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Sr. Manufacturing Engineer - Paint
Rivian
Normal, IL · Social Circle, GA
Take ownership of a portion of Rivian’s conveyor and material handling systems, partnering with Production, Quality, Process Engineering, Maintenance, Controls, and other cross-functional…
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Product Guide IV - Roswell Service Center
Rivian
Roswell, GA
- $21.01 to $26.25 USD / hour
…engaging experiences. In this customer-oriented role, you will lead the delivery of intuitive, innovative interactions that inspire loyalty and trust. We're searching for enthusiastic…
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Sales Advisor IV - West Palm Beach Showroom
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West Palm Beach, FL
…community. You will manage the entire customer relationship from lead qualification to close, ensuring a personalized purchase experience throughout. You will educate and inspire customers…
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Sales Advisor IV - Stanford Showroom
Rivian
Palo Alto, CA
…community. You will manage the entire customer relationship from lead qualification to close, ensuring a personalized purchase experience throughout. You will educate and inspire customers…
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Assistant General Manager
Mister Car Wash
Lockport, IL
We are hiring for an Assistant General Manager in Training (AGMIT) -- this accelerated development program is designed to prepare you for the Assistant General Manager position. This is an…
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Service Production Supervisor - Phoenix, AZ
Rivian
Phoenix, AZ
- $75,900 to $94,900 USD / year
…Your mission is to orchestrate a seamless, efficient, and high-quality service experience, empowering your team to get our owners back on their…
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Product Guide III (Part-time) - Brickell Spaces
Rivian
Miami, FL
- $21.39 to $23.75 USD / hour
- Part-time
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Product Guide III (Part-time) - Venice Showroom
Rivian
Venice, CA
- $23.41 to $26.79 USD / hour
- Part-time
…engaging experiences. In this customer-oriented role, you will lead the delivery of intuitive, innovative interactions that inspire loyalty and trust. We're searching for enthusiastic…
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Staff Technical Program Manager, Electronics
Rivian
Palo Alto, CA
Own integrated program plans for both in-house and vendor electronics for sensormodules including scope, requirements, schedules, milestones, dependencies, risks,and production-readiness…
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Senior HW Test Engineer
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Palo Alto, CA
In this role, the Senior Hardware Test Engineer will lead efforts to ensure the quality,
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Normal, IL
- $28 to $33 USD / hour
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Product Guide IV - Salt Lake City Service Center
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Salt Lake City, UT
- $20 to $26.5 USD / hour
…engaging experiences. In this customer-oriented role, you will lead the delivery of intuitive, innovative interactions that inspire loyalty and trust. We're searching for enthusiastic…
Added 3 mins ago
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Software Engineer III - Java/ Go - GNST
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Phoenix, AZ
- $103,750 to $174,750 USD / year
…servicing and availability to ensure an uninterrupted, high-quality customer experience. Technology provides the foundation for everything we do in the company while driving differentiation…
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Mechanical Assembler (Up To 30/hr)
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…manufacturing procedures to ensure precise assembly, consistent quality, and reliable system…
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Senior Java Full Stack Engineer – Spring Boot & AWS
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Lead the design and development of scalable full-stack applications using Java, Spring Boot, React, and AWS, applying cloud-native and microservices architecture patterns.
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Family Support Coordinator
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- $21 to $23.1 USD / hour
…people-first mindset is at the heart of the compassionate and high-quality programming we provide – every day – for the individuals and families we serve, and other key stakeholders.…
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Senior Vice President of Sales (Pipeline)
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- $300,000 USD / year
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CMC Mechanical Analysis Lead Engineer
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Program Manager/ Implementation Lead (Ketryx)
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- $83,000 to $94,500 USD / year
Program Manager / Implementation Lead (Ketryx )
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Program Manager / Implementation Lead (Ketryx)
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- $83,000 to $94,500 USD / year
As a Ketryx Program Manager , you will make an impact by leading the implementation of Ketryx and associated quality and engineering platforms in a regulated environment. You will be a…
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Director, Architecture and Data
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Deep Origin

Principal/ AD Medicinal Chemist

Remote, United States

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Job details

Experience: PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Posting language: English
Posted: Oct 5, 2026

Original job description

About Deep Origin Deep Origin is a biotechnology company building an operating system for science that transforms how life science research is conducted. Our AI-powered platforms simulate biology, streamline R&D workflows, and enable scientists to model complex biological systems at scale. As part of strategic government-backed initiatives and the expansion of our AI-driven simulation infrastructure, we are scaling our capabilities in whole-human modeling and predictive toxicology. Exceptional modeling talent is a critical lever in accelerating our mission to reduce disease and extend human health span.

About the Role We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior, hands-on scientific leadership role requiring deep expertise in medicinal chemistry, strategic thinking, and cross-functional collaboration. The candidate will direct work to be completed at a CRO. This position calls for a highly creative and experienced chemist who can independently design and execute medicinal chemistry strategies while contributing to the integration of computational and AI-driven approaches into drug discovery workflows. The ideal candidate will combine strong technical depth with the ability to guide internal teams and external partners toward impactful outcomes. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Proven track record of advancing drug discovery programs through key milestones (Hit-to-Lead and Lead Optimization)
Deep expertise in synthetic organic chemistry, including modern methods and reaction mechanisms
Strong experience in structure-based and ligand-based drug design
Demonstrated ability to optimize compounds for potency, selectivity, and DMPK/safety properties
High level of creativity, productivity, and independent problem-solving ability
Experience managing external CROs and collaborating across disciplines
Excellent communication skills with the ability to clearly present complex scientific concepts

Nice-to-Have

Experience working on small molecule degraders, proximity-inducing chemistry
Experience integrating computational chemistry, machine learning, or AI-driven design into medicinal chemistry workflows
Background in predictive toxicology or ADMET modeling
Prior experience contributing to IND-enabling studies or clinical candidate selection
Familiarity with modern data science tools and cheminformatics platforms

Key Responsibilities

Propose and independently drive medicinal chemistry strategies to progress programs from hit identification through lead optimization to development candidate selection
Lead chemistry efforts within cross-functional project teams, which include bench biologists, DMPK lead, non-clinical tox lead, computational scientists, ML engineers
Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches to optimize potency, selectivity, pharmacokinetics and developability
Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression
Contribute to and integrate AI-driven and computational modeling insights into compound design strategies
Serve as a technical leader and mentor for internal chemists and external collaborators
Manage external CRO partnerships to ensure high-quality and timely delivery of chemistry objectives
Communicate program strategy, data, risks, and recommendations to senior leadership
Author and contribute to patent strategies and applications, scientific publications, and internal reports
Competitive compensation aligned with market benchmarks
Equity participation reflecting long-term impact
Remote-friendly culture across Europe and the U.S
Flexible working structure with cross-time-zone collaboration

Values & Cultural Alignment

Operates with ownership and urgency in ambiguous scientific environments
Communicates complex modeling concepts with clarity and precision
Thrives in cross-disciplinary collaboration between science and engineering
Approaches scientific challenges with intellectual rigor and curiosity
Balances research depth with practical execution toward milestone delivery

Why This Role Matters Now Deep Origin is at a pivotal moment in scaling its AI-driven platform to transform drug discovery. As we expand into whole-human modeling and predictive toxicology, medicinal chemistry plays a critical role in translating computational insights into real-world therapeutic candidates. This role sits at the intersection of cutting-edge AI and traditional drug discovery, offering the opportunity to redefine how medicines are designed - faster, more efficiently, and with greater precision than ever before.

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More about this job

Skills

Organic chemistry
Problem solving
Communication skills
Machine learning
ML
Pharmacokinetics
Pharmacology
Collaboration
Research

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