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Senior Manager, Statistical Programming - Job ID: 2068
Ascendis Pharma
Remote, United States
Proven experience as a lead programmer for clinical trials and complex technical projects.
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Ascendis Pharma

Senior Manager, Statistical Programming - Job ID: 2068

Remote, United States

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Job details

Posting language: English
Posted: Oct 19, 2026

Original job description

Ascendis Pharma is a dynamic, fast-growing global biopharmaceutical company with locations in Denmark, Europe, and the United States. Today, we're advancing programs in Endocrinology Rare Disease and Oncology. Here at Ascendis, we pride ourselves on exceptional science, visionary leadership, and skilled and passionate colleagues. Guided by our core values of Patients, Science, and Passion, we use our TransCon® drug development platform to fulfill our mission of developing new and potentially best-in-class therapies to address unmet medical needs. Our culture fosters a place where skilled, adaptable, and highly resourceful professionals can truly make their mark. We offer a dynamic workplace for employees to grow and develop their skills. The Senior Manager, Statistical Programming, will be expected to provide timely and strategic programming support to clinical study teams in alignment with project goals. This role combines hands-on programming responsibilities with leadership in study execution and tool development. The successful candidate will serve as the Statistical Programming Lead for one or more clinical trials, taking responsibility for all programming deliverables from study start through regulatory submission. In addition, this person will support the development and maintenance of departmental programming tools, such as standard macros and specification templates of SDTM and ADaM used across clinical studies. This position requires expertise in CDISC standards (SDTM, ADaM), strong communication and leadership skills, and a deep understanding of clinical trial data and analysis workflows.

This position is based in Palo Alto, CA or may be remote.

Key Responsibilities

Serve as the Statistical Programming Lead for clinical trials, overseeing all programming deliverables from study start to submission.
Represent Statistical Programming in cross-functional study team meetings and contribute to project planning and timelines.
Develop, validate, and maintain SDTM and ADaM datasets, following CDISC standards and study specifications.
Generate or validate tables, listings, and figures (TLFs) for clinical study reports, ISS/ISE, and regulatory submissions.
Support statisticians with planned and ad hoc analyses.
Develop and maintain reusable macros, templates, and specification tools to support consistent and efficient programming practices across studies.
Collaborate with cross-functional teams including Biostatistics, Data Management, and Medical Writing to ensure high-quality deliverables.
Ensure programming activities meet project timelines and quality expectations, following internal SOPs and industry best practices.
Bachelor’s degree in Statistics, Mathematics, Computer Science, or related field with at least 10 years of programming experience in the pharmaceutical or biotech industry; or a Master’s degree with at least 7 years of relevant experience.
Proven experience as a lead programmer for clinical trials and complex technical projects.
Excellent knowledge of CDISC standards, including SDTM and ADaM.
Understanding of the clinical drug development process and regulatory requirements.
Proficiency in SAS programming, including the ability to develop and validate reusable macros.
Familiarity with other programming languages or tools (e.g., R, Python, Git, VB) is a plus.
Experience contributing to departmental tools (e.g., macro libraries, specification templates, or automation tools) is preferred.
Strong verbal and written communication skills, with the ability to collaborate effectively across functions.
Self-motivated and detail-oriented, with the ability to manage multiple tasks and adapt to shifting priorities under tight deadlines.

The estimated salary range for this position is $170-180K/year. Actual salary determination is dependent on a variety of factors some of which include: experience, qualifications, and geographic location. This position may be eligible for a discretionary annual bonus or an incentive compensation plan (eligibility varies based on role and position level), discretionary stock-based long-term incentives, paid time off, and a comprehensive benefits package.

A note to recruiters:

We do not allow external search party solicitation. Presentation of candidates without written permission from the Ascendis Pharma Inc Human Resources team (specifically from: Talent Acquisition Partner or Human Resources Director) is not allowed. If this occurs your ownership of these candidates will not be acknowledged.

401(k) plan with company match
Medical, dental, and vision plans
Company-offered Life and Accidental Death & Dismemberment (AD&D) insurance
Company-provided short and long-term disability benefits
Unique offerings of Pet Insurance and Legal Insurance
Employee Assistance Program
Employee Discounts
Professional Development
Health Saving Account (HSA)
Flexible Spending Accounts
Various incentive compensation plans
Accident, Critical Illness, and Hospital Indemnity Insurance
Mental Health resources
Paid leave benefits for new parents

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