Jobs in the United States

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Added 11 mins ago
Systems Engineer / Principal Systems Engineer (AHT)
Northrop Grumman
Manhattan Beach, CA
Northrop Grumman Defense Systems sector (NGDS) is seeking a Systems Engineer or Principal Systems Engineer to join our growing team of diverse professionals. The candidate will support…
Added 11 mins ago
Principal Systems Engineer (Top Secret Clearance)
Northrop Grumman
Manhattan Beach, CA
Northrop Grumman Defense Systems sector (NGDS) is seeking a Principal Systems Engineer to join our growing team of diverse professionals. The candidate will support Agile development of MS…
Added 12 mins ago
Sr. Applications Engineer - FIB/PFIB
ThermoFisher Scientific
Fremont, CA
Join our team at Thermo Fisher Scientific as a Senior Field Applications Engineer, where you'll provide technical expertise to semiconductor and life sciences companies. Working at the…
Added 12 mins ago
AE
Campus Undergraduate Full-Time Engineer - 2027 AI Engineer I, Enterprise Technology Services- Palo Alto, CA
American Express
Palo Alto, CA
- $78,000 to $124,750 USD / year
- Full-time
…integrations, AI agents, agentic workflows, and AI-enabled software features. You’ll collaborate with engineering, product, data, security, risk, and business partners to help deliver…
Added 12 mins ago
AE
Campus Graduate Masters Full-Time Engineer - 2027 AI Engineer I, Enterprise Technology Services- Palo Alto, CA
American Express
Palo Alto, CA
- $78,000 to $124,750 USD / year
- Full-time
…integrations, AI agents, agentic workflows, and AI-enabled software features. You’ll collaborate with engineering, product, data, security, risk, and business partners to help deliver…
Added 12 mins ago
C
Technical Marketing Engineer I (Full Time) - United States
Cisco
San Jose, CA · Milpitas, CA
- Full-time
…products. You will work closely with experienced mentors in Product Management, UX, and Sales, gaining exposure to the full product lifecycle while helping to solve real-world customer…
Added 12 mins ago
Staff Software Engineer, Data & Scalability Platform
Cisco
San Francisco, CA · San Jose, CA
As a Staff Software Engineer on the Data & Scalability Platform team, you will provide technical leadership for the architecture, scalability, and cost of the entire data plane: the stores…
Added 12 mins ago
SI
Software Engineer, Specs Lenses C++, Level 5
Snap Inc.
Los Angeles, CA · San Francisco, CA · Palo Alto, CA
- $178,000 to $313,000 USD / year
We’re looking for a Software Engineer to join Lens Studio at Snap Inc!
Added 53 mins ago
Sr. Software Development Engineer, AWS Quick
Amazon
Bellevue, WA
…accomplish and figures out how to get it done. We are looking for a Software Development Engineer III to design and deliver the third-party integrations that connect Quick to the business…
Added 53 mins ago
Software Development Manager, Management Plane
Amazon
Seattle, WA
You'll join a diverse team of software, hardware, and network engineers, supply chain specialists, security experts, operations managers, and other vital roles. You'll collaborate with…
Added 2 hours ago
MS
Business Development Engineer (BDE), USSOCOM
Motorola Solutions, Inc.
Denver, CO
- $40,123 USD / year
…requirements, and operational needs, helping translate them into product roadmap inputs, and tracking engineering progress against operational…
Added 2 hours ago
MI
Systems Engineer
Maxar Intelligence I
Westminster, CO
- $105,000 to $140,000 USD / year
Experience serving as a technical Product Owner or systems engineer responsible for software capability definition and development priorities.
Added 2 hours ago
Director I, Chief Information Security Officer Monroe Community College
Monroe Community College
ROCHESTER, NY
Monroe Community College Position Title: Director I, Chief Information Security Officer - Monroe Community College Location: Rochester, NY Category: Professional Staff Job Type: Full Time…
Added 2 hours ago
Lead Systems Engineer
Safran Federal Systems
ROCHESTER, NY
The Opportunity: This Lead Systems Engineer will have a unique opportunity to develop a product line from a blank page. This engineer will join a motivated team and rapidly iterate and test…
Added 2 hours ago
Staff Software Engineer, Data & Scalability Platform
Cisco
New York, NY
As a Staff Software Engineer on the Data & Scalability Platform team, you will provide technical leadership for the architecture, scalability, and cost of the entire data plane: the stores…
Added 2 hours ago
AE
Campus Graduate Masters Summer Internship Program - 2027 AI Engineer, Enterprise Technology Services- New York, NY
American Express
New York, NY
- $24.05 to $63 USD / hour
…model evaluation, AI agents, agentic workflows, or AI-enabled software features. You’ll work with engineers, product partners, data practitioners, security partners, and business…
Added 2 hours ago
AE
Campus Graduate Masters Summer Internship Program - 2027 Software Engineer, Enterprise Technology Services- New York, NY
American Express
New York, NY
- $24.05 to $63 USD / hour
…high-quality experience for customers and colleagues. We also provide product management for core enterprise platforms, and lead technology risk and information security, enterprise data…
Added 2 hours ago
AE
Campus Graduate Masters Full-Time Engineer - 2027 AI Engineer I, Enterprise Technology Services- New York, NY
American Express
New York, NY
- $78,000 to $124,750 USD / year
- Full-time
…integrations, AI agents, agentic workflows, and AI-enabled software features. You’ll collaborate with engineering, product, data, security, risk, and business partners to help deliver…
Added 2 hours ago
AE
Campus Graduate Masters Full-Time Engineer - 2027 Software Engineer II, Enterprise Technology Services- New York, NY
American Express
New York, NY
- $89,250 to $150,250 USD / year
- Full-time
At American Express, we empower technologists to learn, innovate, and make an impact from day one. As a Software Engineer in the full-time Technology Graduate Program, you’ll join a…
Added 2 hours ago
AE
Campus Undergraduate Full-Time Engineer - 2027 Software Engineer I, Enterprise Technology Services- New York, NY
American Express
New York, NY
- $78,000 to $124,750 USD / year
- Full-time
At American Express, we empower technologists to learn, innovate, and make an impact from day one. As a Software Engineer in the full-time Technology Graduate Program, you’ll join a…
Added 2 hours ago
AE
Campus Undergraduate Full-Time Engineer - 2027 AI Engineer I, Enterprise Technology Services- New York, NY
American Express
New York, NY
- $78,000 to $124,750 USD / year
- Full-time
…integrations, AI agents, agentic workflows, and AI-enabled software features. You’ll collaborate with engineering, product, data, security, risk, and business partners to help deliver…
Added 2 hours ago
AE
Sr Software Engineer II
American Express
New York, NY
- $123,000 to $215,250 USD / year
…(GCP), data engineering, APIs, distributed systems, and data security. The engineer will design and develop secure, scalable, resilient, and observable solutions that connect Salesforce…
Added 3 hours ago
MS
Business Development Engineer (BDE), US Marine Corps
Motorola Solutions, Inc.
Denver, CO
- $40,123 USD / year
Business Development Engineer, US Marine Corps
Added 3 hours ago
MS
Business Development Engineer (BDE), US Air Force
Motorola Solutions, Inc.
Denver, CO
- $40,123 USD / year
…feedback and operational requirements, helping translate them into product roadmap inputs, and tracking engineering progress against operational…
Added 3 hours ago
CI
ESS Design Engineer – Secret Clearance | Remote
Cambridge International Systems Inc
Charleston, SC
- $90,000 to $110,000 USD / year
As an ESS Design Engineer, you will play a critical role in design, installation, testing, and implementation of Electronic Security Systems (ESS), ensuring solutions meet customer…

Axiom

Software Engineer, Platform Infrastructure

South San Francisco, CA, United States

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Job details

Posting language: English
Posted: Nov 1, 2026

Original job description

Description:

Build the secure, reliable platform that powers Axiom’s scientific AI agents, experimental data pipelines, and products used by the largest pharmaceutical companies and AI labs in the world.

About Axiom:

Axiom’s mission is to eliminate unexpected drug toxicity and unlock an abundance of ultra safe medicines. We are starting with the liver, where toxicity remains a leading cause of drug failure. Our high-throughput human liver safety platform combines advanced human cell systems with imaging, transcriptomics, mass spectrometry, and drug metabolism measurements. Our AI agents integrate these data with chemical structure, human exposure, and thousands of clinical reference compounds to predict whether a drug will be toxic in humans, why, and how to make it safer.

We work with seven of the world’s top twenty pharmaceutical companies to design safety into molecules from the earliest stages. This applied work feeds directly into our partnerships with leading frontier AI labs, turning real discovery challenges and experimental feedback loops into scientific skill trees and reinforcement learning environments that train increasingly superhuman scientists. We then deploy these frontier models to make cancer therapies safer, unlock treatments for chronic diseases that demand exceptional safety, revive promising drugs abandoned because of toxicity, and much more.

Our ultimate ambition is to build a superhuman AI agent that predicts how a drug will behave across all major human organ systems before the first patient receives it. With insanely accurate safety predictions, we aim to enable rapid, high-throughput testing of novel drugs in humans with zero risk of toxicity. This is the key to unlocking an abundance of ultra safe, effective medicines.

What you will do:

Build and operate the shared infrastructure behind Axiom’s scientific data pipelines, AI agents, research workflows, and Translate product.
Own cloud infrastructure, compute, storage, databases, and networking, making systems reliable, secure, scalable, and cost-efficient.
Develop workflow orchestration that lets scientists, engineers, and agents run complex computational pipelines with clear dependencies, durable state, and recovery from failures.
Build secure execution environments for agents, with controlled access to scientific tools, models, and data, strict customer isolation, and resource and budget limits.
Make scientific results reproducible through data versioning, lineage, snapshots, and automated checks that catch stale inputs, inconsistent features, and incomplete outputs.
Build fast development environments, CI, and deployment systems that let people and agents ship changes confidently across development, staging, and production.
Own authentication, permissions, secrets, and workload identity across internal systems, customer workspaces, laboratory partners, and model providers.
Make systems observable through logs, metrics, traces, execution histories, and alerts that help people and agents investigate failures and verify results.
Manage database migrations, backups, and recovery, and resolve production issues across Axiom’s platform and infrastructure providers.
Work directly with scientists, ML researchers, and product engineers to remove operational bottlenecks and turn recurring manual work into reliable, self-service tools.

What we look for:

Exceptional software engineering ability and experience building reliable production systems, with depth in infrastructure, distributed systems, platform engineering, or developer tools.
Strong systems judgment. You simplify complex problems, choose clear abstractions, and build systems that remain understandable as they grow.
End-to-end ownership. You identify what matters, make progress without a detailed specification, and follow through from design to deployment and operation.
An instinct for reliability and correctness. You anticipate failure modes, make failures visible, and prevent silent errors from reaching scientific results or customers.
Strong security judgment. You understand permissions, credentials, isolation, and trust boundaries, and make secure workflows easy to use.
A talent for debugging across application code, databases, networks, cloud services, and execution environments.
Experience building with AI agents and a drive to make them effective users of infrastructure, tools, and data, with appropriate controls and verification.
Care for developer and scientist productivity. You notice recurring friction and replace manual work with dependable tools and automation.
Clear communication, intellectual curiosity, and the willingness to learn biology, chemistry, and ML to build better systems for scientific discovery.

Technical skills we value:

Python, SQL, asynchronous programming, APIs, and production backend systems.
AWS, Modal, Docker, Terraform, cloud networking, and infrastructure as code.
DuckDB/MotherDuck, Postgres, S3, Parquet, database migrations, backups, and recovery.
Workflow orchestration, dependency management, distributed execution, checkpointing, retries, and durable state.
Data versioning, lineage, reproducible pipelines, and automated consistency checks.
IAM, SSO, OAuth/OIDC, workload identity, secrets management, and customer isolation.
Agent execution environments, sandboxing, tool access, model APIs, and resource and budget controls.
CI/CD, GitHub Actions, isolated development environments, automated testing, and deployment strategies.
Observability, including structured logs, metrics, tracing, alerting, Datadog, and production debugging.
TypeScript, SvelteKit, Vercel, and internal developer tools are a plus.

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