Jobs in the United States

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Added 7 mins ago
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IM Transcend Deployment Lead Analyst
Jobgether
Remote, United States
- $96,000 to $155,250 USD / year
This position is listed on behalf of a partner company, which manages all applications and next steps. Our partner is looking for an IM Transcend Deployment Lead Analyst based in the United…
Added 7 mins ago
J
Financial Accounting
Jobgether
Remote, United States
- $81,500 to $108,500 USD / year
This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Financial Accounting (Senior Accountant) based in the…
Added 7 mins ago
Chief of Staff to the CEO
Jobgether
Remote, United States
This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Chief of Staff to the CEO based in the United States.
Added 9 mins ago
Director, HR Enablement & Transformation - Americas
Novanta Corporation
Apex, NC · Bedford, MA
…extreme precision and performance for a range of mission-critical applications - from minimally invasive surgery to robotics to 3D metal…
Added 20 mins ago
Principal/ AD Medicinal Chemist
Deep Origin
Remote, United States
Author and contribute to patent strategies and applications, scientific publications, and internal reports
Added 20 mins ago
Principal/ AD Medicinal Chemist
Deep Origin
Remote, United States
Author and contribute to patent strategies and applications, scientific publications, and internal reports
Added 28 mins ago
Director of Home Nursing Clinical Services (RN)
Silvan Sage
Winnetka, IL
Shape clinical standards, digital workflows, and emerging AI applications.
Added 33 mins ago
Senior Brand Strategist, Job Seekers
Indeed
Annapolis, MD
Added 33 mins ago
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Zone Mechanic
Aerotek
Baltimore, MD
- $25 to $30 USD / hour
…sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that…
Added 33 mins ago
PKI Engineer, Senior
BOOZ, ALLEN & HAMILTON, INC.
Laurel, MD
Ability to support the end-to-end deployment of secure, PKI-based web applications
Added 41 mins ago
Prospective Candidates
Jobgether
Remote, United States
This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for Prospective Candidates based in United States.
Added 42 mins ago
Software, Data & AI Sales Manager & Account Executive
Dean Dorton
Remote, United States
…and business management software to advanced analytics and AI applications, we deliver secure, scalable, and integrated solutions that align technology with strategy - helping businesses…
Added 50 mins ago
Platform Tooling Engineer
GD Information Technology, Inc.
United States
Experience supporting Linux servers, containerized applications, Kubernetes platforms, and AWS cloud infrastructure.
Added 50 mins ago
Deputy Program Manager
GD Information Technology, Inc.
United States
…stakeholders with reliable access to the computing, storage, and applications they require in support of the Agency’s mission. The Deputy PM is a critical link between…
Added 50 mins ago
GI
BCRC Customer Service Representative
GD Information Technology, Inc.
United States
- $17.33 to $23.45 USD / hour
Ability to navigate several applications while speaking with callers and documenting interactions.
Added 51 mins ago
Sales Associate
Carter's Retail Inc.
Nashville-Opry Mills, TN
Applications will be accepted until at least 7 days after the posting date.
Added 53 mins ago
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Technical Program Manager, Mechanical Infrastructure - Data Centers (on-site Nashville, TN)
Oracle
Nashville, TN
- $126,200 to $264,100 USD / year
Added 53 mins ago
O
Technical Program Manager, Electrical Infrastructure - Data Centers (on-site Nashville, TN)
Oracle
Nashville, TN
- $126,200 to $264,100 USD / year
Added 56 mins ago
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Summer 2027 Internship Program: Engineering Opportunities - Waltham, MA
natgridProd
Waltham, MA
- $20 to $35 USD / hour
Added 56 mins ago
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Summer 2027 Internship Program: Engineering Opportunities - Northborough, MA
natgridProd
Northboro, MA
- $23 to $35 USD / hour
…and operational data used to support machine learning and AI applications. You will also assist with evaluating and enhancing information and knowledge management practices, including…
Added 56 mins ago
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Summer 2027 Internship Program: Engineering Opportunities - Syracuse, NY
natgridProd
N Syracuse, NY · Syracuse, NY
- $20 to $31 USD / hour
Added 56 mins ago
Graduate Development Program, Associate Engineer, Electrical Planning and Design
natgridProd
Syracuse, NY · Buffalo, NY · Albany, NY
Added 56 mins ago
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Summer 2027 Internship Program: Engineering Opportunities - Northport, NY
natgridProd
Northport, NY
- $25 to $36 USD / hour
Added 56 mins ago
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Summer 2027 Internship Program: Power Generation Engineering Opportunities - Long Island, NY
natgridProd
Hicksville, NY
- $25 to $36 USD / hour
Added 56 mins ago
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Summer 2027 Internship Program: Engineering Opportunities - Long Island, NY
natgridProd
Brightwaters, NY · Bellmore, NY · Hicksville, NY · Melville, NY
- $22 to $36 USD / hour
…You will also develop skills in data analysis, reporting, GIS applications, and network…

Deep Origin

Principal/ AD Medicinal Chemist

Remote, United States

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Job details

Experience: PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Posting language: English
Posted: Oct 16, 2026

Original job description

About Deep Origin Deep Origin is a biotechnology company building an operating system for science that transforms how life science research is conducted. Our AI-powered platforms simulate biology, streamline R&D workflows, and enable scientists to model complex biological systems at scale. As part of strategic government-backed initiatives and the expansion of our AI-driven simulation infrastructure, we are scaling our capabilities in whole-human modeling and predictive toxicology. Exceptional modeling talent is a critical lever in accelerating our mission to reduce disease and extend human health span.

About the Role We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies. This is a senior, hands-on scientific leadership role requiring deep expertise in medicinal chemistry, strategic thinking, and cross-functional collaboration. The candidate will direct work to be completed at a CRO. This position calls for a highly creative and experienced chemist who can independently design and execute medicinal chemistry strategies while contributing to the integration of computational and AI-driven approaches into drug discovery workflows. The ideal candidate will combine strong technical depth with the ability to guide internal teams and external partners toward impactful outcomes. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

PhD in Organic Chemistry or a related field with 3-8 years of industry experience in medicinal chemistry
Proven track record of advancing drug discovery programs through key milestones (Hit-to-Lead and Lead Optimization)
Deep expertise in synthetic organic chemistry, including modern methods and reaction mechanisms
Strong experience in structure-based and ligand-based drug design
Demonstrated ability to optimize compounds for potency, selectivity, and DMPK/safety properties
High level of creativity, productivity, and independent problem-solving ability
Experience managing external CROs and collaborating across disciplines
Excellent communication skills with the ability to clearly present complex scientific concepts

Nice-to-Have

Experience working on small molecule degraders, proximity-inducing chemistry
Experience integrating computational chemistry, machine learning, or AI-driven design into medicinal chemistry workflows
Background in predictive toxicology or ADMET modeling
Prior experience contributing to IND-enabling studies or clinical candidate selection
Familiarity with modern data science tools and cheminformatics platforms

Key Responsibilities

Propose and independently drive medicinal chemistry strategies to progress programs from hit identification through lead optimization to development candidate selection
Lead chemistry efforts within cross-functional project teams, which include bench biologists, DMPK lead, non-clinical tox lead, computational scientists, ML engineers
Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches to optimize potency, selectivity, pharmacokinetics and developability
Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression
Contribute to and integrate AI-driven and computational modeling insights into compound design strategies
Serve as a technical leader and mentor for internal chemists and external collaborators
Manage external CRO partnerships to ensure high-quality and timely delivery of chemistry objectives
Communicate program strategy, data, risks, and recommendations to senior leadership
Author and contribute to patent strategies and applications, scientific publications, and internal reports
Competitive compensation aligned with market benchmarks
Equity participation reflecting long-term impact
Remote-friendly culture across Europe and the U.S
Flexible working structure with cross-time-zone collaboration

Values & Cultural Alignment

Operates with ownership and urgency in ambiguous scientific environments
Communicates complex modeling concepts with clarity and precision
Thrives in cross-disciplinary collaboration between science and engineering
Approaches scientific challenges with intellectual rigor and curiosity
Balances research depth with practical execution toward milestone delivery

Why This Role Matters Now Deep Origin is at a pivotal moment in scaling its AI-driven platform to transform drug discovery. As we expand into whole-human modeling and predictive toxicology, medicinal chemistry plays a critical role in translating computational insights into real-world therapeutic candidates. This role sits at the intersection of cutting-edge AI and traditional drug discovery, offering the opportunity to redefine how medicines are designed - faster, more efficiently, and with greater precision than ever before.

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