Jobs in the United States

25+ jobs

Group jobs by employerEmail me new jobs Save this search

Added just now
BIM / VDC Coordinator II / III
Dennis Group
Springfield, MA
Contribute to the development of BIM Execution Plan (BEP) strategies and lead client interactions with support from the BIM/VDC Manager.
Added just now
System Assessment Senior Systems Engineer (Job ID: 4693)
Valkyrie
Huntsville, AL
Must have understanding of MDA systems engineering processes and procedures · Must have experience with MDA system elements (e.g., Patriot, THAAD, Aegis, C2BMC)
Added just now
Junior Optical Engineer or Physicist (Job ID:4692)
Valkyrie
Huntsville, AL
Must have a BA/BS in optical engineering, physics or related area and at least 0-10 years of related experience · Must have the ability to conduct research and perform analysis on optical requirements and designs
Added 1 min ago
Summer 2027 Software Engineer enGen Graduate Intern
Highmark Health
Jefferson City, MO
The Summer 2027 Software Engineer enGen Graduate Internship provides graduate students with an opportunity to gain hands-on experience developing and modernizing enterprise healthcare…
Added 1 min ago
Knowledge and Data Manager
BB&E
Tyndall Air Force Base, FL
…our team, managing daily operations for the Air Force Civil Engineer Execution (AFCEC/CFD) Special Programs Division at Tyndall, AFB located in Panama City, FL. The role will handle…
Added 1 min ago
Environmental Engineer/Scientist/Geologist
BB&E
Remote, United States
BB&E is seeking a dynamic and detail-oriented Environmental Engineer/Scientist/Geologist to join our team, supporting the Air Force Civil Engineer Center (AFCEC)/Environmental Restoration…
Added 1 min ago
End-to-End Space Systems Engineers (Experienced, Lead or Senior)
The Boeing Company
El Segundo, CA
Boeing Defense, Space & Security (BDS), Space Mission Systems (SMS) Division, seeks an End-to-End Space Systems Engineer (Experienced, Lead or Senior) to join our team in El Segundo,…
Added 1 min ago
Mid-Level, Lead or Senior Satellite Systems Ground Systems Engineer
The Boeing Company
El Segundo, CA
The Boeing Space & Mission Systems MILSATCOM Program is seeking a Mid-Level, Lead or Senior Ground Systems Engineer to develop our nation’s next generation of satellite ground systems in El…
Added 1 min ago
Systems Engineer - Digital Signal Processing (Lead or Senior)
The Boeing Company
El Segundo, CA
…trades, concept studies and system definition, to satellite unit development and test. You will belong to a systems engineering team interacting with customers, suppliers, program…
Added 1 min ago
Senior Software Engineer - DevSecOps
The Boeing Company
Huntington Beach, CA
The Boeing Company is looking for a Senior Software Engineer - DevSecOps to join the P-8A Acoustic Programs team located in Huntington Beach, California. This position will focus on…
Added 1 min ago
Software Engineer, Data Systems (Experienced or Senior) | Rocky Program
The Boeing Company
Albuquerque, NM · El Segundo, CA
Boeing Defense, Space & Security (BDS) has an exciting opportunity for a Software Engineer, Data Systems to support the Space Mission Systems (SMS) Rapid Space Capabilities (RSC) portfolio,…
Added 1 min ago
Software Test & Verification Engineer (Experienced or Senior)
The Boeing Company
Albuquerque, NM · El Segundo, CA
The Boeing Company has an exciting opportunity for a Software Test & Verification Engineer to support the Space Mission Systems (SMS) Rapid Space Capabilities (RSC) portfolio, focused on…
Added 1 min ago
Structural & Payload Design Engineer (Senior or Principal)
The Boeing Company
El Segundo, CA
Boeing Defense, Space & Security (BDS) is seeking a Senior or Principal Structural & Payload Design Engineer (Level 5 or 6) in El Segundo, CA.
Added 1 min ago
Lead Electrophysics Engineer
The Boeing Company
Huntington Beach, CA · Seal Beach, CA · El Segundo, CA
Boeing Defense Space & Security (BDS) is seeking highly motivated Lead Electrophysics Engineer (Level 5) to support various programs located in Huntington Beach, CA, Seal Beach, CA, or El…
Added 1 min ago
Satellite Data Systems Full-Stack Software Engineer (Experienced or Senior)
The Boeing Company
El Segundo, CA
This position requires proven experience within the software development lifecycle, project execution/leadership, and critical thinking/problem-solving skills to engineer new solutions and…
Added 1 min ago
Computer Systems Engineer – Space Payload Emulators – (Experienced or Lead)
The Boeing Company
El Segundo, CA
As a Computer Systems Engineer, you will support the development and integration of space payload emulators in El Segundo, CA. In support of Boeing Defense Systems next-generation space…
Added 2 mins ago
Senior Staff Software Engineer, R&D - IntelliScript (Remote)
Milliman
Brookfield, WI
The Senior Staff Software Engineer will play a pivotal role in shaping the future of our organization by driving early-stage innovation and zero-to-one development of new products and…
Added 3 mins ago
Senior Production Engineer (PE -Richmond Hill Site)
MOBIS
Richmond Hill, GA
The Senior Production Engineer leads manufacturing process optimization, production improvement initiatives, and advanced problem-solving activities within a highly automated automotive…
Added 3 mins ago
Statewide Design Engineer
State of Utah Office of the Governor
Salt Lake City, UT
Current Licensure as a Professional Engineer (PE) in Utah.
Added 3 mins ago
Java Developer
ADT
Irving, TX
Workstyle: Hybrid schedule - employees work onsite a minimum of four days per week, with one remote day
Added 3 mins ago
MO
Platform & Analytics Engineer
Mutual of Omaha Mortgage
Irvine, CA
- $100 USD / hour
Mutual of Omaha Mortgage is looking for a hands-on Platform & Analytics Engineer who lives in two worlds: building the dashboards and reporting that drive decisions across our forward and…
Added 3 mins ago
Sr Platform Engineer II
Pacific Life Insurance Company
United States
We’re actively seeking a talented Sr Platform Appian Engineer II to join our BPM Enablement Platform team in Newport Beach, CA. This role is hybrid as we believe in empowering our employees…
Added 4 mins ago
RA
Senior Software Systems, Battery Algorithms Engineer
Rivian and Volkswagen Group Technologies
Irvine, CA
- $135,100 to $179,040 USD / year
As a Senior Battery Algorithms Engineer at RV Tech (RVT), you will contribute to electric vehicle (EV) technology that serves both Rivian and Volkswagen Group programs. You will develop and…
Added 4 mins ago
VH
Senior Data Engineer
Vatica Health
Remote, United States
- $115,000 to $125,000 USD / year
As a Senior Data Engineer, you will design, build, and operate the data pipelines and APIs that support our data-driven and AI-enabled products. You will own how data moves from ingestion…
Added 5 mins ago
Project Engineer II
Aerospace
Phoenix, AZ
YOU MUST HAVE

A-Alpha Bio

Scientist II, Applied Machine Learning

Seattle, WA, United States

$139,000 to $175,000 USD / year

Apply on aalphabio.com About employer

Applications open in a new tab.

Job details

Pay: $139,000 to $175,000 USD / year
Work location: Candidates must reside in the United States
Posting language: English
Posted: Nov 10, 2026

Original job description

A-Alpha Bio is an early-stage, rapidly growing biotechnology platform company headquartered in Seattle, WA. We are focused on building the foundational data layer for AI-driven protein engineering. We provide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models. In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics.

A-Alpha Bio is headquartered in Seattle, WA, but remote applicants are welcome to apply. Candidates must reside in the United States.

Starting Salary Range: $139,000 - $175,000 annually

Exemption Status: Exempt

Location Expectations: Remote-Eligible (expected travel to Seattle HQ once per quarter)

Reporting To: Director, Applied Machine Learning

Role Description

A-Alpha Bio is seeking a Scientist II to join our Applied Machine Learning team in turning large-scale protein interaction data into insights and models that advance antibody and protein engineering. In this role, you’ll lead computational work for both internal research and external collaborations, from defining scientific questions and analysis plans to developing models and communicating results. Working with AlphaSeq datasets, you’ll connect experimental measurements with protein sequence and structural information to understand binding, evaluate computational design methods, and guide future experiments. Success in this role will depend on ability to state assumptions, clearly define goals and objectives, and explain your procedures thoughtfully.

Key Responsibilities

Lead scientific analyses:Define and execute analysis plans for large-scale protein interaction datasets (often 1M PPIs), including evaluating binding affinity, specificity, and the performance of antibody and protein design methods.
Develop and evaluate ML models: Build, train, and apply models using experimental measurements, protein sequences, and structural information. Design rigorous benchmarks and assess model performance, uncertainty, and generalization.
Connect computation with experiments: Collaborate with experimental scientists to shape study designs, interpret results, investigate unexpected findings, and recommend follow-up experiments.
Deliver results to external partners: Serve as the computational lead for assigned projects, producing clear presentations, reports, and well-documented datasets for both internal teams and external collaborators. Many projects may have open-source elements, requiring a strong eye for detail and narrative.
Build reusable methods: Translate project-specific work into reliable analytical tools and workflows. Contribute maintainable Python code, review contributions, and document methods so others can use them.
Advance our scientific capabilities: Identify and develop new computational approaches that increase the value of AlphaSeq data for protein engineering.

Qualifications & Experience

Required

PhD in a relevant field with 2+ years of experience working on large-scale data analysis using biological sequence or structure data; or a bachelor’s degree with 10+ years of relevant experience, including 5+ years working onlarge-scale data analysis using biological sequence or structure data; or an equivalent education and experience.
Demonstrated expertise in Python for scientific computing, data analysis, visualization, and ML model development.
Experience analyzing large experimental datasets and making scientifically defensible decisions about data quality, statistical methods, and interpretation.
Strong understanding of model evaluation, including appropriate baselines, data leakage, and the limits of conclusions drawn from a benchmark.
Ability to translate an open-ended scientific question into an executable plan and deliver reproducible results with limited supervision.
Clear communication skills, including the ability to explain methods, findings, and limitations to computational and experimental audiences.
Experience contributing to a shared codebase through version control, code review, and documentation.

Preferred

Experience with antibody or protein engineering, particularly the relationship between sequence, structure, and binding.
Familiarity with the structural modeling of protein complexes and evaluation of structure prediction or generative design methods.
Use of modern ML frameworks such as PyTorch, TensorFlow, or Hugging Face.
Experience processing and analyzing next-generation sequencing data, (Illumina, Oxford Nanopore, etc.).
Experience developing analytical tools or workflows used by other scientists.

In 2018, A-Alpha Bio spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company’s inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.

A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle’s Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!

Apply on aalphabio.com About employer

Report this job

Work requirements

Jobs in the United States