Jobs in the United States

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Added 1 min ago
Rhapsody Integration Engineer / Healthcare Integration Developer
INFO ORIGIN INC
Boise, ID
Role: Rhapsody Integration Engineer / Healthcare Integration Developer
Added 2 mins ago
Senior DevOps Engineer
Hilton
Memphis, TN · Dallas, TX · McLean, VA
Build cloud platforms and containerization or orchestration technologies, such as AWS, Azure, Google Cloud, Docker, Kubernetes, or Amazon EKS.
Added 4 mins ago
Ansible Automation Engineer
Stefanini Group
Dallas, TX
Develop and maintain RESTful APIs using modern frameworks (FastAPI, Flask) to orchestrate automation workflows and implement integration patterns that connect diverse enterprise systems
Added 5 mins ago
SW
Principal, Software Engineer
Sam's West, Inc.
United States
- $143,000 to $286,000 USD / year
…results in stores quickly. We run a multi-cloud environment on Azure and GCP with multi-region resilience and progressive delivery, and we partner closely with product, positioning vendors,…
Added 5 mins ago
SF
Forward Deployed Engineer
Spring Fertility
San Francisco, CA
- $150,000 to $180,000 USD / year
…role combines software engineering, AI implementation, systems integration, product development, and operational problem solving. The engineer will work directly with clinical, laboratory,…
Added 6 mins ago
Internship - Software Development
Shive Hattery Group, Inc.
Iowa City, IA
Candidates must have current and ongoing authorization to work in the United States without employer sponsorship
Added 6 mins ago
Associate Manager, Agentic AI Engineer
Avanade Inc. Company
United States
…software engineering, generative AI, workflow automation, data integration, and technical architecture skills to build AI solutions capable of reasoning over enterprise information,…
Added 7 mins ago
Rhapsody Integration Engineer
ExecRecruitment
Remote, United States
A critical requirement for this role is strong experience with the Rhapsody Integration Engine and Integrated Disease Surveillance Systems (IDSS), as the contractor will be responsible for…
Added 8 mins ago
Ansible Automation Engineer
Stefanini Group
Dallas, TX
Develop and maintain RESTful APIs using modern frameworks (FastAPI, Flask) to orchestrate automation workflows and implement integration patterns that connect diverse enterprise systems
Added 10 mins ago
Senior Technical Project Manager
Codal
Chicago, IL
Lead technical discovery with Solution Architects and Tech Leads: facilitate architecture and integration workshops, document system dependencies, and surface feasibility risks before…
Added 10 mins ago
Senior Project Manager
Electric Power Engineers
Austin, TX
Collaborate with external stakeholders and internal teams to ensure seamless integration of software initiatives and products.
Added 19 mins ago
Data Engineer III
FedEx Dataworks
Plano, TX · Memphis, TN · Coraopolis, PA
5. Build and manage ETL (Extract, Transform, Load) processes for data integration and automate data ingestion and transformation tasks.
Added 20 mins ago
Sr. Director, DevOps
Veeam Software
San Jose, CA
…build, deploy, secure, and operate the platform across AWS, Azure, and GCP. You’ll turn infrastructure into a product, security into a default, and reliability into a measurable promise to…
Added 21 mins ago
IG
Principal QA Architect
Insight Global
Remote, United States
- $145,000 to $210,000 USD / year
Strong AI integration experience, including implementing AI-enabled solutions, intelligent automation, or LLM technologies into software development and QA workflows.
Added 21 mins ago
IG
LATAM/ India - Data Brick Engineer
Insight Global
Remote, United States
- From $45 USD / hour
Data ingestion, transformation, integration, and troubleshooting
Added 21 mins ago
AI Lead Developer
Continental Resources, Inc.
Oklahoma City, OK
Minimum ten (10) years of recent software development, application development, or systems integration experience as a seasoned, hands-on developer delivering applications to production.
Added 25 mins ago
Software Engineer Supervisor
1 CLICK LOGISTICS
Sparks, NV
…position leads the evolution of applications, champions scalable integration patterns, and ensures systems align with long term business strategy. As a key technical leader, this role…
Added 26 mins ago
Controls Automation Engineer - Maintenance
The Jackson Laboratory
Farmington, CT
…of Line (MOL) controls, automation, robotics, and instrument integration support for JMCRS, with initial emphasis on daily operational readiness and uptime for the CT CMAP (Cellular Models…
Added 28 mins ago
Senior Software Engineer
First Citizens Bank
Raleigh, NC · Columbus, OH
…activities including workflow processing, document ingestion, integration services, and performance…
Added 34 mins ago
ME
ME00702-Software Engineer / AI/ML Developer
Momentum Engineering, Inc.
Annapolis Junction, MD
- $200,000 to $245,000 USD / year
Must have active Top Secret/SCI clearance with NSA Full Scope Polygraph
Added 38 mins ago
Lead Engineer, Data & Analytics Systems & App Administration
AmerisourceBergen Services Corporation
Remote, United States
Register Azure apps and configure API permissions for Power BI.
Added 39 mins ago
Software Test Manager
Syms Strategic Group, LLC (SSG)
Blacksburg, VA
Support functional, integration, regression, user acceptance, system, and end-to-end testing activities
Added 39 mins ago
Software Test Manager
Syms Strategic Group, LLC (SSG)
Ashburn, VA
Support functional, integration, regression, user acceptance, system, and end-to-end testing activities
Added 39 mins ago
Software Test Manager
Syms Strategic Group, LLC (SSG)
Charlottesville, VA
Support functional, integration, regression, user acceptance, system, and end-to-end testing activities
Added 39 mins ago
Sr Software Engineer
Comcast
Reston, VA
Apply deep, hands-on expertise in one or more major cloud platforms (AWS, OCI, Azure, or GCP), driving the adoption of best practices in automation, CI/CD pipelines, infrastructure as code,…

ALS TDI

Scientist II

Watertown, MA, United States

$125,000 to $135,000 USD / year

Apply on als.applicantpro.com About employer

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Job details

Pay: $125,000 to $135,000 USD / year
Experience: Proven track record of 5+ years of experience in data science, with a focus on biomedical data analysis and interpretation.
Posting language: English
Posted: Nov 6, 2026

Original job description

About Us

ALS TDI is the world's leading nonprofit biotechnology organization dedicated solely to discovering and developing effective treatments for ALS. Operating without regard to profit or politics, our Watertown, Massachusetts-based lab is fueled by a global network of supporters unified to end ALS. Led by experts in drug development and individuals with ALS, we are driven by our mission to bring hope to those affected by this disease.

The Opportunity

We are seeking a highly skilled Scientist II to co-lead the management, analysis, and interpretation of complex natural history data associated with deep digital clinical phenotyping, as well as multiomics data including genomics, transcriptomics, metabolomics, and proteomics. As our research portfolio has grown, this role shares scientific leadership of the function with an existing domain expert and leads analytic planning and prioritization across a growing set of projects. This role will focus on the study of amyotrophic lateral sclerosis (ALS). The ideal candidate will possess a strong background in data science, statistics, and bioinformatics, coupled with a strong grounding in biomedical research methodologies and, ideally, direct experience in neurodegenerative disease.

What You'll Do

Analytic Planning and Grant Support:

Co-lead analytic planning and prioritization across the research portfolio in partnership with the existing domain expert.
Contribute to grant applications, progress reports, and other funder deliverables.

Data Management and Sharing:

Develop and implement robust data management strategies for clinical natural history data and multiomics datasets.
Oversee data acquisition, cleaning, curation, and integration from diverse sources to ensure data quality and consistency.
Collaborate with internal and external stakeholders to facilitate data sharing initiatives and compliance with data governance policies.
Maintain reproducible, version-controlled analytic code and documentation using Git and GitHub.

Data Harmonization and Integration:

Lead efforts to harmonize heterogeneous datasets, including clinical, genomic, transcriptomic, and proteomic data, including single-cell, single-nucleus, and spatial modalities, to enable comprehensive analysis.
Develop and apply advanced algorithms and methods for data integration to extract meaningful insights and identify correlations across different data modalities.

Data Analysis and Interpretation:

Utilize statistical and machine learning techniques to analyze multiomics datasets, with a focus on identifying disease biomarkers, prognostic factors, and therapeutic targets relevant to ALS and other neurodegenerative diseases.
Conduct exploratory data analysis and hypothesis testing to uncover patterns, trends, and associations within the data.
Work closely with domain experts to validate findings and translate analytical results into actionable insights for research and clinical applications.

Communication and External Engagement:

Communicate findings effectively through compelling data visualizations, reports, and presentations tailored to diverse audiences, including researchers, clinicians, and stakeholders.
Collaborate with cross-functional teams to disseminate research findings through scientific publications, conference presentations, and other knowledge-sharing platforms.
Serve as a scientific point of contact for funders and collaborators, and represent the work at conferences and collaborator meetings, which involves periodic off-site travel.

What You'll Bring

Advanced proficiency in programming languages including R and/or Python along with Linux command line fluency.
Comfort with technical documentation and with version control using Git and GitHub for collaborative, reproducible work.
PhD or equivalent advanced degree in data science, bioinformatics, computational biology, or a related field.
Proven track record of 5+ years of experience in data science, with a focus on biomedical data analysis and interpretation.
Expertise in statistical modeling and machine learning applied to complex biomedical datasets, including longitudinal mixed-effects models, survival and time-to-event analysis, and the development and validation of prognostic models.
Familiarity with cloud computing platforms (AWS, GCP, and/or Azure), including compute, storage, and access management for data sharing.
Experience in neuroscience, neurology, or a related biomedical domain (ALS or other neurodegenerative disease experience strongly preferred), and familiarity with relevant clinical research methodologies and data resources.
Experience working with natural history data and multiomics datasets.
Familiarity with data from digital health technologies (e.g., wearable sensors, speech recordings, and app-based assessments) and with time-series methods for analyzing them.
Familiarity with standardized clinical vocabularies and common data models, particularly the OMOP Common Data Model and OHDSI tooling.
Excellent communication and interpersonal skills, with the ability to collaborate effectively with multidisciplinary teams and communicate technical concepts to non-technical stakeholders.
Proven ability to manage multiple projects simultaneously, prioritize tasks, and deliver high-quality results within tight deadlines, and to coordinate contributions from others across a team.
Familiarity with data sharing policies, ethical considerations, and regulatory requirements in biomedical research.

Nice to have: We do not expect any single candidate to have experience in all of the following areas:

Genetics and integrative genomics

Whole-genome or whole-exome sequencing analysis, including variant calling and repeat-expansion detection (e.g., C9orf72).
Integrative genomics linking cell-specific expression to genotype (e.g., eQTLs, allele-specific expression, GWAS loci, rare variants, colocalization).

Single-cell, spatial, and RNA biology

Single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq), ideally including snRNA-seq of human brain or spinal cord tissue.
Single-cell experimental design and statistical analysis, including quality control, normalization, batch correction, donor-level effects, cell annotation, differential expression and abundance, and pseudobulk approaches.
Single-cell multimodal analysis (e.g., scATAC-seq, 10x Multiome).
Spatial transcriptomics or other spatial omics.
Cell-state and trajectory analysis (e.g., pseudotime, RNA velocity, pathway and regulatory network analysis, cell-cell communication).
Integration of bulk and single-cell data, including deconvolution of bulk RNA-seq.
RNA splicing, transcript isoform, or RNA-protein interaction (e.g., CLIP-seq) analysis.

Functional genomics and cellular phenotyping

Perturbational and functional genomics (e.g., CRISPR screens, RNAi or antisense oligonucleotide perturbations, transcriptional responses to compounds).
High-content cellular phenotyping, including integration of microscopy-derived phenotypes with transcriptomic and other molecular data.

Proteomics, workflow engineering, and data standards

Proteomics data analysis, particularly from affinity-based platforms (e.g., SomaScan, Olink), including normalization, quality control, and handling of platform-specific technical artifacts.
Omics workflow engineering (e.g., Nextflow or Snakemake, containers, HPC or cloud pipelines), including reproducible processing from raw sequencing data onward.
GA4GH standards and phenotype ontologies such as Phenopackets, Mondo, and the Human Phenotype Ontology.
Interest in LinkML or similar tools for defining and validating data schemas.

What We Offer

Meaningful, Mission-Driven Work: Play a vital role in the fight against ALS. You'll engage passionate supporters and see the direct impact of your work on a mission that truly matters.

Flexibility & Collaboration: Enjoy a hybrid position supported by a highly connected, collaborative team.

Exceptional Benefits Package: We are proud to invest in our team's health, wealth, and well-being with a comprehensive benefits package:

Outstanding Health Coverage: Medical insurance with a company-funded HRA that covers 100% of your deductible for you and your dependents, plus comprehensive dental and vision plans.
Financial Security: A 403(b) retirement plan with a 4% company match and access to Flexible Spending Accounts (FSA).
Complete Peace of Mind: We provide company-paid short-term disability, long-term disability, and life insurance at no cost to you.
Generous Time Off: Recharge with our Unlimited PTO policy, in addition to 12 paid company holidays.

Engage Our Community: Represent ALS TDI and connect with our incredible supporters at major marathons and community events across the country.

A Culture of Respect & Integrity: Join a team where tenacity, resourcefulness, and compassion are at the heart of everything we do.

Join Us

Join our dynamic team at the forefront of neurodegenerative disease research, and contribute to advancing our understanding of ALS through innovative data-driven approaches.

ALS-TDI is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

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Jobs in the United States