Postdoctoral Scholar

Case Western Reserve University Postdoctoral Scholar

Department of Biochemistry

Case Western Reserve University, Department of Biochemistry is seeking a qualified candidate to fill a postdoctoral scholar position. This is a one-year appointment with the possibility of renewing for an additional year. Postdoctoral scholar to work full-time on understanding the functions of protein post-translational modifications in human cancers. The research will particularly focus on the regulatory mechanisms and physiological functions of arginine methyltransferases and in genomic instability and cancer progression. The goal of these studies is to explore druggable targets for cancer therapy. Studies will use a range of complementary methods including biochemistry, molecular and cellular biology, functional cell-based assays and mouse genetic models. The candidate should be highly motivated with a solid background and skills in molecular and cell biology, cell signaling, and cancer biology.

Responsibilities and Duties:

1. Using cell culture models to dissect the regulatory mechanisms of arginine methyltransferases and their downstream targets. These duties include cell culture, transfection, protein exaction, immunoprecipitation, western blot, cell proliferation, and colony formation.
2. Design and executes experiments using mouse genetic models and cells prepared form these models to study the role of arginine methyltransferases in cancer progression and metastasis. These duties include genotyping of mice, mice maintenance, mice breeding, treatment studies, monitoring for cancer development.
3. Perform molecular biology experiments including DNA/RNA purification, plasmid construction, PCR, RT-qPCR.
4. Collaborates with the PI to prepare manuscripts and grants. Duties include keeping current with the literature, preparing figures based on data collected, writing manuscripts and sections of grants with the PI and senior team members, presenting current work in research in progress seminars, attending departmental seminars and participating in journal clubs.
5. Collaborates with other lab members to maintain the laboratory, including making buffers, equipment maintenance, cleanup of lab areas, monitoring usage and deliver of lab supplies.

In compliance with the City of Cleveland’s Pay Transparency Ordinance (effective October 27, 2025), the annual starting base salary range for this position is $62,00 - $65,000. CWRU considers factors such as (but not limited to) the specific grant funding and the terms of the research grant when extending an offer. Postdocs receive individual and family healthcare benefits, life insurance, and employee assistance.

Case Western Reserve University is an equal opportunity employer. All applicants are protected under federal and state laws and university policy from discrimination based on race, color, religion, sex, sexual orientation, gender identity or expression, national or ethnic origin, protected veteran status, disability, age and genetic information.

Case Western Reserve University complies with the Americans with Disabilities Act regarding reasonable accommodations for applicants with disabilities Applications requiring a reasonable accommodation for any part of the application and hiring process should contact the CWRU Office of Equity at 216.368.3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Qualifications

Doctorate in Biochemistry, Molecular Biology, or a related field.

0-5 years of experience with molecular and cell biology, cell signaling, and cancer biology.

Excellent written and oral communication skills necessary.

Must be eligible to work in the United States. Application instructions Submit application through Interfolio. Please include your curriculum vitae (CV). If you have any questions about the position, please contact: Dr. Wenjian Gan, wxg208@case.edu