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Senior Principal Software Engineer – GlobalProtect (Windows & macOS Internals)
Palo Alto Networks, Inc.
CA
As a Senior Principal Software Engineer for GlobalProtect, you will be the hands-on technical authority for our endpoint networking stack across the Windows driver and macOS…
Added just now
Principal Product Manager - Synthetic Monitoring / Digital Experience Monitoring (Cortex XCOR/Chronosphere)
Palo Alto Networks, Inc.
United States
We are looking for a Principal Product Manager to own synthetic monitoring for Cortex XCOR. You will translate front-end testing requirements from SREs and frontend developers (browser…
Added 2 mins ago
Digital Innovation Software Engineering Leader
Barry-Wehmiller
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The DI Software Engineering Leader leads the planning, execution, and continuous improvement of software engineering development, ensuring consistent delivery of high-quality, secure, and…
Added 2 mins ago
Principal RF System Analysis Engineer
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United States
Our Advanced Radar RF & Systems Engineering Department has an immediate need for a Principal RF Systems Analysis Engineer to support the design, integration, production, test, and…
Added 3 mins ago
Civil Engineering Lead
Sunde Engineering
Bloomington, MN
Sunde Engineering is a civil and environmental engineering consulting firm serving developers, architects, landowners, and municipalities across the Midwest. The firm provides site…
Added 5 mins ago
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Principal Research Scientist I
AbbVie
North Chicago, IL
- $124,500 to $236,500 USD / year
For the Principal Research Scientist I position, we are seeking a highly motivated and experienced data scientist to provide scientific and technical leadership for analytical data science,…
Added 6 mins ago
Principal Software Development Engineer (AI Innovation)
CVS Health
Richardson, TX
The Principal Software Development Engineer will drive innovative, enterprise-wide solution designs at the business unit level for highly complex, strategic initiatives. In this high-impact…
Added 18 mins ago
MS
Principal Software Engineer - Digital Media - Dallas, TX
Military Spouse Jobs & VetJobs
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- $120,000 to $180,000 USD / year
As a Manager, New Initiatives / Digital Media, you will oversee Avery Dennison’s innovative software products and lead cross-functional development teams while directing the software…
Added 23 mins ago
Sr Business Analyst - AI
REPUBLIC SERVICES, INC.
Remote, United States
Works jointly with other IT Managers to create detailed work plans for software development and enhancement projects.
Added 23 mins ago
Principal Software Engineer, Agentic UX
Workday, Inc.
CA
As a Principal Software Engineer, Agentic UX in Agent Factory, you’ll help build the conversational AI experience and ambient capabilities that bring Workday’s agents to life. You are an…
Added 25 mins ago
Principal Information Systems Project Manager BOSS#20537
CORP-Corporate Office
United States
Must have knowledge/experience of Systems Engineering “V” Life Cycle, or Software Development Life Cycle (SDLC) process.
Added 25 mins ago
Principal / Sr Principal Modeling Simulation Systems Engineer - 18976
CORP-Corporate Office
United States
Northrop Grumman Defense Systems is seeking a Principal / Sr Principal Modeling Simulation Engineer Systems. This opening is in Roy, UT and will support the Sentinel Program. Northrop…
Added 25 mins ago
Sentinel - Principal / Sr Principal Systems Engineer - 18977
CORP-Corporate Office
United States
Northrop Grumman Defense Systems is seeking a Principal / Sr Principal Systems Engineer. This opening is in Roy, UT and will support the Sentinel Program. Northrop Grumman supports the Air…
Added 25 mins ago
Sentinel - Nuclear Hardness Survivability Engineer - 20483*
CORP-Corporate Office
United States
…Program. Northrop Grumman supports the Air Force’s sustainment, development, production and deployment of hardware and system modifications for Intercontinental Ballistic Missile (ICBM)…
Added 25 mins ago
Senior Principal Systems Engineer *
CORP-Corporate Office
United States
In this role, the Systems Engineer – Level 4 will work in tandem with a scrum team of other software and systems engineers responsible for defining the product vision, managing the product…
Added 25 mins ago
Principal or Sr. Principal DevOps Engineer
CORP-Corporate Office
United States
Northrop Grumman Mission Systems is looking for you to join our Software and Digital Technology Team as a Principal or Sr. Principal DevOps Engineer based out of Baltimore, MD.
Added 25 mins ago
Sentinel - Systems Engineer / Principal Systems Engineer - 20060
CORP-Corporate Office
United States
Strong understanding and broad application of complex engineering systems (engineering standards, configuration management, material review board, process control, tooling, facilities,…
Added 25 mins ago
Sr Principal Engineer Systems
CORP-Corporate Office
United States
…leadership needed to establish and maintain a world class Systems Engineering organization, supporting multiple divisions and programs across a wide portfolio. The role will have…
Added 25 mins ago
DevOps Engineer - Level 3 or 4
CORP-Corporate Office
United States
You will integrate development pipelines leveraging automation with test-driven development tools and continuous integration/test frameworks. You will implement provisioning and deployment…
Added 25 mins ago
Software Configuration Analyst / Principal Software Configuration Analyst
CORP-Corporate Office
United States
NGMS in the Apopka, FL area is seeking a Software Configuration Analyst/Principal Software Configuration Analyst to help develop, enforce, and maintain Software Configuration Management…
Added 25 mins ago
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Principal Software Engineer
Disney Entertainment & Sports LLC
Glendale, CA
- $191,300 to $256,500 USD / year
As the Principal Software Engineer for the Rights & Accounting team within Content Platforms, you will serve as a senior technical leader, driving engineering standards, leading…
Added 26 mins ago
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Principal Platform AI Engineer, Healthcare Agentic AI
Insight Global
Louisville-Jefferson County, KY
- From $86 USD / hour
12+ years of software engineering at senior, staff or principal level, including 3+ years building production generative AI, RAG, agentic AI or AI platforms (not just POCs)
Added 35 mins ago
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Principal Scientist, Product Transfer
HIKMA
Cherry Hill, NJ
- $98,000 to $161,700 USD / year
B.S. in Chemistry, Engineering, Pharmacy, or related scientific discipline with 8+ years of relevant pharmaceutical experience, or 10+ years of relevant experience in another technical…
Added 36 mins ago
Staff Acoustical Consultant
Resolut Group
Denver, CO
At Resolut, our dedication to our clients is matched by our commitment to our employees. We are a multidisciplinary engineering and consulting firm specializing in mechanical, electrical,…
Added 36 mins ago
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Bioinformatics Scientist I - Neonatology
The Children's Hospital of Philadelphia
United States
- $92,100 to $117,400 USD / year
This includes the support of internal bioinformatics software, implementation and modification of existing algorithms, pathway analysis and the development of new computational tools within…

CURIA

Principal Engineer

United States

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Job details

Experience: Experience: Minimum 10+ years of pharmaceutical engineering experience in sterile drug product manufacturing or CDMO technical operations
Posting language: English
Posted: Nov 4, 2026

Original job description

Principal Engineer – Filling & Lyophilization – United States Build your future at Curia, where our work has the power to save lives. The Principal Engineer will lead equipment engineering for large capital projects in sterile filling and lyophilization to support Curia’s strategic growth. This includes leading network-wide capital execution to expand, modernize, and standardize manufacturing infrastructure. The incumbent will direct the specification, procurement, installation, commissioning, and qualification of advanced aseptic technologies to increase capacity, efficiency, and compliance for drug product programs. This position interfaces with Curia’s network manufacturing sites, client technical teams, and global leadership. The role provides technical oversight, mentorship, and engineering guidance across site-based teams and major capital project teams. Curia is a global contract development and manufacturing organization (CDMO) with over 30 years of experience partnering with pharmaceutical and biotech companies to provide life-saving treatments to patients. At Curia, we are on a mission to advance our customers’ therapies from curiosity to cure and ultimately to improve patients’ lives. We proudly offer

Generous benefit options (eligible first day of employment)
Paid training, vacation and holidays (vacation accrual begins on first day of employment)
Career advancement opportunities
Education reimbursement
401K program with matching contributions
Learning platform
And more!

Responsibilities

Capital Project Execution: Lead filling and lyophilization equipment engineering for major capital projects ($10M–$50M+) from conceptual design through Commissioning, Qualification, and Validation (CQV)
Technical Transfer & Client Support: Drive robust, on-time technical transfers of API and Drug Product (DP) programs, partnering with the Global Program Management Office and site technical operation teams to satisfy client expectations
Equipment Specification & Procurement: Author User Requirement Specifications (URS), drive vendor selection, conduct capital cost estimation, and lead Factory/Site Acceptance Testing (FAT/SAT) for primary equipment (fill lines, isolators, lyos, VHP, capping)
Network Capability & Talent Development: Mentor site-based engineering teams across the Curia network, sharing best practices, upgrading skill sets, and driving technical standardization
Operational Excellence & Continuous Improvement: Partner with sites to troubleshoot complex equipment deviations, increase OEE, reduce cycle times, and execute cost-improvement programs
Vendor & Engineering Firm Management: Oversee external engineering design firms, equipment vendors, and field contractors for filling and lyophilization installations
Regulatory Compliance: Ensure all equipment and system designs comply with cGMP, EU Annex 1 (Contamination Control Strategy), FDA guidance, and global regulatory standards
This job has no direct supervisory responsibilities; serves as a technical lead and matrix manager for project teams and site engineering resources
Travel Requirement: Up to 40% travel, including international travel to plant sites and vendor facilities Education and Experience
Education: BS in Mechanical, Chemical, Electrical, or Biomedical Engineering (or related discipline)
Experience: Minimum 10+ years of pharmaceutical engineering experience in sterile drug product manufacturing or CDMO technical operations
Capital Projects: Proven track record leading major capital equipment execution projects exceeding $10M Technical Expertise: Advanced expertise in
Aseptic processing, high-speed sterile filling (vials, syringes, cartridges), and barrier technology (Isolators/RABS)
Lyophilization processes and automated loading/unloading systems (ALUS)
Decontamination systems (VHP / Hydrogen Peroxide Vapor)
Sterilization processes (SIP, Autoclaves, Depyrogenation Tunnels)
Critical Utilities (WFI, Clean Steam, Clean Compressed Air, Process Gases, Cleanrooms, and HVAC)
Commissioning, Qualification, and Validation (CQV / ISPE Baseline Guide approach)
Regulatory & Quality Knowledge: Deep understanding of global pharmaceutical regulations (FDA cGMP, EMA, EU Annex 1, PIC/S) Skills & Capabilities
Analytical & Problem Solving: Demonstrated root-cause analysis skills (e.g., FMEA, 6-Sigma) to address complex process and equipment deviations
Communication & Stakeholder Management: Excellent verbal and written communication skills with experience presenting technical concepts to executive leadership, site teams, and external clients
Computer & Software Skills: Proficient in project management software, CAD systems, CMMS, Trackwise/QMS systems, MS Office Suite (Word, Excel, PowerPoint), and process automation systems (PLC/SCADA/DCS) Other Qualifications & Requirements
Must pass a background check and drug screen
Ability to work in cleanroom environments (Gowning required) Physical Demands & Work Environment
Physical Demands: Regularly required to talk, hear, sit, stand, walk, reach, and lift up to 25–50 lbs
Work Environment: Mix of office environment, active construction sites, and cGMP cleanrooms. Moderate noise level with exposure to moving mechanical parts and industrial chemical/utility systems This job description in no way states or implies that these are the only duties to be performed by the employee(s) incumbent in this position. Employees will be required to follow any other job-related instructions and to perform any other job-related duties requested by any person authorized to give instructions or assignments. All duties and responsibilities are essential functions and requirements and are subject to possible modification to reasonably accommodate individuals with disabilities. To perform this job successfully, the incumbents will possess the skills, aptitudes, and abilities to perform each duty proficiently. Some requirements may exclude individuals who pose a direct threat or significant risk to the health or safety of themselves or others. The requirements listed in this document are the minimum levels of knowledge, skills, or abilities. This document does not create an employment contract, implied or otherwise, other than an “at will” relationship.

Salary range:$120,200-$144,100/year Education, experience, location and tenure may be considered along with internal equity when job offers are extended. We do not accept unsolicited assistance from any headhunters or recruitment firms for any of our job openings. All resumes or profiles submitted by search firms to any employee at Curia, in any form without a valid, signed search agreement by an authorized signatory in place for the specific position, approved by Talent Acquisition, will be deemed the sole property of Curia. No fee will be paid in the event the candidate is hired by Curia because of the unsolicited referral.

All interested applicants must apply online. Please be aware of scammers. Curia will only send offer letters and requests for sensitive personal information from a curiaglobal.com email address. Curia is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Curia is an E-Verify employer.

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More about this job

Skills

Procurement
Regulatory compliance
Program management
Microsoft Office
Estimating
Process improvement
Troubleshoot
Biomedical engineering
Pharmaceutical technology
SIP
HVAC
Pharmaceutical legislation
Problem solving
Root cause analysis
Communication skills
Stakeholder management
Project management
CMMS
Microsoft Word
Microsoft Excel
Microsoft PowerPoint
PLC
SCADA
DCS
Heavy lifting

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