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Amgen

Scientist - LC-MS Bioanalytical

Thousand Oaks, CA, United States

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Job details

Posting language: English
Posted: Sep 25, 2026

Original job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission - to serve patients living with serious illnesses - drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier live.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist - LC-MS Bioanalytical

What you will do

Let’s do this. Let’s change the world. This lab-based role supports the design, development, validation, and implementation of robust LC–MS/MS bioanalytical methods for therapeutic modalities including small molecules, oligonucleotides, proteins, and other complex molecular entities. The initial focus is to expand discovery-stage support within PKDM–BA, while maintaining flexibility to support GLP preclinical and regulated clinical activities as needed. The role will also contribute to modernization of automation and instrumentation to improve assay throughput and sensitivity, working closely with multidisciplinary research and development teams across Amgen.

Key responsibilities include:

Plan, execute, and document quantitative LC–MS/MS bioanalytical experiments.
Develop and implement fit-for-purpose bioanalytical methods with rapid turnaround.
Perform small- and large-molecule bioanalysis in nonclinical and clinical matrices, including plasma, urine, CSF, and tissues.
Prepare biological samples using protein precipitation, solid-phase extraction, liquid–liquid extraction, affinity capture, and related techniques.
Organize, analyze, interpret, and present bioanalytical data with strong attention to data integrity and fidelity.
Maintain complete, accurate, and concise documentation in electronic laboratory notebooks and other laboratory systems.
Ensure data and records meet applicable regulatory expectations for global submissions and remain current with relevant industry guidance.
Author and review study reports, analytical methods, SOPs, technical memos, and other regulatory-compliant documents.
Communicate bioanalytical results to discovery and development teams; contribute to publications and present findings at scientific meetings.
Support report quality control, effective time management, and clear cross-functional communication.
Follow all safety, training, documentation, and site-specific procedural requirements.
Perform routine laboratory housekeeping and operational support activities as needed.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is a key contributor with these qualifications.

Basic Qualifications:

Doctorate degree

Master’s degree and 2 years of relevant industrial/technical experience

Bachelor’s degree and 4 years of relevant industrial/technical experience

Preferred Qualifications:

Prefer Bachelor's or Master's experience
Prior experience in CRO or pharma/biotech strongly desired
Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms as well as HRMS
Experience with an array of analytical technologies that can accelerate bioanalysis inclusive of automation and/or micro-sampling
Prior GLP and GCP experience.
Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, serum, tissues, cerebrospinal fluid).
Hands-on experience with automated or semi-automated sample preparation for LC-MS bioanalysis, including protein precipitation, SPE, affinity capture, and other high-throughput workflows, using platforms such as KingFisher APEX/FLEX, automated SPE systems, and robotic liquid handlers.
Prior experience in bioanalytical (regulated) assay execution and transfer to CROs
Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines.
Demonstrated ability to resolve scientific challenges efficiently and prioritize effectively
Excellent scientific problem-solving skills
Excellent project and time management abilities
Ability to work collaboratively with internal and external stakeholders
Supervisory and mentoring experience in a lab-based setting

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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Jobs in the United States