Jobs in the United States

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Assistant Manager
MEALS-ON-WHEELS GREATER SAN DIEGO INC
Chula Vista, CA
- $24 to $26 USD / hour
…administrative functions of the Meals on Wheels San Diego County program, ensuring efficient service delivery to at-risk seniors living independently. The Assistant Manager will be…
Added 2 mins ago
Head of Partnerships Governance
S & P GLOBAL MARKET INTELLIGENCE INC
NY
Design, launch, and lead the Enterprise Partnerships Council (EPC) - establishing its charter, RACI, meeting cadence, and escalation protocol to give ELT-sponsored leadership a structured…
Added 5 mins ago
SO
OFFICE ASSOCIATE
State of Illinois
Kankakee, IL
- $4,144 to $5,429 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 5 mins ago
SO
ACCOUNT TECHNICIAN I (UMP)
State of Illinois
Centralia, IL
- $4,407 to $5,879 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 5 mins ago
SO
ADMINISTRATIVE LAW JUDGE
State of Illinois
Chicago, IL
- $8,060 to $11,851 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 5 mins ago
SO
PLUMBER
State of Illinois
Elgin, IL
- $10,788 to $11,381.34 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 5 mins ago
SO
OFFICE ASSOCIATE
State of Illinois
Chicago, IL
- $4,144 to $5,429 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 5 mins ago
SO
OFFICE ASSOCIATE
State of Illinois
Chester, IL
- $4,144 to $5,655 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 5 mins ago
SO
MEDICAL SERVICE NURSE (REGISTERED NURSE I) (UMP)
State of Illinois
Kankakee, IL
- $6,604 to $8,960 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 5 mins ago
SO
STATIONARY ENGINEER
State of Illinois
Elgin, IL
- $10,565.28 to $11,146.44 USD / month
Applications submitted via email or any paper manner (mail, fax, hand delivery) will not be considered.
Added 7 mins ago
Senior Specialist, Training-Operations
Southwire Company LLC
Florence, AL
…programs at the operational level. This role focuses on the delivery and support of training initiatives, mentoring others, and contributing to change management and compliance…
Added 8 mins ago
MM
Performance Leader, 2nd shift
Moog Military Aircraft LLC
Torrance, CA
- $90,000 to $130,000 CAD / year
Bachelor’s Degree in a related discipline or equivalent experience and 6 years directly related experience in production environment and previous supervision or team lead experience or
Added 16 mins ago
UFT Nursing, A.D. Faculty (Rapids Campus)
Anoka-Ramsey Community College
United States
…allows for an easy transition to our partner universities. Our program is intended for individuals wishing to attain either an Associate of Science Degree in Nursing and/or a Bachelor of…
Added 16 mins ago
UFT Nursing, A.D. Faculty (Cambridge Campus)
Anoka-Ramsey Community College
United States
…allows for an easy transition to our partner universities. Our program is intended for individuals wishing to attain either an Associate of Science Degree in Nursing and/or a Bachelor of…
Added 17 mins ago
AU
Project Manager
ABM US
Los Angeles, CA
- $100,000 USD / year
Lead and manage diverse operations teams to ensure high-quality service delivery
Added 20 mins ago
Mobile Program Manager (48196)
Dilkon Medical Center | Winslow Indian Health Care
Dilkon, AZ
Under the general supervision of the Director of Hozhoogo Iina Wellness, the Mobile Program Manager will oversee operations of the mobile program. The incumbent works in collaboration with…
Added 22 mins ago
Manager, Project Management - Community Engagement
Quality Technology Services, LLC
United States
This position requires strong program and change management capability, the ability to influence across and up the organization, and accountability for budgets, resources, risk mitigation,…
Added 24 mins ago
GC
Program Administrator
GRACE CARE HOMES
Salem, OR
- $84,000 to $94,000 USD / year
Grace Care Homes is seeking a dedicated Program Administrator to lead the operations and ensure the success of our Residential Treatment Home. Additionally, the Program Administrator will…
Added 24 mins ago
Principal/ AD Medicinal Chemist
Deep Origin
Remote, United States
We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior,…
Added 24 mins ago
Principal/ AD Medicinal Chemist
Deep Origin
Remote, United States
We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior,…
Added 24 mins ago
Senior Research Associate, Cell Biology & Assay Development
Deep Origin
South San Francisco, CA
Drug discovery experience in biotech or pharma, including work on a target-to-lead or lead-optimization program.
Added 25 mins ago
DIM Services Lead
TOMARCO CONTRACTOR SPECIALTIES LLP
Matthews, NC
ISAT Total Support is seeking a DIM Service Lead to support the successful delivery of complex construction projects through coordinated engineering, digital design, fabrication, and…
Added 25 mins ago
Sr. DIM Services Lead
TOMARCO CONTRACTOR SPECIALTIES LLP
Matthews, NC
…coordinated, executable deliverables. The Senior DIM Service Lead oversees fabrication execution from early planning and design coordination through production, delivery, installation…
Added 30 mins ago
OO
Office Director
Office of Shared Administration (WV)
Charleston, WV
- $34.25 to $57.09 USD / hour
The Deputy Director will serve as the second-in-command and operational lead, facilitating collaboration across agencies, health systems, and community partners; overseeing complex grant…
Added 37 mins ago
Registered Nurse Labor and Delivery
Ascension
Kokomo, IN
Department: Labor, Delivery, Recovery, and Postpartum

Deep Origin

Principal/ AD Medicinal Chemist

Remote, United States

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Job details

Experience: PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Posting language: English
Posted: Oct 16, 2026

Original job description

About Deep Origin Deep Origin is a biotechnology company building an operating system for science that transforms how life science research is conducted. Our AI-powered platforms simulate biology, streamline R&D workflows, and enable scientists to model complex biological systems at scale. As part of strategic government-backed initiatives and the expansion of our AI-driven simulation infrastructure, we are scaling our capabilities in whole-human modeling and predictive toxicology. Exceptional modeling talent is a critical lever in accelerating our mission to reduce disease and extend human health span.

About the Role We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior, hands-on scientific leadership role requiring deep expertise in medicinal chemistry, strategic thinking, and cross-functional collaboration. The candidate will direct work to be completed at a CRO. This position calls for a highly creative and experienced chemist who can independently design and execute medicinal chemistry strategies while contributing to the integration of computational and AI-driven approaches into drug discovery workflows. The ideal candidate will combine strong technical depth with the ability to guide internal teams and external partners toward impactful outcomes. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Proven track record of advancing drug discovery programs through key milestones (Hit-to-Lead and Lead Optimization)
Deep expertise in synthetic organic chemistry, including modern methods and reaction mechanisms
Strong experience in structure-based and ligand-based drug design
Demonstrated ability to optimize compounds for potency, selectivity, and DMPK/safety properties
High level of creativity, productivity, and independent problem-solving ability
Experience managing external CROs and collaborating across disciplines
Excellent communication skills with the ability to clearly present complex scientific concepts

Nice-to-Have

Experience working on small molecule degraders, proximity-inducing chemistry
Experience integrating computational chemistry, machine learning, or AI-driven design into medicinal chemistry workflows
Background in predictive toxicology or ADMET modeling
Prior experience contributing to IND-enabling studies or clinical candidate selection
Familiarity with modern data science tools and cheminformatics platforms

Key Responsibilities

Propose and independently drive medicinal chemistry strategies to progress programs from hit identification through lead optimization to development candidate selection
Lead chemistry efforts within cross-functional project teams, which include bench biologists, DMPK lead, non-clinical tox lead, computational scientists, ML engineers
Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches to optimize potency, selectivity, pharmacokinetics and developability
Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression
Contribute to and integrate AI-driven and computational modeling insights into compound design strategies
Serve as a technical leader and mentor for internal chemists and external collaborators
Manage external CRO partnerships to ensure high-quality and timely delivery of chemistry objectives
Communicate program strategy, data, risks, and recommendations to senior leadership
Author and contribute to patent strategies and applications, scientific publications, and internal reports
Competitive compensation aligned with market benchmarks
Equity participation reflecting long-term impact
Remote-friendly culture across Europe and the U.S
Flexible working structure with cross-time-zone collaboration

Values & Cultural Alignment

Operates with ownership and urgency in ambiguous scientific environments
Communicates complex modeling concepts with clarity and precision
Thrives in cross-disciplinary collaboration between science and engineering
Approaches scientific challenges with intellectual rigor and curiosity
Balances research depth with practical execution toward milestone delivery

Why This Role Matters Now Deep Origin is at a pivotal moment in scaling its AI-driven platform to transform drug discovery. As we expand into whole-human modeling and predictive toxicology, medicinal chemistry plays a critical role in translating computational insights into real-world therapeutic candidates. This role sits at the intersection of cutting-edge AI and traditional drug discovery, offering the opportunity to redefine how medicines are designed - faster, more efficiently, and with greater precision than ever before.

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