Find work in the United States.

A simpler way to find your next job.

Jobs in the United States

25+ jobs

Save this search

Added 3 mins ago
SAP IS-U ABAP Developer Consultant - Resources/Utilities
Accenture LLP Company
NY
You bring the communication and people skills to inspire teams to bring their A-game and to advise senior client stakeholders with confidence.
Added 3 mins ago
SAP IS-U ABAP Developer Manager - Resources/Utilities
Accenture LLP Company
NY
You bring the communication and people skills to inspire teams to bring their A-game and to advise senior client stakeholders with confidence.
Added 14 mins ago
Senior AI Engineer
Suffolk Construction Company, Inc
Boston, MA
Own full lifecycle delivery - design, development, testing, deployment, monitoring, and maintenance.
Added 18 mins ago
Sr. Technical Delivery Manager - Infrastructure/Data Center (General)
World Wide Technology
Maryland Heights, MO
…problems. Our goal is to bring together business acumen with full-stack technical know-how to develop innovative solutions for our clients' most complex…
Added 20 mins ago
AI Engineer 4 (AI Safety and Multimodal)
Capital One
San Jose, CA · McLean, VA · Cambridge, MA · NY
Leverage a broad stack of Open Source and SaaS AI technologies such as AWS Ultraclusters, Huggingface, VectorDBs, PyTorch, and more.
Added 20 mins ago
Senior Director, AI Engineering -Agentic AI Platform(Remote Eligible)
Capital One
San Jose, CA · San Francisco, CA · McLean, VA · Cambridge, MA · NY
Make high judgment build-vs-buy decisions across a broad stack of Open Source and SaaS AI technologies such as AWS Ultraclusters, Huggingface, VectorDBs, PyTorch, and more.
Added 21 mins ago
Staff Data Engineer
DAT Solutions, LLC
Seattle, WA
…methods and processes to be utilized within our technology stack, including dbt, Airflow, Snowflake, Kafka, and traditional…
Added 22 mins ago
AI & Distributed Systems Fullstack Engineer - Senior - Consulting - Location OPEN
EY
Saint Louis, MO
As a Senior Application Designer and Developer, you will play a pivotal role in delivering innovative solutions. Your time will be spent on various responsibilities, including:
Added 22 mins ago
AI & Distributed Systems Fullstack Engineer - Senior - Consulting - Location OPEN
EY
Kansas City, MO
As a Senior Application Designer and Developer, you will play a pivotal role in delivering innovative solutions. Your time will be spent on various responsibilities, including:
Added 22 mins ago
AI & Distributed Systems Fullstack Engineer - Senior - Consulting - Location OPEN
EY
Jefferson City, MO
As a Senior Application Designer and Developer, you will play a pivotal role in delivering innovative solutions. Your time will be spent on various responsibilities, including:
Added 25 mins ago
Senior Director, AI & Data Science Solutions
Otsuka America Pharmaceutical Inc.
Jefferson City, MO
…team is a centralized capability and comprises of programmers, full-stack AI and data scientist who work closely with other Data and Analytics, AI engineers, Data Engineers, various roles…
Added 31 mins ago
Infrastructure Maturity & Assessment Senior Manager
Accenture
Saint Louis, MO
+ Financial Modelling & Business Case Development: Full-stack TCO analysis (on-prem, colo, cloud), NPV/ROI investment scenario modelling, and financial quantification of the "cost of…
Added 37 mins ago
Senior Forward Deployed Engineer
Workday, Inc.
CA · GA
You’ll work with the full Workday Developer Platform stack. You’ll run custom agents on the Workday Agent Harness, the same agent runtime and infrastructure Workday uses internally. You’ll…
Added 37 mins ago
Forward Deployed Engineer
Workday, Inc.
CA · GA
You’ll work with the full Workday Developer Platform stack. You’ll run custom agents on the Workday Agent Harness, the same agent runtime and infrastructure Workday uses internally. You’ll…
Added 37 mins ago
Principal Forward Deployed Engineer
Workday, Inc.
CA · GA
You’ll work with the full Workday Developer Platform stack. You’ll run custom agents on the Workday Agent Harness, the same agent runtime and infrastructure Workday uses internally, and…
Added 37 mins ago
National Manager, Software Engineering
Toyota
Plano, TX
…within the domain. Own and drive key initiatives across our full software stack - from customer-facing features to backend…
Added 37 mins ago
National Manager, Software Engineer
Toyota
Plano, TX
…within the domain. Own and drive key initiatives across our full software stack - from customer-facing features to backend…
Added 38 mins ago
T
SailPoint Practice Architect II-IAM (Fulltime Remote)
TEKsystems
Dallas, TX
- $148,200 to $222,400 USD / year
- Full-time
The IAM Practice Architect is a senior technical leader responsible for the execution and delivery of enterprise Identity and Access Management (IAM) solutions. This role balances…
Added 38 mins ago
T
Workday Architect
TEKsystems
Houston, TX
- $80 to $120 USD / hour
…across North America, Europe and Asia. As an industry leader in Full-Stack Technology Services, Talent Services, and real-world application, we work with progressive leaders to drive…
Added 39 mins ago
Senior Frontend Engineer - Vehicle Software Integrity
General Motors
Austin, TX
As a Senior Software Engineer, you will own complex, full-stack systems end-to-end, from data ingestion to the interfaces that surface insight. You will architect solutions across a React…
Added 39 mins ago
Senior Full Stack Software Engineer – .NET, FinTech & AI Development
Innovest Systems LLC
Fort Worth, TX
Job Title: Senior Full Stack Software Engineer – .NET, FinTech & AI Development
Added 40 mins ago
EG
Senior Java Full-Stack Developer
Eliassen Group
Austin, TX
- $70 to $80 USD / hour
Our client is seeking a Senior Java Full-Stack Developer to design, build, and support scalable software solutions across the full application stack. This individual will work as part of a…
Added 41 mins ago
Sr. Agentic Operations & Observability Consultant - Automation
World Wide Technology
Maryland Heights, MO
…brilliance. Our goal is to bring together business acumen with full-stack technical know-how to develop innovative solutions for our clients' most complex…
Added 46 mins ago
Senior Fullstack Engineer, FanX AI
SeatGeek
NY
Adaptability: You have comfort working full stack in Python when needed to get things done. You have some experience with design tools like Figma or Sketch. If you've never worked with any…
Added 46 mins ago
Senior Fullstack Engineer, FanX AI
SeatGeek
Remote, United States
Adaptability: You have comfort working full stack in Python when needed to get things done. You have some experience with design tools like Figma or Sketch. If you've never worked with any…

Amgen

Principal Machine Learning Engineer

Washington D.C., DC, United States

Apply About employer

Applications open in a new tab.

Job details

Posting language: English
Posted: Sep 27, 2026

Original job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission - to serve patients living with serious illnesses - drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Machine Learning Engineer

What you will do

Let’s do this. Let’s change the world. In this vital role you will Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud/on-prem.

We are seeking a Principal Machine Learning Engineer - Amgen’s most senior individual-contributor authority on building and scaling end-to-end machine-learning and generative-AI solutions. Sitting at the intersection of engineering excellence and data-science enablement, you will develop, deploy and monitor models - classical ML, deep learning and LLMs - securely and cost-effectively. Acting as a “player-coach,” you will establish AI solution strategy, define technical standards, and partner with DevOps, Security, Compliance and Product teams to deliver a frictionless, enterprise-grade AI solutions.

Roles & Responsibilities:

Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud/on-prem.
Build production ML/GenAI solutions and lightweight apps delivering sub-second insights.
Build end-to-end ML pipelines - data ingestion, feature engineering, training, hyper-parameter optimisation, evaluation, registration and automated promotion - using Kubeflow, SageMaker Pipelines, Open AI SDK or equivalent MLOps stacks.
Build and maintain full-stack AI applications by integrating model services with lightweight UI components, workflow engines or business-logic layers so insights reach users with sub-second latency.
Establish observability, SLOs, and safe deploys (blue-green/canary, shadow, rollbacks) with incident runbooks.
Lead rigorous evaluation (offline/online, A/B), drift detection, and automated retraining.
Architect LLM/RAG with prompt management, safety guardrails, and optimized inference.
Enforce data quality , lineage, and model/data cards; apply privacy-preserving techniques where needed.
Contribute reusable ML/GenAI components - feature stores, model registries, experiment-tracking libraries - and evangelize best practices that raise engineering velocity across squads.
Perform exploratory data analysis and feature ideation on complex, high-dimensional datasets to inform algorithm selection and ensure model robustness.
Prototype and benchmark new algorithms , offering guidance on scalability trade-offs and production-readiness while co-owning model-performance KPIs.
Translate domain needs (R&D, Manufacturing, Commercial) into roadmaps; mentor teams and communicate trade-offs.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Principal Machine Learning Engineer with these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of Machine Learning Engineer experience

Master’s degree and 6 years of Machine Learning Engineer experience

Bachelor’s degree and 8 years of Machine Learning Engineer experience

Associate’s degree and 10 years of Machine Learning Engineer experience

High school diploma / GED and 12 years of Machine Learning Engineer experience

In addition to meeting at least one of the above requirements, you must have a minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources. Your managerial experience may run concurrently with the required technical experience referenced above

3-5 years in AI/ML and enterprise software.
Strong command of machine-learning algorithms - regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, deep-learning architectures (CNNs, RNNs, transformers) and modern LLM/RAG techniques - with the judgment to choose, tune and operationalize the right method for a given business problem.
Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale.
Expert knowledge of GenAI tooling: vector databases, RAG pipelines, prompt-engineering DSLs and agent frameworks (e.g., LangChain, LangGraph, Semantic Kernel).
Proficiency in Python and Java; containerization (Docker/K8s); cloud (AWS, Azure or GCP) and modern DevOps/MLOps (GitHub Actions, Bedrock/SageMaker Pipelines).
Strong business-case skills - able to model TCO vs. NPV and present trade-offs to executives.
Exceptional stakeholder management; can translate complex technical concepts into concise, outcome-oriented narratives.

Preferred Qualifications:

Experience in Biotechnology or pharma industry is a big plus
Published thought-leadership or conference talks on enterprise GenAI adoption.
Master’s degree in Computer Science and or Data Science
Familiarity with Agile methodologies and Scaled Agile Framework (SAFe) for project delivery.

Education and Professional Certifications

Master’s degree with 10-12 + years of experience in Computer Science, IT or related field

Bachelor’s degree with 12-14 + years of experience in Computer Science, IT or related field
Certifications on GenAI/ML platforms (AWS AI, Azure AI Engineer, Google Cloud ML, etc.) are a plus.

Soft Skills:

Excellent analytical and troubleshooting skills.
Strong verbal and written communication skills
Ability to work effectively with global, virtual teams
High degree of initiative and self-motivation.
Ability to manage multiple priorities successfully.
Team-oriented, with a focus on achieving team goals.
Ability to learn quickly, be organized and detail oriented.
Strong presentation and public speaking skills.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Apply About employer

Report this job