Jobs in the United States

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Added 1 min ago
Shopper Experience Associate Manager – Sam's Club
The Clorox Sales Company
Bentonville, AR
5+ Years of Experience: Progressive background in CPG shopper marketing, customer/commerce marketing, eCommerce, retail media, brand marketing, or customer development.
Added 2 mins ago
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Executive Operations Coordinator, Enrollment Management and Retention
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Fort Collins, CO
- $56,606 to $59,436 USD / year
…in expanding educational opportunities, supporting workforce development, and serving diverse communities across…
Added 3 mins ago
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NM
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BLS certification REQUIRED at time of hire
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Amylyx Pharmaceuticals

Associate Director, CMC, Program Management

Cambridge, MA, United States

$178,000 - $200,000 USD

Apply on job-boards.greenhouse.io About employer

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Job details

Pay: $178,000 - $200,000 USD
Posting language: English
Posted: Sep 4, 2026

Original job description

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

Amylyx is seeking an experienced Associate Director, CMC Program Management to provide strategic and operational program management leadership across our CMC portfolio. This individual will partner closely with CMC asset leads and colleagues across Regulatory, Quality, Analytical Development, Supply Chain, External Manufacturing, Clinical, and Nonclinical Development to translate CMC strategies into integrated, executable plans.

The Associate Director will establish clear timelines, milestones, dependencies, budgets, and governance practices for assigned CMC programs. This role will facilitate CMC teams, monitor critical-path activities, drive timely decision-making, identify and escalate risks, and ensure that technical, manufacturing, and regulatory deliverables remain aligned with program objectives. The ideal candidate is an experienced biopharmaceutical program manager who combines strong CMC knowledge with disciplined execution, strategic thinking, and the ability to influence in a cross-functional matrix environment.

Responsibilities

Lead program management for one or more CMC programs, developing and maintaining integrated plans that include scope, timelines, milestones, dependencies, deliverables, resources, budgets, and key decision points.
Partner with CMC asset leads and functional subject matter experts to translate CMC strategy into coordinated execution plans that support development, manufacturing, lifecycle management, regulatory filings, and program objectives.
Lead CMC team meetings and governance processes, including agendas, minutes, action-item tracking, decision logs, risk registers, and escalation of issues requiring leadership attention.
Proactively monitor critical-path activities, identify strategic and operational risks, assess downstream impacts, and partner with stakeholders to develop mitigation and contingency plans.
Coordinate CMC deliverables across Regulatory, Quality, Analytical Development, Technical Development, and Supply Chain ensuring clear ownership, accountability, and communication across workstreams.
Develop concise program dashboards and status reports that provide visibility into milestones, risks, decisions, budget status, resource needs, and overall CMC readiness.
Support planning and execution of complex CMC initiatives, which may include technical transfers, process development and validation activities, regulatory submission readiness, and lifecycle-management programs.
Establish and continuously improve scalable CMC program management tools, templates, metrics, meeting structures, and ways of working that strengthen execution across the broader CMC organization.

Required Qualifications

Bachelor’s degree in life sciences, chemistry, engineering, pharmaceutical sciences, or a related discipline.
Eight to ten years of relevant experience in the pharmaceutical or biotechnology industry, including significant experience in project or program management supporting CMC, Technical Operations, manufacturing, or product development.
Demonstrated understanding of CMC development, regulatory CMC requirements, and cGMP-compliant pharmaceutical development and manufacturing.
Experience building and managing complex, integrated plans across multiple technical workstreams, including timelines, milestones, dependencies, risks, budgets, and resource requirements.
Proven ability to lead cross-functional teams and drive execution through influence in a matrixed environment without relying on direct authority.
Experience proactively identifying, communicating, escalating, and managing program risks, issues, decisions, and competing priorities.
Strong written, verbal, facilitation, stakeholder-management, analytical, and organizational skills, with the ability to communicate technical and program information clearly to different audiences.
Proficiency with project-management and collaboration tools used to maintain plans, trackers, dashboards, actions, and program documentation.

Preferred Requirements

Master’s degree in a scientific, engineering, or business discipline.
Direct experience supporting CMC programs from early development through late-stage development, and commercialization readiness.
Project Management Professional certification or an equivalent project or program management credential, along with experience using tools such as Smartsheet, Microsoft Project, or SharePoint.

Work Location and Conditions

At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

Base salary is one component of Amylyx’s total rewards package. In addition to competitive base pay, eligible employees may receive annual performance-based bonuses and equity awards, providing an opportunity to share in the company’s long-term success. Amylyx also offers a comprehensive benefits package designed to support the health, well-being, and financial security of our employees.

Estimated Pay Range

$178,000 - $200,000 USD

To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn.

To return to our website please click here.

Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Apply on job-boards.greenhouse.io About employer

More about this job

Skills

Program management
Supply chain management
Decision making
Leadership
Communication skills
Biotechnology
Stakeholder management
Organizational skills
Project management
Collaboration
Documentation
PMP
Smartsheet
Microsoft Project
Microsoft SharePoint

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Work requirements

Jobs in the United States