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Added 1 min ago
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Associate Director, Digital Paid Media
UnitedHealth Group
Minneapolis, MN · Chicago, IL · Saint Louis, MO · Atlanta, GA · Phoenix, AZ · Houston, TX
- $112,700 to $193,200 USD / year
Working closely with the Senior Director of Digital Media, Digital Channel Leads, channel managers, specialists, analytics and measurement teams, and external media partners, the Associate…
Added 4 mins ago
Manager - SAP MDG & Master Data
Deloitte
Saint Louis, MO
+ Facilitate senior stakeholder workshops and identify opportunities to expand client value through MDM, analytics, automation, and AI-enabled governance capabilities.
Added 4 mins ago
Manager - SAP MDG & Master Data
Deloitte
Kansas City, MO
+ Facilitate senior stakeholder workshops and identify opportunities to expand client value through MDM, analytics, automation, and AI-enabled governance capabilities.
Added 4 mins ago
PB
Cloud & Communication Services Manager (Full Time)
PROSPERITY BANK
Lubbock, TX · Sugar Land, TX · Plano, TX
- Full-time
Escalation of network issues to Senior IT Management.
Added 4 mins ago
Assistant Director, Experiential Learning - School of Business
Wake Forest University
Winston Salem, NC
…operational execution, hands-on program management, and instructional development for student-facing experiential learning (EL) initiatives. Reporting directly to the Senior Associate…
Added 8 mins ago
C.N.A./Care Associate-Assisted Living-Nights
Morningside Ministries
San Antonio, TX
…renovated Assisted Living facility at Morningside Ministries Senior Living Community, located just north of downtown San Antonio. We welcome you to join our team as we work together to…
Added 9 mins ago
A
SAP Mid-market Sales Executive - East Coast/Mid West
Accenture
Saint Louis, MO
- $87,400 to $140,400 USD / year
This is an entrepreneurial role where the best candidate will thrive on thought leadership and hands-on development of a newly established business area for SAP. As a Sales Leader, you will…
Added 9 mins ago
A
Technology Chemical & Natural Resources Sales Capture Senior Manager
Accenture
Saint Louis, MO
- $136,800 to $237,600 USD / year
…qualification, sales pursuit and close by applying deep sales process and technical expertise. You develop relationships with key buyers and decision-makers at new and existing clients by…
Added 11 mins ago
Infrastructure Advisory & Transformation Manager
Accenture
Saint Louis, MO
+ Identify opportunities to improve efficiency through automation, AI-enabled operations, and process optimization.
Added 11 mins ago
Infrastructure Advisory & Transformation Senior Manager
Accenture
Saint Louis, MO
As a trusted advisor to senior client stakeholders, you will lead the development of infrastructure strategies, transformation roadmaps, cloud adoption initiatives, operating model…
Added 11 mins ago
RE
VP Actuary - Valuation Policy and Standards
RGA Enterprise Services Company
Chesterfield, MO
- $198,270 to $294,450 USD / year
…work environment. Mentors associates and gives guidance on associate…
Added 11 mins ago
BH
Sr. Compliance Coordinator-Billing & Coding
BJC HealthCare
Saint Louis, MO
- $57,304 to $93,288 USD / year
…trends identified based upon internal reviews or requests from senior leadership; performs special projects as requested/assigned by management; monitors trends across the organization and…
Added 14 mins ago
Pharma and Life Sciences R&D Operations Consultant, Senior Associate
PwC
Kansas City, MO
As a Pharma and Life Sciences R&D Operations Consultant, Senior Associate, you will engage with clients to advise on strategic and operational areas throughout the drug development…
Added 16 mins ago
A
Sourcing & Procurement Manager - NASPFY26
Accenture
Saint Louis, MO
- $94,400 to $293,800 USD / year
…799,000 people with proprietary assets and platforms, deep process and industry expertise, and leading ecosystem relationships to deliver end-to-end solutions and measurable outcomes at…
Added 16 mins ago
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Supply Chain and Engineering- Software Defined Vehicle (SDV) Go-To-Market, Senior Manager / Associate Director
Accenture
Saint Louis, MO
- $132,500 to $271,000 USD / year
As a Software Defined Vehicle (SDV) Go-to-Market Senior Manager / Associate Director, you will play a critical role in shaping client solutions, supporting complex sales pursuits, and…
Added 16 mins ago
Registered Nurse Residency Program- Spring 2027 Graduates
Saint Luke's
Kansas City, MO
With a supportive team environment, mentorship opportunities, professional development programs, and a commitment to exceptional patient care, Saint Luke's North provides a strong…
Added 17 mins ago
Senior Director of Finance
Ascension
WICHITA, KS
…required, with 2 of those years being in leadership/management OR Associate's degree/Bachelor's degree with 3 years of applicable cumulative job specific experience required, with 2 of…
Added 18 mins ago
Senior Product Associate - Payments
JPMC page
Chicago, IL · Jersey City, NJ · Brooklyn, NY · NY
As a Product Associate in Embedded Payments, you play a crucial role in supporting the product development process and contributing to the discovery of innovative solutions that address…
Added 18 mins ago
Wealth Management - Data Owner - Senior Associate
JPMC page
Jersey City, NJ · Plano, TX · Wilmington, DE
As a Data Owner Senior Associate in Wealth Management, you will play a crucial role in developing and implementing procedures that ensure data supports business operations, business…
Added 18 mins ago
Wealth Management - Data Owner - Senior Associate
JPMC page
Jersey City, NJ · Plano, TX · Wilmington, DE
As a Data Owner Senior Associate in Wealth Management, you will play a crucial role in developing and implementing procedures that ensure data supports business operations, business…
Added 20 mins ago
Registered Nurse Residency - Saint Luke's East - Spring 2027 Graduates
Saint Luke's
Lee's Summit, MO
…supportive team environment, mentorship opportunities, professional development programs, and a commitment to exceptional patient care, Saint Luke's East provides a strong foundation for…
Added 20 mins ago
RN Residency - Saint Luke's Plaza - Spring 2027 Graduates
Saint Luke's
Kansas City, MO
With a supportive team environment, mentorship opportunities, professional development programs, and a commitment to exceptional patient care, Saint Luke's Hospital provides a strong…
Added 21 mins ago
Sr Project Manager (Science & Technology) - (San Francisco & Seattle)
Hellmuth, Obata + Kassabaum, Inc.
Seattle, WA
Assists senior management in developing and validating project scope and fee, budget, and scope of services during the marketing and contract development process.
Added 21 mins ago
Sr Interiors Project Manager
Hellmuth, Obata + Kassabaum, Inc.
Seattle, WA
Assists senior management in developing and validating project scope and fee, budget, and scope of services during the marketing and contract development process.
Added 21 mins ago
Project Manager (Healthcare Experience)
Hellmuth, Obata + Kassabaum, Inc.
Seattle, WA
Assists senior management in developing and validating project scope and fee, budget, and scope of services during the marketing and contract development process.

Amgen

Principal Machine Learning Engineer

Washington D.C., DC, United States

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Job details

Posting language: English
Posted: Sep 27, 2026

Original job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission - to serve patients living with serious illnesses - drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Machine Learning Engineer

What you will do

Let’s do this. Let’s change the world. In this vital role you will Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud/on-prem.

We are seeking a Principal Machine Learning Engineer - Amgen’s most senior individual-contributor authority on building and scaling end-to-end machine-learning and generative-AI solutions. Sitting at the intersection of engineering excellence and data-science enablement, you will develop, deploy and monitor models - classical ML, deep learning and LLMs - securely and cost-effectively. Acting as a “player-coach,” you will establish AI solution strategy, define technical standards, and partner with DevOps, Security, Compliance and Product teams to deliver a frictionless, enterprise-grade AI solutions.

Roles & Responsibilities:

Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud/on-prem.
Build production ML/GenAI solutions and lightweight apps delivering sub-second insights.
Build end-to-end ML pipelines - data ingestion, feature engineering, training, hyper-parameter optimisation, evaluation, registration and automated promotion - using Kubeflow, SageMaker Pipelines, Open AI SDK or equivalent MLOps stacks.
Build and maintain full-stack AI applications by integrating model services with lightweight UI components, workflow engines or business-logic layers so insights reach users with sub-second latency.
Establish observability, SLOs, and safe deploys (blue-green/canary, shadow, rollbacks) with incident runbooks.
Lead rigorous evaluation (offline/online, A/B), drift detection, and automated retraining.
Architect LLM/RAG with prompt management, safety guardrails, and optimized inference.
Enforce data quality , lineage, and model/data cards; apply privacy-preserving techniques where needed.
Contribute reusable ML/GenAI components - feature stores, model registries, experiment-tracking libraries - and evangelize best practices that raise engineering velocity across squads.
Perform exploratory data analysis and feature ideation on complex, high-dimensional datasets to inform algorithm selection and ensure model robustness.
Prototype and benchmark new algorithms , offering guidance on scalability trade-offs and production-readiness while co-owning model-performance KPIs.
Translate domain needs (R&D, Manufacturing, Commercial) into roadmaps; mentor teams and communicate trade-offs.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Principal Machine Learning Engineer with these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of Machine Learning Engineer experience

Master’s degree and 6 years of Machine Learning Engineer experience

Bachelor’s degree and 8 years of Machine Learning Engineer experience

Associate’s degree and 10 years of Machine Learning Engineer experience

High school diploma / GED and 12 years of Machine Learning Engineer experience

In addition to meeting at least one of the above requirements, you must have a minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources. Your managerial experience may run concurrently with the required technical experience referenced above

3-5 years in AI/ML and enterprise software.
Strong command of machine-learning algorithms - regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, deep-learning architectures (CNNs, RNNs, transformers) and modern LLM/RAG techniques - with the judgment to choose, tune and operationalize the right method for a given business problem.
Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale.
Expert knowledge of GenAI tooling: vector databases, RAG pipelines, prompt-engineering DSLs and agent frameworks (e.g., LangChain, LangGraph, Semantic Kernel).
Proficiency in Python and Java; containerization (Docker/K8s); cloud (AWS, Azure or GCP) and modern DevOps/MLOps (GitHub Actions, Bedrock/SageMaker Pipelines).
Strong business-case skills - able to model TCO vs. NPV and present trade-offs to executives.
Exceptional stakeholder management; can translate complex technical concepts into concise, outcome-oriented narratives.

Preferred Qualifications:

Experience in Biotechnology or pharma industry is a big plus
Published thought-leadership or conference talks on enterprise GenAI adoption.
Master’s degree in Computer Science and or Data Science
Familiarity with Agile methodologies and Scaled Agile Framework (SAFe) for project delivery.

Education and Professional Certifications

Master’s degree with 10-12 + years of experience in Computer Science, IT or related field

Bachelor’s degree with 12-14 + years of experience in Computer Science, IT or related field
Certifications on GenAI/ML platforms (AWS AI, Azure AI Engineer, Google Cloud ML, etc.) are a plus.

Soft Skills:

Excellent analytical and troubleshooting skills.
Strong verbal and written communication skills
Ability to work effectively with global, virtual teams
High degree of initiative and self-motivation.
Ability to manage multiple priorities successfully.
Team-oriented, with a focus on achieving team goals.
Ability to learn quickly, be organized and detail oriented.
Strong presentation and public speaking skills.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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