Find work in the United States.

A simpler way to find your next job.

Jobs in the United States

25+ jobs

Save this search

Added 7 hours ago
Physician Assistant
Federal Aviation Administration
Oklahoma City, OK
Added 7 hours ago
FF
Senior Project Manager
FOUNDATION FINANCE COMPANY, LLC
ROTHSCHILD, WI
- $105,000 USD / year
Added 14 hours ago
Regional Biology Lead
BKF
Remote, United States
…with business development. The position is compatible with remote work, but a physical presence in the Bay Area is required. This position is ideal for an experienced candidate who wants to…
Added 14 hours ago
Regional Biology Lead
BKF
Remote, United States
…with business development. The position is compatible with remote work, but a physical presence in the Bay Area is required. This position is ideal for an experienced candidate who wants to…
Added 14 hours ago
Regional Biology Lead
BKF
Remote, United States
…with business development. The position is compatible with remote work, but a physical presence in the Bay Area is required. This position is ideal for an experienced candidate who wants to…
Added 14 hours ago
Regional Biology Lead
BKF
Remote, United States
…with business development. The position is compatible with remote work, but a physical presence in the Bay Area is required. This position is ideal for an experienced candidate who wants to…
Added 14 hours ago
Regional Biology Lead
BKF
Remote, United States
…with business development. The position is compatible with remote work, but a physical presence in the Bay Area is required. This position is ideal for an experienced candidate who wants to…
Added 15 hours ago
Senior Manager, QC Analytical-1
Bristol Myers Squibb
Devens, MA
Bristol Myers Squibb is seeking a Senior Manager for QC Analytical at the Cell Therapy Facility (CTF) in Devens, MA. This role supports the QC analytical operations team, develops and…
Added 23 hours ago
Senior Store Manager, Optimization Remote Central & West
David's Bridal
King of Prussia, PA
The Field Support Manager travels to David’s Bridal stores when a Store Manager position is open or the management team is incomplete. The role provides leadership coverage, restores store…
Added 1 day ago
Systems Operations Engineer
Arlington County VA
Arlington, VA
…Meter Section, and may serve as the acting Operating Engineer/Manager in their…
Added 1 day ago
Business Development Manager
SFC Payroll Inc
Remote, United States
…pick-up truck rentals for or clients, with a commitment to on-time delivery, anywhere in North…
Added 1 day ago
Business Development Manager
SFC Payroll Inc
Remote, United States
…pick-up truck rentals for or clients, with a commitment to on-time delivery, anywhere in North…
Added 1 day ago
BS
Subcontracts Manager
Brookhaven Science Associates, LLC
Upton, NY
- $128,900 to $213,950 USD / year
May perform duties of Acting Procurement Operations Manager in his/her absence as directed.
Added 1 day ago
SN
Payroll Associate
Southern New Hampshire University
Remote, United States
- $23.93 to $38.27 USD / hour
…processing. You will work with Payroll, Human Resources, Benefits, Time and Absence, and other university departments to maintain payroll integrity and follow established payroll controls,…
Added 1 day ago
C6
Senior Manager, Software Quality Assurance
Company 601 LivaNova USA Inc
United States
- $150,000 to $175,000 USD / year
…investigations, CAPAs, and provide audit support.. This is a full-time, remote position and may include up to 25%…
Added 1 day ago
Senior Manager, QC Analytical-1
Devens
Devens, MA
Bristol Myers Squibb is seeking a Senior Manager for QC Analytical at the Cell Therapy Facility (CTF) in Devens, MA. This role supports the QC analytical operations team, develops and…
Added 1 day ago
SITEC - COMSEC Custodian - Okinawa, Japan
Peraton
FPO
Planning and execution of Out-Of-Band-Key Transfer (OOBKT) for remote rekey of enterprise encryptors on multiple networks using GEM-X HAIPE Manager. Requires experience in Suite-A and…
Added 1 day ago
TS
Plant Manager
The Scotts Miracle-Gro Company
Carrollton, KY
- $123,500 to $145,300 USD / year
We are looking for a Plant Manager to join our ScottsMiracle-Gro team in Carrollton, KY!
Added 1 day ago
Senior Manager, Workday Payroll & HR Systems
SanDisk
Milpitas, CA
We are seeking an experienced Senior Manager, Workday Payroll & HR Systems to lead the support, enhancement, and strategic roadmap for Workday Payroll, Benefits, Time Tracking, and Absence.…
Added 1 day ago
Customer Service Representative 4
Arizona Department of Administration
AZ
…providing training, guidance and information regarding the program to internal and external customers; and explains repercussions from convictions for violations per ARS Title 4, 13, 28 and…
Added 1 day ago
AU
Payroll, Benefits and Leaves Manager
Augsburg University
Minneapolis, MN
- $11.41 USD / hour
The Payroll, Benefits, and Leaves Manager manages end-to-end payroll processing, employee benefits administration, and leave-of-absence programs while ensuring compliance with federal and…
Added 1 day ago
Alternate Program Manager, AFCAP VI
KVG
Remote, United States
Act as Program Manager in the PM’s absence, with authority to commit KVG’s funds and resources to the Contracting Officer.
Added 1 day ago
Oracle Cloud HCM Functional Lead
ManpowerGroup
Cockeysville, MD
…models, and lifecycle actions) and extend coverage into Payroll, Time & Labor, Benefits, Absence Management, and/or Compensation as your depth…
Added 2 days ago
Spec, Clinical Integration
HILL-ROM COMPANY, INC. USA
Remote, United States
…Flexible Spending Accounts, educational assistance programs, and time-off benefits such as paid holidays, paid time off ranging from 20 to 35 days based on length of service, family and…
Added 2 days ago
Executive Director, Global Medical Oncology, Iza-Bren Medical Product Lead (MPL)
Bristol Myers Squibb
Summit, NJ
…co-developed with SystImmune, with a broad multi-tumor development program spanning breast, lung, gastrointestinal and genitourinary cancers. The MPL will lead a mission-focused team…

Bristol Myers Squibb

Principal Scientist - Computational Sciences

San Diego, CA, United States

Apply About employer

Applications open in a new tab.

Job details

Posting language: English
Posted: Oct 6, 2026

Original job description

At Bristol Myers Squibb, our employees often ask, “Who are you working for?” - a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

Computational Sciences is seeking an exceptional Principal Scientist to join our Small Molecule Computational Design team. Using computational chemistry, cheminformatics, and machine learning, you will work as a member of our multidisciplinary Protein Homeostasis project teams to proactively generate and test scientific hypotheses and directly translate those into actionable molecular designs that meaningfully advance our discovery programs. We are looking for a scientist who is equally excited about building a structural model as they are to build the machine learning model, dataset, or analysis that influences how an entire program reasons about its chemistry. If you thought you had to choose between structure-based design and cheminformatics and would rather not, this position was written for you.

What You'll Do

Serve independently as the computational scientist on Protein Homeostasis project teams, bringing both structure-based and data-driven approaches to bear on the same problem, and holding accountability for delivery of the computational objectives of those programs.
Design, prioritize, and triage degrader and molecular glue chemical matter, applying multi-parameter optimization to advance potency, selectivity, ternary complex formation and cooperativity, degradation efficiency, and ADME properties, while proactively identifying and mitigating potential toxicological risks.
Develop, validate, and deploy predictive models and cheminformatics workflows and drive their adoption by project teams as routine decision-making tools rather than one-off analyses.
Integrate structural information from co-crystal structures, cryo-EM, and predicted or modeled structures with large-scale data analysis and visualization to deepen structure-activity relationship insight and shape project strategy.
Curate and steward the chemical and biological data resources, reusable tooling, and analysis infrastructure that the group depends on, ensuring analyses are reproducible, discoverable, and useful to scientists beyond their original author.
Provide scientific leadership within Computational Sciences and our close partners on emerging technologies, platforms, targets, etc., taking calculated risk to test and advance innovative approaches within the group and among stakeholders
Act as an active mentor to colleagues, serve as a recognized internal subject area resource, and grow internal and external scientific visibility through publications, presentations, and patent applications.

What We're Looking For

We're seeking an experienced, innovative scientist that passionate about the role of computation in drug design. The ideal candidate will bring:

Ph.D. with 4+ years of academic or industry experience, Master’s degree with 6+ years of experience, Bachelor’s degree with 8+ years of experience in computational chemistry, cheminformatics, computational biophysics, chemistry, or a related discipline.
Strong history of directly impacting small molecule discovery programs in biotech or pharmaceutical industry, with a solid working knowledge of medicinal chemistry principles.
Demonstrated hands-on depth across both computer-aided drug design and cheminformatics/machine learning . This dual capability is the defining requirement of the role.
Experience with targeted protein degradation, molecular glues, or other induced-proximity modalities - including ternary complex modeling, cooperativity assessment, or E3 ligase chemical space - is preferred.
Demonstrated experience applying computational methods to a variety of biological targets (e.g., proteins, DNA, RNA) and familiarity with diverse therapeutic modalities such as covalent and non-covalent inhibitors, allosteric modulators, targeted protein degraders, antibodies, and antibody-drug conjugates.
Superior communication skills and a collaboriative mindset that thrives in multidisciplinary and geographically dispared project teams.
Track record of publications in peer-reviewed scientific journals.

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview:

San Diego - CA - US: $156,890 - $190,117

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working. (https://careers.bms.com/life-at-bms/ways-of-working/)

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

For roles based in Washington State only: If you live in or expect to work from Washington State if hired for this position, please visit this page (https://www.atg.wa.gov/fair-chance-act) for important information about the Washington Fair Chance Act.

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection .

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at TAEnablement@bms.com with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1607160 : Principal Scientist - Computational Sciences

Req Number: R1607160

Location: San Diego - California - US

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

Apply About employer

More about this job

Skills

Decision making
Data analysis
Leadership
Presentation skills
Pharmaceutical industry
Machine learning
Communication skills

Report this job