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Closed listing

AstraZeneca Pharmaceuticals LP Company

Senior Engineer, Process Data Science and Statistics

Gaithersburg, MD, United States

The annual base pay (or hourly rate of compensation) for this position ranges from $101,643.20 - $152,464.80.

This opening has closed.

The original listing is kept below for reference.

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Job details

Pay: The annual base pay (or hourly rate of compensation) for this position ranges from $101,643.20 - $152,464.80.
Closing date: Nov 30, 2026
Posting language: English
Posted: Nov 5, 2026

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Original job description

Archived listing. The details below describe a past opening.

The Sr Engineer will develop and maintain analytical workflows for multivariate process monitoring, predictive modeling of batch outcomes from incoming material, and anomaly detection on high-dimensional process data. This role builds and maintains data systems, analytical platforms, and AI-enabled tooling that connect process characterization and manufacturing execution data to statistical analysis and decision support - scaling from early process development through late-stage clinical development and commercial and post-commercial manufacturing. The role will also support development of hybrid mechanistic and data-driven models and human-supervised agentic AI applications.

This position reports to the Director, Process Data Science and Statistics lead, Process Engineering, Cell Therapy Development and Operations, and is located Required Qualifications Education

Ph.D. in Chemical Engineering, Biochemical Engineering, Biotechnology, Data Science, Statistics, or related field with 2+ year of relevant experience
OR M.S. in Chemical Engineering, Biochemical Engineering, Biotechnology, Data Science, Statistics, or related field with 4+ years of relevant experience
OR B.S. in Chemical Engineering, Biochemical Engineering, Biotechnology, Data Science, Statistics, or related field with 5+ years of relevant experience Technical Skills
Demonstrated experience in applied data science and statistical methods for process development or manufacturing (process capability, variance components, DOE, control charting, and multivariate analysis)
Proficiency in Python (pandas, scipy, statsmodels, scikit-learn, plotly) and SQL for data analysis and pipeline development
Experience developing and evaluating predictive models, including data preparation, validation, and interpretation of model results
Experience with software development practices including version control, automation, and reproducible analysis workflows
Ability to prepare clear technical documentation and translate complex statistical findings into actionable insights for cross-functional audiences Soft Skills
Excellent cross-functional communication and collaboration in matrixed environments
Ability to work independently, set priorities, and deliver under time-sensitive program and regulatory timelines
Practical problem-solving with ability to translate analytical concepts into maintainable tools and workflows Preferred Qualifications
Experience working with cloud data systems (AWS, Snowflake, Databricks, or similar)
Experience building interactive analytical applications (Streamlit, Dash, or similar)
Experience with multivariate SPC methods, including PCA/PLS, Hotelling T-squared, SPE/DModX, and anomaly detection
Experience with hybrid mechanistic and data-driven modeling, process simulation, digital shadows, or neural ODEs
Experience with AI/ML methods applied to manufacturing or bioprocess problems, including incoming-material batch-outcome prediction and LLM-based or agentic tooling
Experience in cell therapy or biologics manufacturing
Experience with DOE design and analysis for process characterization
Track record of building and deploying automated reporting and process monitoring systems

Accountabilities Statistical Strategy & Regulatory Support

Support statistical analysis for comparability assessments (site transfers, significant process changes), process characterization, and control strategy development for cell therapy programs
Apply rigorous statistical frameworks (equivalence testing, process capability analysis, variance component analysis, tolerance intervals) to evaluate drug product quality and support defensible regulatory narratives under tight timelines
Design and analyze DOE studies for process characterization and LVV manufacturing, including risk-based parameter selection and interaction modeling
Support process and product characterization for early development activities

Process Monitoring & Reporting

Develop and maintain process monitoring workflows for pivotal and commercial manufacturing, including statistical control charts, alert/action limits, and trend detection
Build multivariate statistical process control capabilities (e.g., principal component analysis or partial least squares), to support continued process verification, batch review, and investigations
Develop and evaluate anomaly detection methods for high-dimensional process data to support investigation triage and batch review
Build structured interactive reports and dashboards delivering batch visibility, in-process trend tracking, and decision support across programs
Develop predictive models linking incoming material attributes to batch outcomes to support assessment ahead of manufacturing run commitment

Data Infrastructure, Digital Systems and AI/ML

Partner with IT to implement data pipelines and analytical platforms (including tools such as Snowflake, Streamlit applications, and other cloud platforms enabling automated reporting) that connect process development and manufacturing execution data to statistical analysis and decision support
Support manufacturing data digitization, working with IT and manufacturing sites to establish scalable data capture and integration for commercial readiness
Develop and evaluate hybrid mechanistic and data-driven models, including digital shadows and, where appropriate, for process understanding, forecasting, and decision support
Build and maintain reproducible AI/ML workflows, including data preparation, model evaluation, documentation, and monitoring, with emphasis on explainability and traceability
Develop constrained, human-supervised agentic AI applications for knowledge retrieval, investigation and deviation triage, digital batch-record assistance, scheduling support, and guided decision support

Technical Leadership & Mentorship

Contribute to digital manufacturing and data science capability development, supporting AI/ML integration and scalable infrastructure to enable commercial readiness
Translate process and manufacturing questions into practical analytical solutions, prioritizing multivariate process monitoring and incoming-material predictive modeling while supporting evaluation of emerging methods
Share statistical methods, reusable code, and applied data science practices with scientists and engineers to elevate organizational capability
Collaborate cross-functionally with R&D, MSAT, Manufacturing Operations, Quality, and IT to align data capabilities with program needs
Required QualificationsEducation
Ph.D. in Chemical Engineering, Biochemical Engineering, Biotechnology, Data Science, Statistics, or related field with 2+ year of relevant experience
OR M.S. in Chemical Engineering, Biochemical Engineering, Biotechnology, Data Science, Statistics, or related field with 4+ years of relevant experience
OR B.S. in Chemical Engineering, Biochemical Engineering, Biotechnology, Data Science, Statistics, or related field with 5+ years of relevant experience
Technical Skills
Demonstrated experience in applied data science and statistical methods for process development or manufacturing (process capability, variance components, DOE, control charting, and multivariate analysis)
Proficiency in Python (pandas, scipy, statsmodels, scikit-learn, plotly) and SQL for data analysis and pipeline development
Experience developing and evaluating predictive models, including data preparation, validation, and interpretation of model results
Experience with software development practices including version control, automation, and reproducible analysis workflows
Ability to prepare clear technical documentation and translate complex statistical findings into actionable insights for cross-functional audiences
Soft Skills
Excellent cross-functional communication and collaboration in matrixed environments
Ability to work independently, set priorities, and deliver under time-sensitive program and regulatory timelines
Practical problem-solving with ability to translate analytical concepts into maintainable tools and workflows
Preferred Qualifications
Experience working with cloud data systems (AWS, Snowflake, Databricks, or similar)
Experience building interactive analytical applications (Streamlit, Dash, or similar)
Experience with multivariate SPC methods, including PCA/PLS, Hotelling T-squared, SPE/DModX, and anomaly detection
Experience with hybrid mechanistic and data-driven modeling, process simulation, digital shadows, or neural ODEs
Experience with AI/ML methods applied to manufacturing or bioprocess problems, including incoming-material batch-outcome prediction and LLM-based or agentic tooling
Experience in cell therapy or biologics manufacturing
Experience with DOE design and analysis for process characterization
Track record of building and deploying automated reporting and process monitoring systems

The annual base pay (or hourly rate of compensation) for this position ranges from $101,643.20 - $152,464.80. Our positions offer eligibility for various incentives - an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted 05-Nov-2026 Closing Date 29-Nov-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

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More about this job

Skills

Manage quantitative data
Statistics
Process engineering
Chemical engineering
Biotechnology
Documentation
Python
pandas
SciPy
Scikit-learn
SQL
Data analysis
Software development
Communication skills
Collaboration
Work independently
Problem solving
AWS
Snowflake
Databricks
SPC
ML
Reporting
Statistical process control
Forecasting
Leadership
Prioritization
Sales

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Jobs in the United States