Jobs in the United States

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Added 3 hours ago
SO
Forensic Structural Engineer II, Minneapolis, MN
Salas O'Brien
Minneapolis, MN
- $100,000 to $140,000 USD / year
Job Summary: We’re seeking a Forensic Structural Engineer in the Minneapolis, MN area. In this remote/home office role, you will investigate and evaluate the cause and extent of structural…
Added 4 hours ago
CO
Engineer I.II - Public Works
City of San Jose
San Jose, CA
- $121,605.12 to $153,928.32 USD / year
Engineer I: $107,256.24 - $135,713.76 annually
Added 7 hours ago
AB
Scientist II, Applied Machine Learning
A-Alpha Bio
Seattle, WA
- $139,000 to $175,000 USD / year
Candidates must reside in the United States
Added 8 hours ago
Senior Structures (Bridge) Design Engineer
CDR Companies
Mechanicsburg, PA
CDR Maguire Engineering delivers solutions that move people, and we are looking for a Senior Structural/Bridge Design Engineer to join our Transportation Engineering Division in our…
Added 8 hours ago
Senior Structures (Bridge) Design Engineer
CDR Companies
Harrisburg, PA
CDR Maguire Engineering delivers solutions that move people, and we are looking for a Senior Structural/Bridge Design Engineer to join our Transportation Engineering Division in our…
Added 8 hours ago
Electrical Design Engineer II-III
Revamp Engineering
Remote, United States
As a Design Engineer on Revamp’s PV BESS Electrical team, you help accelerate the clean energy transition by designing the electrical systems for utility-scale solar PV and battery energy…
Added 8 hours ago
EM
Associate Engineer I/II
Eastern Municipal Water District
Perris, CA
- $68.98 to $85.92 USD / hour
Under direction (Associate Engineer I) to general direction (Associate Engineer II), performs complex professional engineering work in the research, planning, hydraulic modeling, design and…
Added 10 hours ago
Senior Construction Inspector
Terracon
El Paso, TX · Las Cruces, NM
…adherence to building code requirements, construction drawings and project specifications. Inspections may cross multiple inspection disciplines or within a specified area of expertise…
Added 10 hours ago
Mechanical Design and Manufacturing Engineer
Canopy A&D
Irvine, CA
Must have professional working proficiency reading, writing, and speaking English
Added 11 hours ago
A
Piping Engineer
Actalent
Downers Grove, IL
- $35 to $48 USD / hour
Job Title: Piping Engineer (Stress Engineer I)Job DescriptionThis early-career Piping Engineer role focuses on piping stress analysis, system flexibility, piping supports, and mechanical…
Added 11 hours ago
A
Piping Engineer
Actalent
Downers Grove, IL
- $35 to $48 USD / hour
Job Title: Piping Engineer (Stress Engineer I)Job DescriptionThis early-career Piping Engineer role focuses on piping stress analysis, system flexibility, piping supports, and mechanical…
Added 12 hours ago
Facilities Engineer II
Westinghouse Electric Company, LLC
Hopkins, SC
As a Principal Facilities Mechanical Engineer, you will provide senior technical leadership and facilities mechanical engineering support for the LEU+ Fuel Fabrication Facility Construction…
Added 12 hours ago
AP
Design Engineer/Sr. Design Engineer
AMPAM Parks Mechanical
Carson, CA · Corona, CA
- From $34 USD / hour
…committed to delivering quality, safety, and excellence in every…
Added 12 hours ago
EN
Refrigeration Design Engineer II
ESPEC North America Inc
Hudsonville, MI
- $73,500 to $84,400 USD / year
· 4 to 8 years of professional experience in a manufacturing environment, serving as a mechanical, manufacturing, process, or project engineer required.
Added 19 hours ago
CM
Quality Engineer II
Cirtec Medical Corporation
Brooklyn Park, MN
- $80,000 to $95,000 USD / year
Must possess excellent verbal communication, organizational and management skills
Added 21 hours ago
Launch Engineer, Fluid Systems (Starship)
SpaceX
Starbase, TX · Brownsville, TX
…and initial sizing, detailed pressurized fluid and thermal analysis, structural engineering, materials, and component selection, and cost/schedule…
Added 21 hours ago
Mechanical Engineer, Launch Mount/Tower (Starship)
SpaceX
Starbase, TX · Brownsville, TX
As a mechanical engineer, you will develop the Starship Tower, Launch Mount, and test stands from system architecture through design, analysis, manufacturing, integration, activation, and…
Added 1 day ago
Sr. Mechanical Design Engineer, Consumer Hardware (Starlink)
SpaceX
Bastrop, TX
Solid understanding and application of GD&T, mechanical engineering fundamentals, structural analysis, and failure modes of complex mechanical systems
Added 1 day ago
Senior Ground Support Engineer I
Rocket Lab Corporation
Middle River, MD
Perform structural analysis through hand calculations and FEA to ensure designs meet margining requirements
Added 1 day ago
Ground Support Engineer II
Rocket Lab Corporation
Middle River, MD
Perform structural analysis through hand calculations and FEA to ensure designs meet margining requirements
Added 1 day ago
Sr Engineer, Mechanical Design
RTX
United States
Qualifications You Must Have
Added 1 day ago
Consulting Engineer
Simpson Gumpertz & Heger
Washington, DC
PE license required; SE license preferred (if applicable)
Added 1 day ago
Design Criteria Engineer (Starshield)
SpaceX
Hawthorne, CA
Must have an ongoing drive for continuous improvement in all aspects of work
Added 1 day ago
Tool Design Engineer II
Rocket Lab Corporation
Long Beach, CA
Based out of Rocket Lab's Headquarters in Long Beach, CA the Tool Design Engineer II is responsible for design, specification, analysis, procurement, and operation of Ground Support…
Added 1 day ago
Advanced Manufacturing Engineer II
HUSCO International, Inc.
Waukesha, WI
As an Advanced Manufacturing Engineer with Husco, you will be responsible for project design/leadership of automation equipment- typically new product lines for OEM applications,…

A-Alpha Bio

Scientist II, Applied Machine Learning

Seattle, WA, United States

$139,000 to $175,000 USD / year

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Job details

Pay: $139,000 to $175,000 USD / year
Work location: Candidates must reside in the United States
Posting language: English
Posted: Nov 10, 2026

Original job description

A-Alpha Bio is an early-stage, rapidly growing biotechnology platform company headquartered in Seattle, WA. We are focused on building the foundational data layer for AI-driven protein engineering. We provide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models. In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics.

A-Alpha Bio is headquartered in Seattle, WA, but remote applicants are welcome to apply. Candidates must reside in the United States.

Starting Salary Range: $139,000 - $175,000 annually

Exemption Status: Exempt

Location Expectations: Remote-Eligible (expected travel to Seattle HQ once per quarter)

Reporting To: Director, Applied Machine Learning

Role Description

A-Alpha Bio is seeking a Scientist II to join our Applied Machine Learning team in turning large-scale protein interaction data into insights and models that advance antibody and protein engineering. In this role, you’ll lead computational work for both internal research and external collaborations, from defining scientific questions and analysis plans to developing models and communicating results. Working with AlphaSeq datasets, you’ll connect experimental measurements with protein sequence and structural information to understand binding, evaluate computational design methods, and guide future experiments. Success in this role will depend on ability to state assumptions, clearly define goals and objectives, and explain your procedures thoughtfully.

Key Responsibilities

Lead scientific analyses:Define and execute analysis plans for large-scale protein interaction datasets (often 1M PPIs), including evaluating binding affinity, specificity, and the performance of antibody and protein design methods.
Develop and evaluate ML models: Build, train, and apply models using experimental measurements, protein sequences, and structural information. Design rigorous benchmarks and assess model performance, uncertainty, and generalization.
Connect computation with experiments: Collaborate with experimental scientists to shape study designs, interpret results, investigate unexpected findings, and recommend follow-up experiments.
Deliver results to external partners: Serve as the computational lead for assigned projects, producing clear presentations, reports, and well-documented datasets for both internal teams and external collaborators. Many projects may have open-source elements, requiring a strong eye for detail and narrative.
Build reusable methods: Translate project-specific work into reliable analytical tools and workflows. Contribute maintainable Python code, review contributions, and document methods so others can use them.
Advance our scientific capabilities: Identify and develop new computational approaches that increase the value of AlphaSeq data for protein engineering.

Qualifications & Experience

Required

PhD in a relevant field with 2+ years of experience working on large-scale data analysis using biological sequence or structure data; or a bachelor’s degree with 10+ years of relevant experience, including 5+ years working onlarge-scale data analysis using biological sequence or structure data; or an equivalent education and experience.
Demonstrated expertise in Python for scientific computing, data analysis, visualization, and ML model development.
Experience analyzing large experimental datasets and making scientifically defensible decisions about data quality, statistical methods, and interpretation.
Strong understanding of model evaluation, including appropriate baselines, data leakage, and the limits of conclusions drawn from a benchmark.
Ability to translate an open-ended scientific question into an executable plan and deliver reproducible results with limited supervision.
Clear communication skills, including the ability to explain methods, findings, and limitations to computational and experimental audiences.
Experience contributing to a shared codebase through version control, code review, and documentation.

Preferred

Experience with antibody or protein engineering, particularly the relationship between sequence, structure, and binding.
Familiarity with the structural modeling of protein complexes and evaluation of structure prediction or generative design methods.
Use of modern ML frameworks such as PyTorch, TensorFlow, or Hugging Face.
Experience processing and analyzing next-generation sequencing data, (Illumina, Oxford Nanopore, etc.).
Experience developing analytical tools or workflows used by other scientists.

In 2018, A-Alpha Bio spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company’s inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.

A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle’s Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!

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Jobs in the United States