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AstraZeneca

Senior Director- Global Development Scientist

Boston, MA, United States
Boston, United States

The annual base pay (or hourly rate of compensation) for this position ranges from 233K - 262K USD Annual.

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Job details

Pay: The annual base pay (or hourly rate of compensation) for this position ranges from 233K - 262K USD Annual.
Apply by: May 1, 2027
Experience: Minimum of 7 years of relevant experience
Posting language: English
Posted: Nov 2, 2026

Original job description

Hematology Research and Development, Early and Late Development Hematology Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs

ROLE AND RESPONSIBILITIES

The Global Development Scientist Director is an important part of the Clinical Project Team (CPT), and Global Study Team (GST) working harmoniously and cross functionally (in a matrix environment) with other CPT & GST members, Site Management & Monitoring (SMM), field-based liaisons, and site personnel. The Senior Global Development Scientist Director and counterpart Global Development Medical Director work collaboratively in the clinical aspects underpinning a product.

This includes shared responsibility with Clinical Operations team members in the planning and execution, including recruitment and delivery of a clinical study. Accountabilities include clinical support for the development and implementation of early and/or late phase AstraZeneca sponsored clinical program strategies. As such, you will provide scientific input into design & implementation of clinical trial(s), their delivery, clinical data review and data cleaning, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e. clinical input to NDA/BLA).

The Global Development Scientist Director may also provide expert input or lead functional process improvement initiatives and provide contributions to cross-asset or cross-indication area working groups depending on the level of experience.

This position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of stakeholders both within and external to AstraZeneca. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws and adhere to Good Clinical Practice (GCP) and regulatory requirements. Depending upon experience level, the role will mentor the development of less experienced members of the clinical team.

Main duties:

Work cross functionally within CPT to ensure the clinical strategy is translated into the development of the study concept document, study protocol and related documents;
Establish key relationships internally with clinical project teams, and externally with regulatory bodies and external service providers.
Provide scientific input into design & implementation of clinical trial(s), their delivery, clinical data review and data cleaning, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e. clinical input to NDA/BLA).
Accountable for the relevance and accuracy of clinical science underpinning of clinical study based on detailed scientific review and consultation, for the clinical and scientific leadership and integrity of protocols and/or components of clinical plans and for the delivery of final protocol and its governance approval.
Lead the development of the protocol and related documents and the development and delivery of the clinical study report to meet GCP, ICH and all AstraZeneca quality standards.
Lead cross functional projects to ensure the successful passage of drugs through all phases of the drug development process, or contribute to one or more elements of such a project as a technical expert.
Review and interpret medical data and clinical trial data and come up with conclusions
Responsible for timely responses to investigational study sites for local ICF changes, protocol & EC/IRB questions/requests.
Support the development of clinical components of regulatory and EC/IRB submission documents for instances where marketing approval is warranted. Prepare and provide input to clinical study reports (CSRs) and clinical portions of Regulatory Documents (e.g., IB, DSUR, PSUR, regulatory responses)
Contribute to development and delivery of face to face or virtual investigator and supervise training Depending upon experience level, the role will mentor the development of less experienced members of the clinical team
Participate or lead as needed the review and assessment of new opportunities and ESRs.
Mentor less experienced Global Development Scientist Directors

QUALIFICATIONS AND EDUCATION REQUIREMENTS

BS required, PhD in a scientific field, PharmD or MD is strongly preferred
Minimum of 7 years of relevant experience
Significant Industry or Academic experience in drug development required with significant experience in malignant Haematology clinical trials strongly preferred.
Sufficient technical knowledge (haemato-oncology background preferred) to be able to interact with confidence with internal and external partner
Possesses sound foundational knowledge of FDA and other major country regulations and detailed knowledge of Good Clinical Practice other regulations governing clinical research.
Possesses general knowledge of 1) medical monitoring 2) Regulatory approval process in relevant countries; 3) pharmaceutical industry/R&D operations; 4) marketing and commercial fundamentals.
Drug Development/Clinical Development Planning: Demonstrates a consistent track record to both independently complete, and lead peers in completion in components of sophisticated plans, related documents, appropriate methodologies, measures, analytical plans and evaluation tools.
Ability to drive/contribute to protocol design, writing and implementation

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay (or hourly rate of compensation) for this position ranges from 233K - 262K USD Annual. Our positions offer eligibility for various incentives - an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted 02-Nov-2026 Closing Date 19-Nov-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

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Skills

Cleaning
Reporting
Regulatory compliance
Google Cloud
CPT
Clinical science
Leadership
Clinical trials
Clinical research
Pharmaceutical industry
Sales

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