Jobs in the United States

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PLUMBER
State of Illinois
Elgin, IL
- $10,788 to $11,381.34 USD / month
…projects at the Elgin Mental Health Center. Maintains a supply of tools, materials, and equipment necessary for the job and reports repairs and replaces various types of equipment as…
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DOC Menard CC Corrections Clerk II
State of Illinois
Menard, IL
- $5,607 to $7,953 USD / month
Prefers at least three (3) years of working experience maintaining inventory and accountability of tools.
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DOC East Moline CC Corrections Leisure Activity Specialist IV
State of Illinois
East Moline, IL
- $7,239 to $10,440 USD / month
Required to utilize digital technology, tools, platforms, and processes in managing and supporting various digital enhancements for greater efficiency, productivity, and digital…
Added 2 mins ago
Senior Specialist, Training-Operations
Southwire Company LLC
Florence, AL
…products, contractor equipment, electrical components, hand tools and jobsite power and lighting solutions. The company also offers digital solutions including contractor planning and…
Added 6 mins ago
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(Chemical Engineering) Intern - Univ/Co-Op Technical (Richland)
Framatome
Richland, WA
- $27.1 to $35.5 USD / hour
Learn to select appropriate tools and criteria for solving technical problems, especially those that require creative or non-routine approaches.
Added 6 mins ago
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IM Transcend Deployment Lead Analyst
Jobgether
Remote, United States
- $96,000 to $155,250 USD / year
Advanced knowledge of SAP ERP, familiarity with Jira, and experience using digital tools such as Power BI and Power Query are additional assets.
Added 7 mins ago
Director of Tax
University of Iowa
IA
Knowledge of/experience with tax reporting and tax reporting tools
Added 7 mins ago
Investment Analytics Group Analyst
U.S. Bancorp Asset Management, Inc.
Minneapolis, MN · Harrisburg, PA
Building and developing tools and dashboards to support investment analytics and internal and external reporting.
Added 8 mins ago
Director, HR Enablement & Transformation - Americas
Novanta Corporation
Apex, NC · Bedford, MA
Ensures consistent execution and adoption of enterprise-wide HR programs, processes, policies, and tools across multiple locations and business units. Drives a One Novanta employee and…
Added 9 mins ago
SC
CNC Machine Operator - Level 2, $1.5k Sign-On Bonus
Swagelok Company
Strongsville
- $18.4 to $25.8 USD / hour
…maintaining a strong focus on safety. You’ll be provided all the tools and gauges necessary to be successful in your…
Added 9 mins ago
SC
CNC Machine Operator - Level 2, $1.5k Sign On Bonus
Swagelok Company
Strongsville
- $18.4 to $25.8 USD / hour
…maintaining a strong focus on safety. You’ll be provided all the tools and gauges necessary to be successful in your…
Added 9 mins ago
SC
CNC Machine Operator - Level 2, $1.5k Sign-On Bonus
Swagelok Company
Strongsville
- $18.4 to $25.8 USD / hour
…maintaining a strong focus on safety. You’ll be provided all the tools and gauges necessary to be successful in your…
Added 9 mins ago
SC
Order Fulfiller - Level 3
Swagelok Company
Strongsville
- $20.25 to $28.35 USD / hour
Use SAP, warehouse management system, and inventory control tools to receive, move, issue, adjust, and verify inventory.
Added 9 mins ago
Fiscal Specialist
Waukesha County
Waukesha, WI
…employee wellness program that offers a variety of programs and tools to help promote an employee's wellness and health, including an on-site health & wellness…
Added 11 mins ago
RC
General Maintenance Worker
Riverland Community College
United States
- $20.87 to $25.88 USD / hour
Methods, tools, and equipment used in maintenance sufficient to use effectively, operate safely and to make minor repairs.
Added 12 mins ago
Social StudiesTeacher at Ruidoso High School
Ruidoso Municipal Schools
Ruidoso, NM
Familiarity with educational technology tools (such as Google Classroom, Docs, Slides, and digital assessment tools).
Added 15 mins ago
WN
Direct Support Professional DR - 000L1 - Thurs-Mon 3PM-11PM
WellLife Network
Flushing, NY
- $19.71 USD / hour
Assist with communication tools or techniques to help individuals express themselves.
Added 16 mins ago
CC
Librarian (Law Liaison)
Chesterfield County
Chesterfield County, VA
- $62,154 to $73,030 USD / year
Proficiency with databases and electronic research tools.
Added 16 mins ago
Manager, Project Management - Community Engagement
Quality Technology Services, LLC
United States
· Partner cross functionally to implement tools and solve complex, ambiguous challenges requiring senior judgment.
Added 16 mins ago
CC
School Bus Technician
Chesterfield County
Chesterfield County, VA
- $53,309 to $81,296 USD / year
…knowledge of the standard practice, methods, materials, and tools used in the repair of school buses. Must be familiar with the design, operation and repair of heavy-duty diesel engines and…
Added 17 mins ago
Director | Pharmacy Business Services
Gundersen Lutheran Admin Svcs
La Crosse, WI
Desired: Proficiency with pharmacy management systems, Epic Willow, inventory software, data analytics tools, and business intelligence platforms
Added 18 mins ago
System Engineering Manager - Rail and Transit
Parsons Transportation Group
CA
Expert in Systems Engineering practices according to ISO/IEC/IEEE 15288, including plans, processes and tools (e.g. DOORS)
Added 18 mins ago
Co-founder in Residence, Next generation insecticides and pest control
Deep Science Ventures
Remote, United States
…endophytic microbial biocontrols, provide a set of promising tools that could provide the foundations for commercially viable propositions. However, each approach presents outstanding…
Added 18 mins ago
Venture Science Doctorate: venture-creation PhD program (funded scholarship)
Deep Science Ventures
Remote, United States
Added 18 mins ago
Founder in Residence, Unlocking systemic drug delivery for brain & CNS disease
Deep Science Ventures
Remote, United States
Lead generation campaigns, screening cascades, computational modelling & AI/ML tools;

Deep Origin

Principal/ AD Medicinal Chemist

Remote, United States

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Job details

Experience: PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Posting language: English
Posted: Oct 16, 2026

Original job description

About Deep Origin Deep Origin is a biotechnology company building an operating system for science that transforms how life science research is conducted. Our AI-powered platforms simulate biology, streamline R&D workflows, and enable scientists to model complex biological systems at scale. As part of strategic government-backed initiatives and the expansion of our AI-driven simulation infrastructure, we are scaling our capabilities in whole-human modeling and predictive toxicology. Exceptional modeling talent is a critical lever in accelerating our mission to reduce disease and extend human health span.

About the Role We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior, hands-on scientific leadership role requiring deep expertise in medicinal chemistry, strategic thinking, and cross-functional collaboration. The candidate will direct work to be completed at a CRO. This position calls for a highly creative and experienced chemist who can independently design and execute medicinal chemistry strategies while contributing to the integration of computational and AI-driven approaches into drug discovery workflows. The ideal candidate will combine strong technical depth with the ability to guide internal teams and external partners toward impactful outcomes. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Proven track record of advancing drug discovery programs through key milestones (Hit-to-Lead and Lead Optimization)
Deep expertise in synthetic organic chemistry, including modern methods and reaction mechanisms
Strong experience in structure-based and ligand-based drug design
Demonstrated ability to optimize compounds for potency, selectivity, and DMPK/safety properties
High level of creativity, productivity, and independent problem-solving ability
Experience managing external CROs and collaborating across disciplines
Excellent communication skills with the ability to clearly present complex scientific concepts

Nice-to-Have

Experience working on small molecule degraders, proximity-inducing chemistry
Experience integrating computational chemistry, machine learning, or AI-driven design into medicinal chemistry workflows
Background in predictive toxicology or ADMET modeling
Prior experience contributing to IND-enabling studies or clinical candidate selection
Familiarity with modern data science tools and cheminformatics platforms

Key Responsibilities

Propose and independently drive medicinal chemistry strategies to progress programs from hit identification through lead optimization to development candidate selection
Lead chemistry efforts within cross-functional project teams, which include bench biologists, DMPK lead, non-clinical tox lead, computational scientists, ML engineers
Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches to optimize potency, selectivity, pharmacokinetics and developability
Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression
Contribute to and integrate AI-driven and computational modeling insights into compound design strategies
Serve as a technical leader and mentor for internal chemists and external collaborators
Manage external CRO partnerships to ensure high-quality and timely delivery of chemistry objectives
Communicate program strategy, data, risks, and recommendations to senior leadership
Author and contribute to patent strategies and applications, scientific publications, and internal reports
Competitive compensation aligned with market benchmarks
Equity participation reflecting long-term impact
Remote-friendly culture across Europe and the U.S
Flexible working structure with cross-time-zone collaboration

Values & Cultural Alignment

Operates with ownership and urgency in ambiguous scientific environments
Communicates complex modeling concepts with clarity and precision
Thrives in cross-disciplinary collaboration between science and engineering
Approaches scientific challenges with intellectual rigor and curiosity
Balances research depth with practical execution toward milestone delivery

Why This Role Matters Now Deep Origin is at a pivotal moment in scaling its AI-driven platform to transform drug discovery. As we expand into whole-human modeling and predictive toxicology, medicinal chemistry plays a critical role in translating computational insights into real-world therapeutic candidates. This role sits at the intersection of cutting-edge AI and traditional drug discovery, offering the opportunity to redefine how medicines are designed - faster, more efficiently, and with greater precision than ever before.

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