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Added 1 min ago
Mechanical Designer/Drafter 4/5
Los Alamos National Laboratory
Los Alamos, NM
Los Alamos National Laboratory (LANL) Mechanical and Thermal Engineering (E-1) Group is seeking motivated, experienced Designers/Drafters to collaborate with engineers, scientists,…
Added 1 min ago
LIP D&D Shift Management (Manager of Projects 3/4)
Los Alamos National Laboratory
Los Alamos, NM
The Associate Laboratory Directorate for Plutonium Infrastructure (ALDPI) at Los Alamos National Laboratory (LANL) supports the infrastructure required to meet plutonium pit production…
Added 1 min ago
Machinist 2
Los Alamos National Laboratory
Los Alamos, NM
Prototype Fabrication (PF) Division is seeking qualified machinists to provide machining support for the machining of components vital to the Lab's mission.
Added 1 min ago
Emergency Management / Response Operator 2 (24/7 EOSC Operator)
Los Alamos National Laboratory
Los Alamos, NM
The position requires an Associate Degree in Systems Engineering, Computer Studies, Public Safety, Communications, or a related field and a minimum of two years of experience; or an…
Added 1 min ago
Operations Specialist 2
Los Alamos National Laboratory
Los Alamos, NM
…Material Requirements (HMR), function in a coordinator role in support of P&T operations such as safety, security, environmental compliance, conduct of operations, regulatory compliance…
Added 1 min ago
Designated Procurement Representative (Vendor Liaison Specialist 1/2)
Los Alamos National Laboratory
Los Alamos, NM
The Procurement Engineering & Acquisition Management Group within the Supply Chain & Logistics (SCL) Division is seeking a highly organized, self-motivated, and customer-focused Vendor…
Added 1 min ago
Nuclear Facilities Engineer 1/2
Los Alamos National Laboratory
Los Alamos, NM
Within this job, successful candidates will have the opportunity to support LANL's mission by serving as the subject matter expert (SME) for nuclear facility electrical, mechanical, and…
Added 1 min ago
R&D Engineer 2/3
Los Alamos National Laboratory
Los Alamos, NM
The Detonator Production Product Engineering group (DP-1) supports inert component fabrication and high explosive operations in the Detonator Production (DP) Division, part of the Associate…
Added 1 min ago
Construction Superientendent 2/3- Term Position
Los Alamos National Laboratory
Los Alamos, NM
…Will ensure that facility modification continuously adhere to engineering designs, engineering document control, specifications, quality standards, schedules, material procurement and…
Added 1 min ago
Designated Procurement Representative (Vendor Liaison Specialist 1/2)
Los Alamos National Laboratory
Los Alamos, NM
Education/Experience for the Vendor Liaison Specialist 1: Position requires an Associate's Degree from an accredited institution; or, equivalent experience directly related to the…
Added 1 min ago
Computerized Maintenance Management System Lead/Planner (Operations Support Specialist 2/3)
Los Alamos National Laboratory
Los Alamos, NM
This position will be filled at either the Operation Support Specialist 2 or Operations Support Specialist 3 level, depending on the skills of the selected candidate. Additional job…
Added 1 min ago
Manager, R&D Advanced and Exploratory Hypersonic Glide Body (5413), Onsite
Sandia National Laboratories
Albuquerque, NM
…designs Hypersonic Test Vehicles, Targets, Countermeasures, and Associate Objects, and we manage operations at the Kauai Test Facility. Additionally, we provide explosives safety, security,…
Added 1 min ago
Cleared Manager - Integrated Technical Systems (5411), Onsite
Sandia National Laboratories
Albuquerque, NM
Sandia National Laboratories is the nation’s premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a…
Added 1 min ago
Senior/Principal R&D Laboratory Support Technologist - Applied Optical and Plasma Sciences, Onsite
Sandia National Laboratories
Albuquerque, NM
Associate's degree in Engineering, Physics, or relevant STEM field or high school diploma plus four (4) years of relevant work experience
Added 1 min ago
Network and Systems Engineer III – IT Solutions Implementor
Amentum
Santa Fe, NM
Amentum is a global leader in advanced engineering and innovative technology solutions, trusted by the United States and its allies to address their most significant and complex challenges…
Added 1 min ago
Senior Informaticist
CenterWell
Santa Fe, NM
Partner with HCPR leadership and teams to support regulatory and compliance reporting requirements and evolving pharmacy needs.
Added 2 mins ago
A
Advanced Mechanical Design Engineer
Aerospace
San Diego, CA
- $117,000 to $146,000 USD / year
Understand and support basic engineering calculations for line impedance, temperature rise and voltage drop in RF and DC circuits.
Added 2 mins ago
Assembly & Test Tech - Level 3 Swing Shift (2:30-11:00 PM)
Aerospace
Tempe, AZ
Collaborate with engineering and quality teams to support continuous improvement initiatives and process enhancements.
Added 3 mins ago
Associate Director, Site Supply Chain - Materials Management
AstraZeneca
Tarzana, CA · Los Angeles, CA · Los Angeles
The Associate Director, Materials Management role is responsible for leading patient materials management at the manufacturing site in Santa Monica and Tarzana facilities across autologous…
Added 4 mins ago
Senior Engineer Data Enablement & Management, Databricks
Stateside
Adelphi, MD
Lead the design, implementation, optimization, and operational maturity of enterprise data engineering capabilities across the Data & AI platform. Establish engineering standards, reusable…
Added 4 mins ago
Simulation Operator/Moulage Technician
CICONIX, LLC
Fort Sam Houston, TX
Associate degree in Biomedical Engineering, Health Sciences, Information Technology, or related field.
Added 6 mins ago
Network Support
GPM Investments, LLC
Richmond, VA
Preferred one year in the field of technology and/or associate degree in Computer Engineering, or other IT certification such as MCP Certificate, A+ Certificate
Added 6 mins ago
LG
Quality Assurance Associate - Temporary
LGC Group
Alexandria, MN
- $20 to $30 USD / hour
At our site in Alexandria, Minnesota, we design, manufacture, test and provide service support of LGC, Biosearch Technologies laboratory instrumentation and consumables. Products produced…
Added 6 mins ago
DevSecOps Engineer (Azure/AI)
Zaden Technologies, Inc.
Huntsville, AL
Zaden Technologies seeks a DevSecOps Engineer (Azure/AI) to support secure cloud architecture and AI-enabled services within our defense programs. This engineer will serve as the team's…
Added 6 mins ago
Manager, Risk and Compliance
RSM US LLP
United States
Stakeholder Coordination and Day to Day Advisory - Partner with product, engineering, and delivery teams to gather inputs, clarify requirements, and support compliance activities. Serve as…

AstraZeneca

Associate Director Principal Engineer

Mt. Vernon, IN, United States
Mt Vernon, IN, United States
Mt Vernon, United States

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Job details

Apply by: May 3, 2027
Education: Bachelor’s degree
Experience: ▪ Minimum of 10 years’ experience in pharmaceutical production, process engineering, project engineering, or project management.
Posting language: English
Posted: Nov 4, 2026

Original job description

The Associate Director Principal Engineer is responsible providing technical support for process manufacturing, including investigation and correction of process-related problems and deviations from standards. Serves as a Subject Matter Expert for multiple processing operations and provides technical leadership within the Process Engineering team. May lead and manage Technology Transfers to and from the site.

Responsibilities

Provides technical support for formulation areas, including investigation and correction of process related problems and deviations from standards.
Responsible for identifying and executing projects to reduce product cost, improve product quality, improve yield, and reduce material usage.
Collaborates with Production, Engineering, Automation, and Quality to optimize productivity, yield, product quality, and supply reliability.
Assists in designs and execution of process qualifications and validations for approved changes.
Initiates process manufacturing area change proposals as required for projects managed by the Formulation or Process Engineering group.
Authors, updates, reviews, and approves area procedures to ensure correct content and compliance with Good Manufacturing Practices.
Authors, reviews, and approves formulation master batch records.
Serves as a subject matter expert for technical projects affecting formulation during internal audits and regulatory inspections.
Leads technology transfer and implementation of new technologies, equipment, and processes from R&D and other sites, to the Mount Vernon site.
Enhances quality and effectiveness of manufacturing systems related to existing products as the Product Owner. This includes the design, execution, and evaluation of experimental plans to ascertain the required process capabilities, specifications, and robustness.
Executes site PAT strategy to monitor and control existing manufacturing processes.
Responsible for providing pharmaceutical process support to new and existing oral solid dose form (tablet and capsule) products/processes.
Trains and mentors new Process Engineers and interns. ▪ Develops Product/Process knowledge in multiple product streams and technologies.
Leads product scale up activities related to volume increases and/or product demand.
Responsible for Technology Transfer for new solid oral dosage form (tablet and capsule) products being transferred to the site as required.
Designs and executes Process Validation Studies supporting the commercialization of the TT products.
Identifies, recommends, and implements equipment modifications to ensure improved/optimized process performance.
Contributes to Equipment URS development and retrofit. Participates in Equipment FATs, SATs, etc.
Justifies processing parameters and conducts scale-up activities.
Introduces new manufacturing processes, technologies (including Process Analytical Technologies), and systems including the definition of equipment and facilities needed.
Executes the transfer and startup of new products/processes through plant trial runs and or clinical/pivotal stability lots, guaranteeing implementation of a robust and efficient process. Provides technical support for process manufacturing areas, including investigation and correction of manufacturing technical/quality issues that could potentially lead to a disruption in product supply.
Collaborates with Production, Engineering, Automation, and Quality to optimize productivity, yield, product quality, and supply reliability.
Conducts statistical process control and process capability analyses for TT projects and existing products.
Investigates and conducts troubleshooting and root-cause analysis of unexpected trends or results related to product quality and financial aspects due to material and/or process related factors during the execution of TT or routine production.
Identifies best practices in industry related to technology transfers and pharmaceutical manufacturing technologies; implements effective best practices to create a competitive advantage for the site.

Accountabilities

Conduct activities and interactions consistent with Company values and in compliance with the Code of Ethics and supporting Policies and Standards relevant to your role. Complete all required training on the AZ Code of Ethics and supporting Policies and Standards on time. Report potential issues of non-compliance.
Ensures compliance with AZ Corporate Policies and Directives, site Standard Operating Procedures, site policies, work instructions, regulatory requirements, and industry best practice (cGMPs, GAMP, ITIL, PMI).
Maintains a safe work environment and performs work in accordance with site, Safety, Health, and Environment (SHE) policies and procedures.
Immediately report potential unsafe conditions to management.
Supports internal, external, and regulatory inspections including FDA, EMEA, and third party inspections.
Participates in the investigation and resolution of product quality problems.
Executes work in compliance with cGMPs, site policies, work instructions, and SOPs.

Essential Requirements

Bachelor’s degree required, preferably in Science, Chemical Engineering, or other related technical discipline.
Minimum of 10 years’ experience in pharmaceutical production, process engineering, project engineering, or project management. Experience in the OSD pharmaceutical industry required.
Strong understanding of cGMPs; demonstrated leadership, management, and technical capabilities. ▪ Thorough knowledge of product and process development, manufacturing scale-up, continuous process improvement, and troubleshooting tools and analysis.
Excellent verbal, written, and interpersonal communication skills are essential. ▪ Must have demonstrated ability to effectively manage multiple major projects at the same time with minimum supervision.
Must have a proven ability to influence

Desired Requirements

Master’s degree and/or PhD is highly desirable.
Experience with IQ/OQ/PQ and Lean Manufacturing is highly desirable. Six Sigma certification is preferred.
Proven experience with Statistical Process Control, Process Capability Analysis.

Date Posted 04-Nov-2026 Closing Date 10-Nov-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

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