Find work in the United States.

A simpler way to find your next job.

Jobs in the United States

25+ jobs

Save this search

Added just now
Junior High School Teacher - Social Studies (5361)
Queen Creek Unified District
Queen Creek, AZ
Plans and implements a program of study that, as much as possible, meets the individual needs, interests and abilities of students within the district curriculum.
Added just now
After School Instructor
Catalyst Family Inc.
Tustin, CA
Provide students with educational enrichment which may include positive youth development strategies, recreation and prevention activities, and the ability to teach youth positive life…
Added just now
After School Instructor
Catalyst Family Inc.
Tustin, CA
Provide students with educational enrichment which may include positive youth development strategies, recreation and prevention activities, and the ability to teach youth positive life…
Added just now
Structures Representative
Kleinfelder Inc
Redmond, WA
Career Development: We are committed to investing in the professional development of our staff, offering each employee every opportunity to grow, develop, and take control of their career…
Added just now
Manager Assistant (Chief of Staff) - DMAT
American Express
New York, NY · NY
…dining technology. It employs a ground-breaking focus with development responsibilities for customer-facing capabilities that deepen and expand digital engagement, as well as core technical…
Added 1 min ago
Youth Engagement Specialist I - Huliau Program
Liliuokalani Trust
Honolulu, HI
…opportunity for intensive case management. Lydia House’s Huliau Program supports re-entry education and workforce, including opportunity for financial and housing support. Lydia House…
Added 1 min ago
Interior Coordinator
Advocate Aurora Health, Inc.
United States
11404 Support Operations Division - Design and Construction: Corp Administration
Added 1 min ago
Facilities Supervisor (AMG North Clinics)
Advocate Health and Hospitals Corporation
United States
Oversees general department operations, establishes work schedules, issues daily work assignments and responds to requests for service. Identifies and addresses all safety issues.
Added 1 min ago
Pharmacy Technician I PRN
Lexington Medical Center
Lexington, NC
May assist in training pharmacy technicians and extenders in orientation to the policies, procedures, and workflows involved in pharmacy operations as applicable at entity level.
Added 1 min ago
Pharmacy Technician I
North Carolina Baptist Hospital
Winston Salem, NC
May assist in training pharmacy technicians and extenders in orientation to the policies, procedures, and workflows involved in pharmacy operations as applicable at entity level.
Added 1 min ago
Float Retail Pharmacy Technician
Aurora Pharmacy, Inc.
United States
May assist in training pharmacy technicians and extenders in orientation to the policies, procedures, and workflows involved in pharmacy operations as applicable at entity level
Added 1 min ago
Manager, Critical Operations
Quality Technology Services, LLC
United States
The Manager, Critical Operations is responsible for the Data Center facility technical strategy, continuous improvement, and development support. This role will support the electrical,…
Added 1 min ago
Summer 2027 Internship: Interior Design Projects
Quality Technology Services, LLC
Duluth, GA
QTS' summer internship program will provide you first hand experience into the fast paced world of the data center industry by providing weekly lunch and learns, a comprehensive orientation…
Added 1 min ago
Senior Development Program Manager (Data Center Construction)
Quality Technology Services, LLC
United States
The Senior Development Program Manager (Data Center Construction) is primarily responsible for leading and managing the design, pre-construction and construction activities on a given…
Added 1 min ago
Development Program Manager - Acoustics Engineering SME
Quality Technology Services, LLC
Irving, TX
The Program Manager will interact daily with Development, Engineering, Procurement, Construction, Operations, Legal, and Community Relations teams, as well as third-party acoustics…
Added 1 min ago
Program Manager
InterImage
Fort Meade, MD
We are seeking an experienced Program Manager to oversee mission-critical hardware engineering, and technical development programs supporting the Intelligence Community. This individual…
Added 1 min ago
WT
Licensed Clinician
WESTERN TIDEWATER COMMUNITY SERVICE BOARD
Suffolk, VA
- $78,611 to $104,159 USD / year
Promote person-centered, recovery-oriented, and trauma-informed care while participating in quality assurance, program development, and professional development
Added 1 min ago
Patient Services Representative (PSR) Lead - Urgent Care Clinic
Aurora Advanced Healthcare, Inc.
Milwaukee, WI
Functions as lead associate for clerical office operations.
Added 1 min ago
Logistics Technician
Advocate Health, Inc.
United States
11500 Enterprise Corporate - Supply Chain: Operations Good Samaritan Hospital
Added 1 min ago
Logistics Technician
Advocate Health, Inc.
United States
11500 Enterprise Corporate - Supply Chain: Operations Good Samaritan Hospital
Added 1 min ago
Maintenance Technician lll
Atrium Health Hospitals, Inc.
Kings Mountain, NC
11918 Atrium Health Lincoln - Plant Operations
Added 1 min ago
Maintenance Technician II
Carolinas Medical Center
Charlotte, NC
11918 Atrium Health Behavioral Health: Charlotte - Plant Operations
Added 1 min ago
Materials Associate
Advocate Health, Inc.
Charlotte, NC
12063 Enterprise Corporate - Supply Chain: Operations Levine Childrens Hospital
Added 1 min ago
Materials Associate
Advocate Health, Inc.
Charlotte, NC
12010 Enterprise Corporate - Supply Chain: Operations Carolinas Medical Center
Added 1 min ago
Pharmacy Technician I Levine Cancer InstituteMorehead
Carolinas Medical Center
Charlotte, NC
May assist in training pharmacy technicians and extenders in orientation to the policies, procedures, and workflows involved in pharmacy operations as applicable at entity level

Amgen

Principal Architect

Washington D.C., DC, United States

Apply About employer

Applications open in a new tab.

Job details

Posting language: English
Posted: Apr 27, 2026

Original job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission - to serve patients living with serious illnesses - drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Architect

What you will do

Let’s do this. Let’s change the world. In this vital role you will play a pivotal role in building and scaling our machine learning models from development to production. Your expertise in both machine learning and operations will be essential in creating efficient and reliable ML pipelines. A background in data engineering, including experience with data pipelines and distributed data processing, is a strong plus.

Lead the end-to-end design, development, and delivery of machine learning and Generative AI (GenAI) solutions, leveraging Databricks, Apache Spark, SQL, and Python for scalable data processing, feature engineering, and model development from problem framing to production deployment and business impact realization.
Act as an Architect for large-scale Data Engineering and ML/GenAI initiatives , driving architecture decisions across lakehouse platforms (Databricks), distributed compute (Spark), and cloud ecosystems (AWS/GCP/Azure) to ensure scalability, reliability, and long-term maintainability.
Design and implement advanced data pipelines and AI systems , including batch and streaming data processing (Spark), data modeling (SQL), and ML workflows (Python) , along with multi-agent architectures, reasoning workflows, tool integration, and autonomous decision-making systems.
Build and optimize robust data foundations for AI by developing high-quality, scalable ETL/ELT pipelines in Databricks , ensuring data availability, consistency, and performance for downstream ML/GenAI use cases.
Define and institutionalize evaluation, validation, and governance frameworks for ML/GenAI systems, including model performance tracking, prompt evaluation, safety guardrails, hallucination mitigation, and compliance.
Partner directly with business stakeholders and product leaders to translate objectives into data-driven AI/ML solutions , ensuring measurable value through well-defined data pipelines, KPIs, and experimentation frameworks.
Establish and enforce best practices in MLOps, LLMOps, DataOps, and DevOps , including CI/CD pipelines, Databricks workflows , monitoring, observability, reproducibility, and cost optimization.
Architect and oversee scalable cloud-based data and AI platforms , integrating Databricks Lakehouse, Spark processing layers, and cloud-native services for unified analytics and AI workloads.
Drive experimentation strategy, including A/B testing, prompt optimization, and data-driven iteration , leveraging SQL analytics and Python-based experimentation frameworks .
Provide mentorship to L4 and L5 engineers in data engineering (Spark, SQL, Databricks) and AI/ML development (Python, GenAI frameworks) , including design reviews, code reviews, and career guidance.
Lead cross-functional collaboration across data engineering, data science, platform engineering, and business teams to deliver integrated, production-grade AI solutions.
Stay at the forefront of advancements in data engineering (Spark ecosystem, lakehouse architectures) and Generative AI/agentic systems , driving adoption of new technologies and best practices.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Principal Architect with these qualifications.

Basic Qualifications

Doctorate degree and 2 years of experience

Master’s degree and 4 years of experience

Bachelor’s degree and 6 years of experience

Associate’s degree and 10 years of experience

High school diploma / GED and 12 years of experience

Preferred Qualifications

Deep expertise in machine learning, deep learning, and Generative AI (LLMs, transformers, embeddings, fine-tuning techniques).
Proven track record of leading and delivering production-grade ML/GenAI systems end-to-end with measurable business impact with strong experience in designing scalable system architectures for ML and GenAI, including distributed systems and high-throughput pipelines.
Expertise in MLOps/LLMOps ecosystems (MLflow, Kubeflow, Airflow, CI/CD, Docker, Kubernetes).
Strong system design, architecture, and problem-solving skills with the ability to operate independently and lead large initiatives.
Demonstrated proficiency in leveraging cloud platforms (AWS, Azure, GCP) for data engineering solutions. Strong understanding of cloud architecture principles and cost optimization strategies.
Proven ability to mentor and guide junior and mid-level engineers (L4/L5).

Good-to-Have Skills:

Cloud certifications (AWS, Azure, or GCP) are a plus.
Strong experience with big data ecosystems, including Apache Spark, Hadoop, and large-scale distributed data processing.
Deep expertise in data engineering, including building and optimizing scalable data pipelines and platforms using Databricks, Spark, SQL, and Python.
Advanced proficiency in Python and modern ML/AI frameworks (e.g., PyTorch, TensorFlow, Hugging Face, LangChain, or similar).
Experience designing robust evaluation and validation frameworks, including automated evaluations, human-in-the-loop systems, safety testing, and monitoring.
Extensive experience with Retrieval-Augmented Generation (RAG) architectures, vector databases, and knowledge-grounded AI systems.
Strong understanding of agentic AI frameworks, including orchestration, planning, memory management, and tool integration.
Solid foundation in statistical modeling, experimentation design (A/B testing), and causal inference.
Experience with NLP, semantic search, embeddings, and vector search systems.
Familiarity with Responsible AI practices, including fairness, explainability, governance, and regulatory compliance.
Hands-on experience with cloud-native AI/ML services across AWS, Azure, or GCP, including cost and performance optimization.
Experience with the Databricks Lakehouse platform for enterprise-scale data engineering, ML, and GenAI workloads.
Exposure to advanced evaluation techniques such as red-teaming, adversarial testing, and synthetic data generation.
Strong experience in data modeling and performance tuning for both OLAP and OLTP systems.
Hands-on experience with workflow orchestration tools such as Apache Airflow, and distributed processing frameworks like Apache Spark.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.

We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation.

Apply About employer

More about this job

Skills

Machine learning
ML
Data engineering
Process data
Databricks
Apache Spark
SQL
Python
AWS
Google Cloud
Microsoft Azure
Data modelling
Decision making
Regulatory compliance
DevOps
CI/CD
Provide mentorship
Collaboration
Deep learning
Tuning techniques
Mlflow
Kubeflow
Apache Airflow
Docker
Kubernetes
Problem solving
Apache Hadoop
PyTorch
TensorFlow
Hugging Face
LangChain
Natural language processing
Workflow
Compensation and benefits
Sales

Report this job