Jobs in the United States

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Added 3 mins ago
BRANCH MANAGER TW
O'Neal Industries
Charlotte, NC
Safety and Employee Well-Being: Lead the branch safety program and build a strong safety culture. Implement and enforce TW Metals safety policies and procedures and ensure compliance with…
Added 5 mins ago
Heavy Equipment Operator Foreman
Edwards Construction Group
Arroyo Grande, CA
…precise, efficient production, and is committed to safety, quality, and developing the next generation of operators. If you can run multiple machines with skill and keep a crew productive…
Added 7 mins ago
Internal Audit & Risk Manager (SOX Focus)
Baker Tilly Advisory Group, LP
United States
Added 18 mins ago
Pointing/Acquisition/Tracking and Controls Engineer-Technical Staff
MIT Lincoln Laboratory
Lexington, MA
…state-of-the-art technology solutions and engage across the program lifecycle, leading projects or major/multiple technical workstreams in partnership with project, program and team/Group…
Added 18 mins ago
Electrical / Physics Engineer Advanced Imaging
MIT Lincoln Laboratory
Lexington, MA
…state-of-the-art technology solutions and engage across the program lifecycle, leading projects or major/multiple technical workstreams in partnership with project, program and team/Group…
Added 21 mins ago
Director, Policy Administration
Kemper
Chesterfield, MO
…Kemper Life. This role ensures efficient, compliant, and high-quality service to agents and policyholders while driving operational improvements and supporting business objectives. The…
Added 22 mins ago
Director, Experiential & Executive Events
Oracle
Jefferson City, MO
…the Director, Experiential & Executive Events owns strategy, program direction, and the customer experience across Oracle's global events portfolio. This role leads the experiential events…
Added 23 mins ago
CNC Machinist 1st Shift
Gleason
Rochester, NY
Read and interpret blueprints, program readouts, and technical directives to determine and obtain materials and cutting tools for the job and to visualize the finished part and critical…
Added 23 mins ago
CNC Machinist 2nd Shift
Gleason
Rochester, NY
Read and interpret blueprints, program readouts, and technical directives to determine and obtain materials and cutting tools for the job and to visualize the finished part and critical…
Added 23 mins ago
CNC Machinist 3rd Shift
Gleason
Rochester, NY
Read and interpret blueprints, program readouts, and technical directives to determine and obtain materials and cutting tools for the job and to visualize the finished part and critical…
Added 24 mins ago
A
Machine Operator
Aerotek
WHEELING, IL
- $21 to $23 USD / hour
…operating, and monitoring Fin Tube milling centers to produce high-quality components that meet precise customer specifications. This role prepares and reviews material scans at the start…
Added 25 mins ago
J
Senior Project Manager (Corporate Events & Experiences Planner)
Jobgether
Remote, United States
- $95,166 to $123,716 USD / year
As a Senior Project Manager, you will lead the planning and delivery of high-impact corporate events, conferences, and brand experiences.
Added 25 mins ago
J
Senior Product Management Specialist - Commercial Modifications (Virtual)
Jobgether
Remote, United States
- $129,200 to $187,450 USD / year
Participate in and lead Change Board Meetings, ensuring effective coordination, documentation, and communication of program changes.
Added 26 mins ago
Quality Control Team Lead - 2nd shift
Amgen Inc.
NC
Let’s do this. Let’s change the world. In this vital role you perform testing and assist with managing the Quality Control Bioassay laboratory. The Specialist, Quality Control Bioassay will…
Added 26 mins ago
Sr. Engineer - Drug Substance Engineering Technical Authority (ETA)
Amgen Inc.
NC
Demonstrated ability to lead the design of process equipment for new facilities and to balance competing factors to deliver equipment that meets process, quality and operability…
Added 27 mins ago
HI
Program Manager
Health Improvement Partnership of Santa Cruz County
Santa Cruz, CA
- $83,388.76 USD / year
…programs across the Central Coastal Region? If so, apply for the Program Manager role that has opened at the Health Improvement Partnership of Santa Cruz County…
Added 27 mins ago
Leadership Council San Mateo County, Executive Director
Edgility Search
South San Francisco, CA
Program & Community Impact: Oversees the Leadership CORPS and Emerging Leaders Immersion Programs, LEAD Local, and the Community Acceleration Projects (CAP) model, ensuring quality,…
Added 27 mins ago
Jalen Rose Leadership Academy, Principal-in-Residence - Middle School
Edgility Search
Detroit, MI
Implement a high-quality, rigorous, learning program that promotes critical thinking, citizenship, and leadership consistent with Jalen Rose Leadership Academy’s mission and vision.
Added 27 mins ago
KIPP Foundation, Executive Director Fellow
Edgility Search
NY · New York, NY
Fellows participate in a rigorous leadership development program that combines immersive learning experiences, executive coaching, mentoring, applied leadership experiences, and a capstone…
Added 27 mins ago
ES
Philly BOLT, Executive Director
Edgility Search
Philadelphia, PA
- $115,000 to $140,000 USD / year
BOLT Youth Leaders Fellowship (YLF): An in-school and summer leadership development program that empowers Philadelphia public high school students to become changemakers in their…
Added 27 mins ago
ES
California Association for Bilingual Education (CABE), Chief Executive Officer
Edgility Search
Walnut, CA
- $230,000 to $250,000 USD / year
…CABE is a nonprofit organization dedicated to promoting high-quality educational experiences and opportunities for all students, with a particular focus on multilingual/English learners and…
Added 28 mins ago
Senior Manager, Statistical Programming
EDETEK
Remote, United States
Acts as lead programmer for assigned projects;
Added 28 mins ago
Sr. Director of Product Engineering
EDETEK
Remote, United States
…Informatics, and biometrics-related solutions. This role will lead product engineering organization and work closely with Product Management, QA, Validation, Cloud Operations, Security,…
Added 32 mins ago
Scheduler
CACI, INC.-FEDERAL
Remote, United States
Lead the development, maintenance, and execution of Integrated Master Schedules (IMS) to support program objectives, technical milestones, and operational requirements
Added 34 mins ago
Health Reinsurance Actuarial Leader, Man
Aon Corporation
Boston, MA
…expertise, managed care knowledge, and strategic insight. You will lead a team of actuaries and analysts delivering advanced analytics that shape risk strategies in the healthcare industry,…

Deep Origin

Principal/ AD Medicinal Chemist

Remote, United States

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Job details

Experience: PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Posting language: English
Posted: Oct 16, 2026

Original job description

About Deep Origin Deep Origin is a biotechnology company building an operating system for science that transforms how life science research is conducted. Our AI-powered platforms simulate biology, streamline R&D workflows, and enable scientists to model complex biological systems at scale. As part of strategic government-backed initiatives and the expansion of our AI-driven simulation infrastructure, we are scaling our capabilities in whole-human modeling and predictive toxicology. Exceptional modeling talent is a critical lever in accelerating our mission to reduce disease and extend human health span.

About the Role We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior, hands-on scientific leadership role requiring deep expertise in medicinal chemistry, strategic thinking, and cross-functional collaboration. The candidate will direct work to be completed at a CRO. This position calls for a highly creative and experienced chemist who can independently design and execute medicinal chemistry strategies while contributing to the integration of computational and AI-driven approaches into drug discovery workflows. The ideal candidate will combine strong technical depth with the ability to guide internal teams and external partners toward impactful outcomes. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Proven track record of advancing drug discovery programs through key milestones (Hit-to-Lead and Lead Optimization)
Deep expertise in synthetic organic chemistry, including modern methods and reaction mechanisms
Strong experience in structure-based and ligand-based drug design
Demonstrated ability to optimize compounds for potency, selectivity, and DMPK/safety properties
High level of creativity, productivity, and independent problem-solving ability
Experience managing external CROs and collaborating across disciplines
Excellent communication skills with the ability to clearly present complex scientific concepts

Nice-to-Have

Experience working on small molecule degraders, proximity-inducing chemistry
Experience integrating computational chemistry, machine learning, or AI-driven design into medicinal chemistry workflows
Background in predictive toxicology or ADMET modeling
Prior experience contributing to IND-enabling studies or clinical candidate selection
Familiarity with modern data science tools and cheminformatics platforms

Key Responsibilities

Propose and independently drive medicinal chemistry strategies to progress programs from hit identification through lead optimization to development candidate selection
Lead chemistry efforts within cross-functional project teams, which include bench biologists, DMPK lead, non-clinical tox lead, computational scientists, ML engineers
Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches to optimize potency, selectivity, pharmacokinetics and developability
Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression
Contribute to and integrate AI-driven and computational modeling insights into compound design strategies
Serve as a technical leader and mentor for internal chemists and external collaborators
Manage external CRO partnerships to ensure high-quality and timely delivery of chemistry objectives
Communicate program strategy, data, risks, and recommendations to senior leadership
Author and contribute to patent strategies and applications, scientific publications, and internal reports
Competitive compensation aligned with market benchmarks
Equity participation reflecting long-term impact
Remote-friendly culture across Europe and the U.S
Flexible working structure with cross-time-zone collaboration

Values & Cultural Alignment

Operates with ownership and urgency in ambiguous scientific environments
Communicates complex modeling concepts with clarity and precision
Thrives in cross-disciplinary collaboration between science and engineering
Approaches scientific challenges with intellectual rigor and curiosity
Balances research depth with practical execution toward milestone delivery

Why This Role Matters Now Deep Origin is at a pivotal moment in scaling its AI-driven platform to transform drug discovery. As we expand into whole-human modeling and predictive toxicology, medicinal chemistry plays a critical role in translating computational insights into real-world therapeutic candidates. This role sits at the intersection of cutting-edge AI and traditional drug discovery, offering the opportunity to redefine how medicines are designed - faster, more efficiently, and with greater precision than ever before.

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