Jobs in the United States

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Added 2 mins ago
MO
Platform & Analytics Engineer
Mutual of Omaha Mortgage
Irvine, CA
- $100 USD / hour
Mutual of Omaha Mortgage is looking for a hands-on Platform & Analytics Engineer who lives in two worlds: building the dashboards and reporting that drive decisions across our forward and…
Added 3 mins ago
VH
Senior Data Engineer
Vatica Health
Remote, United States
- $115,000 to $125,000 USD / year
As a Senior Data Engineer, you will design, build, and operate the data pipelines and APIs that support our data-driven and AI-enabled products. You will own how data moves from ingestion…
Added 5 mins ago
Electronics Engineer
Booz Allen Hamilton_United States
El Paso, TX
As an Electronics Engineer specializing in drone forensics, you will play a vital role in supporting law enforcement and national security investigations involving unmanned aerial systems…
Added 5 mins ago
Digital Forensic Analyst
Booz Allen Hamilton_United States
El Paso, TX
…specialized toolsets needed to develop new capabilities, reverse‑engineer electronic systems, and uncover artifacts that others overlook. Working alongside a multidisciplinary team of…
Added 5 mins ago
Data Engineer, Senior
Booz Allen Hamilton_United States
Huntsville, AL
…unstructured data available today than ever before. As a data engineer, you know that organizing data can yield pivotal insights when it’s gathered from disparate sources. We need an…
Added 5 mins ago
Electronics Technician
Booz Allen Hamilton_United States
El Paso, TX
…specialized toolsets needed to develop new capabilities, reverse‑engineer electronic systems, and uncover artifacts that others overlook. Working alongside a multidisciplinary team of…
Added 5 mins ago
Site Reliability Engineer, Senior
Booz Allen Hamilton_United States
Annapolis Junction, MD
Site Reliability Engineer, SeniorThe Opportunity:
Added 5 mins ago
Digital Twin Simulation Engineer
Booz Allen Hamilton_United States
Beavercreek, OH · Las Vegas, NV · Rome, NY
Experience with software engineering using C++ and C#, Java, or Python
Added 5 mins ago
Mechanical Engineer: RF Subsystems
HRL Laboratories
Calabasas, CA
More information on how IBM protects your personal information, including the safeguards applicable to cross-border data transfers, is available here.
Added 5 mins ago
Manufacturing Engineer [C]
Novanta Corporation
North Syracuse, NY
As a Manufacturing Engineer contractor, you will be responsible for designing, implementing and improving manufacturing processes. You will work closely with cross-functional teams to…
Added 6 mins ago
Data Engineer IV
Grainger Businesses
LAKE FOREST, IL
As the senior technical engineer, design and implement highly efficient, reusable, and scalable data processing systems and pipelines across the tech stack, including Kubernetes,…
Added 6 mins ago
Reliability Engineer (Hybrid, Remote)
Emprise Bank 2
Wichita, KS · Kansas City, MO · Omaha, NE · Sioux Falls, SD
We are currently seeking a Reliability Engineer to join our Technology team. This role is an integral part of our technology team, connecting production operations with infrastructure,…
Added 6 mins ago
Data Platform Manager- Hybrid (Applicants must reside in Pittsburgh, PA)
A.C. Coy
Remote, United States
Certifications (Preferred): Microsoft Certified: Azure Data Engineer Associate (DP-203), Databricks Certified Data Engineer Professional, or Azure Solutions Architect Expert
Added 7 mins ago
UG
Associate Software Engineer
UnitedHealth Group
Hartford, CT
- $60,200 to $107,400 USD / year
…intelligent, AI-powered solutions. As an Associate Software Engineer, you will work on an innovative portfolio of web and backend services, leveraging advanced frameworks such as React,…
Added 7 mins ago
UG
Principal Business Data Consultant - Remote
UnitedHealth Group
Schaumburg, IL
- $112,700 to $193,200 USD / year
area, you will be required to work in the office a minimum of four days per week
Added 7 mins ago
UG
Data Engineer with AI/ML
UnitedHealth Group
Minnetonka, MN
- $72,800 to $130,000 USD / year
area, you will be required to work in the office for a minimum of four days per week
Added 7 mins ago
Senior Java/Kotlin Developer
Vytwo
Dallas, TX
Mandatory technology requirement: Candidates must have strong hands-on experience with both Java and Kotlin
Added 8 mins ago
T
Sr Security Software Specialist - API Security Engineer
TIAA
Dallas, TX · Charlotte, NC
- $160,000 to $210,000 USD / year
Sr Security Software Development Engineer leads the development strategy of the API Security engineering team which is responsible for building horizontal enterprise level security…
Added 8 mins ago
Systems Reliability Engineer
T-Mobile USA, Inc.
Overland Park, KS · Frisco, TX · Bellevue, WA
The System Reliability Engineer (SRE) improves and protects the software and systems behind all of T-Mobile's IT services, including management of scalability, availability, latency,…
Added 12 mins ago
VDC Process Technician
Faith Technologies, Inc.
Remote, United States
The VDC Process Technician reports directly to the VDC Process Engineer and plays a critical role in supporting digital workflow optimization, maintaining model and data integrity, and…
Added 12 mins ago
GIS Solution Engineer - Defense
Esri
Denver, CO · Vienna, VA
Programming and scripting experience with languages such as Python and JavaScript
Added 12 mins ago
GIS Solution Engineer - Defense
Esri
Vienna, VA
Programming and scripting experience with languages such as Python and JavaScript
Added 13 mins ago
AB
Scientist II, Applied Machine Learning
A-Alpha Bio
Seattle, WA
- $139,000 to $175,000 USD / year
Candidates must reside in the United States
Added 14 mins ago
Network Operations Engineer (Tier 2 / L2)
Kyndryl, Inc.
Remote, United States
Flexibility and willingness to work 12-hour day shifts on an alternating staggered schedule aligned with Eastern Time (ET) client operational hours
Added 15 mins ago
Sales, Marketing, and Content Enablement Intern
Texas Instruments
Dallas, TX
Put your talent to work with us as a Product Marketing Engineer Intern !

A-Alpha Bio

Scientist II, Applied Machine Learning

Seattle, WA, United States

$139,000 to $175,000 USD / year

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Job details

Pay: $139,000 to $175,000 USD / year
Work location: Candidates must reside in the United States
Posting language: English
Posted: Nov 10, 2026

Original job description

A-Alpha Bio is an early-stage, rapidly growing biotechnology platform company headquartered in Seattle, WA. We are focused on building the foundational data layer for AI-driven protein engineering. We provide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models. In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics.

A-Alpha Bio is headquartered in Seattle, WA, but remote applicants are welcome to apply. Candidates must reside in the United States.

Starting Salary Range: $139,000 - $175,000 annually

Exemption Status: Exempt

Location Expectations: Remote-Eligible (expected travel to Seattle HQ once per quarter)

Reporting To: Director, Applied Machine Learning

Role Description

A-Alpha Bio is seeking a Scientist II to join our Applied Machine Learning team in turning large-scale protein interaction data into insights and models that advance antibody and protein engineering. In this role, you’ll lead computational work for both internal research and external collaborations, from defining scientific questions and analysis plans to developing models and communicating results. Working with AlphaSeq datasets, you’ll connect experimental measurements with protein sequence and structural information to understand binding, evaluate computational design methods, and guide future experiments. Success in this role will depend on ability to state assumptions, clearly define goals and objectives, and explain your procedures thoughtfully.

Key Responsibilities

Lead scientific analyses:Define and execute analysis plans for large-scale protein interaction datasets (often 1M PPIs), including evaluating binding affinity, specificity, and the performance of antibody and protein design methods.
Develop and evaluate ML models: Build, train, and apply models using experimental measurements, protein sequences, and structural information. Design rigorous benchmarks and assess model performance, uncertainty, and generalization.
Connect computation with experiments: Collaborate with experimental scientists to shape study designs, interpret results, investigate unexpected findings, and recommend follow-up experiments.
Deliver results to external partners: Serve as the computational lead for assigned projects, producing clear presentations, reports, and well-documented datasets for both internal teams and external collaborators. Many projects may have open-source elements, requiring a strong eye for detail and narrative.
Build reusable methods: Translate project-specific work into reliable analytical tools and workflows. Contribute maintainable Python code, review contributions, and document methods so others can use them.
Advance our scientific capabilities: Identify and develop new computational approaches that increase the value of AlphaSeq data for protein engineering.

Qualifications & Experience

Required

PhD in a relevant field with 2+ years of experience working on large-scale data analysis using biological sequence or structure data; or a bachelor’s degree with 10+ years of relevant experience, including 5+ years working onlarge-scale data analysis using biological sequence or structure data; or an equivalent education and experience.
Demonstrated expertise in Python for scientific computing, data analysis, visualization, and ML model development.
Experience analyzing large experimental datasets and making scientifically defensible decisions about data quality, statistical methods, and interpretation.
Strong understanding of model evaluation, including appropriate baselines, data leakage, and the limits of conclusions drawn from a benchmark.
Ability to translate an open-ended scientific question into an executable plan and deliver reproducible results with limited supervision.
Clear communication skills, including the ability to explain methods, findings, and limitations to computational and experimental audiences.
Experience contributing to a shared codebase through version control, code review, and documentation.

Preferred

Experience with antibody or protein engineering, particularly the relationship between sequence, structure, and binding.
Familiarity with the structural modeling of protein complexes and evaluation of structure prediction or generative design methods.
Use of modern ML frameworks such as PyTorch, TensorFlow, or Hugging Face.
Experience processing and analyzing next-generation sequencing data, (Illumina, Oxford Nanopore, etc.).
Experience developing analytical tools or workflows used by other scientists.

In 2018, A-Alpha Bio spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company’s inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.

A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle’s Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!

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Jobs in the United States