transformation; Electromagnetic Warfare; Interactive Training & Simulation; Physical Sciences Research; Platform Lifecycle Support; and Foreign Military Sales. Unified by decades of trusted…
Added 15 mins ago
Clinical Education & Quality Manager
Northwest Ambulance
Everett, WA
Use AI tools to draft and update course content, case scenarios, simulation scripts, and exam items, then review and validate every output for clinical accuracy and protocol alignment…
Added 15 mins ago
L
Applied Research Scientist, Manufacturing
Lumafield
San Francisco, CA
- $210,000 to $230,000 USD / year
Are well-versed in scientific computing and simulation packages.
Added 21 mins ago
JSE Fighter Pilot Operations SME - Langley AFB, VA 1
Serco USA
Langley AFB, VA · Norfolk, VA · Arlington, VA · Andrews AFB, MD · Washington, DC · Hampton, VA · Chesapeake, VA · Virginia Beach, VA · Newport News, VA · San Diego, CA · Jacksonville, FL · Yorktown, VA · Columbia, SC · Suffolk, VA · Air Force Academy, CO · Annapolis, MD · Atlanta, GA · Beaufort, SC · Camp Lejeune, NC · Cherry Point, NC · Chicopee, MA · China Lake, CA · Columbus AFB, MS · Corpus Christi, TX · Des Moines, IA · Edwards AFB, CA · Eglin AFB, FL · Eielson AFB, AK · El Centro, CA · Enid, OK · Fallon, NV · Fort Worth, TX · Glendale Luke AFB, AZ · Goldsboro, NC · Hill AFB, UT · Houston, TX · JB Elmendorf-Richardson, AK · JBSA Randolph, TX · Joint Base Lewis-McChord, WA · Joint Base Pearl-Hickam, HI · Key West, FL · Kingsville, TX · Laughlin AFB, TX · Madison, WI · Maxwell AFB-Gunter Annex, AL · Meridian, MS · Miami, FL · Milton, FL · Montgomery, AL · Mountain Home AFB, ID · NAS Lemoore, CA · Nellis AFB, NV · New Orleans, LA · New River, NC · North Island, CA · Panama City Beach, FL · Panama City, FL · Patuxent River, MD · Pearl Harbor - Hickam, HI · Pensacola, FL · Peterson AFB, CO · Point Loma, CA · Portland, OR · Schriever AFB, CO · Shaw AFB, SC · Sheppard AFB, TX · Sioux City, IA · Twenty-Nine Palms, CA · VT · Whidbey Island, WA · Yuma, AZ
You’ll be involved in developing and testing the distribution of Joint Simulation Environment (JSE) over the DMO Network.
Added 22 mins ago
KN
Senior Offensive Security Engineer (Red Team)
KeyBank National Association
Brooklyn, OH
- $96,000 to $181,000 USD / year
The ideal candidate will have prior extensive experience in adversary simulation, red teaming, and offensive security operations across hybrid environments (on-prem, cloud, and physical).…
Added 25 mins ago
School of Nursing - Open Rank - Nurse Executive Pathway (DNP Program)
University of Alabama - Birmingham
AL
…centers. The School also is home to state-of-the-art nursing simulation and skills laboratories with some of the most current technology in health care, providing interdisciplinary…
Added 27 mins ago
Infrastructure Engineer/Architect - DDIL SME
Mantis Security Corporation
Reston, VA
Experience conducting modeling, simulation, and hardware-in-the-loop (HWIL) testing to replicate tactical link degradation, electronic warfare (EW) effects, and packet-loss profiles.
Added 27 mins ago
Infrastructure Engineer/Architect - DDIL SME
Mantis Security Corporation
Charleston, SC
Experience conducting modeling, simulation, and hardware-in-the-loop (HWIL) testing to replicate tactical link degradation, electronic warfare (EW) effects, and packet-loss profiles.
Added 28 mins ago
MSTC I/O Site Lead
Advanced Computer Learning Company
Little Falls, MN
ACLC is seeking a qualified Instructor/Operator (I/O) Site Lead to support Medical Simulation Training Center operations under the Training Instructor Operator Support Services II contract…
Added 28 mins ago
MSTC I/O Site Lead
Advanced Computer Learning Company
Camp Atterbury, IN
ACLC is seeking a qualified Instructor/Operator (I/O) Site Lead to support Medical Simulation Training Center operations under the Training Instructor Operator Support Services II contract…
Added 29 mins ago
WISH Director of Team Performance
University of Washington
Seattle, WA
Reporting to the Executive Director of the Division of Healthcare Simulation Science, the WISH Director of Team Performance is responsible for providing strategic leadership for WISH…
Added 31 mins ago
Senior Software Engineer
Apple
Cupertino, CA
…correctness (such as tests with fault injection, and race condition simulation). Combined with the powerful borrow checker and strong type system of Rust, we can develop complex systems…
Added 35 mins ago
Industrial Engineer
NABRICO Marine Products
Caruthersville, MO · Ashland City, TN
Experience with simulation and modeling software such as Arena, AnyLogic, Simio, or similar platforms preferred.
Added 38 mins ago
Extended Campus Nursing Support Coordinator
University of Detroit Mercy
Grand Rapids, MI
Maintain accurate records and up-to-date inventory Of equipment, supplies, Simulation warranties,
Added 38 mins ago
H
Vice President, SC Network, Resilience, Analytics Transformation
HP
Spring, TX
- $266,000 to $318,000 USD / year
…responsible use of data, advanced analytics, generative AI, simulation, and digital-twin capabilities across the supply…

Eli Lilly and Company

Director Late Phase Process Development SMDD

United States

The anticipated wage for this position is $153,000 - $264,000

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Job details

Pay: The anticipated wage for this position is $153,000 - $264,000
Posting language: English
Posted: Nov 9, 2026

Original job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work - but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

The Synthetic Molecule Design and Development (SMDD) team is involved in key activities for the development of synthetic active pharmaceutical ingredients (API) from pre-clinical through commercialization of drug substances and drug products. Our chemists, engineers, and scientists develop key technical and business solutions across the portfolio using their deep technical expertise to accelerate testing of the clinical hypothesis and overall drug development. SMDD delivers on these responsibilities by recognizing that diverse talent and cultures are vital to bring the next generation of life-changing medicines to patients.

Position Summary:

Our team is looking for experienced and creative individuals to lead late-phase synthetic molecule process development. This includes finalizing the commercial route and process, characterizing the process, and defining the control strategy to support Phase 3 clinical supply, registration stability, regulatory submissions, process validation, and commercial hand-off. The position presents an opportunity to lead dynamic teams comprised of process chemists, analytical chemists, material scientists, and engineers. Additionally, candidates will provide oversight for external R&D, tech transfer, and campaign execution.

Responsibilities:

Demonstrate a deep expertise and demonstrated capability in the utilization of modern synthetic organic and process chemistry techniques to address key CMC challenges
Lead and/or supervise the finalization of commercial synthetic routes and the development of robust, scalable, and well-characterized API manufacturing processes, including starting materials selection and justification of the commercial route
Design experimental laboratory plans in support of route and process design, definition, optimization, and technology transfer objectives
Exhibit a high learning agility with the ability to understand and exploit new scientific concepts and methods across multiple fields; be able to apply these takeaways to a dynamic portfolio of small molecule programs
Possess solid understanding in unit operation design and scale-up methodologies; build and apply groundbreaking technology and novel platforms within a time constrained environment
Apply risk-based process characterization, design space definition, and control strategy development to ensure readiness for process validation and commercial manufacture.
Leverage predictive modeling, simulation, and machine learning to inform design space definition, impurity fate and purge, scale-up, and control strategy, reducing experimental burden and strengthening regulatory justification
Lead a cross-disciplinary team to refine manufacturing routes and manufacturing technologies to advance an exciting small molecule portfolio
Deliver commercial-ready manufacturing processes, including impurity control, process robustness, and lifecycle strategy, and enable effective handoff to internal and external commercial manufacturing sites
Collaborate in technology transfer activities to CRO/CMO organizations and internal Lilly manufacturing nodes to ensure processes are technically robust, well developed and characterized, and safe
Integrate process and property data with a fundamental understanding of the underlying physical processes; build and apply mechanistic, kinetic, and data-driven models to predict process performance and guide development decisions
Utilize modern artificial intelligence and machine learning tools to accelerate development and deepen process understanding
Collaborate across internal CMC networks (Drug Product Delivery, Project Management, Quality, Manufacturing, and Regulatory) to implement and deliver material and information for clinical trials and regulatory submissions
Embrace diversity in thoughts, background, and experiences through supervision, mentoring, and development of a diverse scientific staff to deliver solutions. Encourage team members to take initiative and accountability to achieve goals and draw out and encourage others to share knowledge on challenging technical issues.
Actively collaborate and exhibit influence in the external scientific environment and demonstrate an ability to recognize and integrate external innovation across the Lilly synthetic portfolio

Minimum Qualifications:

Ph.D. in organic chemistry, or a related field with 8+ years of pharmaceutical process development experience OR MS in Organic Chemistry or related field with 15+ years' experience.

Additional Skills/Preferences:

Experience within the pharmaceutical sector is preferred; however, other experience may meet expectations. Prior experience in active ingredient development and associated formulated product is acceptable. Experience with developing chemical processes for Phase 3 through commercialization of small molecule projects.
Experience with technical transfer of processes into manufacturing operations
Experience with authoring regulatory submissions and responding to regulatory questions
Established external reputation and strong publication record
Knowledge and experience with management of a technical project and ability to build ideas for future work plans
Experience with modern analytical techniques and process analytical technologies (PAT)
Experience applying Quality by Design (QbD) principles, design of experiments (DoE), and risk assessments to establish process understanding, proven acceptable ranges, and design space.
Plan and lead short term and long-term development activities; develop and/or review technical agendas and timelines for project work; advise resource allocation to accomplish projects according to plans, communicate progress and propose changes in timeline, objectives, or direction.
Experience with modeling and simulation tools, data analytics, predictive analytics, and AI/ML
Ability to transform ideas into marketable products and processes
Demonstrated leadership capabilities, good communication skills and a sustained tendency for collaboration
Ability to prioritize multiple activities and handle ambiguity
Ability to influence others to promote a positive work environment

Additional Information:

Potential exposure to chemicals, allergens, and loud noises.
Travel: 0 to 20%
Position Location: Indianapolis, IN; Lilly Technology Center-North (LTC-N)

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $153,000 - $264,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

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More about this job

Skills

Manufacturing processes
Design process
Machine learning
Artificial intelligence
Project management
Clinical trials
Organic chemistry
Pharmaceutical industry
Chemical processes
Data analysis
ML
Leadership
Communication skills
Collaboration

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