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Biogen

Principal Scientist, Oral Formulation Development

Cambridge, MA, United States

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Job details

Experience: PhD in Chemical Engineering, Chemistry, Pharmaceutical Sciences, or a related scientific discipline with a minimum of 10 years’ experience in oral drug product development.
Posting language: English
Posted: Nov 10, 2026

Original job description

About the Role

Biogen is seeking a Principal Scientist, Oral Formulation Development to provide scientific leadership for the development of small molecule oral drug products. This role leads formulation and process development across clinical programs, with a focus on enabling technologies for challenging compounds, clinical manufacturing readiness, and technology transfer. The role requires the ability to manage multiple interfaces with manufacturing, quality, regulatory CMC, other technical functions. This role will also be responsible for managing external partnerships and advancing new technologies and workflows that strengthen Biogen’s oral drug product development capabilities.

What You’ll Do

Lead formulation design, process development, manufacturability assessment, scale-up, technology transfer, and clinical manufacturing of small molecule oral dosage forms across all stages of development.
Develop enabling formulation approaches for challenging compounds, including poorly soluble, poorly permeable, unstable, or complex molecules.
Serve as the drug product representative on cross-functional CMC and asset teams, driving alignment across regulatory, quality, manufacturing, analytical, clinical pharmacology, DMPK, and external partner functions.
Influence portfolio decisions through assessment of developability, manufacturability, biopharmaceutical performance, technical risk, and investment priorities.
Champion technology transfer, clinical manufacturing readiness, and scale-up activities at internal and external manufacturing sites.
Identify and implement new formulation technologies, predictive tools, digital workflows, and best practices that improve development efficiency and portfolio execution.
Oversee completion of drug product sections for regulatory submissions and related technical documentation.

Required Skills

PhD in Chemical Engineering, Chemistry, Pharmaceutical Sciences, or a related scientific discipline with a minimum of 10 years’ experience in oral drug product development.
Demonstrated track record leading formulation and process development for oral solid dosage forms from early development through clinical manufacturing.
Strong understanding and hands on experience with oral solid dose manufacturing unit operations and manufacturability considerations.
Experience with scale-up, technology transfer, clinical manufacturing, and external manufacturing organizations.
Strong knowledge of CMC development, regulatory expectations, technical documentation, and phase-appropriate development strategies.

Preferred Skills

Deep expertise in enabling technologies such as amorphous solid dispersions, spray drying, hot-melt extrusion, lipid-based formulations, modified release, or particle engineering.
Experience implementing new technologies, digital tools, knowledge platforms, or best practices across multiple programs.
Demonstrated success managing external CDMO/CMO relationships and technology transfer activities.
Experience with late-stage development, commercial readiness, process characterization, and process validation.

Job Level: Management Additional Information

The base compensation range for this role is: $159,000.00-$219,000.00 Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being; including, but not limited to:

Medical, Dental, Vision, & Life insurances
Fitness & Wellness programs including a fitness reimbursement
Short- and Long-Term Disability insurance
A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
Up to 12 company paid holidays + 3 paid days off for Personal Significance
80 hours of sick time per calendar year
Paid Maternity and Parental Leave benefit
401(k) program participation with company matched contributions
Employee stock purchase plan
Tuition reimbursement of up to $10,000 per calendar year
Employee Resource Groups participation

Why Biogen? We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about Biogen.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

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Skills

Leadership
Pharmacology
Documentation
Chemical engineering
Biotechnology

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Work requirements

Jobs in the United States