Jobs in the United States

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Added 1 min ago
AC
Director, Internal Legal Counsel & Regulatory Compliance
American Consumer Credit Counseling
Remote, United States
- $170,000 to $180,000 USD / year
The Director, Internal Legal Counsel & Regulatory Compliance serves as ACCC's primary
Added 1 min ago
AS
Director of Lifesharing, ID/A Residential Program
Access Services
Fort Washington, PA
- From $80,750 USD / year
Access Services is seeking a Director of Lifesharing to lead and advance our Lifesharing program across the Lehigh Valley, Schuylkill-Carbon, and Delaware Valley regions. As this role…
Added 1 min ago
AS
Director of Lifesharing, ID/A Residential Program
Access Services
Bethlehem, PA
- From $80,750 USD / year
Access Services is seeking a Director of Lifesharing to lead and advance our Lifesharing program across the Lehigh Valley, Schuylkill-Carbon, and Delaware Valley regions. As this role…
Added 6 mins ago
XP
Senior Director, Field Access
Xenon Pharmaceuticals
Remote, United States
- $272,000 to $300,000 USD / year
The Senior Director, Field Access, will build and lead a national team of Field Access Managers, responsible for optimizing access to azetukalner (AZK), Xenon’s first product launch, for…
Added 6 mins ago
Paid Media Specialist
GEMINI AGENCY
Eden Prairie, MN
You'll report to the Director of Paid Media and work closely with account managers, project managers, and fellow search specialists. Experience in home services is a plus and will help you…
Added 6 mins ago
Regional Medical Scientific Director (aka Medical Science Liaison) – Myeloid – FL, GA, AL, AR, LA, MS
Merck
Nashville, TN
The Regional Medical Scientific Director (Regional Medical Scientific Director) is a credentialed (i.e., PhD, PharmD, DNP, MD) therapeutic and disease expert who engages in bidirectional…
Added 7 mins ago
EG
Business Systems Analyst (BSA)
Eliassen Group
Nashville, TN
- $70 to $80 USD / hour
Use AI tools such as Claude to accelerate research, planning, communications, synthesis, and artifact development.
Added 8 mins ago
Lead Director Product Membership
Oak Street Health MSO LLC
Remote, United States
Reporting directly to the Executive Director, Digital Product – Patient Growth & Engagement, you will serve as the dedicated domain engineering and product leader responsible for driving…
Added 9 mins ago
CC
Director, Mechanical Engineering
CONMED Corporation
Denver, CO
- $40,123 USD / year
The Director of Mechanical Engineering in Advanced Surgical's R&D department will lead all elements of R&D for the Mechanical Engineering team. This role oversees the entire product…
Added 23 mins ago
EG
Business Systems Analyst (BSA)
Eliassen Group
Topeka, KS
- $70 to $80 USD / hour
Use AI tools such as Claude to accelerate research, planning, communications, synthesis, and artifact development.
Added 32 mins ago
EG
Business Systems Analyst (BSA)
Eliassen Group
Salem, OR
- $70 to $80 USD / hour
Use AI tools such as Claude to accelerate research, planning, communications, synthesis, and artifact development.
Added 40 mins ago
Engineering Director
Modine Grenada LLC
Grenada, MS
Added 40 mins ago
Manager, Content Strategy-R-01031341
Fresenius Kabi USA, LLC
Corinth, MS
Job Summary The Manager, Marketing Content Strategy, Cell & Gene Therapy Technologies (CGT), serves as the content strategy and scientific communications subject matter expert for the CGT…
Added 40 mins ago
EG
Business Systems Analyst (BSA)
Eliassen Group
Jackson, MS
- $70 to $80 USD / hour
Use AI tools such as Claude to accelerate research, planning, communications, synthesis, and artifact development.
Added 43 mins ago
Director of Data (P&C Insurance)
Sutton National Insurance Company
Remote, United States
Sutton National Group, a rapidly growing national property and casualty insurance carrier group, seeks a Director of Data to own and drive the Company’s enterprise data strategy. This role…
Added 52 mins ago
Director of Preconstruction - Data Centers
GPAC
Irving, TX
A national commercial general contractor with a growing Dallas-Fort Worth presence is looking for a Director of Preconstruction to lead its data center and mission critical pursuits. You'll…
Added 56 mins ago
VN
Senior Environmental, Health and Safety Manager
Veolia North America
Wantagh, NY
- $115,000 to $140,000 USD / year
Reporting to the Senior Director of Environmental, Health and Safety (EHS), the Senior Environmental, Health, and Safety Manager (Sr. EHS Mgr.) will support the development and…
Added 57 mins ago
Director of Residential and Online Master's Program (Hybrid)
Cornell University
ITHACA, NY
…or related academic programs and understand how to balance strategy with execution. You are skilled at building partnerships, leading organizational change, and creating alignment across…
Added 57 mins ago
Director of Development Lab of Ornithology
Cornell University
ITHACA, NY
Cornell University welcomes candidates for the position of Director of Development at the Cornell Lab of Ornithology, based in Ithaca, New York. This leadership role offers an exciting…
Added 57 mins ago
Immigration Program Director
Robert Half
Bronx, NY
Description We are looking for an experienced immigration legal leader to guide a nonprofit legal services program in New York. This position oversees attorneys and support staff,…
Added 57 mins ago
NR
Executive Director, NYU Wireless
NYU Rory Meyers College of Nursing
Brooklyn, NY
- $160,000 to $200,000 USD / year
The Executive Director, NYU Wireless will serve as the primary architect of the center’s external partnerships, ensuring its long-term growth and sustained leadership. This role is designed…
Added 58 mins ago
New Directions Department Director
Action for a Better Community, Inc.
Rochester, NY
The New Directions Department Director provides strategic leadership, operational oversight, and fiscal stewardship for the New Directions Substance Abuse Services Clinic and related…
Added 58 mins ago
AE
Analyst, KYC Strategy
American Express
New York, NY
- $65,500 to $102,500 USD / year
Reporting to the Director, KYC POA Strategy, the Analyst will play a key role in developing and executing the global KYC POA strategy across merchant onboarding, refresh methodology,…
Added 58 mins ago
Director, Project Management - Design Operations
Capital One
New York, NY
As a Director Project Management at Capital One, you will create strategy and lead a team through high priority projects for the company. You will collaborate with smart and passionate…
Added 58 mins ago
NL
Health System Director, Clinical Engineering
NYU Langone Medical Center
New York, NY
- $152,240.27 to $262,614.25 USD / year
We have an exciting opportunity to join our team as a Health System Director, Clinical Engineering.

Dyne Therapeutics

Associate Director, Oligonucleotide Development

Waltham, MA, United States

$159,000 - $200,000 USD

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Job details

Pay: $159,000 - $200,000 USD
Experience: 8+ years of relevant pharmaceutical or biotechnology industry experience, or an equivalent combination of education and experience.
Posting language: English
Posted: Aug 27, 2026

Original job description

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.

Role Summary

The Associate Director, Oligonucleotide Development leads chemical synthesis and development strategies for PMO and modified ASO payload molecules, overseeing execution internally and through external CDMOs. This role provides technical leadership across preclinical process and analytical development through technology transfer and GMP manufacturing for IND-enabling studies.

The Associate Director ensures the development of robust, scalable, and cost-effective manufacturing processes and serves as a key technical lead with external manufacturing partners. The role contributes to CMC strategy for preclinical and clinical-stage programs and supports global regulatory filings, including authoring and reviewing relevant Module 3 content.

This role is based in Waltham, MA and is not eligible for remote work. Physical presence onsite is expected 5 days per week.

Primary Responsibilities include:

Oligonucleotide Process & Analytical Development

Lead process development, optimization, and scale-up strategies for PMO and modified ASO payload molecules to support preclinical and clinical supply.
Provide technical leadership for oligonucleotide synthesis, purification, characterization, and associated manufacturing processes.
Support analytical development strategies, including impurity control, raw material specifications, and physicochemical characterization of oligonucleotide payloads and conjugated drug substances.
Identify and implement technologies and process improvements that enhance product quality, scalability, manufacturing robustness, and efficiency.
Prepare technical source documents, scientific presentations, and other development documentation.

External Manufacturing & Technology Transfer

Serve as a key technical lead for CDMOs responsible for oligonucleotide process development and manufacturing.
Lead technology transfer of manufacturing processes and analytical methods to external partners, ensuring effective execution, knowledge transfer, and data integrity.
Provide technical oversight of external development and manufacturing activities to ensure alignment with program timelines, quality expectations, and CMC objectives.
Lead investigation and resolution of complex process, manufacturing, and analytical challenges using scientifically rigorous and data-driven approaches.

CMC, Regulatory & GMP Execution

Contribute to CMC strategies supporting the advancement of preclinical and clinical-stage programs.
Author and review relevant CMC and product-related documentation for global regulatory submissions, including INDs and IMPDs.
Review and approve development and cGMP documentation, including technology transfer protocols, process characterization documents, Master Batch Records, and campaign summary reports.
Partner cross-functionally with Analytical Development, Quality, Regulatory, Manufacturing, and other CMC functions to ensure development and manufacturing activities support program objectives.

Experience and Skills Requirements:

Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry, Pharmaceutical Sciences, or a related scientific discipline; advanced degree preferred.
8+ years of relevant pharmaceutical or biotechnology industry experience, or an equivalent combination of education and experience.
Demonstrated expertise in the process chemistry and development of PMO and/or modified ASO oligonucleotides, including synthesis, purification, and scale-up.
Experience supporting pharmaceutical development programs, preferably within a clinical-stage biotechnology or pharmaceutical organization.
Demonstrated experience providing technical oversight of CDMOs and leading technology transfer activities.
Strong understanding of analytical development principles, including impurity control strategies, raw material specifications, and physicochemical characterization.
Experience contributing to CMC regulatory submissions, including INDs, IMPDs, or comparable global filings.
Working knowledge of cGMP requirements and development-stage manufacturing documentation.
Strong scientific judgment and problem-solving skills with the ability to assess technical risk, establish priorities, and drive solutions in a rapidly evolving development environment.
Demonstrated ability to influence and collaborate effectively across cross-functional teams and with external partners.

MA Pay Range

$159,000 - $200,000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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More about this job

Skills

Leadership
Good manufacturing practices
Manufacturing processes
Presentation skills
Documentation
Chemical engineering
Biotechnology
Problem solving

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